Emmanuele A Jannini

Summary

Affiliation: University of L'Aquila
Country: Italy

Publications

  1. ncbi Male homosexuality: nature or culture?
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    J Sex Med 7:3245-53. 2010
  2. ncbi Epidemiology of premature ejaculation
    Emmanuele A Jannini
    Course of Medical Sexology and Endocrinology, Department of Experimental Medicine, University of L Aquila, Italy
    Curr Opin Urol 15:399-403. 2005
  3. ncbi Is sex just fun? How sexual activity improves health
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, L Aquila 67100, Italy
    J Sex Med 6:2640-8. 2009
  4. doi Who's afraid of the G-spot?
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, Italy
    J Sex Med 7:25-34. 2010
  5. doi Ethical aspects of sexual medicine. Internet, vibrators, and other sex aids: toys or therapeutic instruments?
    Emmanuele A Jannini
    School of Sexology, Course of Medical Sexology, Department of Biotechnological and Applied Clinical Sciences, University of L Aquila, L Aquila, Italy
    J Sex Med 9:2994-3001. 2012
  6. doi Female orgasm(s): one, two, several
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, Italy
    J Sex Med 9:956-65. 2012
  7. doi How to evaluate the efficacy of the phosphodiesterase type 5 inhibitors
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    J Sex Med 9:26-33. 2012
  8. doi The controversial role of phosphodiesterase type 5 inhibitors in the treatment of premature ejaculation
    Emmanuele A Jannini
    Department of Experimental Medicine, University of L Aquila, Italy Australian Centre for Sexual Health, Berry Road Medical Centre, Leonards, NSW, Australia
    J Sex Med 8:2135-43. 2011
  9. ncbi Clinical and basic science research in sexual medicine must rely, in part, on pharmaceutical funding?
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    J Sex Med 7:2331-7. 2010
  10. ncbi Organic vs. psychogenic? The Manichean diagnosis in sexual medicine
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, University of L Aquila, L Aquila, Italy
    J Sex Med 7:1726-33. 2010

