A Laviano

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. ncbi Improving food intake in anorectic cancer patients
    Alessandro Laviano
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Curr Opin Clin Nutr Metab Care 6:421-6. 2003
  2. ncbi Omega-3 fatty acids in cancer
    Alessandro Laviano
    Department of Clinical Medicine, Sapienza University, Rome, Italy
    Curr Opin Clin Nutr Metab Care 16:156-61. 2013
  3. ncbi The growth hormone secretagogue receptor (Ghs-R)
    Alessandro Laviano
    Department of Clinical Medicine, Sapienza University, Viale dell Universita 37, 00185 Rome, Italy
    Curr Pharm Des 18:4749-54. 2012
  4. ncbi Neuroinflammation: a contributing factor to the pathogenesis of cancer cachexia
    Alessandro Laviano
    Department of Clinical Medicine, Sapienza University, Rome, Italy
    Crit Rev Oncog 17:247-51. 2012
  5. ncbi Carnitine administration reduces cytokine levels, improves food intake, and ameliorates body composition in tumor-bearing rats
    Alessandro Laviano
    Department of Clinical Medicine, Sapienza University of Rome, Italy
    Cancer Invest 29:696-700. 2011
  6. ncbi Hypothalamic inflammation is reversed by endurance training in anorectic-cachectic rats
    Fabio S Lira
    Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo USP, Sao Paulo, SP Brazil
    Nutr Metab (Lond) 8:60. 2011
  7. ncbi Influence of taste disorders on dietary behaviors in cancer patients under chemotherapy
    Karla Sanchez-Lara
    Oncology Center Diana Laura Riojas de Colosio, Medica Sur Clinic and Foundation, Mexico City, Mexico
    Nutr J 9:15. 2010
  8. ncbi Antimyopathic effects of carnitine and nicotine
    Alessandro Laviano
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Curr Opin Clin Nutr Metab Care 9:442-8. 2006
  9. ncbi Tumor-induced changes in host metabolism: a possible role for free tryptophan as a marker of neoplastic disease
    Alessandro Laviano
    Department of Clinical Medicine, University of Rome La Sapienza, Rome, Italy
    Adv Exp Med Biol 527:363-6. 2003
  10. ncbi Therapy insight: Cancer anorexia-cachexia syndrome--when all you can eat is yourself
    Alessandro Laviano
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Nat Clin Pract Oncol 2:158-65. 2005

Collaborators

Detail Information

Publications50

  1. ncbi Improving food intake in anorectic cancer patients
    Alessandro Laviano
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Curr Opin Clin Nutr Metab Care 6:421-6. 2003
    ..This article discusses the currently proposed hypothesis of its pathogenesis, and reviews the available and future therapeutic options as they relate to the pathogenic mechanisms...
  2. ncbi Omega-3 fatty acids in cancer
    Alessandro Laviano
    Department of Clinical Medicine, Sapienza University, Rome, Italy
    Curr Opin Clin Nutr Metab Care 16:156-61. 2013
    ..A new concept is emerging which is based on the early combination of chemotherapy and nutrition therapy...
  3. ncbi The growth hormone secretagogue receptor (Ghs-R)
    Alessandro Laviano
    Department of Clinical Medicine, Sapienza University, Viale dell Universita 37, 00185 Rome, Italy
    Curr Pharm Des 18:4749-54. 2012
    ..Among many other syndromes and diseases, cancer cachexia, aging related cognitive decline, obesity and diabetes may significantly benefit from the use of GHS-R1a agonists or antagonists...
  4. ncbi Neuroinflammation: a contributing factor to the pathogenesis of cancer cachexia
    Alessandro Laviano
    Department of Clinical Medicine, Sapienza University, Rome, Italy
    Crit Rev Oncog 17:247-51. 2012
    ....
  5. ncbi Carnitine administration reduces cytokine levels, improves food intake, and ameliorates body composition in tumor-bearing rats
    Alessandro Laviano
    Department of Clinical Medicine, Sapienza University of Rome, Italy
    Cancer Invest 29:696-700. 2011
    ..01 vs. controls). Cytokines? levels decreased in PC rats vs. controls (p < .02). Results suggest that carnitine may ameliorate cancer anorexia?cachexia, via reduction of the inflammatory status...
  6. ncbi Hypothalamic inflammation is reversed by endurance training in anorectic-cachectic rats
    Fabio S Lira
    Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo USP, Sao Paulo, SP Brazil
    Nutr Metab (Lond) 8:60. 2011
    ..abstract:..
  7. ncbi Influence of taste disorders on dietary behaviors in cancer patients under chemotherapy
    Karla Sanchez-Lara
    Oncology Center Diana Laura Riojas de Colosio, Medica Sur Clinic and Foundation, Mexico City, Mexico
    Nutr J 9:15. 2010
    ..To determine the relationship between energy and nutrient consumption with chemosensory changes in cancer patients under chemotherapy...
