D Kanduc

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. ncbi "Self-nonself" peptides in the design of vaccines
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, 70126 Bari, Italy
    Curr Pharm Des 15:3283-9. 2009
  2. ncbi Correlating low-similarity peptide sequences and allergenic epitopes
    D Kanduc
    Department of Biochemistry and Molecular Biology Ernesto Quagliariello, University of Bari, Italy
    Curr Pharm Des 14:289-95. 2008
  3. ncbi Epitope definition by proteomic similarity analysis: identification of the linear determinant of the anti-Dsg3 MAb 5H10
    Alberta Lucchese
    Department of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70126 Bari, Italy
    J Transl Med 2:43. 2004
  4. ncbi Homology, similarity, and identity in peptide epitope immunodefinition
    Darja Kanduc
    Department of Biosciences, Biotechnologies and Pharmacological Sciences, University of Bari, Bari, Italy
    J Pept Sci 18:487-94. 2012
  5. ncbi Peptide cross-reactivity: the original sin of vaccines
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, Bari, Italy
    Front Biosci (Schol Ed) 4:1393-401. 2012
  6. ncbi Circumscribing the conformational peptide epitope landscape
    Guglielmo Lucchese
    Department of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70126 Bari, Italy
    Curr Pharm Des 18:832-9. 2012
  7. ncbi The oligodeoxynucleotide sequences corresponding to never-expressed peptide motifs are mainly located in the non-coding strand
    Giovanni Capone
    Department of Biochemistry and Molecular Biology Ernesto Quagliariello, University of Bari, Bari, Italy
    BMC Bioinformatics 11:383. 2010
  8. ncbi Quantifying the possible cross-reactivity risk of an HPV16 vaccine
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, Italy
    J Exp Ther Oncol 8:65-76. 2009
  9. ncbi Gene therapy in cancer: the missing point
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, Italy
    J Exp Ther Oncol 5:151-8. 2005
  10. ncbi Peptimmunology: immunogenic peptides and sequence redundancy
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, 70126 Bari, Italy
    Curr Drug Discov Technol 2:239-44. 2005

Collaborators

Detail Information

Publications42

  1. ncbi "Self-nonself" peptides in the design of vaccines
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, 70126 Bari, Italy
    Curr Pharm Des 15:3283-9. 2009
    ..Biologically, the low-similarity hypothesis further supports sequence uniqueness as the molecular signature of "nonselfness" in the currently ongoing self/non-self debate...
  2. ncbi Correlating low-similarity peptide sequences and allergenic epitopes
    D Kanduc
    Department of Biochemistry and Molecular Biology Ernesto Quagliariello, University of Bari, Italy
    Curr Pharm Des 14:289-95. 2008
    ..The present literature analysis might be of relevance in devising and designing short amino acid modules to be used for blocking pathogenic IgE...
  3. ncbi Epitope definition by proteomic similarity analysis: identification of the linear determinant of the anti-Dsg3 MAb 5H10
    Alberta Lucchese
    Department of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70126 Bari, Italy
    J Transl Med 2:43. 2004
    ..NMR spectroscopy analyses confirmed the specificity of MAb 5H10 for the predicted epitope. CONCLUSIONS: This report promotes the concept that low level of sequence similarity to the host's proteome may modulate peptide epitopicity...
  4. ncbi Homology, similarity, and identity in peptide epitope immunodefinition
    Darja Kanduc
    Department of Biosciences, Biotechnologies and Pharmacological Sciences, University of Bari, Bari, Italy
    J Pept Sci 18:487-94. 2012
    ....
  5. ncbi Peptide cross-reactivity: the original sin of vaccines
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, Bari, Italy
    Front Biosci (Schol Ed) 4:1393-401. 2012
    ....
  6. ncbi Circumscribing the conformational peptide epitope landscape
    Guglielmo Lucchese
    Department of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70126 Bari, Italy
    Curr Pharm Des 18:832-9. 2012
    ..Potentially, low-similarity peptide epitopes pave the way for novel effective vaccines in cancer, autoimmunity, and infectious diseases...
