Cristina Lanni

Summary

Affiliation: University of Pavia
Country: Italy

Publications

  1. pmc Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?
    Serena Stanga
    Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Italy
    Aging (Albany NY) 2:545-54. 2010
  2. doi request reprint Do we need pharmacogenetics to personalize antidepressant therapy?
    Cristina Lanni
    Department of Drug Sciences Pharmacology Section, Center of Excellence in Applied Biology, University of Pavia, IUSS Pavia Istituto Universitario di Studi Superiori Pavia, Viale Taramelli 14, 27100, Pavia, Italy
    Cell Mol Life Sci 70:3327-40. 2013
  3. doi request reprint Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Italian patients
    Cristina Lanni
    Department of Drug Sciences, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    J Alzheimers Dis 32:919-26. 2012
  4. doi request reprint Zyxin is a novel target for β-amyloid peptide: characterization of its role in Alzheimer's pathogenesis
    Cristina Lanni
    Department of Drug Sciences, Centre of Excellence in Applied Biology, University of Pavia, 27100 Pavia, Italy
    J Neurochem 125:790-9. 2013
  5. doi request reprint p53 at the crossroads between cancer and neurodegeneration
    Cristina Lanni
    Department of Drug Sciences, Centre of Excellence in Applied Biology, University of Pavia, 27100 Pavia, Italy
    Free Radic Biol Med 52:1727-33. 2012
  6. pmc Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival
    Cristina Lanni
    Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    PLoS ONE 5:e10171. 2010
  7. doi request reprint Unfolded p53 in blood as a predictive signature signature of the transition from mild cognitive impairment to Alzheimer's disease
    Cristina Lanni
    Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    J Alzheimers Dis 20:97-104. 2010
  8. pmc Dual effect of beta-amyloid on α7 and α4β2 nicotinic receptors controlling the release of glutamate, aspartate and GABA in rat hippocampus
    Elisa Mura
    Department of Drug Sciences, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    PLoS ONE 7:e29661. 2012
  9. doi request reprint CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity
    Raffaella Colombo
    Dipartimento di Chimica Farmaceutica, University of Pavia, Pavia, Italy
    Electrophoresis 30:1418-29. 2009
  10. doi request reprint Recruitment of casein kinase 2 is involved in AbetaPP processing following cholinergic stimulation
    Silvia C Lenzken
    Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    J Alzheimers Dis 20:1133-41. 2010

