Mauro Krampera

Summary

Affiliation: University of Verona
Country: Italy

Publications

  1. doi Immunological characterization of multipotent mesenchymal stromal cells--The International Society for Cellular Therapy (ISCT) working proposal
    Mauro Krampera
    Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Policlinico G B Rossi, Verona, Italy
    Cytotherapy 15:1054-61. 2013
  2. ncbi HB-EGF/HER-1 signaling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multilineage differentiation
    Mauro Krampera
    Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
    Blood 106:59-66. 2005
  3. ncbi Regenerative and immunomodulatory potential of mesenchymal stem cells
    Mauro Krampera
    Department of Clinical and Experimental Medicine, Section of Haematology, P le L A Scuro 10, 37134 Verona, Italy
    Curr Opin Pharmacol 6:435-41. 2006
  4. ncbi Methodological approach to minimal residual disease detection by flow cytometry in adult B-lineage acute lymphoblastic leukemia
    Mauro Krampera
    Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Universita di Verona
    Haematologica 91:1109-12. 2006
  5. ncbi Induction of neural-like differentiation in human mesenchymal stem cells derived from bone marrow, fat, spleen and thymus
    Mauro Krampera
    Department of Clinical, Section of Haematology, University of Verona, Italy
    Bone 40:382-90. 2007
  6. ncbi Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair
    Mauro Krampera
    Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
    Bone 39:678-83. 2006
  7. ncbi Outcome prediction by immunophenotypic minimal residual disease detection in adult T-cell acute lymphoblastic leukaemia
    Mauro Krampera
    Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Universita di Verona, Italy
    Br J Haematol 120:74-9. 2003
  8. doi Mesenchymal stromal cell 'licensing': a multistep process
    M Krampera
    Stem Cell Research Laboratory, Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
    Leukemia 25:1408-14. 2011
  9. ncbi Immune regulation by mesenchymal stem cells derived from adult spleen and thymus
    Mauro Krampera
    Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
    Stem Cells Dev 16:797-810. 2007
  10. pmc Comparison of epithelial differentiation and immune regulatory properties of mesenchymal stromal cells derived from human lung and bone marrow
    Mario Ricciardi
    Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, Italy
    PLoS ONE 7:e35639. 2012

Collaborators

Detail Information

Publications51

  1. doi Immunological characterization of multipotent mesenchymal stromal cells--The International Society for Cellular Therapy (ISCT) working proposal
    Mauro Krampera
    Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Policlinico G B Rossi, Verona, Italy
    Cytotherapy 15:1054-61. 2013
    ..Thus, the MSC Committee of the International Society for Cellular Therapy has decided to put forward for general discussion a working proposal for a standardized approach based on a critical view of literature data. ..
  2. ncbi HB-EGF/HER-1 signaling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multilineage differentiation
    Mauro Krampera
    Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
    Blood 106:59-66. 2005
    ..These data show that HB-EGF/HER-1 signaling is relevant to MSC biology, by regulating both proliferation and differentiation...
  3. ncbi Regenerative and immunomodulatory potential of mesenchymal stem cells
    Mauro Krampera
    Department of Clinical and Experimental Medicine, Section of Haematology, P le L A Scuro 10, 37134 Verona, Italy
    Curr Opin Pharmacol 6:435-41. 2006
    ..Thus, MSCs appear to be a very promising tool for regenerative and immunoregulatory cell therapy...
  4. ncbi Methodological approach to minimal residual disease detection by flow cytometry in adult B-lineage acute lymphoblastic leukemia
    Mauro Krampera
    Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Universita di Verona
    Haematologica 91:1109-12. 2006
    ..2%). Blast phenotypes were stable in culture and at relapse, and were useful for MRD monitoring in patients. Marker combinations for childhood ALL are also applicable to adult cases...
  5. ncbi Induction of neural-like differentiation in human mesenchymal stem cells derived from bone marrow, fat, spleen and thymus
    Mauro Krampera
    Department of Clinical, Section of Haematology, University of Verona, Italy
    Bone 40:382-90. 2007
    ..This evidence provides new insights into BM-like tissue plasticity and may have important implications for future therapeutic interventions in chronic neuropathies...