  7. ncbi The oligodeoxynucleotide sequences corresponding to never-expressed peptide motifs are mainly located in the non-coding strand
    Giovanni Capone
    Department of Biochemistry and Molecular Biology Ernesto Quagliariello, University of Bari, Bari, Italy
    BMC Bioinformatics 11:383. 2010
    ..As a final step, we analyse the pentadecamer oligodeoxynucleotide sequences corresponding to the never-expressed pentapeptides...
  8. ncbi Quantifying the possible cross-reactivity risk of an HPV16 vaccine
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, Italy
    J Exp Ther Oncol 8:65-76. 2009
    ..Using the HPV16 proteome as a model, we quantified the actual and theoretical risks of anti-HPV16 vaccination, and defined the potential disease spectrum derived from concomitant cross-reactions with the human organism...
  9. ncbi Gene therapy in cancer: the missing point
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, Italy
    J Exp Ther Oncol 5:151-8. 2005
    ..On the light of cancer statistics 2005, we discuss the need of exactly defining the cancer targets in order to exploit the high potential of gene therapy...
  10. ncbi Peptimmunology: immunogenic peptides and sequence redundancy
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, 70126 Bari, Italy
    Curr Drug Discov Technol 2:239-44. 2005
    ..This mini-review schematically describes: 1) the available methods to identify epitopic peptides; 2) the sequence redundancy concept as a possible basis for peptide immunogenicity...
  11. ncbi Non-redundant peptidomes from DAPs: towards "the vaccine"?
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, Italy
    Autoimmun Rev 6:290-4. 2007
    ..The hypothesis that immunogenicity of peptide sequences is linked to proteomic redundancy is discussed...
  12. ncbi Immunogenicity in peptide-immunotherapy: from self/nonself to similar/dissimilar sequences
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70126 Bari, Italy
    Adv Exp Med Biol 640:198-207. 2008
    ....
  13. ncbi Epitopic peptides with low similarity to the host proteome: towards biological therapies without side effects
    Darja Kanduc
    University of Bari, Department of Biochemistry and Molecular Biology, Bari, Italy
    Expert Opin Biol Ther 9:45-53. 2009
    ..The most attractive feature of the similarity concept is that it appears to guarantee the highest specificity and lowest cross-reactivity when designing effective, safe and theoretically infallible (immuno)therapeutic tools...
  14. ncbi Individuation of monoclonal anti-HPV16 E7 antibody linear peptide epitope by computational biology
    D Kanduc
    CARSO Cancer Research Center, University of Bari, Italy
    Peptides 22:1981-5. 2001
    ..Peptide ability to bind to MHC II molecules appears a necessary but not sufficient condition to determine peptide immunodominance, by needing to be supported by a low degree of peptide similarity to the host's proteome...
  15. ncbi Massive peptide sharing between viral and human proteomes
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, Bari 70126, Italy
    Peptides 29:1755-66. 2008
    ....
  16. ncbi P-170 peptides with low similarity to the human proteome: tracing an effective and safe biological way towards effective and safe cancer chemotherapy
    Darja Kanduc
    Department of Biochemistry and Molecular Biology Ernesto Quagliariello, University of Bari, Italy
    J Exp Ther Oncol 8:151-5. 2009
    ....
  17. ncbi Potential cross-reactivity between HPV16 L1 protein and sudden death-associated antigens
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, Italy
    J Exp Ther Oncol 9:159-65. 2011
    ..The present data may help evaluate the potential crossreactivity risks in anti-tumor vaccination protocols based on HPV16 L1 protein...
  18. ncbi NMR probing of in silico identification of anti-HPV16 E7 mAb linear peptide epitope
    Darja Kanduc
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY, USA
    Peptides 25:243-50. 2004
    ..In this report, two-dimensional nuclear magnetic resonance spectroscopic experiments unequivocally probe the HPV16 E7 epitope individuation...
  19. ncbi Cell death: apoptosis versus necrosis (review)
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, USA
    Int J Oncol 21:165-70. 2002
    ....
