Andrea Leonardi

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. doi request reprint Allergy and allergic mediators in tears
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padua, Via Giustiniani 2, 35128 Padova, Italy Electronic address
    Exp Eye Res 117:106-17. 2013
  2. doi request reprint Is visual function affected in severe ocular allergies?
    Andrea Leonardi
    Ophthalmology Unit, Department of Neuroscience, University of Padua, Padua, Italy
    Curr Opin Allergy Clin Immunol 13:558-62. 2013
  3. doi request reprint Vernal keratoconjunctivitis-like disease in adults
    Andrea Leonardi
    Ophthalmology Unit, Department of Neuroscience, University of Padua, Padua, Italy
    Am J Ophthalmol 155:796-803. 2013
  4. doi request reprint Ocular allergy: recognizing and diagnosing hypersensitivity disorders of the ocular surface
    A Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy
    Allergy 67:1327-37. 2012
  5. doi request reprint Corneal confocal microscopy in patients with vernal keratoconjunctivitis
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padova, Padova, Italy
    Ophthalmology 119:509-15. 2012
  6. doi request reprint Cytokine and chemokine levels in tears and in corneal fibroblast cultures before and after excimer laser treatment
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padua, Italy
    J Cataract Refract Surg 35:240-7. 2009
  7. ncbi request reprint Matrix metalloproteases in vernal keratoconjunctivitis, nasal polyps and allergic asthma
    A Leonardi
    Ophthalmology Unit, Department of Neuroscience, University of Padua, Italy
    Clin Exp Allergy 37:872-9. 2007
  8. ncbi request reprint Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures
    A Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy
    Clin Exp Allergy 36:777-84. 2006
  9. ncbi request reprint Case series of 406 vernal keratoconjunctivitis patients: a demographic and epidemiological study
    Andrea Leonardi
    Department of Neuroscience, Clinical Ophthalmology Unit, University of Padua, Padua, Italy
    Acta Ophthalmol Scand 84:406-10. 2006
  10. ncbi request reprint Th1- and Th2-type cytokines in chronic ocular allergy
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology Unit, Via Giustiniani 2, 35128, Padova, Italy
    Graefes Arch Clin Exp Ophthalmol 244:1240-5. 2006

Detail Information

Publications45

  1. doi request reprint Allergy and allergic mediators in tears
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padua, Via Giustiniani 2, 35128 Padova, Italy Electronic address
    Exp Eye Res 117:106-17. 2013
    ..However, to date, there is no a single specific laboratory test suitable for the diagnosis and monitoring of allergic conjunctivitis. ..
  2. doi request reprint Is visual function affected in severe ocular allergies?
    Andrea Leonardi
    Ophthalmology Unit, Department of Neuroscience, University of Padua, Padua, Italy
    Curr Opin Allergy Clin Immunol 13:558-62. 2013
    ..Furthermore, different treatment options are discussed based on the sight-threatening effects of corticosteroid use...
  3. doi request reprint Vernal keratoconjunctivitis-like disease in adults
    Andrea Leonardi
    Ophthalmology Unit, Department of Neuroscience, University of Padua, Padua, Italy
    Am J Ophthalmol 155:796-803. 2013
    ..To identify clinical, demographic, immunologic, and health-related quality-of-life data from a cohort of vernal keratoconjunctivitis (VKC) patients with the onset of the disease after puberty (VKC-like disease)...
  4. doi request reprint Ocular allergy: recognizing and diagnosing hypersensitivity disorders of the ocular surface
    A Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy
    Allergy 67:1327-37. 2012
    ....
  5. doi request reprint Corneal confocal microscopy in patients with vernal keratoconjunctivitis
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padova, Padova, Italy
    Ophthalmology 119:509-15. 2012
    ..To compare corneal morphologic features using in vivo confocal microscopy in vernal keratoconjunctivitis (VKC) patients compared with normal subjects...
