Affiliation: University of Foggia
Lapice E, Pinelli M, Pisu E, Monticelli A, Gambino R, Pagano G, et al
. Uncoupling protein 2 G(-866)A polymorphism: a new gene polymorphism associated with C-reactive protein in type 2 diabetic patients. Cardiovasc Diabetol. 2010;9:68 pubmed publisher
..The study shows for the first time, in type 2 diabetic patients, a significant association of hs-CRP levels with the G(-866)A polymorphism of UCP2 beyond the effect of major confounders. ..
Lapice E, Masulli M, Vaccaro O. Iron deficiency and cardiovascular disease: an updated review of the evidence. Curr Atheroscler Rep. 2013;15:358 pubmed publisher
..Extreme conditions of iron deficiency, as well as of iron overload, are associated with modestly increased CVD risk, although with different proposed mechanisms. ..
Lapice E, Vaccaro O. Interaction between Pro12Ala polymorphism of PPARÎ³2 and diet on adiposity phenotypes. Curr Atheroscler Rep. 2014;16:462 pubmed publisher
Lapice E, Monticelli A, Cocozza S, Pinelli M, Cocozza S, Bruzzese D, et al
. The PPARÎ³2 Pro12Ala variant is protective against progression of nephropathy in people with type 2 diabetes. J Transl Med. 2015;13:85 pubmed publisher
..32 (0.12-0.80). This study found that among patients with type 2 diabetes, the PPARÎ³2 Pro12Ala polymorphism is protective against progression of nephropathy and decay of renal function independent of major confounders. ..
Lapice E, Monticelli A, Pinelli M, Massimino E, Giacco A, Rivellese A, et al
. The combination of UCP3-55CT and PPAR?2Pro12Ala polymorphisms affects BMI and substrate oxidation in two diabetic populations. Nutr Metab Cardiovasc Dis. 2016;26:400-6 pubmed publisher
..The relative importance of these mechanism(s) may be different in non diabetic people. ..