Research Topics
Genomes and Genes | Mauro KramperaSummaryAffiliation: University of Verona Country: Italy Publications
| Collaborators
|
Detail Information
Publications
HB-EGF/HER-1 signaling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multilineage differentiationMauro Krampera
Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
Blood 106:59-66. 2005..These data show that HB-EGF/HER-1 signaling is relevant to MSC biology, by regulating both proliferation and differentiation...- Regenerative and immunomodulatory potential of mesenchymal stem cellsMauro Krampera
Department of Clinical and Experimental Medicine, Section of Haematology, P le L A Scuro 10, 37134 Verona, Italy
Curr Opin Pharmacol 6:435-41. 2006..Thus, MSCs appear to be a very promising tool for regenerative and immunoregulatory cell therapy... - Methodological approach to minimal residual disease detection by flow cytometry in adult B-lineage acute lymphoblastic leukemiaMauro Krampera
Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Universita di Verona
Haematologica 91:1109-12. 2006..2%). Blast phenotypes were stable in culture and at relapse, and were useful for MRD monitoring in patients. Marker combinations for childhood ALL are also applicable to adult cases... - Induction of neural-like differentiation in human mesenchymal stem cells derived from bone marrow, fat, spleen and thymusMauro Krampera
Department of Clinical, Section of Haematology, University of Verona, Italy
Bone 40:382-90. 2007..This evidence provides new insights into BM-like tissue plasticity and may have important implications for future therapeutic interventions in chronic neuropathies... - Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repairMauro Krampera
Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
Bone 39:678-83. 2006..We discuss here the potential use of MSCs in degenerative or inflammatory diseases involving bone, cartilage, tendon and muscle tissues, on the basis of the experimental evidence... 
Mesenchymal stromal cell 'licensing': a multistep processM Krampera
Stem Cell Research Laboratory, Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
Leukemia 25:1408-14. 2011..Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects...- Outcome prediction by immunophenotypic minimal residual disease detection in adult T-cell acute lymphoblastic leukaemiaMauro Krampera
Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Universita di Verona, Italy
Br J Haematol 120:74-9. 2003..Our data suggest that immunophenotypic MRD monitoring in the first year of treatment is a useful outcome predictor for adult T-ALL patients... - Immune regulation by mesenchymal stem cells derived from adult spleen and thymusMauro Krampera
Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
Stem Cells Dev 16:797-810. 2007..Our data suggest that not only do spleen and thymus have a stem cell reservoir to build up their stromal architecture, but also contain microenviromental immunoregulatory cells with the same properties of BM-MSCs... 
Comparison of epithelial differentiation and immune regulatory properties of mesenchymal stromal cells derived from human lung and bone marrowMario Ricciardi
Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, Italy
PLoS ONE 7:e35639. 2012....- Efficacy assessment of interferon-alpha-engineered mesenchymal stromal cells in a mouse plasmacytoma modelSilvia Sartoris
Department of Pathology and Diagnostics, University of Verona, Verona, Italy
Stem Cells Dev 20:709-19. 2011.... - Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cellsArmel Hervé Nwabo Kamdje
Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, Italy
Blood 118:380-9. 2011..Our data suggest that the stromal cell-mediated antiapoptotic effect on B- ALL cells is mediated by Notch-3 and -4 or Jagged-1/-2 and DLL-1 in a synergistic manner... - Stem molecular signature of adipose-derived stromal cellsDaniele Peroni
Department of Morphological and Biomedical Sciences, Section of Anatomy and Histology, University of Verona, Italy
Exp Cell Res 314:603-15. 2008..Thus, our findings strongly support a close relationship between ADSCs and BM-MSCs, suggest an unexpected similarity between MSCs and embryonic stem cells, and possibly support the potential therapeutic application of ADSCs... - Macrophages may promote cancer growth via a GM-CSF/HB-EGF paracrine loop that is enhanced by CXCL12Antonella Rigo
Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