  6. doi request reprint Cytokine and chemokine levels in tears and in corneal fibroblast cultures before and after excimer laser treatment
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padua, Italy
    J Cataract Refract Surg 35:240-7. 2009
    ..To measure multiple cytokine and chemokine production in tears of myopic patients before and after laser in situ keratomileusis (LASIK) and in human corneal fibroblast (HCF) cultures before and after excimer laser treatment...
  7. ncbi request reprint Matrix metalloproteases in vernal keratoconjunctivitis, nasal polyps and allergic asthma
    A Leonardi
    Ophthalmology Unit, Department of Neuroscience, University of Padua, Italy
    Clin Exp Allergy 37:872-9. 2007
    ..The aim of the study was to investigate whether matrix metalloproteases contribute to different tissue remodelling aspects in different organs...
  8. ncbi request reprint Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures
    A Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy
    Clin Exp Allergy 36:777-84. 2006
    ....
  9. ncbi request reprint Case series of 406 vernal keratoconjunctivitis patients: a demographic and epidemiological study
    Andrea Leonardi
    Department of Neuroscience, Clinical Ophthalmology Unit, University of Padua, Padua, Italy
    Acta Ophthalmol Scand 84:406-10. 2006
    ..To evaluate the specific allergic sensitization and epidemiological characteristics of vernal keratoconjunctivitis (VKC)...
  10. ncbi request reprint Th1- and Th2-type cytokines in chronic ocular allergy
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology Unit, Via Giustiniani 2, 35128, Padova, Italy
    Graefes Arch Clin Exp Ophthalmol 244:1240-5. 2006
    ..The purpose of this study is to measure levels and mRNA expression of Th1- and Th2-type cytokines in patients with active vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC)...
  11. ncbi request reprint In-vivo diagnostic measurements of ocular inflammation
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy
    Curr Opin Allergy Clin Immunol 5:464-72. 2005
    ..The purpose of this review is to describe recent and less recent methods to assess ocular allergic inflammation...
  12. pmc Clinical and biological efficacy of preservative-free NAAGA eye-drops versus levocabastine eye-drops in vernal keratoconjunctivitis patients
    A Leonardi
    Clinica Oculistica, Department of Neuroscience, Ophthalmology Unit, Via Giustiniani 2, 35128 Padua, Italy
    Br J Ophthalmol 91:1662-6. 2007
    ..This comparative and randomised pilot study assessed the clinical and biological efficacy of Naaxia Sine(R) eye-drops versus levocabastine eye-drops in the treatment of vernal keratoconjunctivitis (VKC)...
  13. ncbi request reprint Immunopathogenesis of ocular allergy: a schematic approach to different clinical entities
    Andrea Leonardi
    Ophthalmology Unit, Department of Neuroscience, University of Padua, Italy
    Curr Opin Allergy Clin Immunol 7:429-35. 2007
    ..Involvement of inflammatory cells, particularly eosinophils and T cells, cytokines and proteases can lead to more serious corneal damage with vision-threatening potential...
  14. doi request reprint Urban eye allergy syndrome: a new clinical entity?
    Andrea Leonardi
    Ophthalmology Unit, Department of Neuroscience, University of Padua, Italy
    Curr Med Res Opin 24:2295-302. 2008
    ..Patients affected by this pseudo-allergic form of vasomotor or idiopathic conjunctivitis usually live in urban polluted areas and may be affected by a new clinical entity called the 'urban eye allergy syndrome'...
  15. pmc Allergy and the eye
    A Leonardi
    Ophthalmology Unit, Department of Neuroscience, University of Padova, Padova, Italy
    Clin Exp Immunol 153:17-21. 2008
    ..None of these agents lacks side effects and none abolishes signs and symptoms completely. New therapeutic strategies are still needed to respond to the complex pathogenesis of severe forms of ocular allergy such as VKC and AKC...
  16. doi request reprint Olopatadine: a drug for allergic conjunctivitis targeting the mast cell
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padua, Via Giustiniani 2, 35128 Padova, Italy
    Expert Opin Pharmacother 11:969-81. 2010
    ..Mast cells are thus the first therapeutic target of ocular anti-allergic treatments...
