C Krausz

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. pmc Phenotypic variation within European carriers of the Y-chromosomal gr/gr deletion is independent of Y-chromosomal background
    C Krausz
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini, 6 Florence 50139, Italy
    J Med Genet 46:21-31. 2009
  2. ncbi request reprint Effects of transmission of Y chromosome AZFc deletions
    Philippos C Patsalis
    Cyprus Institute of Neurology and Genetics, Cyprus
    Lancet 360:1222-4. 2002
  3. ncbi request reprint Genetic risk factors in male infertility
    Csilla Krausz
    Andrology Unit, Department of Clinical Physiopathology, Viale Pieraccini, 6 Firenze, Italy
    Arch Androl 53:125-33. 2007
  4. ncbi request reprint Gene polymorphisms/mutations relevant to abnormal spermatogenesis
    Francesca Nuti
    Andrology Unit, Department of Clinical Physiopathology, Viale Pieraccini, 6, 50139 Florence, Italy
    Reprod Biomed Online 16:504-13. 2008
  5. doi request reprint Partial AZFc deletions and duplications: clinical correlates in the Italian population
    Claudia Giachini
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139, Firenze, Italy
    Hum Genet 124:399-410. 2008
  6. pmc Novel insights into DNA methylation features in spermatozoa: stability and peculiarities
    Csilla Krausz
    Department of Clinical Physiopathology, Andrology Unit, University of Florence, Florence, Italy
    PLoS ONE 7:e44479. 2012
  7. ncbi request reprint Y chromosome and male infertility: update, 2006
    Csilla Krausz
    Department of Clinical Physiopathology Center for Research, Transfer and High Education, DENOthe, University of Florence, 50139 Florence, Italy
    Front Biosci 11:3049-61. 2006
  8. ncbi request reprint Sperm cryopreservation in male infertility due to genetic disorders
    Csilla Krausz
    Andrology Unit, Department of Clinical Physiopathology, Viale Pieraccini, 6, Firenze, Italy
    Cell Tissue Bank 7:105-12. 2006
  9. ncbi request reprint The clinical significance of the POLG gene polymorphism in male infertility
    C Krausz
    Andrology Unit, Department of Clinical Physiopathology, Viale Pieraccini 6, 50139 Florence, Italy
    J Clin Endocrinol Metab 89:4292-7. 2004
  10. ncbi request reprint Genetic aspects of testicular germ cell tumors
    Csilla Krausz
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Cell Cycle 7:3519-24. 2008

