Lorenzo Leoncini

Summary

Affiliation: University of Siena
Country: Italy

Publications

  1. pmc Alteration of microRNAs regulated by c-Myc in Burkitt lymphoma
    Anna Onnis
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    PLoS ONE 5:. 2010
  2. pmc Epstein-Barr nuclear antigen 1 induces expression of the cellular microRNA hsa-miR-127 and impairing B-cell differentiation in EBV-infected memory B cells. New insights into the pathogenesis of Burkitt lymphoma
    A Onnis
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Blood Cancer J 2:e84. 2012
  3. pmc HIV-1 Tat mimetic of VEGF correlates with increased microvessels density in AIDS-related diffuse large B-cell and Burkitt lymphomas
    J Nyagol
    Department of Human Pathology and Oncology, University of Siena, Via delle Scotte 6, 53100, Siena, Italy
    J Hematop 1:3-10. 2008
  4. ncbi request reprint Expression of p34(cdc2) and cyclins A and B compared to other proliferative features of non-Hodgkin's lymphomas: a multivariate cluster analysis
    L Leoncini
    Institute of Pathology, University of Sassari, Sassari, Italy
    Int J Cancer 83:203-9. 1999
  5. ncbi request reprint Aggressive B-cell lymphomas: a review based on the workshop of the XI Meeting of the European Association for Haematopathology
    L Leoncini
    Dipartimento di Patologia Umana ed Oncologia, University of Siena, Nuovo Policlinico Le Scotte, Italy
    Histopathology 46:241-55. 2005
  6. pmc Burkitt's lymphoma: new insights into molecular pathogenesis
    C Bellan
    Institute of Pathological Anatomy and Histology, University of Siena, Nuovo Policlinico Le Scotte, Via delle Scotte, 6, 53100 Siena, Italy
    J Clin Pathol 56:188-92. 2003
  7. doi request reprint B-cell differentiation in EBV-positive Burkitt lymphoma is impaired at posttranscriptional level by miRNA-altered expression
    Eleonora Leucci
    Department of Human Pathology and Oncology, University of Siena, 53100 Siena, Italy
    Int J Cancer 126:1316-26. 2010
  8. ncbi request reprint Retinoblastoma gene family expression in lymphoid tissues
    L Leoncini
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Oncogene 25:5309-14. 2006
  9. pmc Cell kinetics and cell cycle regulation in lymphomas
    L Leoncini
    Institute of Pathological Anatomy and Histology, University of Siena, Italy
    J Clin Pathol 55:648-55. 2002
  10. doi request reprint Cdk9/Cyclin T1 complex: a key player during the activation/differentiation process of normal lymphoid B cells
    Giulia De Falco
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    J Cell Physiol 215:276-82. 2008

Detail Information

Publications53

  1. pmc Alteration of microRNAs regulated by c-Myc in Burkitt lymphoma
    Anna Onnis
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    PLoS ONE 5:. 2010
    ..It is also emerging that c-Myc modulates miRNA expression, revealing an intriguing crosstalk between c-Myc and miRNAs...
  2. pmc Epstein-Barr nuclear antigen 1 induces expression of the cellular microRNA hsa-miR-127 and impairing B-cell differentiation in EBV-infected memory B cells. New insights into the pathogenesis of Burkitt lymphoma
    A Onnis
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Blood Cancer J 2:e84. 2012
    ..A good understanding of these mechanisms will help to clarify the complex regulatory networks between host and pathogen, and favor the design of more specific treatments for EBV-associated malignancies...
  3. pmc HIV-1 Tat mimetic of VEGF correlates with increased microvessels density in AIDS-related diffuse large B-cell and Burkitt lymphomas
    J Nyagol
    Department of Human Pathology and Oncology, University of Siena, Via delle Scotte 6, 53100, Siena, Italy
    J Hematop 1:3-10. 2008
    ....
  4. ncbi request reprint Expression of p34(cdc2) and cyclins A and B compared to other proliferative features of non-Hodgkin's lymphomas: a multivariate cluster analysis
    L Leoncini
    Institute of Pathology, University of Sassari, Sassari, Italy
    Int J Cancer 83:203-9. 1999
    ..Anaplastic large-cell lymphomas predominated in cluster 3 and responded best to therapy...
  5. ncbi request reprint Aggressive B-cell lymphomas: a review based on the workshop of the XI Meeting of the European Association for Haematopathology
    L Leoncini
    Dipartimento di Patologia Umana ed Oncologia, University of Siena, Nuovo Policlinico Le Scotte, Italy
    Histopathology 46:241-55. 2005
    ....