  17. doi request reprint Transforming growth factor-β/Smad - signalling pathway and conjunctival remodelling in vernal keratoconjunctivitis
    A Leonardi
    Ophthalmology Unit, Department of Neuroscience, University of Padua, Padua, Italy
    Clin Exp Allergy 41:52-60. 2011
    ..Sma- and Mad-related proteins (Smad) modulate extracellular matrix gene expression during wound healing, inflammation and tissue remodelling...
  18. doi request reprint Histamine H4 receptors in normal conjunctiva and in vernal keratoconjunctivitis
    A Leonardi
    Ophthalmology Unit, Department of Neuroscience, University of Padua, Italy
    Allergy 66:1360-6. 2011
    ..Our aim was to evaluate histamine receptor expression in normal and vernal keratoconjunctivitis conjunctiva...
  19. ncbi request reprint Emerging drugs for ocular allergy
    Andrea Leonardi
    Department of Neuroscience, University of Padua, Via Giustiniani 2, 35128 Padova, Italy
    Expert Opin Emerg Drugs 10:505-20. 2005
    ..This review provides a background to ocular allergic diseases, the medical need for therapy and current and potential new treatments...
  20. ncbi request reprint Urokinase plasminogen activator, uPa receptor, and its inhibitor in vernal keratoconjunctivitis
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy
    Invest Ophthalmol Vis Sci 46:1364-70. 2005
    ..The serine protease urokinase (uPA) is a potent chemoattractant for leukocytes that may be involved in the pathogenesis of severe forms of allergic conjunctivitis such as vernal keratoconjunctivitis (VKC)...
  21. ncbi request reprint The anti-allergic effects of a cromolyn sodium-chlorpheniramine combination compared to ketotifen in the conjunctival allergen challenge model
    A Leonardi
    Department of Neuroscience, Ophthalmology and Ocular Inflammation Unit, University of Padova, Italy
    Eur J Ophthalmol 13:128-33. 2003
    ..05% on the clinical allergic reaction induced by the conjunctival allergen challenge (CAC)...
  22. ncbi request reprint Tumor necrosis factor-alpha (TNF-alpha) in seasonal allergic conjunctivitis and vernal keratoconjunctivitis
    A Leonardi
    Department of Neuroscience, Ophthalmology and Ocular Inflammation Unit, University of Padova, Padova, Italy
    Eur J Ophthalmol 13:606-10. 2003
    ..To quantify the presence of the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) in allergic conjunctivitis...
  23. ncbi request reprint Tear levels and activity of matrix metalloproteinase (MMP)-1 and MMP-9 in vernal keratoconjunctivitis
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology and Ocular Inflammation Unit, University of Padua, Padua, Italy
    Invest Ophthalmol Vis Sci 44:3052-8. 2003
    ..To study levels and activity of matrix metalloproteinase (MMP)-1 and -9 and their tissue inhibitor (TIMP-1) in tears of patients with vernal keratoconjunctivitis (VKC), with and without severe corneal damage...
  24. ncbi request reprint Efficacy and comfort of olopatadine versus ketotifen ophthalmic solutions: a double-masked, environmental study of patient preference
    Andrea Leonardi
    Ophthalmology Unit, University of Padova, Padova, Italy
    Curr Med Res Opin 20:1167-73. 2004
    ..1% (Opatanol; Patanol [US]) and ketotifen 0.025% (Zaditen; Zaditor [US]). Patient preference for an eye drop can often be a primary factor in determining the level of compliance and satisfaction with any given therapy...
  25. ncbi request reprint Effects of Th2 cytokines on expression of collagen, MMP-1, and TIMP-1 in conjunctival fibroblasts
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology and Ocular Inflammation Unit, University of Padua, via Foscari 8, 35127 Padua, Italy
    Invest Ophthalmol Vis Sci 44:183-9. 2003
    ..To determine whether cytokines involved in chronic allergic conjunctival disorders may affect formation of giant papillae and tissue remodeling...
