A Lapolla

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi request reprint Epidemiology of diabetes in pregnancy: a review of Italian data
    A Lapolla
    Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
    Diabetes Nutr Metab 17:358-67. 2004
  2. ncbi request reprint Glyco-oxidation in diabetes and related diseases
    Annunziata Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche Cattedra di Malattie del Metabolismo, Universita degli Studi di Padova, Via Giustiniani 2, 35100 Padova, Italy
    Clin Chim Acta 357:236-50. 2005
  3. pmc A pilot study on dietary approaches in multiethnicity: two methods compared
    Romina Valentini
    Department of Medical and Surgical Sciences, U O of Metabolic Diseases and Diabetology, University of Padua, Via Giustiniani 2, 35143 Padua, Italy
    Int J Endocrinol 2012:985136. 2012
  4. pmc Mass spectrometry for diabetic nephropathy monitoring: new effective tools for physicians
    Annunziata Lapolla
    Department of Medicine, University of Padova, Via Giustiniani 2, 35137 Padova, Italy
    ISRN Endocrinol 2012:768159. 2012
  5. pmc Management of gestational diabetes mellitus
    Annunziata Lapolla
    Department of Medical and Surgical Sciences, Padova University, Italy
    Diabetes Metab Syndr Obes 2:73-82. 2009
  6. pmc DALI: Vitamin D and lifestyle intervention for gestational diabetes mellitus (GDM) prevention: an European multicentre, randomised trial - study protocol
    Judith G M Jelsma
    Department of Public and Occupational Health, EMGO Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    BMC Pregnancy Childbirth 13:142. 2013
  7. ncbi request reprint Evaluation of advanced glycation end products and carbonyl compounds in patients with different conditions of oxidative stress
    Annunziata Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche Cattedra di Malattie del Metabolismo, Universita di Padova, Padova, Italy
    Mol Nutr Food Res 49:685-90. 2005
  8. ncbi request reprint Pentosidine plasma levels and relation with metabolic control in diabetic patients
    A Lapolla
    Department of Medical and Surgical Sciences, University of Padua, Italy
    Horm Metab Res 37:252-6. 2005
  9. ncbi request reprint Lymphocyte subsets and cytokines in women with gestational diabetes mellitus and their newborn
    A Lapolla
    Metabolic Disorders Section, Department of Medical and Surgical Sciences, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    Cytokine 31:280-7. 2005
  10. ncbi request reprint Evaluation of glyoxal and methylglyoxal levels in uremic patients under peritoneal dialysis
    A Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche, Cattedra di Malattie del Metabolismo, Via Giustiniani 2, 35100 Padova, Italy
    Ann N Y Acad Sci 1043:217-24. 2005

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Epidemiology of diabetes in pregnancy: a review of Italian data
    A Lapolla
    Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
    Diabetes Nutr Metab 17:358-67. 2004
    ..This article reviews the existing epidemiologic studies on diabetes in pregnancy performed in Italy...
  2. ncbi request reprint Glyco-oxidation in diabetes and related diseases
    Annunziata Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche Cattedra di Malattie del Metabolismo, Universita degli Studi di Padova, Via Giustiniani 2, 35100 Padova, Italy
    Clin Chim Acta 357:236-50. 2005
    ..In this context, non-enzymatic protein glyco-oxidation leads to the formation of a series of products whose intra- and extra-cellular accumulation is of key importance in the pathogenesis of these chronic diseases...
  3. pmc A pilot study on dietary approaches in multiethnicity: two methods compared
    Romina Valentini
    Department of Medical and Surgical Sciences, U O of Metabolic Diseases and Diabetology, University of Padua, Via Giustiniani 2, 35143 Padua, Italy
    Int J Endocrinol 2012:985136. 2012
    ..Conclusions. This preliminary study indicates the positive effect of an ethnic approach to diet on the outcome of pregnancy...