  6. pmc Burkitt's lymphoma: new insights into molecular pathogenesis
    C Bellan
    Institute of Pathological Anatomy and Histology, University of Siena, Nuovo Policlinico Le Scotte, Via delle Scotte, 6, 53100 Siena, Italy
    J Clin Pathol 56:188-92. 2003
    ..The results point out the heterogeneity of BL and suggest that AIDS related BL may have a different pathogenesis from that of classic BL...
  7. doi request reprint B-cell differentiation in EBV-positive Burkitt lymphoma is impaired at posttranscriptional level by miRNA-altered expression
    Eleonora Leucci
    Department of Human Pathology and Oncology, University of Siena, 53100 Siena, Italy
    Int J Cancer 126:1316-26. 2010
    ..The overexpression of this miRNA may thus represent a key event in the lymphomagenesis of EBV positive BL, by blocking the B-cell differentiation process...
  8. ncbi request reprint Retinoblastoma gene family expression in lymphoid tissues
    L Leoncini
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Oncogene 25:5309-14. 2006
    ..In this review, we will summarize the current knowledge about the role of the RB proteins in reactive and neoplastic lymphoid tissue...
  9. pmc Cell kinetics and cell cycle regulation in lymphomas
    L Leoncini
    Institute of Pathological Anatomy and Histology, University of Siena, Italy
    J Clin Pathol 55:648-55. 2002
    ..A re-evaluation of parameters of cell kinetics in view of our increasing knowledge of the molecular pathways of cell cycle control may provide more prognostic information for the management of patients with malignant lymphomas...
  10. doi request reprint Cdk9/Cyclin T1 complex: a key player during the activation/differentiation process of normal lymphoid B cells
    Giulia De Falco
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    J Cell Physiol 215:276-82. 2008
    ..Taken together this data suggests an active role for the Cdk9/Cyclin T1 complex during lymphoid differentiation through germinal center reaction...
  11. ncbi request reprint Interaction between HIV-1 Tat and pRb2/p130: a possible mechanism in the pathogenesis of AIDS-related neoplasms
    Giulia De Falco
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Oncogene 22:6214-9. 2003
    ..The interaction between Tat and pRb2/p130 seems to result in the deregulation of the control exerted by pRb2/p130 on the cell cycle. Taken together, these results open a window on the role of pRb2/p130 in AIDS-related oncogenesis...
  12. doi request reprint Geographic variation and environmental conditions as cofactors in Chlamydia psittaci association with ocular adnexal lymphomas: a comparison between Italian and African samples
    Alessandro Carugi
    Department Human Pathology and Oncology, University of Siena, 53100 Siena, Italy
    Hematol Oncol 28:20-6. 2010
    ..psittaci-positive cases. We may conclude that the role of epidemiologic, environmental and genetic factors, must be considered in the aetiology of this disease...
  13. ncbi request reprint Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 infection in reactive lymphoid tissues: a model for KSHV/HHV-8-related lymphomas?
    Stefano Lazzi
    Department of Human Pathology and Oncology, University of Siena, 53100, Italy
    Hum Pathol 37:23-31. 2006
    ..In conclusion, the maturation stage of KSHV/HHV-8-positive B cells as well as the type of viral infection may well determine the morphological, phenotypic, and clinical characteristics of KSHV/HHV-8-associated lymphomas...
  14. ncbi request reprint Gene-expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt lymphoma cell lines and primary tumors
    Giulia De Falco
    Department of Human Pathology and Oncology, University of Siena, Italy
    Blood 110:1301-7. 2007
    ..In conclusion, these data suggest that, as RBL2/p130 modulates the expression of target genes, which are important for cell growth and viability, its inactivation may be relevant for the occurrence of BL...
  15. doi request reprint Rare lymphoid neoplasms coexpressing B- and T-cell antigens. The role of PAX-5 gene methylation in their pathogenesis
    Stefano Lazzi
    Department of Human Pathology and Oncology, University of Siena, 53100 Siena, Italy
    Hum Pathol 40:1252-61. 2009
    ..Interestingly, these cases were all characterized by poor clinical outcome...
  16. ncbi request reprint The role of the Cdk9/Cyclin T1 complex in T cell differentiation
    Eleonora Leucci
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    J Cell Physiol 212:411-5. 2007
    ....
