Laura Lentini

Summary

Affiliation: University of Palermo
Country: Italy

Publications

  1. pmc Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells
    Viviana Barra
    Department of Molecular and Biomolecular Science and Technology STEMBIO University of Palermo, Italy
    Cell Div 7:2. 2012
  2. pmc Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype
    Laura Lentini
    Department of Cellular and Developmental Biology A, Monroy, University of Palermo, Viale delle Scienze, Palermo, Italy
    BMC Cancer 7:212. 2007
  3. pmc RNAi mediated acute depletion of retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation
    Angela Amato
    Dipartimento di Biologia Cellulare e dello Sviluppo A, Monroy, Universita di Palermo, Viale delle Scienze, Palermo, Italy
    BMC Cell Biol 10:79. 2009
  4. ncbi request reprint Aurora-A transcriptional silencing and vincristine treatment show a synergistic effect in human tumor cells
    Laura Lentini
    Dipartimento di Biologia Cellulare e dello Sviluppo A Monroy, Universita di Palermo, Viale delle Scienze, Palermo, Italy
    Oncol Res 17:115-25. 2008
  5. pmc RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts
    Flora Iovino
    Department of Cellular and Developmental Biology A Monroy, University of Palermo, Italy
    Mol Cancer 5:38. 2006
  6. doi request reprint MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p53 pathway preventing aneuploid cells propagation
    Laura Lentini
    Department of Molecular and Biomolecular Science and Technology STEMBIO University of Palermo, Palermo, Italy
    J Cell Physiol 227:3324-32. 2012
  7. pmc CENPA overexpression promotes genome instability in pRb-depleted human cells
    Angela Amato
    Dipartimento di Biologia Cellulare e dello Sviluppo, Palermo, Italy
    Mol Cancer 8:119. 2009
  8. ncbi request reprint Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts
    Laura Lentini
    Dipartimento di Biologia Cellulare e dello Sviluppo A Monroy, Universita di Palermo, and Centro di OncoBiologia Sperimentale, viale delle Scienze 90128, Palermo, Italy
    Cancer Lett 238:153-60. 2006
  9. pmc Functional inactivation of pRB results in aneuploid mammalian cells after release from a mitotic block
    Laura Lentini
    Department of Cell and Developmental Biology A Monroy, University of Palermo, viale delle Scienze 90128, Palermo, Italy
    Neoplasia 4:380-7. 2002
  10. ncbi request reprint Does the evidence matter in medicine? The retinoblastoma paradigm
    Domenico Mastrangelo
    Department of Ophthalmology, Ocular Oncology Unit, University of Siena, Italy
    Int J Cancer 121:2501-5. 2007

Collaborators

Detail Information

Publications10

  1. pmc Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells
    Viviana Barra
    Department of Molecular and Biomolecular Science and Technology STEMBIO University of Palermo, Italy
    Cell Div 7:2. 2012
    ..abstract:..
  2. pmc Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype
    Laura Lentini
    Department of Cellular and Developmental Biology A, Monroy, University of Palermo, Viale delle Scienze, Palermo, Italy
    BMC Cancer 7:212. 2007
    ..Also, alterations in genes required for mitotic progression could be involved in CIN.A major candidate is represented by Aurora-A/STK15 that associates with centrosomes and is overexpressed in several types of human tumour...
  3. pmc RNAi mediated acute depletion of retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation
    Angela Amato
    Dipartimento di Biologia Cellulare e dello Sviluppo A, Monroy, Universita di Palermo, Viale delle Scienze, Palermo, Italy
    BMC Cell Biol 10:79. 2009
    ..Primary human fibroblasts were transfected transiently with short interfering RNA (siRNA) specific for human pRb to investigate the effects of pRb acute loss on chromosomal stability...
  4. ncbi request reprint Aurora-A transcriptional silencing and vincristine treatment show a synergistic effect in human tumor cells
    Laura Lentini
    Dipartimento di Biologia Cellulare e dello Sviluppo A Monroy, Universita di Palermo, Viale delle Scienze, Palermo, Italy
    Oncol Res 17:115-25. 2008
    ..Finally, Aurora-A transcriptional silencing seems to confer cancer cells a greater sensitivity to chemotherapy by vincristine, indicating Aurora-A as a possible gene target in cancer therapy...
  5. pmc RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts
    Flora Iovino
    Department of Cellular and Developmental Biology A Monroy, University of Palermo, Italy
    Mol Cancer 5:38. 2006
    ..Moreover, since pRb is a transcriptional repressor, microarray analysis was done on pRb-competent and pRb-deficient MEFs to evaluate changes in expression of genes for centrosome homeostasis and for correct mitosis...
  6. doi request reprint MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p53 pathway preventing aneuploid cells propagation
    Laura Lentini
    Department of Molecular and Biomolecular Science and Technology STEMBIO University of Palermo, Palermo, Italy
    J Cell Physiol 227:3324-32. 2012
    ....
  7. pmc CENPA overexpression promotes genome instability in pRb-depleted human cells
    Angela Amato
    Dipartimento di Biologia Cellulare e dello Sviluppo, Palermo, Italy
    Mol Cancer 8:119. 2009
    ..Functional inactivation of the Retinoblastoma protein (pRb) has been indicated as a cause promoting chromosomal instability as well centrosome amplification. However, the underlying molecular mechanism still remains to be clarified...
  8. ncbi request reprint Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts
    Laura Lentini
    Dipartimento di Biologia Cellulare e dello Sviluppo A Monroy, Universita di Palermo, and Centro di OncoBiologia Sperimentale, viale delle Scienze 90128, Palermo, Italy
    Cancer Lett 238:153-60. 2006
    ..Finally, our results suggest that pRB dysfunction both in human and murine fibroblasts transiently arrested in G1/S by hydroxyurea allows centrosomes amplification, in the absence of DNA synthesis, that in turn could drive aneuploidy...
  9. pmc Functional inactivation of pRB results in aneuploid mammalian cells after release from a mitotic block
    Laura Lentini
    Department of Cell and Developmental Biology A Monroy, University of Palermo, viale delle Scienze 90128, Palermo, Italy
    Neoplasia 4:380-7. 2002
    ..However, these cells escaped the arrest and became aneuploid upon pRB ablation by CRE recombinase, suggesting pRB as a major component of a checkpoint that controls cellular ploidy...
  10. ncbi request reprint Does the evidence matter in medicine? The retinoblastoma paradigm
    Domenico Mastrangelo
    Department of Ophthalmology, Ocular Oncology Unit, University of Siena, Italy
    Int J Cancer 121:2501-5. 2007
    ..Overall, the "two hit" theory represents a rather simplistic and outdated model to explain tumour development and clinical evolution of retinoblastoma...