Umberto Laforenza

Summary

Affiliation: University of Pavia
Country: Italy

Publications

  1. doi request reprint Solute transporters and aquaporins are impaired in celiac disease
    Umberto Laforenza
    Department of Physiology, University of Pavia, Pavia, Italy
    Biol Cell 102:457-67. 2010
  2. pmc Aquaporin-6 expression in the cochlear sensory epithelium is downregulated by salicylates
    Paola Perin
    Department of Physiology, Section of General Physiology, University of Pavia, 27100 Pavia, Italy
    J Biomed Biotechnol 2010:264704. 2010
  3. pmc Expression and localization of ryanodine receptors in the frog semicircular canal
    Paola Perin
    Department of Physiology, Section of General Physiology, University of Pavia, 27100 Pavia, Italy
    J Biomed Biotechnol 2012:398398. 2012
  4. pmc Aquaporin-10 represents an alternative pathway for glycerol efflux from human adipocytes
    Umberto Laforenza
    Department of Molecular Medicine, University of Pavia, Pavia, Italy
    PLoS ONE 8:e54474. 2013
  5. doi request reprint Water channel proteins in the gastrointestinal tract
    Umberto Laforenza
    Department of Molecular Medicine, Section of Human Physiology, University of Pavia, Via Forlanini 6, I 27100 Pavia, Italy
    Mol Aspects Med 33:642-50. 2012
  6. pmc Aquaporin-6 is expressed along the rat gastrointestinal tract and upregulated by feeding in the small intestine
    Umberto Laforenza
    Department of Physiology, Section of Human Physiology, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy
    BMC Physiol 9:18. 2009
  7. ncbi request reprint Aquaporin-8 is involved in water transport in isolated superficial colonocytes from rat proximal colon
    Umberto Laforenza
    Dipartimento di Medicina Sperimentale, Sezione di Fisiologia Umana, Universita di Pavia, Italy
    J Nutr 135:2329-36. 2005
  8. ncbi request reprint Expression and immunolocalization of aquaporin-7 in rat gastrointestinal tract
    Umberto Laforenza
    Department of Experimental Medicine, Section of Human Physiology, University of Pavia, Via Forlanini 6, I 27100 Pavia, Italy
    Biol Cell 97:605-13. 2005
  9. ncbi request reprint Osmotic water permeability of rat intestinal brush border membrane vesicles: involvement of aquaporin-7 and aquaporin-8 and effect of metal ions
    Simona Tritto
    Department of Experimental Medicine, Section of Human Physiology, University of Pavia, Via Forlanini 6, Pavia, Italy
    Biochem Cell Biol 85:675-84. 2007
  10. doi request reprint Canonical transient receptor potential 3 channel triggers vascular endothelial growth factor-induced intracellular Ca2+ oscillations in endothelial progenitor cells isolated from umbilical cord blood
    Silvia Dragoni
    1 Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy
    Stem Cells Dev 22:2561-80. 2013