  4. pmc Mass spectrometry for diabetic nephropathy monitoring: new effective tools for physicians
    Annunziata Lapolla
    Department of Medicine, University of Padova, Via Giustiniani 2, 35137 Padova, Italy
    ISRN Endocrinol 2012:768159. 2012
    ..This paper provides a short description of the basic aspects of the mass spectrometric methods used for diabetic nephropathy monitoring, reporting and discussing the results obtained using different approaches...
  5. pmc Management of gestational diabetes mellitus
    Annunziata Lapolla
    Department of Medical and Surgical Sciences, Padova University, Italy
    Diabetes Metab Syndr Obes 2:73-82. 2009
    ..Numerous studies have found glyburide and metformin safe in women with GDM but more randomized controlled trials are needed, with a long-term follow-up of mother and child, to confirm these results...
  6. pmc DALI: Vitamin D and lifestyle intervention for gestational diabetes mellitus (GDM) prevention: an European multicentre, randomised trial - study protocol
    Judith G M Jelsma
    Department of Public and Occupational Health, EMGO Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    BMC Pregnancy Childbirth 13:142. 2013
    ..Gestational diabetes mellitus (GDM) is an increasing problem world-wide. Lifestyle interventions and/or vitamin D supplementation might help prevent GDM in some women...
  7. ncbi request reprint Evaluation of advanced glycation end products and carbonyl compounds in patients with different conditions of oxidative stress
    Annunziata Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche Cattedra di Malattie del Metabolismo, Universita di Padova, Padova, Italy
    Mol Nutr Food Res 49:685-90. 2005
    ....
  8. ncbi request reprint Pentosidine plasma levels and relation with metabolic control in diabetic patients
    A Lapolla
    Department of Medical and Surgical Sciences, University of Padua, Italy
    Horm Metab Res 37:252-6. 2005
    ....
  9. ncbi request reprint Lymphocyte subsets and cytokines in women with gestational diabetes mellitus and their newborn
    A Lapolla
    Metabolic Disorders Section, Department of Medical and Surgical Sciences, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    Cytokine 31:280-7. 2005
    ..In conclusion, GDM women and their newborn have lymphocyte subset impairments, which are more important in patients positive for autoantibodies and/or treated with insulin...
  10. ncbi request reprint Evaluation of glyoxal and methylglyoxal levels in uremic patients under peritoneal dialysis
    A Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche, Cattedra di Malattie del Metabolismo, Via Giustiniani 2, 35100 Padova, Italy
    Ann N Y Acad Sci 1043:217-24. 2005
    ....
  11. doi request reprint Some views on proteomics in diabetes
    Annunziata Lapolla
    Universita di Padova, Dipartimento di Scienze Mediche e Chirurgiche, Padova, Italy
    Clin Chem Lab Med 49:943-57. 2011
    ....
  12. doi request reprint The general use of glycated haemoglobin for the diagnosis of diabetes and other categories of glucose intolerance: still a long way to go
    A Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche, Cattedra di Malattie del Metabolismo, Universita degli Studi di Padova, Padova, Italy
    Nutr Metab Cardiovasc Dis 21:467-75. 2011
    ..The impact of its use on the epidemiology of diabetes and other categories of glucose intolerance, as seen from recent reports, is also discussed...
  13. ncbi request reprint Importance of measuring products of non-enzymatic glycation of proteins
    Annunziata Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche, Cattedra di Malattie del Metabolismo, Universita di Padova, Padova, Italy
    Clin Biochem 38:103-15. 2005
    ..This review summarizes current knowledge about the diagnostic utility of measuring non-enzymatic glycation products...
  14. ncbi request reprint The complexity of non-enzymatic glycation product sets of human globins
    A Lapolla
    Department of Medical and Surgical Sciences, Metabolic Diseases, University of Padua, Padua, Italy
    Diabetologia 47:1712-5. 2004
    ..The aim of this study was to provide an accurate description and evaluation of glycated and glyco-oxidated globins from diabetic subjects and their relationship with HbA1c and plasma glucose values...
