Research Topics
Species | Andrea LeonardiSummaryAffiliation: University of Padova Country: Italy Publications
| Collaborators
|
Detail Information
Publications
Ocular allergy: recognizing and diagnosing hypersensitivity disorders of the ocular surfaceA Leonardi
Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy
Allergy 67:1327-37. 2012....- Corneal confocal microscopy in patients with vernal keratoconjunctivitisAndrea Leonardi
Department of Neuroscience, Ophthalmology Unit, University of Padova, Padova, Italy
Ophthalmology 119:509-15. 2012..To compare corneal morphologic features using in vivo confocal microscopy in vernal keratoconjunctivitis (VKC) patients compared with normal subjects... 
Immunopathogenesis of ocular allergy: a schematic approach to different clinical entitiesAndrea Leonardi
Ophthalmology Unit, Department of Neuroscience, University of Padua, Italy
Curr Opin Allergy Clin Immunol 7:429-35. 2007..Involvement of inflammatory cells, particularly eosinophils and T cells, cytokines and proteases can lead to more serious corneal damage with vision-threatening potential...- Tumor necrosis factor-alpha (TNF-alpha) in seasonal allergic conjunctivitis and vernal keratoconjunctivitisA Leonardi
Department of Neuroscience, Ophthalmology and Ocular Inflammation Unit, University of Padova, Padova, Italy
Eur J Ophthalmol 13:606-10. 2003..To quantify the presence of the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) in allergic conjunctivitis... - Matrix metalloproteases in vernal keratoconjunctivitis, nasal polyps and allergic asthmaA Leonardi
Ophthalmology Unit, Department of Neuroscience, University of Padua, Italy
Clin Exp Allergy 37:872-9. 2007..The aim of the study was to investigate whether matrix metalloproteases contribute to different tissue remodelling aspects in different organs... - Efficacy and comfort of olopatadine versus ketotifen ophthalmic solutions: a double-masked, environmental study of patient preferenceAndrea Leonardi
Ophthalmology Unit, University of Padova, Padova, Italy
Curr Med Res Opin 20:1167-73. 2004..1% (Opatanol; Patanol [US]) and ketotifen 0.025% (Zaditen; Zaditor [US]). Patient preference for an eye drop can often be a primary factor in determining the level of compliance and satisfaction with any given therapy... - Urokinase plasminogen activator, uPa receptor, and its inhibitor in vernal keratoconjunctivitisAndrea Leonardi
Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy
Invest Ophthalmol Vis Sci 46:1364-70. 2005..The serine protease urokinase (uPA) is a potent chemoattractant for leukocytes that may be involved in the pathogenesis of severe forms of allergic conjunctivitis such as vernal keratoconjunctivitis (VKC)... - Emerging drugs for ocular allergyAndrea Leonardi
Department of Neuroscience, University of Padua, Via Giustiniani 2, 35128 Padova, Italy
Expert Opin Emerg Drugs 10:505-20. 2005..This review provides a background to ocular allergic diseases, the medical need for therapy and current and potential new treatments... - In-vivo diagnostic measurements of ocular inflammationAndrea Leonardi
Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy
Curr Opin Allergy Clin Immunol 5:464-72. 2005..The purpose of this review is to describe recent and less recent methods to assess ocular allergic inflammation... - Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast culturesA Leonardi
Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy
Clin Exp Allergy 36:777-84. 2006.... - Th1- and Th2-type cytokines in chronic ocular allergyAndrea Leonardi
Department of Neuroscience, Ophthalmology Unit, Via Giustiniani 2, 35128, Padova, Italy
Graefes Arch Clin Exp Ophthalmol 244:1240-5. 2006..The purpose of this study is to measure levels and mRNA expression of Th1- and Th2-type cytokines in patients with active vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC)... - Tear levels and activity of matrix metalloproteinase (MMP)-1 and MMP-9 in vernal keratoconjunctivitisAndrea Leonardi
Department of Neuroscience, Ophthalmology and Ocular Inflammation Unit, University of Padua, Padua, Italy
Invest Ophthalmol Vis Sci 44:3052-8. 2003..To study levels and activity of matrix metalloproteinase (MMP)-1 and -9 and their tissue inhibitor (TIMP-1) in tears of patients with vernal keratoconjunctivitis (VKC), with and without severe corneal damage... - The anti-allergic effects of a cromolyn sodium-chlorpheniramine combination compared to ketotifen in the conjunctival allergen challenge modelA Leonardi
Department of Neuroscience, Ophthalmology and Ocular Inflammation Unit, University of Padova, Italy
Eur J Ophthalmol 13:128-33. 2003..05% on the clinical allergic reaction induced by the conjunctival allergen challenge (CAC)... - Case series of 406 vernal keratoconjunctivitis patients: a demographic and epidemiological studyAndrea Leonardi
Department of Neuroscience, Clinical Ophthalmology Unit, University of Padua, Padua, Italy
Acta Ophthalmol Scand 84:406-10. 2006..To evaluate the specific allergic sensitization and epidemiological characteristics of vernal keratoconjunctivitis (VKC)... - Histamine H4 receptors in normal conjunctiva and in vernal keratoconjunctivitisA Leonardi
Ophthalmology Unit, Department of Neuroscience, University of Padua, Italy
Allergy 66:1360-6. 2011..Our aim was to evaluate histamine receptor expression in normal and vernal keratoconjunctivitis conjunctiva... - Transforming growth factor-β/Smad - signalling pathway and conjunctival remodelling in vernal keratoconjunctivitisA Leonardi
Ophthalmology Unit, Department of Neuroscience, University of Padua, Padua, Italy
Clin Exp Allergy 41:52-60. 2011..Sma- and Mad-related proteins (Smad) modulate extracellular matrix gene expression during wound healing, inflammation and tissue remodelling... - Cytokine and chemokine levels in tears and in corneal fibroblast cultures before and after excimer laser treatmentAndrea Leonardi
Department of Neuroscience, Ophthalmology Unit, University of Padua, Italy
J Cataract Refract Surg 35:240-7. 2009..To measure multiple cytokine and chemokine production in tears of myopic patients before and after laser in situ keratomileusis (LASIK) and in human corneal fibroblast (HCF) cultures before and after excimer laser treatment... - Olopatadine: a drug for allergic conjunctivitis targeting the mast cellAndrea Leonardi
Department of Neuroscience, Ophthalmology Unit, University of Padua, Via Giustiniani 2, 35128 Padova, Italy
Expert Opin Pharmacother 11:969-81. 2010..Mast cells are thus the first therapeutic target of ocular anti-allergic treatments... 