  17. ncbi request reprint Missing expression of pRb2/p130 in human retinoblastomas is associated with reduced apoptosis and lesser differentiation
    Cristiana Bellan
    Institute of Pathologic Anatomy and Histology, University of Siena, Italy
    Invest Ophthalmol Vis Sci 43:3602-8. 2002
    ..However, only limited information is available on the role of pRb2/p130 in controlling apoptosis. The purpose of this study was to determine the extent of a role of this gene in the neoplasms that give the Rb family its name...
  18. ncbi request reprint Immunoglobulin gene analysis reveals 2 distinct cells of origin for EBV-positive and EBV-negative Burkitt lymphomas
    Cristiana Bellan
    Department of Human Pathology and Oncology, University of Siena, Italy
    Blood 106:1031-6. 2005
    ..The different types of C-MYC translocation reported in BL may also be related to the different stages of B-cell maturation...
  19. pmc CD34+ cord blood cell-transplanted Rag2-/- gamma(c)-/- mice as a model for Epstein-Barr virus infection
    Mario Cocco
    Department of Human Pathology and Oncology, Division of Pathological Anatomy, University of Siena, Siena, Italy
    Am J Pathol 173:1369-78. 2008
    ..Future experiments might allow understanding of the mechanisms responsible for persistent EBV infection and provide targets for more highly tailored therapeutic interventions...
  20. doi request reprint Role of EBV in microRNA dysregulation in Burkitt lymphoma
    Giulia De Falco
    Department of Human Pathology and Oncology, University of Siena, Via delle Scotte, 6, 53100 Siena, Italy
    Semin Cancer Biol 19:401-6. 2009
    ..In this review, we will focus on the role of EBV in malignant transformation of Burkitt lymphoma, with a particular insight in the interplay between the virus and cellular miRNAs...
  21. ncbi request reprint Urocortin expression is downregulated in human endometrial carcinoma
    Pasquale Florio
    Department of Paediatrics, Obstetrics and Reproductive Medicine, University of Siena, Italy
    J Endocrinol 190:99-105. 2006
    ..These data and the evidence that endometrial cancer expresses UCN receptors and UCN is involved in tumorigenesis of several tissues together suggest a role for UCN in endometrial tumoral cell growth and proliferation...
  22. ncbi request reprint CDK9/CYCLIN T1 expression during normal lymphoid differentiation and malignant transformation
    Cristiana Bellan
    Department of Human Pathology and Oncology, University of Siena, Italy
    J Pathol 203:946-52. 2004
    ..The molecular mechanism through which the CDK9/CYCLIN T1 complex is altered in malignant transformation needs to be elucidated...
  23. ncbi request reprint Cdk9 regulates neural differentiation and its expression correlates with the differentiation grade of neuroblastoma and PNET tumors
    Giulia De Falco
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Cancer Biol Ther 4:277-81. 2005
    ..Conversely, no significant alteration of Cdk9 expression was observed in astrocytoma tumor samples of different grades, thus confirming the results obtained for the cell lines...
  24. ncbi request reprint VEGF-D is expressed in activated lymphoid cells and in tumors of hematopoietic and lymphoid tissues
    Monia Bardelli
    Department of Molecular Biology, University of Siena, Siena, Italy
    Leuk Lymphoma 48:2014-21. 2007
    ..These data suggest that VEGF-D could contribute to leukemia and lymphoma growth via the induction of angiogenesis in bone marrow and lymphoid tissues...
  25. doi request reprint Analysis of the IgVH genes in T cell-mediated and antibody-mediated rejection of the kidney graft
    Cristiana Bellan
    Section of Pathological Anatomy, Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    J Clin Pathol 64:47-53. 2011
    ..Analysis of gene-expression patterns also provides a window on the biology and pathogenesis of renal allograft rejection...
  26. doi request reprint Selective influences in the expressed immunoglobulin heavy and light chain gene repertoire in hairy cell leukemia
    Francesco Forconi
    DM, Sezione di Ematologia e Trapianti, Dipartimento di Medicina Clinica e Scienze Immunologiche, Universita di Siena, AOUS, Viale Bracci, 53100 Siena, Italy
    Haematologica 93:697-705. 2008
    ..Those analyses raised questions on the incidence and type of selective influences occurring on the tumor B-cell receptor of hairy cell leukemia...
  27. ncbi request reprint Expression of RB2/p130 tumor-suppressor gene in AIDS-related non-Hodgkin's lymphomas: implications for disease pathogenesis
    Stefano Lazzi
    Institute of Pathological Anatomy and Histology, University of Siena, Siena, Italy
    Hum Pathol 33:723-31. 2002
    ..In conclusion, our results seem to suggest that pRb2/p130 oncosuppressor protein may be a target in the interaction between the HIV-1 gene products and host proteins...