  15. doi request reprint Pregnancy outcome in morbidly obese women before and after laparoscopic gastric banding
    Annunziata Lapolla
    Department of Medical and Surgical Sciences, University of Padova, Via Giustiniani n 2, 35100, Padova, Italy
    Obes Surg 20:1251-7. 2010
    ..Increasing numbers of pregnancies are seen in obese women treated surgically with laparoscopic adjustable gastric banding (LAGB). We compared their maternal and fetal outcomes with obese women without LAGB and normal-weight controls...
  16. doi request reprint Outcome of pregnancy in type 1 diabetic patients treated with insulin lispro or regular insulin: an Italian experience
    Annunziata Lapolla
    Dipartimento Scienze Mediche e Chirurgiche, Cattedra di Malattie del Metabolismo, Universita di Padova, Via Giustiniani, 2, 35100, Padua, Italy
    Acta Diabetol 45:61-6. 2008
    ..These findings suggest that insulin lispro could be useful for the treatment of hyperglycemia in type 1 diabetic pregnant women...
  17. doi request reprint Pregnancy complicated by type 2 diabetes: an emerging problem
    Annunziata Lapolla
    Department of Medical and Surgical Sciences, Chair of Metabolic Diseases, Via Giustiniani 2, Padova University, 35128 Padova, Italy
    Diabetes Res Clin Pract 80:2-7. 2008
    ....
  18. doi request reprint Diabetes related autoimmunity in gestational diabetes mellitus: is it important?
    A Lapolla
    Department of Clinical and Surgical Sciences Chair of Metabolic Disease, Padova University, Via Giustiniani n 2, 35100 Padova, Italy
    Nutr Metab Cardiovasc Dis 19:674-82. 2009
    ..Since women with autoimmune GDM must be considered at high risk of developing type 1 diabetes in any of its clinical forms, these women should be regarded as future candidates for the immunomodulatory strategies used in type 1 diabetes...
  19. ncbi request reprint Nonenzymatically glycated lipoprotein ApoA-I in plasma of diabetic and nephropathic patients
    Annunziata Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche, Cattedra di Malattie del Metabolismo, Universita di Padova, Padova, Italy
    Ann N Y Acad Sci 1126:295-9. 2008
    ....
  20. ncbi request reprint Early detection of insulin sensitivity and beta-cell function with simple tests indicates future derangements in late pregnancy
    A Lapolla
    Department of Medical and Surgical Sciences, Via Giustiniani n 2, 35100 Padova, Italy
    J Clin Endocrinol Metab 93:876-80. 2008
    ..Insulin sensitivity and secretion during early and late pregnancy were assessed in women with normal glucose tolerance and gestational diabetes mellitus (GDM)...
  21. ncbi request reprint A multicenter Italian study on pregnancy outcome in women with diabetes
    Annunziata Lapolla
    Department of Clinical and Surgical Sciences, Padova University, Via Giustiniani 2, 35100 Padova, Italy
    Nutr Metab Cardiovasc Dis 18:291-7. 2008
    ..To determine pregnancy outcome in women with type 1 and type 2 diabetes...
  22. ncbi request reprint Off-line liquid chromatography-MALDI by with various matrices and tandem mass spectrometry for analysis of glycated human serum albumin tryptic peptides
    Annunziata Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche, Universita di Padova, Italy
    Mol Nutr Food Res 51:456-61. 2007
    ..These unique product ions can be used as effective markers to establish the presence of a glucose molecule within a peptide ion...
  23. ncbi request reprint Can plasma glucose and HbA1c predict fetal growth in mothers with different glucose tolerance levels?
    A Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche Cattedra di Malattie del Metabolismo, Universita di Padova, Via Giustinuani n 2, 35100 Padua, Italy
    Diabetes Res Clin Pract 77:465-70. 2007
    ..HbA1c at 24-27g.w. does not predict fetal overgrowth. Mild alterations in glucose tolerance correlate with fetal overgrowth and needs monitoring and treatment...