  20. ncbi Cancer prevention and therapy: strategies and problems
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70126, Italy
    J Exp Ther Oncol 3:108-14. 2003
    ..e we need to critically analyze the extensive multi-step process of cancer development that still remains poorly understood...
  21. ncbi Correlating low-similarity peptide sequences and HIV B-cell epitopes
    Darja Kanduc
    Department of Biochemistry and Molecular Biology Ernesto Quagliariello, University of Bari, Italy
    Autoimmun Rev 7:291-6. 2008
    ..The present literature analysis provides relevant insights that may be applied to design anti-HCV therapeutic approaches exempt from autoimmune collateral effects...
  22. ncbi Translational regulation of human papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha(1)-globin and human cytokeratin 7
    Darja Kanduc
    CARSO Cancer Research Center, Valenzano, Regione Puglia, Italy
    J Virol 76:7040-8. 2002
    ..The in vitro data were confirmed by the occurrence of HPV16 E7 mRNA-cytokeratin 7 binding in squamous cervical cancer SiHa cells...
  23. ncbi Mapping the human proteome for non-redundant peptide islands
    G Capone
    Department of Biochemistry and Molecular Biology Ernesto Quagliariello, University of Bari, Bari, Italy
    Amino Acids 35:209-16. 2008
    ..This library represents a highly specific catalogue of molecular protein signatures, the possible use of which in cancer/autoimmunity research is discussed, with a major focus on non-redundant dodecamer sequences...
  24. ncbi Sub-epitopic dissection of HCV E1315-328HRMAWDMMMNWSPT sequence by similarity analysis
    L Polimeno
    Department of Emergency and Organ Transplantation, Gastroenterology Section, University of Bari, Bari, Italy
    Amino Acids 34:479-84. 2008
    ....
  25. ncbi Computational peptide dissection of Melan-a/MART-1 oncoprotein antigenicity
    Raj Tiwari
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Peptides 25:1865-71. 2004
    ....
  26. ncbi Peptidology: short amino acid modules in cell biology and immunology
    G Lucchese
    Department of Biochemistry and Molecular Biology Ernesto Quagliariello, University of Bari, Bari, Italy
    Amino Acids 33:703-7. 2007
    ..As an example, specific short peptide fragments might be used to elicit antibodies capable of reacting with the full-length proteins containing the peptide fragment's amino acid sequence, so abolishing the risk of cross-reactivity...
  27. ncbi Monoclonal and polyclonal humoral immune response to EC HER-2/NEU peptides with low similarity to the host's proteome
    Abraham Mittelman
    Department of Medicine, Division of Oncology/Hematology, New York Medical College, Valhalla NY, USA
    Int J Cancer 98:741-7. 2002
    ....
  28. ncbi Role of MHC II affinity and molecular mimicry in defining anti-HER-2/neu MAb-3 linear peptide epitope
    Alberta Lucchese
    CARSO Cancer Research Center, Regione Puglia, Valenzano, Italy
    Peptides 24:193-7. 2003
    ..Here we report that the linear peptide determinant of the anti-HER-2/neu MAb-3 is characterized by a low degree of sequence similarity to mouse proteome in combination with high binding potential to specific MHC II molecule...
  29. ncbi Peptide mimotopes of oncoproteins as therapeutic agents in breast cancer
    B T Ashok
    Department of Microbiology and Immunology and Medicine, New York Medical College, Valhalla, NY 10595, USA
    Int J Mol Med 11:465-71. 2003
    ....
  30. ncbi Proteome-based epitopic peptide scanning along PSA
    Angela Stufano
    Department of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, Bari 70125, Italy
    Exp Mol Pathol 86:36-40. 2009
    ..The pentapeptide motif is characterized by having no sequence similarity to the murine proteome and a low number of potential proteolytic sites...
  31. ncbi Proposing low-similarity peptide vaccines against Mycobacterium tuberculosis
    Guglielmo Lucchese
    Department of Biochemistry and Molecular Biology Ernesto Quagliariello, University of Bari, Bari, Italy
    J Biomed Biotechnol 2010:832341. 2010
    ....