Allergy and the eyeA Leonardi
Ophthalmology Unit, Department of Neuroscience, University of Padova, Padova, Italy
Clin Exp Immunol 153:17-21. 2008..None of these agents lacks side effects and none abolishes signs and symptoms completely. New therapeutic strategies are still needed to respond to the complex pathogenesis of severe forms of ocular allergy such as VKC and AKC...- Urban eye allergy syndrome: a new clinical entity?Andrea Leonardi
Ophthalmology Unit, Department of Neuroscience, University of Padua, Italy
Curr Med Res Opin 24:2295-302. 2008..Patients affected by this pseudo-allergic form of vasomotor or idiopathic conjunctivitis usually live in urban polluted areas and may be affected by a new clinical entity called the 'urban eye allergy syndrome'... - Clinical and biological efficacy of preservative-free NAAGA eye-drops versus levocabastine eye-drops in vernal keratoconjunctivitis patientsA Leonardi
Clinica Oculistica, Department of Neuroscience, Ophthalmology Unit, Via Giustiniani 2, 35128 Padua, Italy
Br J Ophthalmol 91:1662-6. 2007..This comparative and randomised pilot study assessed the clinical and biological efficacy of Naaxia Sine(R) eye-drops versus levocabastine eye-drops in the treatment of vernal keratoconjunctivitis (VKC)... - Effects of Th2 cytokines on expression of collagen, MMP-1, and TIMP-1 in conjunctival fibroblastsAndrea Leonardi
Department of Neuroscience, Ophthalmology and Ocular Inflammation Unit, University of Padua, via Foscari 8, 35127 Padua, Italy
Invest Ophthalmol Vis Sci 44:183-9. 2003..To determine whether cytokines involved in chronic allergic conjunctival disorders may affect formation of giant papillae and tissue remodeling... - Double-masked, randomized, placebo-controlled clinical study of the mast cell-stabilizing effects of treatment with olopatadine in the conjunctival allergen challenge model in humansAndrea Leonardi
Ophthalmology Unit, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
Clin Ther 25:2539-52. 2003..This inhibition of mediator release correlated with reduction of itching and redness... - Tear and mucus eotaxin-1 and eotaxin-2 in allergic keratoconjunctivitisAndrea Leonardi
Department of Ophthalmology, University of Padua, via Foscari 8, 35127 Padua, Italy
Ophthalmology 110:487-92. 2003..The purpose of this study was to measure these chemokines in tear and mucus samples of active-disease patients and in vitro cultured conjunctival epithelial cells and fibroblasts... - Histamine-induced cytokine production and ICAM-1 expression in human conjunctival fibroblastsAndrea Leonardi
Department of Ophthalmology and Inflammatory Eye Diseases, University of Padua, Padua, Italy
Curr Eye Res 25:189-96. 2002..Conjunctival fibroblasts stimulated with histamine (H) may be directly involved in the inflammatory and remodeling processes of chronic allergic conjunctival diseases... - The central role of conjunctival mast cells in the pathogenesis of ocular allergyAndrea Leonardi
Department of Ophthalmology, University of Padova, via Foscari 8, 35127 Padova, Italy
Curr Allergy Asthma Rep 2:325-31. 2002..This review discusses the role of conjunctival mast cells in the development of ocular allergic diseases... - Efficacy and safety of desonide phosphate for the treatment of allergic conjunctivitisAndrea Leonardi
Department of Ophthalmology and Laboratory Medicine, University of Padova, via Foscari 8, 35127 Padua, Italy
Cornea 21:476-81. 2002..25% ophthalmic solution, for inhibition of the clinical allergic reaction induced by conjunctival provocation (CPT) and for the treatment of seasonal allergic conjunctivitis (SAC)... - In vitro effects of fluoroquinolone and aminoglycoside antibiotics on human keratocytesAndrea Leonardi
Department of Neuroscience, Ophthalmology Unit, University of Padova, Italy
Cornea 25:85-90. 2006..This finding is particularly relevant in deciding the optimal antibiotic to be applied in clinical situations in which the epithelium is absent or compromised, as after photorefractive keratectomy, alkali burns, or ulcerative keratitis... - Altered expression of neurotransmitter receptors and neuromediators in vernal keratoconjunctivitisLaura Motterle
Department of Neuroscience, Ophthalmology Unit, University of Padova, Padova, Italy