  26. ncbi request reprint Double-masked, randomized, placebo-controlled clinical study of the mast cell-stabilizing effects of treatment with olopatadine in the conjunctival allergen challenge model in humans
    Andrea Leonardi
    Ophthalmology Unit, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
    Clin Ther 25:2539-52. 2003
    ..The purpose of this study was to assess the effects of olopatadine on the release of mast cell-derived mediators after conjunctival allergen challenge(CAC) in humans...
  27. ncbi request reprint Tear and mucus eotaxin-1 and eotaxin-2 in allergic keratoconjunctivitis
    Andrea Leonardi
    Department of Ophthalmology, University of Padua, via Foscari 8, 35127 Padua, Italy
    Ophthalmology 110:487-92. 2003
    ..The purpose of this study was to measure these chemokines in tear and mucus samples of active-disease patients and in vitro cultured conjunctival epithelial cells and fibroblasts...
  28. ncbi request reprint Histamine-induced cytokine production and ICAM-1 expression in human conjunctival fibroblasts
    Andrea Leonardi
    Department of Ophthalmology and Inflammatory Eye Diseases, University of Padua, Padua, Italy
    Curr Eye Res 25:189-96. 2002
    ..Conjunctival fibroblasts stimulated with histamine (H) may be directly involved in the inflammatory and remodeling processes of chronic allergic conjunctival diseases...
  29. ncbi request reprint The central role of conjunctival mast cells in the pathogenesis of ocular allergy
    Andrea Leonardi
    Department of Ophthalmology, University of Padova, via Foscari 8, 35127 Padova, Italy
    Curr Allergy Asthma Rep 2:325-31. 2002
    ..This review discusses the role of conjunctival mast cells in the development of ocular allergic diseases...
  30. ncbi request reprint Efficacy and safety of desonide phosphate for the treatment of allergic conjunctivitis
    Andrea Leonardi
    Department of Ophthalmology and Laboratory Medicine, University of Padova, via Foscari 8, 35127 Padua, Italy
    Cornea 21:476-81. 2002
    ..25% ophthalmic solution, for inhibition of the clinical allergic reaction induced by conjunctival provocation (CPT) and for the treatment of seasonal allergic conjunctivitis (SAC)...
  31. ncbi request reprint In vitro effects of fluoroquinolone and aminoglycoside antibiotics on human keratocytes
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padova, Italy
    Cornea 25:85-90. 2006
    ..The purpose of this study was to assess the cytotoxic effects of the fluoquinolone ofloxacin and the aminoglycoside netilmicin on stromal human keratocytes in vitro...
  32. ncbi request reprint Altered expression of neurotransmitter receptors and neuromediators in vernal keratoconjunctivitis
    Laura Motterle
    Department of Neuroscience, Ophthalmology Unit, University of Padova, Padova, Italy
    Arch Ophthalmol 124:462-8. 2006
    ..There is growing evidence that autonomic innervation is involved in the pathogenesis of mucus hypersecretion, goblet cell hyperplasia, and conjunctival hyperreactivity...
  33. pmc Anti-inflammatory and antiallergic effects of ketorolac tromethamine in the conjunctival provocation model
    A Leonardi
    Department of Ophthalmology, University of Padua, Italy
    Br J Ophthalmol 84:1228-32. 2000
    ....
  34. pmc Disinfection of ocular cells and tissues by atmospheric-pressure cold plasma
    Paola Brun
    Histology Unit, Department of Biomedical Sciences, University of Padua, Padua, Italy
    PLoS ONE 7:e33245. 2012
    ..This study explored whether atmospheric-pressure cold plasma (APCP) generated by a new portable device that ionizes a flow of helium gas can inactivate ocular pathogens without causing significant tissue damage...