Collaborators

Detail Information

Publications32

  1. pmc Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?
    Serena Stanga
    Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Italy
    Aging (Albany NY) 2:545-54. 2010
    ..Here we discuss about these findings and the potential relevance of HIPK2 as a target for AD and highlight the existence of a novel amyloid-based mechanism in AD potentially leading to the survival of injured dysfunctional cells...
  2. doi request reprint Do we need pharmacogenetics to personalize antidepressant therapy?
    Cristina Lanni
    Department of Drug Sciences Pharmacology Section, Center of Excellence in Applied Biology, University of Pavia, IUSS Pavia Istituto Universitario di Studi Superiori Pavia, Viale Taramelli 14, 27100, Pavia, Italy
    Cell Mol Life Sci 70:3327-40. 2013
    ..The role of target polymorphism, however, is much more difficult to establish and may be more relevant for disease susceptibility and presentation rather than for response to therapy...
  3. doi request reprint Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Italian patients
    Cristina Lanni
    Department of Drug Sciences, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    J Alzheimers Dis 32:919-26. 2012
    ..To our knowledge, this synergistic effect is here shown for the first time on a population sample representative of Caucasian patients...
  4. doi request reprint Zyxin is a novel target for β-amyloid peptide: characterization of its role in Alzheimer's pathogenesis
    Cristina Lanni
    Department of Drug Sciences, Centre of Excellence in Applied Biology, University of Pavia, 27100 Pavia, Italy
    J Neurochem 125:790-9. 2013
    ..We demonstrate for the first time that zyxin is a novel target of Aβ activities in AD. These results may help the studies on the pathogenesis of AD, through the fine dissection of events related to beta-amyloid activities...
  5. doi request reprint p53 at the crossroads between cancer and neurodegeneration
    Cristina Lanni
    Department of Drug Sciences, Centre of Excellence in Applied Biology, University of Pavia, 27100 Pavia, Italy
    Free Radic Biol Med 52:1727-33. 2012
    ....
  6. pmc Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival
    Cristina Lanni
    Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    PLoS ONE 5:e10171. 2010
    ..We recently reported an altered conformational state of p53 in tissues from patients with Alzheimer's Disease (AD) that led to an impaired and dysfunctional response to stressors...
  7. doi request reprint Unfolded p53 in blood as a predictive signature signature of the transition from mild cognitive impairment to Alzheimer's disease
    Cristina Lanni
    Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    J Alzheimers Dis 20:97-104. 2010
    ..The same protein also predicted progression to AD in preclinical patients with MCI two years before clinical diagnosis of AD was made. Herein, we describe these findings and discuss the potential of the test in diagnosing AD...
  8. pmc Dual effect of beta-amyloid on α7 and α4β2 nicotinic receptors controlling the release of glutamate, aspartate and GABA in rat hippocampus
    Elisa Mura
    Department of Drug Sciences, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    PLoS ONE 7:e29661. 2012
    ..Particularly, we focused on some neurotransmitters that are usually involved in learning and memory: glutamate, aspartate and GABA...
  9. doi request reprint CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity
    Raffaella Colombo
    Dipartimento di Chimica Farmaceutica, University of Pavia, Pavia, Italy
    Electrophoresis 30:1418-29. 2009
    ..Interestingly, in vitro cell viability experiments indicated that pixantrone significantly reduces A beta(1-42) neurotoxicity...
  10. doi request reprint Recruitment of casein kinase 2 is involved in AbetaPP processing following cholinergic stimulation
    Silvia C Lenzken
    Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    J Alzheimers Dis 20:1133-41. 2010
    ..On the basis of our results, we add another player to the complex cellular mechanisms regulating non-amyloidogenic processing of AbetaPP...
  11. ncbi request reprint Dangerous liaisons between beta-amyloid and cholinergic neurotransmission
    Stefano Govoni
    University of Pavia, Dept of Drug Sciences, Phamacology Section, Viale Taramelli 14, 27100 Pavia, Italy
    Curr Pharm Des 20:2525-38. 2014
    ..Also emerges the inherent difficulty of targeting beta-amyloid in a context in which the peptide exerts several actions beyond neurotoxicity...
  12. doi request reprint AβPP intracellular C-terminal domain function is related to its degradation processes
    Erica Buoso
    Department of Drug Sciences, Pharmacology Unit, Center of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    J Alzheimers Dis 30:393-405. 2012
    ....
  13. doi request reprint Specific neuromodulatory actions of amyloid-beta on dopamine release in rat nucleus accumbens and caudate putamen
    Elisa Mura
    Department of Experimental and Applied Pharmacology, University of Pavia, Pavia, Italy
    J Alzheimers Dis 19:1041-53. 2010
    ..Altogether, these results show that Abeta may have different neuromodulatory actions depending upon the secretory stimulus and, in vivo, the brain area investigated...
  14. ncbi request reprint Role of acetylcholinesterase inhibitors in pharmacological regulation of amyloid precursor protein processing
    Marco Racchi
    CEBA Centre of Excellence in Applied Biology and Department of Experimental and Applied Pharmacology, University of Pavia, Italy
    Aging Clin Exp Res 18:149-52. 2006
    ....
  15. ncbi request reprint Searching for predictive blood biomarkers: misfolded p53 in mild cognitive impairment
    Serena Stanga
    Department of Drug Sciences, University of Pavia, Pavia, Italy
    Curr Alzheimer Res 9:1191-7. 2012
    ....
  16. ncbi request reprint Nicotinic component of galantamine in the regulation of amyloid precursor protein processing
    Silvia C Lenzken
    Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Viale Taramelli 14, CAP 27100 Pavia, Italy
    Chem Biol Interact 165:138-45. 2007
    ..The effect of GAL was prevented by pre-treatment with alpha-bungarotoxin (40nM) but not low (nanomolar) atropine concentrations, suggesting the specific involvement of nicotinic cholinergic receptors...