  24. ncbi request reprint Pregnancy complicated by diabetes: what is the best level of HbA1c for conception?
    Annunziata Lapolla
    Department of Medical and Surgical Sciences, Padova University, Italy
    Acta Diabetol 47:187-92. 2010
    ....
  25. doi request reprint New International Association of the Diabetes and Pregnancy Study Groups (IADPSG) recommendations for diagnosing gestational diabetes compared with former criteria: a retrospective study on pregnancy outcome
    A Lapolla
    Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
    Diabet Med 28:1074-7. 2011
    ....
  26. doi request reprint Prepregnancy BMI influences maternal and fetal outcomes in women with isolated gestational hyperglycaemia: a multicentre study
    A Lapolla
    Department of Clinical and Surgical Sciences, Padua University, Via Giustiniani 2, 35100 Padua, Italy
    Diabetes Metab 36:265-70. 2010
    ..This multicentre study analyzed the maternal and fetal outcomes of women who had one elevated 3-h oral glucose tolerance test (isolated gestational hyperglycaemia [IGH])...
  27. ncbi request reprint Antepartum and early postpartum predictors of type 2 diabetes development in women with gestational diabetes mellitus
    M G Dalfrà
    Department of Medical and Surgical Sciences, Padova University, Via E Vendramini 7, 35137 Padua, Italy
    Diabetes Metab 27:675-80. 2001
    ....
  28. ncbi request reprint A matrix-assisted laser desorption/ionization mass spectrometry study of the non-enzymatic glycation products of human globins in diabetes
    A Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche, Malattie del Metabolismo, University of Padova, Via Giustiniani 2, I 35100, Padova, Italy
    Rapid Commun Mass Spectrom 19:162-8. 2005
    ..These data could indicate different individual proclivities to oxidation and/or different oxidation kinetics related to behavioural and environmental factors...
  29. ncbi request reprint Analysis of outcome of pregnancy in type 1 diabetics treated with insulin pump or conventional insulin therapy
    A Lapolla
    Department of Medical and Surgical Sciences, University of Padua, Via E Vendramini 7, I 35137, Padua, Italy
    Acta Diabetol 40:143-9. 2003
    ..Our data suggest that insulin pump therapy is useful in problematic, complicated cases of women who want a baby...
  30. ncbi request reprint Lipoprotein abnormalities in well-treated type II diabetic patients
    E Manzato
    Department of Internal Medicine, University of Padova, Italy
    Diabetes Care 16:469-75. 1993
    ..To investigate lipoprotein levels and composition in well-treated type II diabetic patients...
  31. doi request reprint Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients
    F Piarulli
    Department of Medical and Surgical Sciences, University of Padova, Via dei Colli 4, Padua, Italy
    Diabetologia 52:1419-25. 2009
    ..This study examined the relationship, if any, between glucose-induced oxidative stress, antioxidant status and microalbuminuria in patients with type 2 diabetes...
  32. ncbi request reprint Advanced glycation end products/peptides: an in vivo investigation
    A Lapolla
    Cattedra di Malattie del Metabolismo, Universita di Padova, Italy
    Ann N Y Acad Sci 1043:267-75. 2005
    ....
  33. doi request reprint Desaturase activities and metabolic control in type 2 diabetes
    G Sartore
    Department of Medical and Surgical Sciences, University of Padua, Via dei Colli, 4, 35143 Padova, Italy
    Prostaglandins Leukot Essent Fatty Acids 79:55-8. 2008
    ....
  34. doi request reprint Gestational diabetes mellitus in Italy: a multicenter study
    Annunziata Lapolla
    Department of Clinical and Surgical Sciences, Padova University, Padova, Italy
    Eur J Obstet Gynecol Reprod Biol 145:149-53. 2009
    ..This prospective study evaluated the impact of gestational diabetes on maternal and fetal outcome in a large cohort of women with gestational diabetes mellitus (GDM) followed up using standardized clinical criteria...