  28. ncbi request reprint High maternal and fetal plasma urocortin levels in pregnancies complicated by hypertension
    Pasquale Florio
    Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
    J Hypertens 24:1831-40. 2006
    ....
  29. ncbi request reprint Routine assessment of hormonal receptor and her-2/neu status underscores the need for more therapeutic targets in Kenyan women with breast cancer
    Joshua Nyagol
    Department of Human Pathology and Oncology, University of Siena, Italy
    Anal Quant Cytol Histol 28:97-103. 2006
    ....
  30. pmc The alteration of lipid metabolism in Burkitt lymphoma identifies a novel marker: adipophilin
    Maria R Ambrosio
    Department of Human Pathology and Oncology, Anatomical Pathology Section, University of Siena, Siena, Italy
    PLoS ONE 7:e44315. 2012
    ..These vacuoles are not identifiable in biopsy section as lipids are "lost" during tissue processing...
  31. doi request reprint Human peripheral blood lymphocytes and fibroblasts as Notch3 expression models
    Giuseppe Di Maio
    Department of Neurological, Neurosurgical and Behavioural Sciences, University of Siena, Policlinico Le Scotte, Siena, Italy
    J Cell Physiol 227:1771-5. 2012
    ....
  32. pmc EBV Reactivation and Chromosomal Polysomies: Euphorbia tirucalli as a Possible Cofactor in Endemic Burkitt Lymphoma
    Susanna Mannucci
    Department Human Pathology and Oncology, University of Siena, 53100 Siena, Italy
    Adv Hematol 2012:149780. 2012
    ..The existence of genomic alterations might determine the accumulation of further genetic alteration, which could eventually lead to a transformed phenotype...
  33. doi request reprint A review of the trends of lymphomas in the equatorial belt of Africa
    Emily A Rogena
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Hematol Oncol 29:111-5. 2011
    ..In this review, we will summarize the state-of-the-art of lymphoma epidemiology, pathobiology and therapy, and will highlight the still existing gaps between developed and African countries...
  34. doi request reprint Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single-agent cladribine and with more aggressive behavior
    Francesco Forconi
    Ematologia e Trapianti, Universita di Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy
    Blood 114:4696-702. 2009
    ..High incidence of TP53 dysfunction indicates a potential mechanism of resistance to cladribine in the UM-HCL group. Overall, our data provide new molecular elements relevant for treatment concerns in HCL...
  35. doi request reprint High incidence of familial gastric cancer in Tuscany, a region in Italy
    Franco Roviello
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Oncology 72:243-7. 2007
    ..We studied a large cohort of gastric cancer patients from Tuscany, a region in Italy, to evaluate the presence of familial clustering of gastric cancer...
  36. ncbi request reprint Activity of rituximab monotherapy in refractory splenic marginal zone lymphoma complicated with autoimmune hemolytic anemia
    Alberto Fabbri
    Division of Hematology and Transplants, Policlinico S Maria alle Scotte, and University of Siena, Italy
    Clin Lymphoma Myeloma 6:496-9. 2006
    ..Maintenance therapy, although expensive, could be useful to improve event-free survival in patients with unfavorable clinical behavior...
  37. ncbi request reprint Immunoglobulin gene rearrangement analysis in composite hodgkin disease and large B-cell lymphoma: evidence for receptor revision of immunoglobulin heavy chain variable region genes in Hodgkin-Reed-Sternberg cells?
    Cristiana Bellan
    Institute of Pathologic Anatomy and Histopathology, University of Siena, Italy
    Diagn Mol Pathol 11:2-8. 2002
    ....
  38. ncbi request reprint pRb2/p130 and VEGF expression in endometrial carcinoma in relation to angiogenesis and histopathologic tumor grade
    Francesca Sanseverino
    Department of Gynecology, University of Siena, Nuovo Policlinico Le Scotte, Siena, Italy
    Cancer Biol Ther 5:84-8. 2006
    ..The pathogenesis of the angiogenetic phenotype may involve the inactivation of different tumor suppressor genes...
  39. doi request reprint Patients with thymomas have an increased risk of developing additional malignancies: lack of immunological surveillance?
    Felice Granato
    Thoracic Surgery Unit, Department of Cardiothoracic and Vascular Surgery, Siena University Hospital, Siena, Italy
    Histopathology 60:437-42. 2012
    ..To assess the risk, for patients with thymoma, of developing an additional malignancy (AM)...
  40. ncbi request reprint Subcutaneous panniculitis lymphoma: erythema nodosum-like
    Massimiliano Risulo
    Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Italy
    Clin Lymphoma Myeloma 7:239-41. 2006
    ....