Collaborators

Detail Information

Publications36

  1. pmc Phenotypic variation within European carriers of the Y-chromosomal gr/gr deletion is independent of Y-chromosomal background
    C Krausz
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini, 6 Florence 50139, Italy
    J Med Genet 46:21-31. 2009
    ..This study set out to test these possibilities in a large sample of gr/gr deletion carriers with known phenotypes spanning the complete range...
  2. ncbi request reprint Effects of transmission of Y chromosome AZFc deletions
    Philippos C Patsalis
    Cyprus Institute of Neurology and Genetics, Cyprus
    Lancet 360:1222-4. 2002
    ..Transmission of Y chromosome microdeletions could potentially have severe clinical consequences other than male infertility, such as the development of sexual ambiguities and Turner stigmata...
  3. ncbi request reprint Genetic risk factors in male infertility
    Csilla Krausz
    Andrology Unit, Department of Clinical Physiopathology, Viale Pieraccini, 6 Firenze, Italy
    Arch Androl 53:125-33. 2007
    ..In this review, recent findings concerning some of the most widely studied polymorphisms and male infertility will be discussed...
  4. ncbi request reprint Gene polymorphisms/mutations relevant to abnormal spermatogenesis
    Francesca Nuti
    Andrology Unit, Department of Clinical Physiopathology, Viale Pieraccini, 6, 50139 Florence, Italy
    Reprod Biomed Online 16:504-13. 2008
    ..Future large-scale studies with stringent study design may provide a more efficient way to identify clinically relevant genetic factors of male infertility...
  5. doi request reprint Partial AZFc deletions and duplications: clinical correlates in the Italian population
    Claudia Giachini
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139, Firenze, Italy
    Hum Genet 124:399-410. 2008
    ....
  6. pmc Novel insights into DNA methylation features in spermatozoa: stability and peculiarities
    Csilla Krausz
    Department of Clinical Physiopathology, Andrology Unit, University of Florence, Florence, Italy
    PLoS ONE 7:e44479. 2012
    ....
  7. ncbi request reprint Y chromosome and male infertility: update, 2006
    Csilla Krausz
    Department of Clinical Physiopathology Center for Research, Transfer and High Education, DENOthe, University of Florence, 50139 Florence, Italy
    Front Biosci 11:3049-61. 2006
    ..Future studies should focus on understanding the biological function of AZF genes which is an essential step for the development of more appropriate and knowledge-based therapies...
  8. ncbi request reprint Sperm cryopreservation in male infertility due to genetic disorders
    Csilla Krausz
    Andrology Unit, Department of Clinical Physiopathology, Viale Pieraccini, 6, Firenze, Italy
    Cell Tissue Bank 7:105-12. 2006
    ..It is therefore important to be aware about the clinical importance and the related genetic risks of these anomalies. In this article we describe the clinical significance of these diseases...
  9. ncbi request reprint The clinical significance of the POLG gene polymorphism in male infertility
    C Krausz
    Andrology Unit, Department of Clinical Physiopathology, Viale Pieraccini 6, 50139 Florence, Italy
    J Clin Endocrinol Metab 89:4292-7. 2004
    ..More importantly, considering that the homozygous mutant genotype has been found in normospermic fertile men, the analysis of the CAG repeat tract of the POLG gene does not appear to have any clinical diagnostic value...
  10. ncbi request reprint Genetic aspects of testicular germ cell tumors
    Csilla Krausz
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Cell Cycle 7:3519-24. 2008
    ..This review focuses on genetic factors (both genomic and somatic) involved in the etiology, progression and treatment sensitivity of TGCTs...
  11. ncbi request reprint The Y chromosome and male fertility and infertility
    Csilla Krausz
    Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Androl 26:70-5. 2003
    ..Past and present unresolved issues are discussed in this review...
  12. ncbi request reprint Natural transmission of USP9Y gene mutations: a new perspective on the role of AZFa genes in male fertility
    Csilla Krausz
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Italy
    Hum Mol Genet 15:2673-81. 2006
    ....
  13. doi request reprint Male infertility: pathogenesis and clinical diagnosis
    Csilla Krausz
    Andrology Unit, Department of Clinical Physiopathology, Viale Pieraccini 6, Florence 50137, Italy
    Best Pract Res Clin Endocrinol Metab 25:271-85. 2011
    ....
  14. doi request reprint The Y chromosome-linked copy number variations and male fertility
    C Krausz
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence 50139, Italy
    J Endocrinol Invest 34:376-82. 2011
    ..While searching for new genetic factors on other chromosomes, our work on the Y chromosome still needs to be completed, with special focus on the biological function of the Y genes...
  15. ncbi request reprint Y chromosome polymorphisms in medicine
    Csilla Krausz
    Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Ann Med 36:573-83. 2004
    ..The situation is rather contradictory for other male-specific or male-associated diseases and further multicenter--possibly multiethnic--studies are needed...
  16. ncbi request reprint Partial AZFc deletions in infertile men with cryptorchidism
    C Giachini
    Andrology Unit, Department of Clinical Physiopathology, Center for Research, Transfer and Higher Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders, University of Florence, 6 Viale Pieraccini, 50139 Firenze, Italy
    Hum Reprod 22:2398-403. 2007
    ..Since both pathologies can be part of the testicular dysgenesis syndrome (TDS), we aimed to define the role of 'gr/gr' deletion in the aethiopathogenesis of another component of the TDS: cryptorchidism...
  17. ncbi request reprint Y chromosome and male infertility
    C Krausz
    Andrology Unit of the University of Florence, Training Centre of the European Academy of Andrology, Florence, Italy
    Andrologia 37:219-23. 2005
  18. ncbi request reprint DAZL polymorphisms and susceptibility to spermatogenic failure: an example of remarkable ethnic differences
    L Becherini
    Andrology Unit, Department of Clinical Physiopathology, Univeristy of Florence, Viale Pieraccini 6, 50134 Firenze, Italy
    Int J Androl 27:375-81. 2004
    ....