  17. ncbi request reprint Acute beta-amyloid administration disrupts the cholinergic control of dopamine release in the nucleus accumbens
    Stefania Preda
    Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    Neuropsychopharmacology 33:1062-70. 2008
    ..We can suggest that, in nucleus accumbens, Abeta disrupted in vivo and in vitro cholinergic control of DA release by acting on muscarinic transduction machinery...
  18. ncbi request reprint Role of acetylcholinesterase inhibitors in the regulation of amyloid beta precursor protein (AbetaPP) metabolism
    Marco Racchi
    Centre of Excellence in Applied Biology CEBA, Department of Experimental and Applied Pharmacology, University of Pavia, Viale Taramelli 14, Pavia 27100, Italy
    Chem Biol Interact 157:335-8. 2005
    ..We also provide preliminary evidence that these molecules may affect a gene expression program beyond the classical pharmacological pattern suggesting an insight on possible unexplored pathways of intervention in AD...
  19. ncbi request reprint In vitro and ex vivo antihydroxyl radical activity of green and roasted coffee
    Maria Daglia
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy
    J Agric Food Chem 52:1700-4. 2004
    ..e., melanoidins), also possessing antiradical activity in coffee. These results could explain the neuroprotective effects found for coffee consumption in recent epidemiological studies...
  20. ncbi request reprint Modulation of Rack-1/PKCβII signalling by soluble AβPPα in SH-SY5Y cells
    Erica Buoso
    Department of Drug Sciences Pharmacology Unit, University of Pavia, Viale Taramelli 14, 27100 Pavia, Italy
    Curr Alzheimer Res 10:697-705. 2013
    ....
  21. ncbi request reprint Mucoadhesive microspheres for nasal administration of cyclodextrins
    Elisabetta Gavini
    Department of Drug Sciences, University of Sassari, Sassari, Italy
    J Drug Target 17:168-79. 2009
    ..The microsphere properties are influenced by the kind of polymer, of cyclodextrin and by cyclodextrin to polymer ratio used. In particular, the alginate formulation containing the higher cyclodextrin content shows the best performance...
  22. doi request reprint beta-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain
    Erica Buoso
    Department of Experimental and Applied Pharmacology, Center of Excellence in Applied Biology, University of Pavia, Viale Taramelli 14, 27100 Pavia, Italy
    Pharmacol Res 62:308-17. 2010
    ..Our work is aimed to analyse the functional role of AICD, integrating also the AICD degradation processes, to better define a potential role of AICD in signal transduction...
  23. ncbi request reprint Acetylcholinesterase inhibitors: novel activities of old molecules
    Marco Racchi
    Department of Experimental and Applied Pharmacology, University of Pavia, Viale Taramelli 14, 27100 Pavia, Italy
    Pharmacol Res 50:441-51. 2004
    ....
  24. ncbi request reprint Unfolded p53: a potential biomarker for Alzheimer's disease
    Cristina Lanni
    Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Italy
    J Alzheimers Dis 12:93-9. 2007
    ....
  25. pmc Neuronal ELAV proteins enhance mRNA stability by a PKCalpha-dependent pathway
    Alessia Pascale
    Department of Experimental and Applied Pharmacology, University of Pavia, Via Taramelli 14, 27100 Pavia, Italy
    Proc Natl Acad Sci U S A 102:12065-70. 2005
    ..These findings suggest a model for gene expression regulation by nELAV proteins through a PKCalpha-dependent pathway that is relevant for the cellular programs in which ARE-mediated control plays a pivotal role...
  26. doi request reprint Cognition enhancers between treating and doping the mind
    Cristina Lanni
    Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Viale Taramelli 14, 27100 Pavia, Italy
    Pharmacol Res 57:196-213. 2008
    ....
  27. doi request reprint Depression and antidepressants: molecular and cellular aspects
    Cristina Lanni
    Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy
    Cell Mol Life Sci 66:2985-3008. 2009
    ....
  28. ncbi request reprint Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein
    Cristina Lanni
    Department of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology and School of Pharmacy, University of Pavia, Viale Taramelli 14, 27100 Pavia, Italy
    Eur J Biochem 271:3068-75. 2004
    ..The response to carbachol is instead completely blocked in PKCepsilon-deficient cells suggesting the importance of PKCepsilon in coupling cholinergic receptors with APP metabolism...
  29. ncbi request reprint Capillary electrophoresis studies on the aggregation process of beta-amyloid 1-42 and 1-40 peptides
    Stefania Sabella
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Pavia, Italy
    Electrophoresis 25:3186-94. 2004
    ..The perturbation of the existing equilibrium among the identified species by the addition of small molecules can in principle interfere with the aggregation process of the peptides and ultimately prevent the plaque formation in vitro...
  30. doi request reprint Opposing effects of cortisol and dehydroepiandrosterone on the expression of the receptor for Activated C Kinase 1: implications in immunosenescence
    Erica Buoso
    Department of Drug Sciences Pharmacology Section, Center of Excellence in Applied Biology, University of Pavia, Viale Taramelli 14, Pavia, Italy
    Exp Gerontol 46:877-83. 2011
    ..Probably by interfering with glucocorticoid receptor binding to GRE sequence, prolonged DHEA exposure counteracted cortisol effects, restoring RACK-1 levels and cytokine production, as assessed by LPS-induced TNF-α release...
  31. doi request reprint Endothelin B receptor antagonists block proliferation and induce apoptosis in glioma cells
    Mayra Paolillo
    Dipartimento di Farmacologia Sperimentale ed Applicata, Universita di Pavia, Viale Taramelli 14, 27100 Pavia, Italy
    Pharmacol Res 61:306-15. 2010
    ..Our findings support the hypothesis that ETB antagonists represent a new promising therapeutic strategy for the treatment of high grade gliomas...
  32. ncbi request reprint Antiradical activity of water soluble components in common diet vegetables
    Marco Racchi
    Department of Experimental and Applied Pharmacology, Faculty of Pharmacy, University of Pavia, Via Taramelli 14, 27100 Pavia, Italy
    J Agric Food Chem 50:1272-7. 2002
    ..Mushroom antiradical activity was also confirmed by a cytofluorimetric analysis...