Arch Ophthalmol 124:462-8. 2006..5, and nerve growth factor expression. These results substantiate the involvement of an autonomic dysfunction in the pathogenesis of VKC... - Anti-inflammatory and antiallergic effects of ketorolac tromethamine in the conjunctival provocation modelA Leonardi
Department of Ophthalmology, University of Padua, Italy
Br J Ophthalmol 84:1228-32. 2000.... - Vernal keratoconjunctivitis: pathogenesis and treatmentAndrea Leonardi
Department of Ophthalmology, University of Padua, Via Giustiniani 2, 35128 Padova, Italy
Prog Retin Eye Res 21:319-39. 2002..New insights into the pathogenesis of VKC should generate the means to better design the strategies for this complex disease... - Unusual high exposure to ultraviolet-C radiationAndrea Trevisan
Department of Environmental Medicine and Public Health, University of Padova
Photochem Photobiol 82:1077-9. 2006.... - Identification of local Th2 and Th0 lymphocytes in vernal conjunctivitis by cytokine flow cytometryA Leonardi
Department of Physiopathologic Optics, Institute of Ophthalmology, University of Padua, Italy
Invest Ophthalmol Vis Sci 40:3036-40. 1999..Cytokine flow cytometry of tear samples was used to identify the phenotypical and functional properties of lymphocytes at the actual site of the allergic reaction... - Disinfection of ocular cells and tissues by atmospheric-pressure cold plasmaPaola Brun
Histology Unit, Department of Biomedical Sciences, University of Padua, Padua, Italy
PLoS ONE 7:e33245. 2012..This study explored whether atmospheric-pressure cold plasma (APCP) generated by a new portable device that ionizes a flow of helium gas can inactivate ocular pathogens without causing significant tissue damage... - Effects of cyclosporin A on human conjunctival fibroblastsA Leonardi
Ophthalmology and Occular Inflammation Unit, Department of Neuroscience, University of Padova, Italy
Arch Ophthalmol 119:1512-7. 2001..To evaluate the effects of cyclosporin A (CsA) on cytokine and/or collagen production, cell growth, and apoptosis in conjunctival fibroblast cultures... - Tear and serum soluble leukocyte activation markers in conjunctival allergic diseasesA Leonardi
Department of Laboratory Medicine, Institute of Physiopathological Optics, Hospital and University of Padova, Padua, Italy
Am J Ophthalmol 129:151-8. 2000..To measure markers of leukocyte activation in patients with an exclusively ocular inflammatory or bacterial disease... - Vernal keratoconjunctivitisAndrea Leonardi
Department of Ophthalmology, University of Padua, Italy
Int Ophthalmol Clin 43:41-58. 2003 - Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patientsA Leonardi
Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy
Allergy 64:710-7. 2009..To detect the presence of multiple mediators and growth factors in tears of vernal keratoconjunctivitis (VKC) patients with active disease using stationary phase antibody arrays... - Randomized, double-masked, placebo-controlled comparison of the efficacy of emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the human conjunctival allergen challenge modelAndrea Leonardi
Catholic Medical Center of Brooklyn, New York, USA
Clin Ther 24:409-16. 2002..CONCLUSION: The results of this study suggest that emedastine and ketotifen are not significantly different with respect to anti-itching efficacy in the CAC model of acute allergic conjunctivitis... - Trypsin inhibitory capacity in vernal keratoconjunctivitisSaeid Ghavami
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Invest Ophthalmol Vis Sci 48:264-9. 2007..To study tear trypsin inhibitory capacity (T-TIC), serum trypsin inhibitory capacity (S-TIC) and their relationship to matrix metalloproteinases (MMP)-1 and -9 in patients with vernal keratoconjunctivitis (VKC)... - Antibody array characterization of inflammatory mediators in allergic and normal tears in the open and closed eye environmentsRobert Sack
SUNY College of Optometry, 33 West 42nd Street, New York, NY 10036, USA
Exp Eye Res 85:528-38. 2007..Other than a modest increase in IL-8, no change could be observed in the profile of OTF after induction of an acute allergic reaction... - Effect of ofloxacin and netilmicin on human corneal and conjunctival cells in vitroVincenzo Papa
Medical Department, SIFI S p A, Catania, Italy
J Ocul Pharmacol Ther 19:535-45. 2003..001). This finding is particularly relevant in deciding the optimal antibiotic to be applied in clinical situations in which the epithelium is compromised...