Collaborators

Detail Information

Publications24

  1. doi request reprint Solute transporters and aquaporins are impaired in celiac disease
    Umberto Laforenza
    Department of Physiology, University of Pavia, Pavia, Italy
    Biol Cell 102:457-67. 2010
    ..The localization of AQPs 3, 7 and 10 and of SGLT1 (Na+/glucose co-transporter 1), PEPT1 (H+/oligopeptide transporter 1) and NHE3 (Na+/H+ exchanger 3) was evaluated by immunohistochemistry...
  2. pmc Aquaporin-6 expression in the cochlear sensory epithelium is downregulated by salicylates
    Paola Perin
    Department of Physiology, Section of General Physiology, University of Pavia, 27100 Pavia, Italy
    J Biomed Biotechnol 2010:264704. 2010
    ....
  3. pmc Expression and localization of ryanodine receptors in the frog semicircular canal
    Paola Perin
    Department of Physiology, Section of General Physiology, University of Pavia, 27100 Pavia, Italy
    J Biomed Biotechnol 2012:398398. 2012
    ..The differential expression of RyR isoforms was studied by RT-PCR and immunoblotting, showing the presence of RyRα in both ampulla and canal arm and RyRβ in the ampulla only...
  4. pmc Aquaporin-10 represents an alternative pathway for glycerol efflux from human adipocytes
    Umberto Laforenza
    Department of Molecular Medicine, University of Pavia, Pavia, Italy
    PLoS ONE 8:e54474. 2013
    ..To this purpose we investigated the expression, the localization and the functioning of aquaglyceroporin-10 in subcutaneous white adipose tissue, in isolated and cultured differentiated adipocytes...
  5. doi request reprint Water channel proteins in the gastrointestinal tract
    Umberto Laforenza
    Department of Molecular Medicine, Section of Human Physiology, University of Pavia, Via Forlanini 6, I 27100 Pavia, Italy
    Mol Aspects Med 33:642-50. 2012
    ..Here we review AQP expression and localization at the tissue, cellular and subcellular level in gastrointestinal epithelia, and their modification in various gut diseases...
  6. pmc Aquaporin-6 is expressed along the rat gastrointestinal tract and upregulated by feeding in the small intestine
    Umberto Laforenza
    Department of Physiology, Section of Human Physiology, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy
    BMC Physiol 9:18. 2009
    ..In this direction we investigated, in some regions of the rat gastrointestinal tract, the presence and localization of aquaporin-6, given its peculiar function as an ion selective channel...
  7. ncbi request reprint Aquaporin-8 is involved in water transport in isolated superficial colonocytes from rat proximal colon
    Umberto Laforenza
    Dipartimento di Medicina Sperimentale, Sezione di Fisiologia Umana, Universita di Pavia, Italy
    J Nutr 135:2329-36. 2005
    ..05). Current results indicate that aquaporin-8 may play a major role in water movement through the colon by acting on the apical side of the superficial cells...
  8. ncbi request reprint Expression and immunolocalization of aquaporin-7 in rat gastrointestinal tract
    Umberto Laforenza
    Department of Experimental Medicine, Section of Human Physiology, University of Pavia, Via Forlanini 6, I 27100 Pavia, Italy
    Biol Cell 97:605-13. 2005
    ....
  9. ncbi request reprint Osmotic water permeability of rat intestinal brush border membrane vesicles: involvement of aquaporin-7 and aquaporin-8 and effect of metal ions
    Simona Tritto
    Department of Experimental Medicine, Section of Human Physiology, University of Pavia, Via Forlanini 6, Pavia, Italy
    Biochem Cell Biol 85:675-84. 2007
    ..AQP8 may contribute to the water-imbalance-related clinical symptoms apparent after ingestion of high doses of Hg2+ and Cu2+...
  10. doi request reprint Canonical transient receptor potential 3 channel triggers vascular endothelial growth factor-induced intracellular Ca2+ oscillations in endothelial progenitor cells isolated from umbilical cord blood
    Silvia Dragoni
    1 Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy
    Stem Cells Dev 22:2561-80. 2013
    ..Therefore, the Ca(2+) response to VEGF in UCB-ECFCs is shaped by a different Ca(2+) machinery as compared with PB-ECFCs, and TRPC3 stands out as a promising target in EPC-based treatment of ischemic pathologies. ..
  11. doi request reprint Histamine H1 receptors are expressed in mouse and frog semicircular canal sensory epithelia
    Laura Botta
    Department of Physiological Pharmacological Cellular Molecular Sciences, University of Pavia, Italy
    Neuroreport 19:425-9. 2008
    ..Our data show that both frog and mouse vestibular epithelia express H1 receptors. Conversely no clear evidence for H3 receptors expression was found...
  12. doi request reprint Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration
    Silvia Dragoni
    Department of Physiology, University of Pavia, Pavia, Italy
    Stem Cells 29:1898-907. 2011
    ..This novel signaling pathway might be exploited to enhance the outcome of CBT and chemotherapy...
  13. ncbi request reprint Guanidine transport across the apical and basolateral membranes of human intestinal Caco-2 cells is mediated by two different mechanisms
    Emanuela Cova