  19. doi request reprint Klinefelter's syndrome: a clinical and therapeutical update
    G Forti
    Endocrinology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Sex Dev 4:249-58. 2010
    ..Furthermore, the genetic risk to the offspring of Klinefelter patients has recently not been found to be greater than that of patients with nonobstructive azoospermia with normal karyotype...
  20. ncbi request reprint Estrogen receptor alpha promoter polymorphism: stronger estrogen action is coupled with lower sperm count
    Elena Guarducci
    Department of Clinical Physiopathology, Andrology Unit, University of Florence, Florence, Italy
    Hum Reprod 21:994-1001. 2006
    ....
  21. ncbi request reprint Cyclic adenosine 3',5'-monophosphate-responsive element modulator gene expression in germ cells of normo- and oligoazoospermic men
    A Peri
    Department of Clinical Physiopathology, University of Florence School of Medicine, Italy
    J Clin Endocrinol Metab 83:3722-6. 1998
    ..Thus, our results indicate that the lack of a switch in the expression of CREM gene isoforms may be related to impaired spermatogenesis in humans...
  22. doi request reprint Small variations in crucial steps of TUNEL assay coupled to flow cytometry greatly affect measures of sperm DNA fragmentation
    Monica Muratori
    Department of Clinical Physiopathology, Andrology Unit, University of Florence, Firenze, Italy
    J Androl 31:336-45. 2010
    ..On the contrary, the TUNEL assay, as measured here, showed low intraassay CVs, resulting in a quite precise technique when performed in established conditions...
  23. ncbi request reprint Difficulties in achieving vs maintaining erection: organic, psychogenic and relational determinants
    G Corona
    Department of Clinical Physiopathology, Andrology Unit, University of Florence, Florence, Italy
    Int J Impot Res 17:252-8. 2005
    ....
  24. ncbi request reprint Y-chromosome microdeletions are not associated with SHOX haploinsufficiency
    C Chianese
    Andrology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence 50139, Italy
    Hum Reprod 28:3155-60. 2013
    ..Are Y-chromosome microdeletions associated with SHOX haploinsufficiency, thus representing a risk of skeletal anomalies for the carriers and their male descendents?..
  25. ncbi request reprint Prognostic value of Y deletion analysis: what is the clinical prognostic value of Y chromosome microdeletion analysis?
    C Krausz
    Immunogenetique Humaine, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence, Italy or
    Hum Reprod 15:1431-4. 2000
    ....
  26. ncbi request reprint Clinical review 100: Evaluation and treatment of the infertile couple
    G Forti
    Department of Clinical Physiopathology, University of Florence, Italy
    J Clin Endocrinol Metab 83:4177-88. 1998
    ..With most ARTs the average delivery rate per cycle is approximately 15% and the cumulative delivery rate after several cycles is about 50%. (ABSTRACT TRUNCATED)..
  27. ncbi request reprint Varicocele and infertility
    G Forti
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Endocrinol Invest 26:564-9. 2003
  28. pmc EAA/EMQN best practice guidelines for molecular diagnosis of Y-chromosomal microdeletions: state-of-the-art 2013
    C Krausz
    Andrology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
    Andrology 2:5-19. 2014
    ..The 12-year experience with the EMQN/EAA scheme has shown a steep decline in diagnostic (genotyping) error rate and a simultaneous improvement on reporting practice. ..
  29. doi request reprint Persistence of expression of the TMPRSS2:ERG fusion gene after pre-surgery androgen ablation may be associated with early prostate specific antigen relapse of prostate cancer: preliminary results
    L Bonaccorsi
    Unit of Andrology, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Endocrinol Invest 32:590-6. 2009
    ..The recently identified TMPRSS2: ERG fusion gene is a candidate oncogene for prostate cancer (PCa)...
  30. doi request reprint Seladin-1 and testicular germ cell tumours: new insights into cisplatin responsiveness
    Francesca Nuti
    Andrology Unit, University of Florence, 50139 Florence, Italy
    J Pathol 219:491-500. 2009
    ..In conclusion, we have demonstrated for the first time an important role for seladin-1 in the biology of TGCTs and provided new insights into cisplatin responsiveness of these tumours...
  31. pmc TSPY1 copy number variation influences spermatogenesis and shows differences among Y lineages
    Claudia Giachini
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence 50139, Italy
    J Clin Endocrinol Metab 94:4016-22. 2009
    ..However, data are scarce on TSPY1 copy number variation in different Y lineages and its role in spermatogenesis...
  32. ncbi request reprint The leucine-rich repeat-containing G protein-coupled receptor 8 gene T222P mutation does not cause cryptorchidism
    Francesca Nuti
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy
    J Clin Endocrinol Metab 93:1072-6. 2008
    ..This conclusion was based on both functional in vitro studies and the lack of mutation in a large group of controls. The geographical origin of the mutation carriers suggested a founder effect in the Mediterranean area...
  33. ncbi request reprint Genetic control of spermiogenesis: insights from the CREM gene and implications for human infertility
    Csilla Krausz
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini, 6, Florence 50139, Italy
    Reprod Biomed Online 10:64-71. 2005
    ..The conservation of these elements and of their regulatory functions in human spermatogenesis indicates that they are likely to provide important insights into understanding the molecular mechanisms of human infertility...
  34. ncbi request reprint Inhibin B: a marker for the functional state of the seminiferous epithelium in patients with azoospermia factor C microdeletions
    Lone Frydelund-Larsen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 87:5618-24. 2002
    ....
  35. doi request reprint Need for standardization and confirmation of STS deletions on the Y chromosome
    Robert Ian McLachlan
    Fertil Steril 90:463-4; author reply 464. 2008
  36. pmc Y-chromosome haplogroups and susceptibility to azoospermia factor c microdeletion in an Italian population
    Barbara Arredi
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    J Med Genet 44:205-8. 2007
    ..Materials and..