  35. ncbi request reprint Vernal keratoconjunctivitis: pathogenesis and treatment
    Andrea Leonardi
    Department of Ophthalmology, University of Padua, Via Giustiniani 2, 35128 Padova, Italy
    Prog Retin Eye Res 21:319-39. 2002
    ..New insights into the pathogenesis of VKC should generate the means to better design the strategies for this complex disease...
  36. ncbi request reprint Unusual high exposure to ultraviolet-C radiation
    Andrea Trevisan
    Department of Environmental Medicine and Public Health, University of Padova
    Photochem Photobiol 82:1077-9. 2006
    ....
  37. ncbi request reprint Identification of local Th2 and Th0 lymphocytes in vernal conjunctivitis by cytokine flow cytometry
    A Leonardi
    Department of Physiopathologic Optics, Institute of Ophthalmology, University of Padua, Italy
    Invest Ophthalmol Vis Sci 40:3036-40. 1999
    ..Cytokine flow cytometry of tear samples was used to identify the phenotypical and functional properties of lymphocytes at the actual site of the allergic reaction...
  38. ncbi request reprint Effects of cyclosporin A on human conjunctival fibroblasts
    A Leonardi
    Ophthalmology and Occular Inflammation Unit, Department of Neuroscience, University of Padova, Italy
    Arch Ophthalmol 119:1512-7. 2001
    ..To evaluate the effects of cyclosporin A (CsA) on cytokine and/or collagen production, cell growth, and apoptosis in conjunctival fibroblast cultures...
  39. ncbi request reprint Tear and serum soluble leukocyte activation markers in conjunctival allergic diseases
    A Leonardi
    Department of Laboratory Medicine, Institute of Physiopathological Optics, Hospital and University of Padova, Padua, Italy
    Am J Ophthalmol 129:151-8. 2000
    ..To measure markers of leukocyte activation in patients with an exclusively ocular inflammatory or bacterial disease...
  40. ncbi request reprint Vernal keratoconjunctivitis
    Andrea Leonardi
    Department of Ophthalmology, University of Padua, Italy
    Int Ophthalmol Clin 43:41-58. 2003
  41. doi request reprint Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients
    A Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy
    Allergy 64:710-7. 2009
    ..To detect the presence of multiple mediators and growth factors in tears of vernal keratoconjunctivitis (VKC) patients with active disease using stationary phase antibody arrays...
  42. ncbi request reprint Randomized, double-masked, placebo-controlled comparison of the efficacy of emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the human conjunctival allergen challenge model
    Peter A D'Arienzo
    Catholic Medical Center of Brooklyn, New York, USA
    Clin Ther 24:409-16. 2002
    ..Emedastine is indicated for the temporary relief of the signs and symptoms of allergic conjunctivitis. Ketotifen is indicated for the temporary relief of ocular itching caused by allergic conjunctivitis...
  43. ncbi request reprint Trypsin inhibitory capacity in vernal keratoconjunctivitis
    Saeid Ghavami
    Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
    Invest Ophthalmol Vis Sci 48:264-9. 2007
    ..To study tear trypsin inhibitory capacity (T-TIC), serum trypsin inhibitory capacity (S-TIC) and their relationship to matrix metalloproteinases (MMP)-1 and -9 in patients with vernal keratoconjunctivitis (VKC)...
  44. ncbi request reprint Antibody array characterization of inflammatory mediators in allergic and normal tears in the open and closed eye environments
    Robert Sack
    SUNY College of Optometry, 33 West 42nd Street, New York, NY 10036, USA
    Exp Eye Res 85:528-38. 2007
    ..Other than a modest increase in IL-8, no change could be observed in the profile of OTF after induction of an acute allergic reaction...
  45. ncbi request reprint Effect of ofloxacin and netilmicin on human corneal and conjunctival cells in vitro
    Vincenzo Papa
    Medical Department, SIFI S p A, Catania, Italy
    J Ocul Pharmacol Ther 19:535-45. 2003
    ..001). This finding is particularly relevant in deciding the optimal antibiotic to be applied in clinical situations in which the epithelium is compromised...