  6. ncbi Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair
    Mauro Krampera
    Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
    Bone 39:678-83. 2006
    ..We discuss here the potential use of MSCs in degenerative or inflammatory diseases involving bone, cartilage, tendon and muscle tissues, on the basis of the experimental evidence...
  7. ncbi Outcome prediction by immunophenotypic minimal residual disease detection in adult T-cell acute lymphoblastic leukaemia
    Mauro Krampera
    Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Universita di Verona, Italy
    Br J Haematol 120:74-9. 2003
    ..Our data suggest that immunophenotypic MRD monitoring in the first year of treatment is a useful outcome predictor for adult T-ALL patients...
  8. doi Mesenchymal stromal cell 'licensing': a multistep process
    M Krampera
    Stem Cell Research Laboratory, Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
    Leukemia 25:1408-14. 2011
    ..Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects...
  9. ncbi Immune regulation by mesenchymal stem cells derived from adult spleen and thymus
    Mauro Krampera
    Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
    Stem Cells Dev 16:797-810. 2007
    ..Our data suggest that not only do spleen and thymus have a stem cell reservoir to build up their stromal architecture, but also contain microenviromental immunoregulatory cells with the same properties of BM-MSCs...
  10. pmc Comparison of epithelial differentiation and immune regulatory properties of mesenchymal stromal cells derived from human lung and bone marrow
    Mario Ricciardi
    Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, Italy
    PLoS ONE 7:e35639. 2012
    ....
  11. doi Efficacy assessment of interferon-alpha-engineered mesenchymal stromal cells in a mouse plasmacytoma model
    Silvia Sartoris
    Department of Pathology and Diagnostics, University of Verona, Verona, Italy
    Stem Cells Dev 20:709-19. 2011
    ....
  12. ncbi Stem molecular signature of adipose-derived stromal cells
    Daniele Peroni
    Department of Morphological and Biomedical Sciences, Section of Anatomy and Histology, University of Verona, Italy
    Exp Cell Res 314:603-15. 2008
    ..Thus, our findings strongly support a close relationship between ADSCs and BM-MSCs, suggest an unexpected similarity between MSCs and embryonic stem cells, and possibly support the potential therapeutic application of ADSCs...
  13. doi Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells
    Armel Hervé Nwabo Kamdje
    Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, Italy
    Blood 118:380-9. 2011
    ..Our data suggest that the stromal cell-mediated antiapoptotic effect on B- ALL cells is mediated by Notch-3 and -4 or Jagged-1/-2 and DLL-1 in a synergistic manner...
  14. ncbi Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells
    Mauro Krampera
    Department of Clinical and Experimental Medicine, University of Verona, Italy
    Stem Cells 24:386-98. 2006
    ..These findings suggest that the beneficial effect on graft-versus-host disease induced by in vivo coinfusion with the graft of MSCs may be due to the activation of the immunomodulatory properties of MSCs by T cell- derived IFN-gamma...
  15. pmc The TNF-family cytokine TL1A inhibits proliferation of human activated B cells
    Chiara Cavallini
    Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
    PLoS ONE 8:e60136. 2013
    ....
  16. pmc Macrophages may promote cancer growth via a GM-CSF/HB-EGF paracrine loop that is enhanced by CXCL12
    Antonella Rigo
    Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
    Mol Cancer 9:273. 2010
    ..Events triggered by CXCL12 may play a part, as CXCL12 drives the migration of both CXCR4-positive cancer cells and macrophages and may promote a molecular crosstalk between them...
  17. doi Neuronal differentiation potential of human adipose-derived mesenchymal stem cells
    Elena Anghileri
    Department of Neurological Sciences and Vision, University of Verona, Verona, Italy
    Stem Cells Dev 17:909-16. 2008
    ..In view of these results and the easy availability of adipose tissue, A-MSC may be a ready source of adult MSC with neuronal differentiation potential, an useful tool to treat neurodegenerative diseases...
  18. pmc Nestin- and doublecortin-positive cells reside in adult spinal cord meninges and participate in injury-induced parenchymal reaction
    Ilaria Decimo
    Department of Public Health and Community Medicine, Section of Pharmacology, University of Verona, Verona, Italy
    Stem Cells 29:2062-76. 2011
    ..Meninges may be considered as a new source of adult stem/precursor cells to be further tested for use in regenerative medicine applied to neurological disorders, including repair from spinal cord injury...