  41. ncbi request reprint Infectious agents and lymphoma
    Giulia De Falco
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Semin Diagn Pathol 28:178-87. 2011
    ..In this review, we will focus on the association between infectious agents and lymphomas, with a look at the molecular mechanisms they use to disturb cell regulation and eventually result in cancer...
  42. ncbi request reprint Expression of the ALK protein by anaplastic large-cell lymphomas correlates with high proliferative activity
    L Leoncini
    Institute of Pathology, University of Sassari, Sassari, Italy
    Int J Cancer 86:777-81. 2000
    ..Our findings support the notion that ALK(+) and ALK(-) ALCLs are 2 distinct disease entities...
  43. ncbi request reprint The effects of HIV-1 Tat protein on cell cycle during cervical carcinogenesis
    J Nyagol
    Department of Human Pathology and Oncology, University of Siena, Italy
    Cancer Biol Ther 5:684-90. 2006
    ..We also found that this HIV-1 Tat-induced cell proliferation was not dependent on the E2F family of transcription factors, and therefore postulate that Sp factors may be involved...
  44. doi request reprint MYC translocation-negative classical Burkitt lymphoma cases: an alternative pathogenetic mechanism involving miRNA deregulation
    E Leucci
    Department of Human Pathology and Oncology, University of Siena, Italy
    J Pathol 216:440-50. 2008
    ..These results indicate for the first time that hsa-mir-34b may influence c-Myc expression in Burkitt lymphoma as the more common aberrant control exercised by the immunoglobulin enhancer locus...
  45. ncbi request reprint Pathologic aspects of AIDS malignancies
    C Bellan
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Oncogene 22:6639-45. 2003
    ..The aim of this paper is to review the pathology of AIDS-related malignancies, taking into account the pathogenetic mechanisms and their potential for improving the treatment of these tumors...
  46. ncbi request reprint Cytokeratin-positive interstitial cell neoplasm: a case report and classification issues
    K Schuerfeld
    Department of Human Pathology and Oncology, Siena University, Siena, Italy
    Histopathology 43:491-4. 2003
    ..We report a case of a CIRC tumour arising in a submandibular lymph node of a 66-year-old male...
  47. pmc p53 mutation in breast cancer. Correlation with cell kinetics and cell of origin
    T Megha
    Institute of Pathologic Anatomy and Histology, University of Siena, 53100, Italy
    J Clin Pathol 55:461-6. 2002
    ..The present study was designed to provide some of this information...
  48. pmc Update on extranodal lymphomas. Conclusions of the Workshop held by the EAHP and the SH in Thessaloniki, Greece
    E Campo
    Department of Pathology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
    Histopathology 48:481-504. 2006
    ....
  49. pmc Hodgkin's lymphoma: the pathologist's viewpoint
    S A Pileri
    Pathologic Anatomy and Haematopathology, Bologna University, Policlinico S Orsola, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Pathol 55:162-76. 2002
    ..Treatments adjusted to the pathobiological characteristics of the tumour in at risk patients have been proposed and are on the way to being applied...
  50. doi request reprint Predicting high-risk human papillomavirus infection, progression of cervical intraepithelial neoplasia, and prognosis of cervical cancer with a panel of 13 biomarkers tested in multivariate modeling
    Margherita Branca
    Unità Citoistopatologia, Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanita, Rome, Italy
    Int J Gynecol Pathol 27:265-73. 2008
    ..However, testing the performance of this marker combination in a screening setting necessitates their analysis in cytological samples...
  51. ncbi request reprint Diffuse large B-cell lymphoma: one or more entities? Present controversies and possible tools for its subclassification
    S A Pileri
    Chair of Pathologic Anatomy and Lymphoma Unit, L and A Seràgnoli Institute of Haematology and Clinical Oncology, Bologna University, Via Massarenti 9, 40138 Bologna, Italy
    Histopathology 41:482-509. 2002
    ..The more recent acquisitions on the pathobiology of DLBCLs are reviewed in the light of the authors' experience, aiming to contribute to the existing debate on the topic...
  52. ncbi request reprint [The Haemolymphopathology Italian Group (H.I.G.): an essential resource for the new technical and organization problems troubling modern haemolymphopathology diagnostics]
    M Paulli
    Sezione di Anatomia Patologica, Dipartimento di Patologia Umana ed Ereditaria, I R C C S Policlinico S Matteo, Universita di Pavia
    Pathologica 98:37-40. 2006
    ....