  35. doi request reprint The effects of psyllium on lipoproteins in type II diabetic patients
    G Sartore
    Department of Medical and Surgical Sciences, University of Padua, Padua, Italy
    Eur J Clin Nutr 63:1269-71. 2009
    ..Our study contributes toward elucidating the effects of psyllium on serum lipids, and suggests that psyllium treatment may help in reducing triglycerides (a known risk factor for cardiovascular disease) in type II diabetic patients...
  36. doi request reprint Type 1 diabetes control and pregnancy outcomes in women treated with continuous subcutaneous insulin infusion (CSII) or with insulin glargine and multiple daily injections of rapid-acting insulin analogues (glargine-MDI)
    D Bruttomesso
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Diabetes Metab 37:426-31. 2011
    ....
  37. ncbi request reprint Low frequency of autoantibodies to islet cell, glutamic acid decarboxylase, and second-islet antigen in patients with gestational diabetes mellitus: a follow-up study
    A Lapolla
    Division of Metabolic Diseases, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
    Ann N Y Acad Sci 958:263-6. 2002
    ..GDM is a complex syndrome, constituted by different types of diabetes mellitus where the autoimmune form is very rare...
  38. ncbi request reprint Insulin therapy in pregnancy complicated by diabetes: are insulin analogs a new tool?
    A Lapolla
    Department of Medical and Surgical Sciences, University of Padova, Italy
    Diabetes Metab Res Rev 21:241-52. 2005
    ..For the moment, the use of insulin glargine during pregnancy is not recommended owing to the lack of data on maternal and fetal effects...
  39. ncbi request reprint Advanced glycation end products: a highly complex set of biologically relevant compounds detected by mass spectrometry
    A Lapolla
    Dipartimento di Scienze Mediche e Chirurghiche, , Via Giustiniani 2, I-35100 Padova, Italy
    J Mass Spectrom 36:370-8. 2001
    ..In the analysis of HPLC/ESI-MS data, identification of AGE-peptides was facilitated by 3D mapping. Structural information was gained by means of multiple mass spectrometric experiments...
  40. pmc Quality of Life, Wishes, and Needs in Women with Gestational Diabetes: Italian DAWN Pregnancy Study
    A Lapolla
    Department of Medicine, University of Padova, Italy
    Int J Endocrinol 2012:784726. 2012
    ..In order to optimize maternal and foetal outcomes, educational projects and improved communication between patients and the healthcare provider team are recommended...
  41. ncbi request reprint On the search for glycated lipoprotein ApoA-I in the plasma of diabetic and nephropathic patients
    Annunziata Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche, Cattedra di Malattie del Metabolismo, Universita di Padova, Padova, Italy
    J Mass Spectrom 43:74-81. 2008
    ..In the case of nephropathic patients, the RBP level increases in parallel with serum creatinin...
  42. ncbi request reprint AGEs, rather than hyperglycemia, are responsible for microvascular complications in diabetes: a "glycoxidation-centric" point of view
    N C Chilelli
    Department of Medicine, Division of Metabolic Diseases, University of Padova, Via Giustiniani n 2, 35128 Padova, Italy
    Nutr Metab Cardiovasc Dis 23:913-9. 2013
    ..Then we focus on the relationship between AGE and metabolic memory, trying to clarify the former's role in the missing link between micro- and macrovascular complications...
  43. ncbi request reprint Effect of lercanidipine compared with ramipril on albumin excretion rate in hypertensive Type 2 diabetic patients with microalbuminuria: DIAL study (diabete, ipertensione, albuminuria, lercanidipina)
    M Dalla Vestra
    Dipartimento di Scienze Mediche e Chirurgiche, Clinica Medica I, Universita di Padova, Italy
    Diabetes Nutr Metab 17:259-66. 2004
    ..Indeed, both lercanidipine and ramipril treatments resulted in a significant reduction in AER without a statistically significant difference between the two groups...