  19. doi Toll-like receptor-3-activated human mesenchymal stromal cells significantly prolong the survival and function of neutrophils
    Marco A Cassatella
    Section of General Pathology, Department of Pathology and Diagnostics, University of Verona, Italy
    Stem Cells 29:1001-11. 2011
    ..Our data highlight a novel mechanism by which MSC sustain and amplify the functions of PMN in response to TLR3- and TLR4-triggering and may consequently contribute to inflammatory disorders...
  20. ncbi Thymic epithelial cells promote survival of human T-cell acute lymphoblastic leukemia blasts: the role of interleukin-7
    Maria T Scupoli
    Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Verona, Italy
    Haematologica 88:1229-37. 2003
    ..In this study we explored the possible effect of TEC on T-ALL cell survival and analyzed the role of interleukin-7 (IL-7) within the microenvironment generated by T-ALL-TEC interactions...
  21. doi Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis
    Gabriela Constantin
    Department of Pathology, University of Verona, Italy
    Stem Cells 27:2624-35. 2009
    ..Overall, our data suggest that ASCs represent a valuable tool for stem cell-based therapy in chronic inflammatory diseases of the CNS...
  22. doi Human bone marrow and adipose tissue mesenchymal stem cells: a user's guide
    Federico Mosna
    Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, Policlinico G B Rossi University of Verona, Verona, Italy
    Stem Cells Dev 19:1449-70. 2010
    ..We chose to use BM-MSCs as a model to describe techniques that have been used for MSC isolation and expansion from very different sources, and AT-MSCs as an example of a reliable and increasingly common alternative source...
  23. doi Novel stem/progenitor cells with neuronal differentiation potential reside in the leptomeningeal niche
    Francesco Bifari
    Department of Clinical and Experimental Medicine, Stem Cell Research Laboratory, Section of Hematology, University of Verona, Verona, Italy
    J Cell Mol Med 13:3195-208. 2009
    ..As leptomeninges cover the entire central nervous system, these findings could have relevant implications for studies on cortical development and for regenerative medicine applied to neurological disorders...
  24. doi Adipose-derived stromal cells (ASCs)
    Giulio Bassi
    Laboratorio di Ricerca sulle Cellule Staminali, Sezione di Ematologia, Dipartimento di Medicina, Universita degli Studi di Verona, Italy
    Transfus Apher Sci 47:193-8. 2012
    ..Thus, more accurate studies, collaborative protocols, high standardization of methods, and safety controls are required to exclude transformation of transplanted ASCs...
  25. doi Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF-kappaB and JNK/AP-1 pathways
    Maria T Scupoli
    Laboratorio Universitario di Ricerca, Medica LURM, Policlinico, G B Rossi, Piazzale L Scuro 10, 37134 Verona, Italy
    Haematologica 93:524-32. 2008
    ..We also investigated the roles of the nuclear factor-kappaB and Jun-N-terminal kinase (JNK)/activating protein (AP)-1 signaling pathways, which contribute to regulate interleukin-8 production in some cells...
  26. doi IFN-gamma-mediated upmodulation of MHC class I expression activates tumor-specific immune response in a mouse model of prostate cancer
    Matteo Martini
    Department of Pathology and Diagnostics, Immunology Section, University of Verona, Italy
    Vaccine 28:3548-57. 2010
    ..To explore possible clinical translation, we delivered IFN-gamma to TRAMP-C2 tumor site by means of genetically engineered MSCs secreting IFN-gamma...
  27. ncbi Helicobacter pylori infection and idiopathic thrombocytopenic purpura: description of 21 newly diagnosed cases
    Dino Veneri
    Dipartimento di Medicina Sperimentale e Clinica, Divisione di Ematologia, Universita di Verona, Italy
    Haematologica 89:ECR08. 2004
  28. pmc VR09 cell line: an EBV-positive lymphoblastoid cell line with in vivo characteristics of diffuse large B cell lymphoma of activated B-cell type
    Ilaria Nichele
    Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, Italy
    PLoS ONE 7:e52811. 2012
    ..small B-cell neoplasms can show plasmacytic differentiation and may potentially progress to aggressive lymphoma (DLBCL). Epstein-Barr virus (EBV) infection may cause the transformation of malignant cells in vitro...