  8. ncbi Antimyopathic effects of carnitine and nicotine
    Alessandro Laviano
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Curr Opin Clin Nutr Metab Care 9:442-8. 2006
    ..This anorexia/cachexia syndrome leads to deterioration of quality of life, and increased morbidity and mortality. The clinical efficacy of currently available therapeutic strategies is limited and more effective treatments are needed...
  9. ncbi Tumor-induced changes in host metabolism: a possible role for free tryptophan as a marker of neoplastic disease
    Alessandro Laviano
    Department of Clinical Medicine, University of Rome La Sapienza, Rome, Italy
    Adv Exp Med Biol 527:363-6. 2003
    ..High plasma free tryptophan concentrations seem to be directly related to the presence of the tumor, since in breast cancer patients they returned to within normal range after eradicative surgery...
  10. ncbi Therapy insight: Cancer anorexia-cachexia syndrome--when all you can eat is yourself
    Alessandro Laviano
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Nat Clin Pract Oncol 2:158-65. 2005
    ....
  11. ncbi NPY and brain monoamines in the pathogenesis of cancer anorexia
    Alessandro Laviano
    Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy
    Nutrition 24:802-5. 2008
    ....
  12. ncbi Neural control of the anorexia-cachexia syndrome
    Alessandro Laviano
    Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy
    Am J Physiol Endocrinol Metab 295:E1000-8. 2008
    ....
  13. ncbi Oxidative stress and wasting in cancer
    Alessandro Laviano
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Curr Opin Clin Nutr Metab Care 10:449-56. 2007
    ..Reported findings indicate that increased production of reactive oxygen species and reduced activity of antioxidant enzymes contribute to development of anorexia and cachexia in cancer...
  14. ncbi VMN/LHA functional inhibition in tumor-bearing rats suggests hypothalamic involvement in cancer anorexia
    A Laviano
    Department of Clinical Medicine, University of Rome La Sapienza, Viale dell Universita 37, 00185 Rome, Italy
    Nutr Neurosci 5:443-56. 2002
    ....
  15. ncbi Neurochemical mechanisms for cancer anorexia
    Alessandro Laviano
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Nutrition 18:100-5. 2002
    ..Further, modulation of hypothalamic activity also might result in reduced catabolic signals to skeletal muscles, thus improving the cachexia associated with cancer...
  16. ncbi Tryptophan in wasting diseases: at the crossing between immune function and behaviour
    Alessandro Laviano
    Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy
    Curr Opin Clin Nutr Metab Care 12:392-7. 2009
    ..Tryptophan metabolism has unique features suggesting a critical role in influencing human metabolism under normal and pathological conditions...
  17. ncbi Metabolic and clinical effects of the supplementation of a functional mixture of amino acids in cerebral hemorrhage
    Alessandro Laviano
    Department of Clinical Medicine, Sapienza University, Rome, Italy
    Neurocrit Care 14:44-9. 2011
    ..The aim of this study was to test whether such effects could be replicated in an acute clinical model of hypercatabolism...
  18. ncbi Cancer anorexia: clinical implications, pathogenesis, and therapeutic strategies
    Alessandro Laviano
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Lancet Oncol 4:686-94. 2003
    ....
  19. ncbi Beyond anorexia -cachexia. Nutrition and modulation of cancer patients' metabolism: supplementary, complementary or alternative anti-neoplastic therapy?
    Alessandro Laviano
    Department of Clinical Medicine, Sapienza University, Rome, Italy
    Eur J Pharmacol 668:S87-90. 2011
    ..This suggests that nutrition therapy should be considered as an important adjuvant strategy in the multidimensional approach to cancer patients...
  20. ncbi Branched-chain amino acids: the best compromise to achieve anabolism?
    Alessandro Laviano
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Curr Opin Clin Nutr Metab Care 8:408-14. 2005
    ..More effective therapies are needed to promote appetite and food intake, to preserve lean body mass, and to ameliorate patients' psychological distress...
  21. ncbi [Treatment of mild malnutrition and reduction of morbidity in major abdominal surgery: randomized trial on 153 patients]
    A Pronio
    Cattedra di Chirurgia Generale, Policlinico Umberto I, Universita La Sapienza, Roma, Italia
    Clin Ter 159:13-8. 2008
    ..Moreover, we evaluated serum albuminemia and lymphocyte count, important nutritional index, as predictive risk factors...