  44. ncbi request reprint Diabetes and mass spectrometry
    A Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche, Cattedra di Malattie del Metabolismo - Padova University, Via Vendramini 7, 35100 Padova, Italy
    Diabetes Metab Res Rev 17:99-112. 2001
    ....
  45. ncbi request reprint Plasma lipoproteins, apoproteins and cardiovascular disease in type 2 diabetic patients. A nine-year follow-up study
    G Roselli della Rovere
    Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
    Nutr Metab Cardiovasc Dis 13:46-51. 2003
    ..To evaluate the role of lipoprotein abnormalities as risk factors for macroangiopathy in Type 2 diabetes...
  46. ncbi request reprint Non-enzymatic glycation of IgG: an in vivo study
    Annunziata Lapolla
    Dipartimento Scienze Mediche e Chirurgiche, Universita di Padova, Via Giustiniani 2, 35100 Padua, Italy
    Horm Metab Res 34:260-4. 2002
    ..Results suggest that the immunodeficiency observed in diabetic patients may be due to the inhibition of molecular recognition between antibody and antigen as a result of a change in functionality of the modified Fab fragment of IgG...
  47. ncbi request reprint Peripheral artery disease in type 2 diabetes: the role of fibrinolysis
    Annunziata Lapolla
    University of Padova, Department of Medical and Surgical Sciences, Padova, Italy
    Thromb Haemost 89:91-6. 2003
    ..Our study suggests that hypofibrinolysis may be involved in the future onset of PAD in type 2 diabetic patients...
  48. ncbi request reprint Accurate mass measurements by Fourier transform mass spectrometry in the study of advanced glycation end products/peptides
    Ester Marotta
    CNR, Istituto di Scienze e Tecnologie Molecolari, Corso Stati Uniti 4, 35100 Padova, Italy
    J Mass Spectrom 38:196-205. 2003
    ..Using this approach, about 20 glycated peptides were detected and their possible structures were postulated by examining the known sequence of HSA...
  49. ncbi request reprint Autoantibodies against oxidized LDLs and atherosclerosis in type 2 diabetes
    Francesco Piarulli
    Department of Medical and Surgical Sciences, University of Padova, Ospedale dei Colli, Via dei Colli 4, 35100 Padova, Italy
    Diabetes Care 28:653-7. 2005
    ....
  50. ncbi request reprint Mass spectrometry of advanced glycation end products
    Annunziata Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche Cattedra di Malattie del Metabolismo, Universita di Padova, 135100 Padova, Italy
    Adv Clin Chem 40:165-217. 2005
    ....
  51. ncbi request reprint Maternal insulin therapy increases fetal endothelial progenitor cells during diabetic pregnancy
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Diabetes Care 31:808-10. 2008
  52. doi request reprint Quality of life in pregnancy and post-partum: a study in diabetic patients
    M G Dalfrà
    DPT Scienze Mediche e Chirurgiche, Universita di Padova, Via Giustiniani 2, 35128, Padova, Italy
    Qual Life Res 21:291-8. 2012
    ..We evaluated quality of life in pregnant women with diabetes followed up at Italian diabetes clinics...
  53. ncbi request reprint Advanced glycation end products and antioxidant status in type 2 diabetic patients with and without peripheral artery disease
    Annunziata Lapolla
    Department of Medical and Surgical Sciences, University of Padova, Via dei Colli 4, 35143 Padova, Italy
    Diabetes Care 30:670-6. 2007
    ..We investigated the relationship of AGEs, MDA, total reactive antioxidant potentials (TRAPs), and vitamin E in type 2 diabetic patients with and without peripheral artery disease (PAD)...
  54. pmc The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Diabetes 59:2306-14. 2010
    ..Genetic deletion of p66Shc prolongs life span and protects against oxidative stress. In the present study, we evaluated the role of p66Shc in an animal model of diabetic wound healing...