Mol Cancer 9:273. 2010..Events triggered by CXCL12 may play a part, as CXCL12 drives the migration of both CXCR4-positive cancer cells and macrophages and may promote a molecular crosstalk between them... - Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cellsMauro Krampera
Department of Clinical and Experimental Medicine, University of Verona, Italy
Stem Cells 24:386-98. 2006..These findings suggest that the beneficial effect on graft-versus-host disease induced by in vivo coinfusion with the graft of MSCs may be due to the activation of the immunomodulatory properties of MSCs by T cell- derived IFN-gamma... - Neuronal differentiation potential of human adipose-derived mesenchymal stem cellsElena Anghileri
Department of Neurological Sciences and Vision, University of Verona, Verona, Italy
Stem Cells Dev 17:909-16. 2008..In view of these results and the easy availability of adipose tissue, A-MSC may be a ready source of adult MSC with neuronal differentiation potential, an useful tool to treat neurodegenerative diseases... - Nestin- and doublecortin-positive cells reside in adult spinal cord meninges and participate in injury-induced parenchymal reactionIlaria Decimo
Department of Public Health and Community Medicine, Section of Pharmacology, University of Verona, Verona, Italy
Stem Cells 29:2062-76. 2011..Meninges may be considered as a new source of adult stem/precursor cells to be further tested for use in regenerative medicine applied to neurological disorders, including repair from spinal cord injury... - Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitisGabriela Constantin
Department of Pathology, University of Verona, Italy
Stem Cells 27:2624-35. 2009..Overall, our data suggest that ASCs represent a valuable tool for stem cell-based therapy in chronic inflammatory diseases of the CNS... - Toll-like receptor-3-activated human mesenchymal stromal cells significantly prolong the survival and function of neutrophilsMarco A Cassatella
Section of General Pathology, Department of Pathology and Diagnostics, University of Verona, Italy
Stem Cells 29:1001-11. 2011..Our data highlight a novel mechanism by which MSC sustain and amplify the functions of PMN in response to TLR3- and TLR4-triggering and may consequently contribute to inflammatory disorders... - Thymic epithelial cells promote survival of human T-cell acute lymphoblastic leukemia blasts: the role of interleukin-7Maria T Scupoli
Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Verona, Italy
Haematologica 88:1229-37. 2003..In this study we explored the possible effect of TEC on T-ALL cell survival and analyzed the role of interleukin-7 (IL-7) within the microenvironment generated by T-ALL-TEC interactions... - Novel stem/progenitor cells with neuronal differentiation potential reside in the leptomeningeal nicheFrancesco Bifari
Department of Clinical and Experimental Medicine, Stem Cell Research Laboratory, Section of Hematology, University of Verona, Verona, Italy
J Cell Mol Med 13:3195-208. 2009..As leptomeninges cover the entire central nervous system, these findings could have relevant implications for studies on cortical development and for regenerative medicine applied to neurological disorders... - Adipose-derived stromal cells (ASCs)Giulio Bassi
Laboratorio di Ricerca sulle Cellule Staminali, Sezione di Ematologia, Dipartimento di Medicina, Universita degli Studi di Verona, Italy
Transfus Apher Sci 47:193-8. 2012..Thus, more accurate studies, collaborative protocols, high standardization of methods, and safety controls are required to exclude transformation of transplanted ASCs... - Human bone marrow and adipose tissue mesenchymal stem cells: a user's guideFederico Mosna
Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, Policlinico G B Rossi University of Verona, Verona, Italy
Stem Cells Dev 19:1449-70. 2010..We chose to use BM-MSCs as a model to describe techniques that have been used for MSC isolation and expansion from very different sources, and AT-MSCs as an example of a reliable and increasingly common alternative source... - IFN-gamma-mediated upmodulation of MHC class I expression activates tumor-specific immune response in a mouse model of prostate cancerMatteo Martini
Department of Pathology and Diagnostics, Immunology Section, University of Verona, Italy
Vaccine 28:3548-57. 2010..To explore possible clinical translation, we delivered IFN-gamma to TRAMP-C2 tumor site by means of genetically engineered MSCs secreting IFN-gamma... - Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF-kappaB and JNK/AP-1 pathwaysMaria T Scupoli