  32. ncbi Identification of monoclonal anti-HMW-MAA antibody linear peptide epitope by proteomic database mining
    Abraham Mittelman
    Departments of Medicine/Oncology, New York Medical College, Valhalla, New York, USA
    J Invest Dermatol 123:670-5. 2004
    ..The present result has been obtained by applying as driving criteria the analysis of the peptide affinity to MHC class II molecules and the non-self discrimination concept...
  33. ncbi Protein information content resides in rare peptide segments
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, Italy
    Peptides 31:983-8. 2010
    ..This study expands on our previous research showing that the immunological information contained in an amino acid sequence is inversely related to the sequence frequency in the host proteome...
  34. ncbi Possible association between HPV16 E7 protein level and cytokeratin 19
    Gianfranco Favia
    Department of Odontostomatology and Surgery, University of Bari, Bari, Italy
    Int J Cancer 111:795-7. 2004
    ..In our study, we have analyzed the interaction occurring between HPV type 16 E7 mRNA and the intermediate cytokeratin filaments 7 and 19 and report data in favor of a possible association between HPV16 E7 protein level and CK19...
  35. ncbi Clinical applications of DNA microarray analysis
    Raghunandan Dudda-Subramanya
    Department of Dermatology, Weill Medical College of Cornell University, New York, NY, USA
    J Exp Ther Oncol 3:297-304. 2003
    ..We focus on molecular strategies for (a) disease classification, (b) disease outcome, and (c) disease mechanisms...
  36. ncbi Proteome-guided search for influenza A B-cell epitopes
    Guglielmo Lucchese
    Department of Biochemistry and Molecular Biology Ernesto Quagliariello, University of Bari, Bari, Italy
    FEMS Immunol Med Microbiol 57:88-92. 2009
    ....
  37. ncbi Proteomic scan for tyrosinase peptide antigenic pattern in vitiligo and melanoma: role of sequence similarity and HLA-DR1 affinity
    Alberta Lucchese
    Department of Odontostomatology and Surgery, University of Bari, Bari, Italy
    J Immunol 175:7009-20. 2005
    ..In particular, these data, for the first time, delineate the linear B epitope pattern on tyrosinase autoantigen and provide definitive evidence of humoral immune responses against tyrosinase...
  38. ncbi Degenerate binding of tyrosinase peptides to MHC II Ad/Ed molecules
    Abraham Mittelman
    Department of Medicine Oncology, New York Medical College, Valhalla, NY 10595, USA
    J Exp Ther Oncol 6:231-9. 2007
    ..We conclude that Ad/Ed binding potential appears influential in the defining of tyrosinase233-247IPYWDWRDAEKCDIC peptide epitopicity...
  39. ncbi Definition of anti-tyrosinase MAb T311 linear determinant by proteome-based similarity analysis
    Jörg Willers
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
    Exp Dermatol 14:543-50. 2005
    ..Moreover tyrosinase peptide antigens might be used as key tools in studying the boundaries between self-tolerance and autoimmunity phenomena...
  40. ncbi Non-self-discrimination as a driving concept in the identification of an immunodominant HMW-MAA epitopic peptide sequence by autoantibodies from melanoma cancer patients
    Reinhard Dummer
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
    Int J Cancer 111:720-6. 2004
    ..Linear B-cell determinant individuation was experimentally validated by dot blot immunoassay and NMR spectroscopy analysis. Regulation of physiologic self-reactivity by the non-self-discrimination principle is discussed...
  41. ncbi Sequence uniqueness and sequence variability as modulating factors of human anti-HCV humoral immune response
    Darja Kanduc
    Infectious Diseases and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Cancer Immunol Immunother 57:1215-23. 2008
    ..These data may be of help in defining the multiple factors which concur in the modulation of the human immune response against HCV, eventually providing information for the design of effective anti-HCV vaccines...
  42. ncbi Widespread and ample peptide overlapping between HCV and Homo sapiens proteomes
    Anthony Kusalik
    Department of Computer Science, University of Saskatchewan, Saskatoon, Canada
    Peptides 28:1260-7. 2007
    ..We conclude that the widespread sharing of numerous perfect exact matches between HCV and human proteomes might explain HCV persistence in humans...