  29. ncbi High prevalence of sustained remission of idiopathic thrombocytopenic purpura after Helicobacter pylori eradication: a long-term follow-up study
    Dino Veneri
    Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Verona, Italy
    Platelets 16:117-9. 2005
    ..2 months. None of the patients still infected by H. pylori after therapy reached normal platelet values. The long-term follow-up confirms the efficacy of H. pylori eradication in H. pylori-infected ITP patients...
  30. doi Notch signaling in acute lymphoblastic leukemia: any role for stromal microenvironment?
    Armel Hervé Nwabo Kamdje
    Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Policlinico G B Rossi, Piazzale L A Scuro 10, Verona, Italy
    Blood 118:6506-14. 2011
    ..Here, the data concerning the development of T- and B-cell acute lymphoblastic leukemia has been critically reviewed in light of the most recent findings on Notch signaling in stromal microenvironment...
  31. ncbi Low-dose epirubicin in combination with cyclophosphamide, vinblastine and prednisone (mini-CEOP) for the treatment of aggressive non-Hodgkin's lymphoma in elderly patients
    Dino Veneri
    Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Universita di Verona, Italy
    Haematologica 87:ELT43. 2002
  32. ncbi Analysis of HFE and TFR2 gene mutations in patients with acute leukemia
    Dino Veneri
    Dipartimento di Medicina Sperimentale e Clinica, Divisione di Ematologia, Universita di Verona, 37134 Verona, Italy
    Leuk Res 29:661-4. 2005
    ..Our study does not support the evidence of an association between hemochromatosis gene mutations and iron overload in AL patients...
  33. ncbi Cell therapy for cardiac regeneration after myocardial infarct: which cell is the best?
    Federico Mosna
    Stem Cell Research Laboratory, Section of Hematology, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Cardiovasc Hematol Agents Med Chem 8:227-43. 2010
    ..This review will critically compare the data from the Literature concerning cell therapy after myocardial infarction. Can we name the best cell?..
  34. pmc Comparative study of immune regulatory properties of stem cells derived from different tissues
    Mariano Di Trapani
    1 Section of Hematology, Stem Cell Research Laboratory, Department of Medicine, University of Verona, Verona, Italy
    Stem Cells Dev 22:2990-3002. 2013
    ..Thus, immune regulation is a general property of SCs and the characterization of this phenomenon may be useful for a proper therapeutic use of SCs. ..
  35. doi Quantitative fluorescence in situ hybridization on paraffin embedded tissue
    Mario Ricciardi
    Department of Pathology, University of Verona, Verona, Italy
    Methods Mol Biol 976:167-73. 2013
    ..Here, we describe the most used protocols to stain, acquire, and analyze fixed human cells in order to evaluate their telomere length...
  36. pmc Neural stem cell niches in health and diseases
    Ilaria Decimo
    Department of Public Health and Community Medicine, Section of Pharmacology, University of Verona, Verona, Italy
    Curr Pharm Des 18:1755-83. 2012
    ..We propose a model where all the NSC niches in the CNS may be connected in a functional network using the threads of the meningeal net as tracks...
  37. doi Plasmacytoid dendritic cell leukemia: a rapidly evolving disease presenting with skin lesions sensitive to radiotherapy plus hyperthermia
    Cristina Tecchio
    Section of Hematology, Department of Clinical and Experimental Medicine, Policlinico G B Rossi, Piazzale L A Scuro, University of Verona, 37134 Verona, Italy
    Oncologist 14:1205-8. 2009
    ..The case presentation is followed by a general discussion with an emphasis on the diagnosis and treatment of this rare malignancy...
  38. ncbi Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells
    Gino Rigotti
    Second Division of Plastic and Reconstructive Surgery, the Institute for Burns, and Regional Center for Breast Reconstruction, Ospedale Maggiore di Verona, Verona, Italy
    Plast Reconstr Surg 119:1409-22; discussion 1423-4. 2007
    ....