  22. ncbi Impaired nutritional status in common variable immunodeficiency patients correlates with reduced levels of serum IgA and of circulating CD4+ T lymphocytes
    M Muscaritoli
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Eur J Clin Invest 31:544-9. 2001
    ..Infections, persistent diarrhoea and malabsorption may result in malnutrition, which may in turn contribute to increased morbidity. In this paper, the prevalence of malnutrition in CVI was evaluated...
  23. ncbi Is spontaneous bacterial peritonitis an inducer of vasopressin analogue side-effects? A case report
    F Vaccaro
    Department of Clinical Medicine, University of Rome La Sapienza, Viale dell Universita 37, 00185 Rome, Italy
    Dig Liver Dis 35:503-6. 2003
    ....
  24. ncbi Predicting the outcome of artificial nutrition by clinical and functional indices
    Lorenzo M Donini
    Department of Medical Physiopathology Food Science Section, Sapienza University of Rome, Italy
    Nutrition 25:11-9. 2009
    ..The aim of the present study was to identify those indices, clinical, functional, or nutritional, that may reliably predict, before the start of AN, those patients who are likely not to benefit from nutritional support...
  25. ncbi Role of brain tryptophan and serotonin in secondary anorexia
    Filippo Rossi-Fanelli
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Adv Exp Med Biol 527:225-32. 2003
    ..Supporting this hypothesis, recent data showed that the manipulation of brain tryptophan availability ameliorates anorexia and food intake in cancer patients...
  26. ncbi The "parallel pathway": a novel nutritional and metabolic approach to cancer patients
    Maurizio Muscaritoli
    Department of Clinical Medicine, Sapienza University of Rome, Viale dell Universita, 37, 00185, Rome, Italy
    Intern Emerg Med 6:105-12. 2011
    ..The "parallel pathway" implies a multiprofessional and multimodal approach aimed at ensuring early, appropriate and continuous nutritional and metabolic support to cancer patients in any phase of their cancer journey...
  27. ncbi Anorexia in hemodialysis patients: the possible role of des-acyl ghrelin
    Maurizio Muscaritoli
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Am J Nephrol 27:360-5. 2007
    ..The aim of this cross-sectional study is to clarify whether anorexia and body weight change in HD patients relate to plasma des-acyl ghrelin levels...
  28. ncbi Cancer anorexia: a model for the understanding and treatment of secondary anorexia
    Filippo Rossi Fanelli
    Department of Clinical Medicine, University La Sapienza, Viale dell Universita 37, 00185 Rome, Italy
    Int J Cardiol 85:67-72. 2002
    ..Thus, interfering pharmacologically with hypothalamic serotonin synthesis and activity may represent an effective therapeutic strategy in anorectic patients, as suggested by recent preliminary clinical data...
  29. ncbi Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics"
    M Muscaritoli
    Department of Clinical Medicine, La Sapienza, University of Rome, Viale dell Universita, 37, Rome 00185, Italy
    Clin Nutr 29:154-9. 2010
    ....
  30. ncbi Free tryptophan/large neutral amino acids ratios in blood plasma do not predict cerebral spinal fluid tryptophan concentrations in interleukin-1-induced anorexia
    Alessio Molfino
    Department of Clinical Medicine, Sapienza University of Rome, 00185 Rome, Italy
    Pharmacol Biochem Behav 89:31-5. 2008
    ..Considering the possible role of the raised CSF TRP in influencing brain serotonin activity, it is postulated that increased serotonergic neurotransmission could be involved in IL-1 induced anorexia...
  31. ncbi Body mass index is related to autonomic nervous system activity as measured by heart rate variability
    A Molfino
    Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy
    Eur J Clin Nutr 63:1263-5. 2009
    ..05). The results support the role of parasympathetic activity in influencing BMI through likely modulation of body weight...
  32. ncbi Caloric restriction and L-carnitine administration improves insulin sensitivity in patients with impaired glucose metabolism
    Alessio Molfino
    Department of Clinical Medicine, Sapienza University, Rome, Italy
    JPEN J Parenter Enteral Nutr 34:295-9. 2010
    ..The aim of the study was to explore the role of L-carnitine supplementation in influencing insulin sensitivity...
  33. ncbi Pathogenesis of cancer anorexia: still doubts after all these years?
    Alessandro Laviano
    Nutrition 19:67-8. 2003
  34. ncbi Tumor anorexia: effects on neuropeptide Y and monoamines in paraventricular nucleus
    Michael M Meguid
    Neuroscience Program, Surgical Metabolism and Nutrition Laboratory, Department of Surgery, University Hospital, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Peptides 25:261-6. 2004
    ..We conclude that the increased 5-HT and the decreased DA and NPY concentrations in PVN are associated with cancer anorexia and that the NPY food stimulatory effect is linked to serotoninergic and dopaminergic systems in hypothalamus...