  55. ncbi request reprint The role of mass spectrometry in the study of non-enzymatic protein glycation in diabetes: an update
    Annunziata Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche, Cattedra di Malattie del Metabolismo, Universita di Padova, Padova, Italy
    Mass Spectrom Rev 25:775-97. 2006
    ..In the latter case, results indicated that these dicarbonyl compounds, already present in the dialysis fluids, show a decrease in plasma and in dialysis fluids; those data suggested their reaction at peritoneal membrane level...
  56. doi request reprint A comparison between MALDI-MS and CE-MS data for biomarker assessment in chronic kidney diseases
    L Molin
    CNR ISTM, Padova, Italy
    J Proteomics 75:5888-97. 2012
    ..In a second step, high resolution CE-MS could be used in those patients only that scored negative for CKD in the MALDI-MS analysis, reducing costs and time of such a program...
  57. doi request reprint Low molecular weight proteins in urines from healthy subjects as well as diabetic, nephropathic and diabetic-nephropathic patients: a MALDI study
    Annunziata Lapolla
    Department of Clinical and Surgical Sciences, Padova University, Via Giustiniani 2, I35100 Padova, Italy
    J Mass Spectrom 44:419-25. 2009
    ..The obtained data seem to indicate that urine is an interesting biological fluid to investigate on the peptide profile and to obtain, consequently, information on the dismetabolism activated by specific pathologies...
  58. ncbi request reprint Glyoxal and methylglyoxal levels in diabetic patients: quantitative determination by a new GC/MS method
    Annunziata Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche, Universita di Padova, Padova, Italy
    Clin Chem Lab Med 41:1166-73. 2003
    ..However, a similar behavior of pentosidine indicates that these alternative pathways can be only partially responsible for glyoxal and methylglyoxal production...
  59. ncbi request reprint Enzymatic digestion and mass spectrometry in the study of advanced glycation end products/peptides
    Annunziata Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche, Cattedra di Malattie del Metabolismo, Universita degli Studi di Padova, Padova, Italy
    J Am Soc Mass Spectrom 15:496-509. 2004
    ..Residues 233K, 276K, 378K, 545K, and 525K seem to be privileged glycation sites, in agreement with the fractional solvent accessible surface values calculated by molecular modeling...
  60. doi request reprint A further investigation on a MALDI-based method for evaluation of markers of renal damage
    Annunziata Lapolla
    Department of Medical and Surgical Sciences, Padova University, Via Giustiniani 2, I35100 Padova, Italy
    J Mass Spectrom 44:1754-60. 2009
    ..The obtained data indicate that a good differentiation of nephropathic patients with advanced renal disease and diabetic patients with advanced nephropathy versus healthy subjects can be easily obtained by this approach...
  61. ncbi request reprint Plasma fatty acids and lipoproteins in type 2 diabetic patients
    Annunziata Lapolla
    Department of Medical and Surgical Sciences, University of Padova, Italy
    Diabetes Metab Res Rev 22:226-31. 2006
    ..The aim of this study was to establish whether the type of dietary fats affects LDL size and density and HDL cholesterol concentrations in these patients...
  62. ncbi request reprint Multivariate analysis of matrix-assisted laser desorption/ionization mass spectrometric data related to glycoxidation products of human globins in nephropathic patients
    Annunziata Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche, Universita di Padova, Padova, Italy
    J Am Soc Mass Spectrom 18:1018-23. 2007
    ..These compounds may have a relevant role as specific markers of the pathological state...
  63. doi request reprint Elevated insulin sensitivity and β-cell function during pregnancy in mothers of growth-restricted newborns
    Maria Grazia Dalfrà
    Department of Medical and Surgical Sciences, University of Padua, Padua, Italy
    Am J Physiol Endocrinol Metab 301:E25-30. 2011
    ....