Laboratorio Universitario di Ricerca, Medica LURM, Policlinico, G B Rossi, Piazzale L Scuro 10, 37134 Verona, Italy
Haematologica 93:524-32. 2008..We also investigated the roles of the nuclear factor-kappaB and Jun-N-terminal kinase (JNK)/activating protein (AP)-1 signaling pathways, which contribute to regulate interleukin-8 production in some cells... - The TNF-Family Cytokine TL1A Inhibits Proliferation of Human Activated B CellsChiara Cavallini
Department of Medicine, Section of Hematology, University of Verona, Verona, Italy Interdepartmental Laboratory for Medical Research LURM, University of Verona, Verona, Italy
PLoS ONE 8:e60136. 2013.... - High prevalence of sustained remission of idiopathic thrombocytopenic purpura after Helicobacter pylori eradication: a long-term follow-up studyDino Veneri
Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Verona, Italy
Platelets 16:117-9. 2005..2 months. None of the patients still infected by H. pylori after therapy reached normal platelet values. The long-term follow-up confirms the efficacy of H. pylori eradication in H. pylori-infected ITP patients... - Notch signaling in acute lymphoblastic leukemia: any role for stromal microenvironment?Armel Hervé Nwabo Kamdje
Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Policlinico G B Rossi, Piazzale L A Scuro 10, Verona, Italy
Blood 118:6506-14. 2011..Here, the data concerning the development of T- and B-cell acute lymphoblastic leukemia has been critically reviewed in light of the most recent findings on Notch signaling in stromal microenvironment... - VR09 cell line: an EBV-positive lymphoblastoid cell line with in vivo characteristics of diffuse large B cell lymphoma of activated B-cell typeIlaria Nichele
Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, Italy
PLoS ONE 7:e52811. 2012..small B-cell neoplasms can show plasmacytic differentiation and may potentially progress to aggressive lymphoma (DLBCL). Epstein-Barr virus (EBV) infection may cause the transformation of malignant cells in vitro... - Analysis of HFE and TFR2 gene mutations in patients with acute leukemiaDino Veneri
Dipartimento di Medicina Sperimentale e Clinica, Divisione di Ematologia, Universita di Verona, 37134 Verona, Italy
Leuk Res 29:661-4. 2005..Our study does not support the evidence of an association between hemochromatosis gene mutations and iron overload in AL patients... - Cell therapy for cardiac regeneration after myocardial infarct: which cell is the best?Federico Mosna
Stem Cell Research Laboratory, Section of Hematology, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
Cardiovasc Hematol Agents Med Chem 8:227-43. 2010..This review will critically compare the data from the Literature concerning cell therapy after myocardial infarction. Can we name the best cell?.. - Low-dose epirubicin in combination with cyclophosphamide, vinblastine and prednisone (mini-CEOP) for the treatment of aggressive non-Hodgkin's lymphoma in elderly patientsDino Veneri
Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, , Italy
Haematologica 87:ELT43. 2002 - Neural stem cell niches in health and diseasesIlaria Decimo
Department of Public Health and Community Medicine, Section of Pharmacology, University of Verona, Verona, Italy
Curr Pharm Des 18:1755-83. 2012..We propose a model where all the NSC niches in the CNS may be connected in a functional network using the threads of the meningeal net as tracks... - Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cellsGino Rigotti
Second Division of Plastic and Reconstructive Surgery, the Institute for Burns, and Regional Center for Breast Reconstruction, Ospedale Maggiore di Verona, Verona, Italy
Plast Reconstr Surg 119:1409-22; discussion 1423-4. 2007.... - Plasmacytoid dendritic cell leukemia: a rapidly evolving disease presenting with skin lesions sensitive to radiotherapy plus hyperthermiaCristina Tecchio
Section of Hematology, Department of Clinical and Experimental Medicine, Policlinico G B Rossi, Piazzale L A Scuro, University of Verona, 37134 Verona, Italy
Oncologist 14:1205-8. 2009..The case presentation is followed by a general discussion with an emphasis on the diagnosis and treatment of this rare malignancy... - Quantitative fluorescence in situ hybridization on paraffin embedded tissueMario Ricciardi
Department of Pathology, University of Verona, Verona, Italy
