Anna M Lavezzi


Affiliation: University of Milan
Country: Italy


  1. Lavezzi A, Mohorovic L, Alfonsi G, Corna M, Matturri L. Brain iron accumulation in unexplained fetal and infant death victims with smoker mothers--the possible involvement of maternal methemoglobinemia. BMC Pediatr. 2011;11:62 pubmed publisher
    ..We propose that the free iron deposition in the brain of sudden fetal and infant death victims could be a catabolic product of maternal methemoglobinemia, a biomarker of oxidative stress likely due to nicotine absorption. ..
  2. Lavezzi A. Toxic Effect of Cigarette Smoke on Brainstem Nicotinic Receptor Expression: Primary Cause of Sudden Unexplained Perinatal Death. Toxics. 2018;6: pubmed publisher
  3. Lavezzi A, Matturri L, Del Corno G, Johanson C. Vulnerability of fourth ventricle choroid plexus in sudden unexplained fetal and infant death syndromes related to smoking mothers. Int J Dev Neurosci. 2013;31:319-27 pubmed publisher
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    Matturri L, Del Corno G, Lavezzi A. Sudden infant death following hexavalent vaccination: a neuropathologic study. Curr Med Chem. 2014;21:941-6 pubmed
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    Lavezzi A, Corna M, Repetti M, Matturri L. Cerebellar Purkinje cell vulnerability to prenatal nicotine exposure in sudden unexplained perinatal death. Folia Neuropathol. 2013;51:290-301 pubmed
    ..This suggests the existence of a Purkinje-Olivo-Dentate network playing a fundamental role in triggering a sudden death mechanism in perinatal life in the presence of specific risk factors. ..
  6. Lavezzi A, Corna M, Alfonsi G, Matturri L. Possible role of the ?7 nicotinic receptors in mediating nicotine's effect on developing lung - implications in unexplained human perinatal death. BMC Pulm Med. 2014;14:11 pubmed publisher
    ..This work stresses the importance of implementing preventable measures to decrease the noxious potential of nicotine in pregnancy. ..
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    Lavezzi A, Ottaviani G, Matturri L. Adverse effects of prenatal tobacco smoke exposure on biological parameters of the developing brainstem. Neurobiol Dis. 2005;20:601-7 pubmed
  8. Lavezzi A, Mecchia D, Matturri L. Neuropathology of the area postrema in sudden intrauterine and infant death syndromes related to tobacco smoke exposure. Auton Neurosci. 2012;166:29-34 pubmed publisher
    ..In conclusion, we suggest that the area postrema should be in depth examined particularly in victims of sudden fetal or infant death with smoker mothers. ..
  9. Lavezzi A, Cappiello A, Pusiol T, Corna M, Termopoli V, Matturri L. Pesticide exposure during pregnancy, like nicotine, affects the brainstem α7 nicotinic acetylcholine receptor expression, increasing the risk of sudden unexplained perinatal death. J Neurol Sci. 2015;348:94-100 pubmed publisher

More Information


  1. Lavezzi A, Ottaviani G, Matturri L. Developmental alterations of the auditory brainstem centers--pathogenetic implications in Sudden Infant Death Syndrome. J Neurol Sci. 2015;357:257-63 pubmed publisher
  2. Lavezzi A, Cappiello A, Termopoli V, Bonoldi E, Matturri L. Sudden Infant Death With Area Postrema Lesion Likely Due to Wrong Use of Insecticide. Pediatrics. 2015;136:e1039-42 pubmed publisher
    ..These results provide an explanation for this sudden infant death, allowing a differential diagnosis from sudden infant death syndrome. ..
  3. Lavezzi A, Corna M, Matturri L. Neuronal nuclear antigen (NeuN): a useful marker of neuronal immaturity in sudden unexplained perinatal death. J Neurol Sci. 2013;329:45-50 pubmed publisher
    ..The exclusive presence of this pattern of expression in SIUDS/SIDS victims, leads us to recommend the NeuN immunohistochemistry as a routine method in neuropathological protocols to convalidate a diagnosis of sudden perinatal death. ..
  4. Lavezzi A, Ferrero S, Matturri L, Roncati L, Pusiol T. Developmental neuropathology of brainstem respiratory centers in unexplained stillbirth: What's the meaning?. Int J Dev Neurosci. 2016;53:99-106 pubmed publisher
  5. Lavezzi A, Corna M, Matturri L. Ependymal alterations in sudden intrauterine unexplained death and sudden infant death syndrome: possible primary consequence of prenatal exposure to cigarette smoking. Neural Dev. 2010;5:17 pubmed publisher
    ..Additionally, we investigated a possible link between alterations of this structure, sudden unexplained fetal and infant death and maternal smoking...
  6. Lavezzi A, Weese Mayer D, Yu M, Jennings L, Corna M, Casale V, et al. Developmental alterations of the respiratory human retrotrapezoid nucleus in sudden unexplained fetal and infant death. Auton Neurosci. 2012;170:12-9 pubmed publisher
    ..05). In conclusion we suggest that developmental abnormalities of the hRTN may seriously compromise chemoreception control, playing a critical role in the pathogenesis of both SIUD and SIDS...
  7. Lavezzi A, Ferrero S, Lattuada D, Piscioli F, Alfonsi G, Matturri L. Pathobiological expression of the brain-derived neurotrophic factor (BDNF) in cerebellar cortex of sudden fetal and infant death victims. Int J Dev Neurosci. 2018;66:9-17 pubmed publisher
    ..This implies modifications of synaptic transmission in the respiratory circuits, with obvious deleterious consequences on survival. ..