Research Topics
Genomes and Genes | Umberto LaforenzaSummaryAffiliation: University of Pavia Country: Italy Publications
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Publications
Solute transporters and aquaporins are impaired in celiac diseaseUmberto Laforenza
Department of Physiology, University of Pavia, Pavia, Italy
Biol Cell 102:457-67. 2010..The localization of AQPs 3, 7 and 10 and of SGLT1 (Na+/glucose co-transporter 1), PEPT1 (H+/oligopeptide transporter 1) and NHE3 (Na+/H+ exchanger 3) was evaluated by immunohistochemistry...
Aquaporin-10 represents an alternative pathway for glycerol efflux from human adipocytesUmberto Laforenza
Department of Molecular Medicine, University of Pavia, Pavia, Italy
PLoS ONE 8:e54474. 2013..To this purpose we investigated the expression, the localization and the functioning of aquaglyceroporin-10 in subcutaneous white adipose tissue, in isolated and cultured differentiated adipocytes...- Water channel proteins in the gastrointestinal tractUmberto Laforenza
Department of Molecular Medicine, Section of Human Physiology, University of Pavia, Via Forlanini 6, I 27100 Pavia, Italy
Mol Aspects Med 33:642-50. 2012..Here we review AQP expression and localization at the tissue, cellular and subcellular level in gastrointestinal epithelia, and their modification in various gut diseases... - Aquaporin-6 is expressed along the rat gastrointestinal tract and upregulated by feeding in the small intestineUmberto Laforenza
Department of Physiology, Section of Human Physiology, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy
BMC Physiol 9:18. 2009..In this direction we investigated, in some regions of the rat gastrointestinal tract, the presence and localization of aquaporin-6, given its peculiar function as an ion selective channel... 
Aquaporin-8 is involved in water transport in isolated superficial colonocytes from rat proximal colonUmberto Laforenza
Dipartimento di Medicina Sperimentale, Sezione di Fisiologia Umana, Universita di Pavia, Italy
J Nutr 135:2329-36. 2005..05). Current results indicate that aquaporin-8 may play a major role in water movement through the colon by acting on the apical side of the superficial cells...- Expression and immunolocalization of aquaporin-7 in rat gastrointestinal tractUmberto Laforenza
Department of Experimental Medicine, Section of Human Physiology, University of Pavia, Via Forlanini 6, I 27100 Pavia, Italy
Biol Cell 97:605-13. 2005.... - Osmotic water permeability of rat intestinal brush border membrane vesicles: involvement of aquaporin-7 and aquaporin-8 and effect of metal ionsSimona Tritto
Department of Experimental Medicine, Section of Human Physiology, University of Pavia, Via Forlanini 6, Pavia, Italy
Biochem Cell Biol 85:675-84. 2007..AQP8 may contribute to the water-imbalance-related clinical symptoms apparent after ingestion of high doses of Hg2+ and Cu2+... - Expression and localization of ryanodine receptors in the frog semicircular canalPaola Perin
Department of Physiology, Section of General Physiology, University of Pavia, 27100 Pavia, Italy
J Biomed Biotechnol 2012:398398. 2012..The differential expression of RyR isoforms was studied by RT-PCR and immunoblotting, showing the presence of RyRα in both ampulla and canal arm and RyRβ in the ampulla only... - Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentrationSilvia Dragoni
Department of Physiology, University of Pavia, Pavia, Italy
Stem Cells 29:1898-907. 2011..This novel signaling pathway might be exploited to enhance the outcome of CBT and chemotherapy... - Aquaporin-6 expression in the cochlear sensory epithelium is downregulated by salicylatesPaola Perin
Department of Physiology, Section of General Physiology, University of Pavia, 27100 Pavia, Italy
J Biomed Biotechnol 2010:264704. 2010.... - Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patientsFrancesco Lodola
Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy
PLoS ONE 7:e42541. 2012..As oncogenesis may be associated to the capability of tumor cells to grow independently on Ca(2+) influx, it is important to assess whether SOCE regulates EPC-dependent angiogenesis also in tumor patients... - Guanidine transport across the apical and basolateral membranes of human intestinal Caco-2 cells is mediated by two different mechanismsEmanuela Cova
Institute of Human Physiology, University of Pavia, Italy
J Nutr 132:1995-2003. 2002.... - PYY-Tag transgenic mice displaying abnormal (H+-K+)ATPase activity and gastric mucosal barrier impairmentUmberto Laforenza
Department of Experimental Medicine, Section of Human Physiology, University of Pavia, Pavia, Italy
Lab Invest 83:47-54. 2003..The abnormal and unregulated levels of circulating peptide YY and glucagon led to gastric acid inhibition and an impairment of gastric barrier function as a result of a striking reduction in epithelial proliferation... - Histamine H1 receptors are expressed in mouse and frog semicircular canal sensory epitheliaLaura Botta
Department of Physiological Pharmacological Cellular Molecular Sciences, University of Pavia, Italy
Neuroreport 19:425-9. 2008..Our data show that both frog and mouse vestibular epithelia express H1 receptors. Conversely no clear evidence for H3 receptors expression was found... - Molecular characteristics of small intestinal and renal brush border thiamin transporters in ratsAnna Verri
Institute of Human Physiology, University of Pavia, Italy
Biochim Biophys Acta 1558:187-97. 2002..In addition, arginine and histidine residues are also essential respectively for renal and small intestinal transporters. Serine was essential for the T/H(+) antiport mechanism... - Store-operated Ca(2+) entry is expressed in human endothelial progenitor cellsYuly Sánchez-Hernández
Department of Physiology, University of Pavia, Pavia, Italy
Stem Cells Dev 19:1967-81. 2010..These findings provide the first evidence that EPCs express SOCE, which might thus be regarded as a novel target to enhance the regenerative outcome of cell-based therapy... - SOD1 mRNA expression in sporadic amyotrophic lateral sclerosisStella Gagliardi
Laboratory of Experimental Neurobiology, IRCCS, Neurological Institute C Mondino, Pavia, Italy
Neurobiol Dis 39:198-203. 2010..These findings provide new insight and understanding of the pathologic causes of sporadic forms of ALS and allow a possible explanation for the molecular involvement of wild-type SOD1... - Protein kinase C regulation of rat jejunal transport systems: mechanisms involved in bicarbonate absorptionMaria Novella Orsenigo
Dipartimento di Fisiologia e Biochimica Generali, Universita di Milano, Via Celoria 26, I 20133 Milano, Italy
Exp Physiol 87:299-309. 2002..The inhibition of both apical Na(+)-H(+) and basolateral Cl(-)-HCO(3)(-) exchange activities suggests that the overall action of PKC causes a reduction of transepithelial bicarbonate transport... - Oxidative stress reduces transintestinal transports and (Na+, K+) -ATPase activity in rat jejunumMaria Novella Orsenigo
Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita di Milano, Via Celoria 26, I 20133, Milano, Italy
Arch Biochem Biophys 466:300-7. 2007..We conclude that H(2)O(2) may be a modulator of jejunal ion and water transport by multiple mechanisms, among which a significant inhibition of the basolateral (Na+, K+) -ATPase... - PKA regulation of bicarbonate and lactate movements across rat jejunal plasma membranesMaria Novella Orsenigo
Dipartimento di Scienze Biomolecolari e Biotechnologie, Universita di Milano, Italy
Cell Physiol Biochem 14:77-90. 2004..Aim of this study was to investigate the possible role of PKA on bicarbonate and lactate transports...