    Institute of Human Physiology, University of Pavia, Italy
    J Nutr 132:1995-2003. 2002
    ....
  14. pmc Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients
    Francesco Lodola
    Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy
    PLoS ONE 7:e42541. 2012
    ..As oncogenesis may be associated to the capability of tumor cells to grow independently on Ca(2+) influx, it is important to assess whether SOCE regulates EPC-dependent angiogenesis also in tumor patients...
  15. ncbi request reprint Ca2+ signalling in endothelial progenitor cells: a novel means to improve cell-based therapy and impair tumour vascularisation
    Francesco Moccia
    Department of Physiology, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy
    Curr Vasc Pharmacol 12:87-105. 2014
    ..For example, genetic manipulation of the Ca(2+) signalling machinery could provide a novel approach to increase the extent of limb regeneration or preventing tumour vascularisation by EPCs. ..
  16. ncbi request reprint Posttranscriptional regulation of SOD1 gene expression under oxidative stress: Potential role of ELAV proteins in sporadic ALS
    Pamela Milani
    Laboratory of Experimental Neurobiology, C Mondino National Institute of Neurology Foundation, IRCCS, Via Mondino 2, 27100 Pavia, Italy Department of Public Health, Neuroscience, Experimental and Forensic Medicine, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy Electronic address
    Neurobiol Dis 60:51-60. 2013
    ..The link between ELAVs and SOD1 may open novel perspectives for ALS research, paving the way for new therapeutic options...
  17. doi request reprint Enhanced expression of Stim, Orai, and TRPC transcripts and proteins in endothelial progenitor cells isolated from patients with primary myelofibrosis
    Silvia Dragoni
    Laboratory of General Physioloy, Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy
    PLoS ONE 9:e91099. 2014
    ..SOCE is up-regulated in RCC-ECFCs due to the over-expression of its underlying molecular components, namely Stim1, Orai1, and TRPC1...
  18. ncbi request reprint PYY-Tag transgenic mice displaying abnormal (H+-K+)ATPase activity and gastric mucosal barrier impairment
    Umberto Laforenza
    Department of Experimental Medicine, Section of Human Physiology, University of Pavia, Pavia, Italy
    Lab Invest 83:47-54. 2003
    ..The abnormal and unregulated levels of circulating peptide YY and glucagon led to gastric acid inhibition and an impairment of gastric barrier function as a result of a striking reduction in epithelial proliferation...
  19. doi request reprint Store-operated Ca(2+) entry is expressed in human endothelial progenitor cells
    Yuly Sánchez-Hernández
    Department of Physiology, University of Pavia, Pavia, Italy
    Stem Cells Dev 19:1967-81. 2010
    ..These findings provide the first evidence that EPCs express SOCE, which might thus be regarded as a novel target to enhance the regenerative outcome of cell-based therapy...
  20. ncbi request reprint Molecular characteristics of small intestinal and renal brush border thiamin transporters in rats
    Anna Verri
    Institute of Human Physiology, University of Pavia, Italy
    Biochim Biophys Acta 1558:187-97. 2002
    ..In addition, arginine and histidine residues are also essential respectively for renal and small intestinal transporters. Serine was essential for the T/H(+) antiport mechanism...
  21. ncbi request reprint SOD1 mRNA expression in sporadic amyotrophic lateral sclerosis
    Stella Gagliardi
    Laboratory of Experimental Neurobiology, IRCCS, Neurological Institute C Mondino, Pavia, Italy
    Neurobiol Dis 39:198-203. 2010
    ..These findings provide new insight and understanding of the pathologic causes of sporadic forms of ALS and allow a possible explanation for the molecular involvement of wild-type SOD1...
  22. ncbi request reprint Oxidative stress reduces transintestinal transports and (Na+, K+) -ATPase activity in rat jejunum
    Maria Novella Orsenigo
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita di Milano, Via Celoria 26, I 20133, Milano, Italy
    Arch Biochem Biophys 466:300-7. 2007
    ..We conclude that H(2)O(2) may be a modulator of jejunal ion and water transport by multiple mechanisms, among which a significant inhibition of the basolateral (Na+, K+) -ATPase...
  23. ncbi request reprint PKA regulation of bicarbonate and lactate movements across rat jejunal plasma membranes
    Maria Novella Orsenigo
    Dipartimento di Scienze Biomolecolari e Biotechnologie, Universita di Milano, Italy
    Cell Physiol Biochem 14:77-90. 2004
    ..Aim of this study was to investigate the possible role of PKA on bicarbonate and lactate transports...
  24. ncbi request reprint Protein kinase C regulation of rat jejunal transport systems: mechanisms involved in bicarbonate absorption
    Maria Novella Orsenigo
    Dipartimento di Fisiologia e Biochimica Generali, Universita di Milano, Via Celoria 26, I 20133 Milano, Italy
    Exp Physiol 87:299-309. 2002
    ..The inhibition of both apical Na(+)-H(+) and basolateral Cl(-)-HCO(3)(-) exchange activities suggests that the overall action of PKC causes a reduction of transepithelial bicarbonate transport...