  35. ncbi Energy expenditure and treating obesity
    Alessandro Laviano
    Science 298:539-41; author reply 539-41. 2002
  36. ncbi Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    FASEB J 18:439-56. 2004
    ..Defective ghrelin signaling from the stomach could contribute to abnormalities in energy balance, growth, and associated gastrointestinal and neuroendocrine functions...
  37. ncbi Interleukin-1beta system in anorectic catabolic tumor-bearing rats
    Nicolas P Turrin
    Molecular Endocrinology and Oncology Research Centre, Laval University Hospital Centre, and Department of Anatomy and Physiology, Laval University, Ste-Foy, , G1V 4G2, Canada
    Curr Opin Clin Nutr Metab Care 7:419-26. 2004
    ..In vivo, the characterization of cytokine components in the brain may provide data for potential pharmacological interventions to ameliorate the anorexia of disease...
  38. ncbi Phase II study of high-dose fish oil capsules for patients with cancer-related cachexia: a Cancer and Leukemia Group B study
    Alessandro Laviano
    Cancer 103:651-2. 2005
  39. ncbi Effects of omega-3 fatty acid supplementation on tumor-bearing rats
    Eduardo J B Ramos
    Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, SUNY Upstate Medical University, University Hospital, Syracuse, NY 13210, USA
    J Am Coll Surg 199:716-23. 2004
    ..Supplementation of omega-3 fatty acids has therapeutic potential in cancer anorexia...
  40. ncbi Hypothalamic integration of immune function and metabolism
    Ana Guijarro
    Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, University Hospital, SUNY Upstate Medical University, 750 Adams St, Syracuse, NY 13210, USA
    Prog Brain Res 153:367-405. 2006
    ....
  41. ncbi Nicotine infusion into rat ventromedial nuclei and effects on monoaminergic system
    Eduardo J B Ramos
    Neuroscience Program, Surgical Metabolism and Nutrition Laboratory, Department of Surgery, SUNY Upstate Medical University, University Hospital, 750 East Adams Street, Syracuse, NY 13210, USA
    Neuroreport 15:2293-7. 2004
    ..Our data suggest that the nicotine-induced hypophagia correlates with VMN and LHA monoaminergic changes...
  42. ncbi Nutritional intervention and quality of life in adult oncology patients
    Mónica María Marín Caro
    Clinical Nutrition, Geneva University Hospital, 1211 Geneva 14, Geneva, Switzerland
    Clin Nutr 26:289-301. 2007
    ..Furthermore, the assessment of QoL should be part of the evaluation of any nutritional support to optimize its adequacy to the patient's needs and expectations...
  43. ncbi Changes in hypothalamic neuropeptide Y and monoaminergic system in tumor-bearing rats: pre- and post-tumor resection and at death
    Eduardo J B Ramos
    Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, University Hospital, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Surgery 136:270-6. 2004
    ..After tumor resection, these alterations normalized, providing evidence that the levels of these substances change with anorexia in tumor-bearing rats...
  44. ncbi Age and sex influence on appetite
    Alessandro Laviano
    Clin Nutr 21:186-7; author reply 187. 2002
  45. ncbi Anorexia and serum leptin levels in hemodialysis patients
    Maurizio Bossola
    Istituto di Clinica Chirurgica, , Roma, Italia
    Nephron Clin Pract 97:c76-82. 2004
    ..CONCLUSION: The present results indicate that mechanisms other than increases in serum leptin levels might be involved in the pathogenesis of HD-related anorexia...
  46. ncbi Plasma leptin, insulin and free tryptophan contribute to cytokine-induced anorexia
    Tomoi Sato
    Surgical Metabolism and Nutrition Laboratory, Department of Surgery, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Adv Exp Med Biol 527:233-9. 2003
    ....
  47. ncbi Impact of nutrition on quality of life during cancer
    Mónica María Marín Caro
    Clinical Nutrition, Geneva University Hospital, Geneva, Switzerland
    Curr Opin Clin Nutr Metab Care 10:480-7. 2007
    ..This review addresses the relationship between nutritional intervention and quality of life in oncology patients...
  48. ncbi Obestatin, acyl ghrelin, and des-acyl ghrelin responses to an oral glucose tolerance test in the restricting type of anorexia nervosa
    Toshiro Harada
    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima City, Japan
    Biol Psychiatry 63:245-7. 2008
    ..We investigated simultaneously obestatin, acyl ghrelin, and des-acyl ghrelin in the restricting type of anorexia nervosa (AN-R) patients...
  49. ncbi Is des-acyl ghrelin contributing to uremic anorexia?
    Alessio Molfino
    Am J Clin Nutr 86:1550-1; author reply 1551-3. 2007
  50. ncbi Role of leucine in regulating food intake
    Alessandro Laviano
    Science 313:1236-8; author reply 1236-8. 2006