  39. pmc Immunological properties of embryonic and adult stem cells
    Francesco Bifari
    Francesco Bifari, Luciano Pacelli, Mauro Krampera, Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Pz le Scuro 10, 37134 Verona, Italy
    World J Stem Cells 2:50-60. 2010
    ..Although these properties are common features of different stem cell types, some peculiarities can be recognized and characterized for their proper clinical use...
  40. ncbi Computer-based drug management in a bone marrow transplant unit: a suitable tool for multiple prescriptions even in critical conditions
    Mauro Krampera
    Department of Clinical and Experimental Medicine, Section of Haematology and Bone Marrow Transplant Unit Pharmacy Service, Policlinico Hospital Service of Informatics, Hospital Public System of Verona, Verona, Italy
    Br J Haematol 125:50-7. 2004
    ..In addition, it contributed to medical updating through warnings on potential problems in case of multiple drug prescriptions, and gave the pharmacy a valuable tool to monitor drug use...
  41. ncbi Efficacy of Helicobacter pylori eradication in raising platelet count in adult patients with idiopathic thrombocytopenic purpura
    Dino Veneri
    Dipartimento di Medicina Clinica e Sperimentale, Divisione di Ematologia, Universita di Verona, Italy
    Haematologica 87:1177-9. 2002
    ..In addition, a significant increase of platelet count following HP eradication has been reported in a proportion of ITP patients. We describe here our experience on the efficacy of anti-HP treatment in ITP patients...
  42. ncbi Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling
    Francesco Liotta
    Excellence Center of the University of Florence De Novo Therapy, Florence, Italy
    Stem Cells 26:279-89. 2008
    ....
  43. ncbi The impact of P53 and P21(waf1) expression on the survival of patients with the germinal center phenotype of diffuse large B-cell lymphoma
    Carlo Visco
    Department of Hematology, Ospedale S Bortolo, Vicenza, Italy
    Haematologica 91:687-90. 2006
    ..Our results show that immunohistochemistry can parallel gene expression profiling in addressing clinical variability of DLBCL patients...
  44. ncbi Interleukin 7 requirement for survival of T-cell acute lymphoblastic leukemia and human thymocytes on bone marrow stroma
    Maria T Scupoli
    Haematologica 92:264-6. 2007
    ..We presented evidence that IL-7 has a major role in the enhanced survival mediated by BM stroma both in T-ALL cells and thymocytes...
  45. ncbi Screening for hemochromatosis in a population with abnormal iron status
    Dino Veneri
    Haematologica 88:593-4. 2003
  46. ncbi Iron overload in acute myeloid leukemia patients is not related to HFE and TFR2 gene mutations
    Dino Veneri
    Haematologica 88:1069-70. 2003
  47. ncbi Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide
    Mauro Krampera
    Department of Immunology and Transplantation Biology, Imperial College Faculty of Medicine, Hammersmith Hospital, London, United Kingdom
    Blood 101:3722-9. 2003
    ..We conclude that MSCs inhibit naive and memory T-cell responses to their cognate antigens. Overall our data suggest that MSCs physically hinder T cells from the contact with APCs in a noncognate fashion...
  48. ncbi Induction of unresponsiveness limits tumor protection by adoptively transferred MDM2-specific cytotoxic T lymphocytes
    Gavin M Bendle
    Department of Immunology, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Cancer Res 64:8052-6. 2004
    ..These experiments suggest that induction of unresponsiveness may be an important mechanism limiting the efficacy of adoptive CTL therapy...
  49. ncbi Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol
    Antonella Vitale
    Department of Cellular Biotechnologies and Hematology, University La Sapienza Roma, Rome, Italy
    Blood 107:473-9. 2006
    ..An extensive biologic workup of adult T-ALL cases at presentation is recommended in order to design tailored therapeutic strategies aimed at improving CR rates...
  50. ncbi Helicobacter pylori eradication in adults with idiopathic thrombocytopenic purpura
    Massimo Franchini
    Am J Med 114:420-1. 2003
  51. ncbi Idiopathic thrombocytopenic purpura, Helicobacter pylori infection, and HLA class II alleles
    Dino Veneri
    Blood 100:1925-6; author reply 1926-7. 2002