  64. ncbi request reprint National survey on the execution of the oral glucose tolerance test (OGTT) in a representative cohort of Italian laboratories
    Marco Orsini Federici
    Dipartimento di Medicina Interna, Centro Regionale di Riferimento per la Malattia Diabetica, Universita di Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Clin Chem Lab Med 44:568-73. 2006
    ..The aim of the present survey was to evaluate the adherence of Italian laboratories to the internationally accepted guidelines in carrying out the OGTT for the diagnosis of diabetes in the general population and for the screening of GDM...
  65. ncbi request reprint Advanced glycation end-products/peptides: a preliminary investigation by LC and LC/MS
    Annunziata Lapolla
    Farmaco 57:845-52. 2002
    ..MS/ MS experiments on selected species seem to be promising as regards structural information...
  66. ncbi request reprint Performance characteristics and clinical utility of an enzymatic method for the measurement of glycated albumin in plasma
    Rita Paroni
    Dip di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Italy
    Clin Biochem 40:1398-405. 2007
    ....
  67. ncbi request reprint Biological variability of albumin excretion rate and albumin-to-creatinine ratio in hypertensive type 2 diabetic patients
    Andrea Mosca
    Department of Sciences and Biomedical Technologies, University of Milan, Milan, Italy
    Clin Chem Lab Med 41:1229-33. 2003
    ..The results of this study confirm that the albumin/ creatinine ratio is much more suitable for monitoring albumin excretion in longitudinal studies than the albumin excretion rate...
  68. ncbi request reprint Effect of protein leaking BK-F PMMA-based hemodialysis on plasma pentosidine levels
    Nicola Tessitore
    Nephrology Division, Universita degli Studi di Verona, Azienda Ospedaliera of Verona, Italy
    J Nephrol 17:707-14. 2004
    ....
  69. ncbi request reprint The fate of glyoxal and methylglyoxal in peritoneal dialysis
    Annunziata Lapolla
    J Mass Spectrom 41:405-8. 2006
  70. ncbi request reprint Preeclampsia in lean normotensive normotolerant pregnant women can be predicted by simple insulin sensitivity indexes
    Elena Parretti
    Department of Gynecology, Perinatology and Human Reproduction, University of Florence, Italy
    Hypertension 47:449-53. 2006
    ..Given their high sensitivity and specificity, these indexes could be useful in predicting the development of preeclampsia in early pregnancy, before the disease become clinically evident...
  71. ncbi request reprint Polymorphisms of insulin receptor substrate 1 and beta3-adrenergic receptor genes in gestational diabetes and normal pregnancy
    Franco Fallucca
    Dipartimento di Scienze Cliniche, Ospedale S Andrea, II Facolta di Medicina e Chirurgia, Universita La Sapienza, Roma
    Metabolism 55:1451-6. 2006
    ..048), suggesting a possible synergistic effect of the 2 gene polymorphisms. These results suggest that the IRS-1 genetic polymorphism is involved in the occurrence of gestational diabetes, as well as type 2 diabetes mellitus...
  72. ncbi request reprint Comprehensive analysis of glycated human serum albumin tryptic peptides by off-line liquid chromatography followed by MALDI analysis on a time-of-flight/curved field reflectron tandem mass spectrometer
    Francesco L Brancia
    Shimadzu Research Laboratory Europe, Manchester, UK
    J Mass Spectrom 41:1179-85. 2006
    ..The specific neutral losses derived from the activated glycated peptides can be used as signature for establishing the occurrence of glycation processes...
  73. ncbi request reprint Reference intervals for hemoglobin A1c in pregnant women: data from an Italian multicenter study
    Andrea Mosca
    Dipartimento di Scienze e Tecnologie Biomediche, Universita degli Studi di Milano, Segrate Milano, Italy
    Clin Chem 52:1138-43. 2006
    ..The reference intervals for hemoglobin A1c (Hb A1c) in pregnant women without diabetes are not well defined, and few examples of reference intervals established by networks of different laboratories are available...