Methods Mol Biol 976:167-73. 2013..Here, we describe the most used protocols to stain, acquire, and analyze fixed human cells in order to evaluate their telomere length... - Immunological properties of embryonic and adult stem cellsFrancesco Bifari
Francesco Bifari, Luciano Pacelli, Mauro Krampera, Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Pz le Scuro 10, 37134 Verona, Italy
World J Stem Cells 2:50-60. 2010..Although these properties are common features of different stem cell types, some peculiarities can be recognized and characterized for their proper clinical use... - Efficacy of Helicobacter pylori eradication in raising platelet count in adult patients with idiopathic thrombocytopenic purpuraDino Veneri
Dipartimento di Medicina Clinica e Sperimentale, Divisione di Ematologia, Universita di Verona, Italy
Haematologica 87:1177-9. 2002..In addition, a significant increase of platelet count following HP eradication has been reported in a proportion of ITP patients. We describe here our experience on the efficacy of anti-HP treatment in ITP patients... - Computer-based drug management in a bone marrow transplant unit: a suitable tool for multiple prescriptions even in critical conditionsMauro Krampera
Department of Clinical and Experimental Medicine, Section of Haematology and Bone Marrow Transplant Unit Pharmacy Service, Policlinico Hospital Service of Informatics, Hospital Public System of Verona, Verona, Italy
Br J Haematol 125:50-7. 2004..In addition, it contributed to medical updating through warnings on potential problems in case of multiple drug prescriptions, and gave the pharmacy a valuable tool to monitor drug use... - Screening for hemochromatosis in a population with abnormal iron statusDino Veneri
Haematologica 88:593-4. 2003 - Induction of unresponsiveness limits tumor protection by adoptively transferred MDM2-specific cytotoxic T lymphocytesGavin M Bendle
Department of Immunology, Imperial College London, Hammersmith Hospital, London, United Kingdom
Cancer Res 64:8052-6. 2004..These experiments suggest that induction of unresponsiveness may be an important mechanism limiting the efficacy of adoptive CTL therapy... - Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptideMauro Krampera
Department of Immunology and Transplantation Biology, Imperial College Faculty of Medicine, Hammersmith Hospital, London, United Kingdom
Blood 101:3722-9. 2003..We conclude that MSCs inhibit naive and memory T-cell responses to their cognate antigens. Overall our data suggest that MSCs physically hinder T cells from the contact with APCs in a noncognate fashion... - The impact of P53 and P21(waf1) expression on the survival of patients with the germinal center phenotype of diffuse large B-cell lymphomaCarlo Visco
Department of Hematology, Ospedale S Bortolo, Vicenza, Italy
Haematologica 91:687-90. 2006..Our results show that immunohistochemistry can parallel gene expression profiling in addressing clinical variability of DLBCL patients... - Iron overload in acute myeloid leukemia patients is not related to HFE and TFR2 gene mutationsDino Veneri
Haematologica 88:1069-70. 2003 - Interleukin 7 requirement for survival of T-cell acute lymphoblastic leukemia and human thymocytes on bone marrow stromaMaria T Scupoli
Haematologica 92:264-6. 2007..We presented evidence that IL-7 has a major role in the enhanced survival mediated by BM stroma both in T-ALL cells and thymocytes... - Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signalingFrancesco Liotta
Excellence Center of the University of Florence De Novo Therapy, Florence, Italy
Stem Cells 26:279-89. 2008.... - Helicobacter pylori infection and idiopathic thrombocytopenic purpura: description of 21 newly diagnosed casesDino Veneri
Dipartimento di Medicina Sperimentale e Clinica, Divisione di Ematologia, , Italy
Haematologica 89:ECR08. 2004 - Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocolAntonella Vitale
Department of Cellular Biotechnologies and Hematology, University La Sapienza Roma, Rome, Italy
Blood 107:473-9. 2006..An extensive biologic workup of adult T-ALL cases at presentation is recommended in order to design tailored therapeutic strategies aimed at improving CR rates... - Idiopathic thrombocytopenic purpura, Helicobacter pylori infection, and HLA class II allelesDino Veneri
Blood 100:1925-6; author reply 1926-7. 2002 - Helicobacter pylori eradication in adults with idiopathic thrombocytopenic purpuraMassimo Franchini
Am J Med 114:420-1. 2003