Collaborators

Detail Information

Publications37

  1. ncbi Male homosexuality: nature or culture?
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    J Sex Med 7:3245-53. 2010
    ..On the other hand, social theorists, without direct evidence confirming their positions, criticize, with good argument, methods and results of the other side. The aim of this Controversy is to understand the reasons of both perspectives...
  2. ncbi Epidemiology of premature ejaculation
    Emmanuele A Jannini
    Course of Medical Sexology and Endocrinology, Department of Experimental Medicine, University of L Aquila, Italy
    Curr Opin Urol 15:399-403. 2005
    ..Accumulating evidence suggests that premature ejaculation is the most common sexual symptom. This review focuses on the epidemiology of premature ejaculation from geographical and medical perspectives...
  3. ncbi Is sex just fun? How sexual activity improves health
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, L Aquila 67100, Italy
    J Sex Med 6:2640-8. 2009
    ..This opinion is now rejected, and intercourse is generally considered healthy. However, while some aspects of the equation "more sex equals more health" have been demonstrated, others still need robust data for confirmation...
  4. doi Who's afraid of the G-spot?
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, Italy
    J Sex Med 7:25-34. 2010
    ..No controversy can be more controversial than that regarding the existence of the G-spot, an anatomical and physiological entity for women and many scientists, yet a gynecological UFO for others...
  5. doi Ethical aspects of sexual medicine. Internet, vibrators, and other sex aids: toys or therapeutic instruments?
    Emmanuele A Jannini
    School of Sexology, Course of Medical Sexology, Department of Biotechnological and Applied Clinical Sciences, University of L Aquila, L Aquila, Italy
    J Sex Med 9:2994-3001. 2012
    ..Sexual health care professionals (SHCP) may face several ethical issues. Some SHCP prescribe Internet pornography for both diagnosis and therapy and some others directly sell vibrators and sex aids in their offices...
  6. doi Female orgasm(s): one, two, several
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, Italy
    J Sex Med 9:956-65. 2012
    ..There is general agreement that it is possible to have an orgasm thru the direct simulation of the external clitoris. In contrast, the possibility of achieving climax during penetration has been controversial...
  7. doi How to evaluate the efficacy of the phosphodiesterase type 5 inhibitors
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    J Sex Med 9:26-33. 2012
    ..Several methods have been so far proposed to compare the effectiveness of the three available phosphodiesterase type 5 inhibitors (PDE5Is)...
  8. doi The controversial role of phosphodiesterase type 5 inhibitors in the treatment of premature ejaculation
    Emmanuele A Jannini
    Department of Experimental Medicine, University of L Aquila, Italy Australian Centre for Sexual Health, Berry Road Medical Centre, Leonards, NSW, Australia
    J Sex Med 8:2135-43. 2011
    ..It is controversial whether or not the most frequent male sexual dysfunctions, premature ejaculation (PE) and erectile dysfunction (ED), share pathogenetic mechanisms and treatments...
  9. ncbi Clinical and basic science research in sexual medicine must rely, in part, on pharmaceutical funding?
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    J Sex Med 7:2331-7. 2010
    ..The aim of this Controversy is to appreciate opinions from both perspectives...
  10. ncbi Organic vs. psychogenic? The Manichean diagnosis in sexual medicine
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, University of L Aquila, L Aquila, Italy
    J Sex Med 7:1726-33. 2010
    ..The aim of this Controversy is to discuss if this philosophy is still useful both in the conceptual and clinical perspective...
  11. doi The ENDOTRIAL study: a spontaneous, open-label, randomized, multicenter, crossover study on the efficacy of sildenafil, tadalafil, and vardenafil in the treatment of erectile dysfunction
    Emmanuele A Jannini
    School of Sexology, Department of Experimental Medicine, University of L Aquila, Coppito, L Aquila, Italy
    J Sex Med 6:2547-60. 2009
    ..Although there are pharmacological differences between these three compounds, few comparative studies have been conducted to date...
  12. doi Is testosterone a friend or a foe of the prostate?
    Emmanuele A Jannini
    Department of Experimental Medicine, University of L Aquila, L Aquila, Italy Men s Health Boston, Harvard Medical School, Boston, MA, USA
    J Sex Med 8:946-55. 2011
    ..Furthermore, currently adequately powered and optimally designed long-term prostate disease data are not available to determine if there is an additional risk from normal T values in cured patients for PCa...
  13. ncbi Torc1/Torc2 inhibitor, Palomid 529, enhances radiation response modulating CRM1-mediated survivin function and delaying DNA repair in prostate cancer models
    Giovanni Luca Gravina
    Division of Radiation Oncology, Department of Clinical and Applied Sciences and Biotechnologies, University of L Aquila, L Aquila, Italy Department of Clinical and Applied Sciences and Biotechnologies, Laboratory of Radiobiology, University of L Aquila, L Aquila, Italy Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy Department of Clinical and Applied Sciences and Biotechnologies, School of Sexology, University of L Aquila, L Aquila, Italy
    Prostate 74:852-68. 2014
    ..However the molecular mechanisms underlying this phenomenon still need to be elucidated. Aim of this study is to dissect molecular mechanisms regulating the radiosensitizing properties of P529 in a wide panel of prostate cancer models...
  14. doi PXD101 potentiates hormonal therapy and prevents the onset of castration-resistant phenotype modulating androgen receptor, HSP90, and CRM1 in preclinical models of prostate cancer
    Giovanni Luca Gravina
    Laboratory of Radiobiology, Department of Experimental Medicine, University of L Aquila, Via Vetoio, Coppito 2, 67100 L Aquila, Italy
    Endocr Relat Cancer 20:321-37. 2013
    ..However, additional data are needed to develop clinical treatment strategies for this disease stage...
  15. doi Differential effects of PXD101 (belinostat) on androgen-dependent and androgen-independent prostate cancer models
    Giovanni Luca Gravina
    Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    Int J Oncol 40:711-20. 2012
    ..Our findings provide evidence that belinostat may be a promising anticancer drug for prostate cancer expressing AR, supporting its clinical role in prostate cancer...
  16. doi The ontogenetic expression pattern of type 5 phosphodiesterase correlates with androgen receptor expression in rat corpora cavernosa
    Eleonora Carosa
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    J Sex Med 6:388-96. 2009
    ..The mechanisms controlling erection in animals and in humans are mainly age-dependent. However, the ontogenesis of the biochemical machinery of erection is largely unknown...
  17. doi Which is first? The controversial issue of precedence in the treatment of male sexual dysfunctions
    Emmanuele A Jannini
    School of Sexology, Course of Medical Sexology, Department of Clinical, Applied and Biotechnological Sciences, University of L Aquila, L Aquila, Italy
    J Sex Med 10:2359-69. 2013
    ..In male sexual dysfunction (MSD), the presence of sexual comorbidities is relatively frequent. However, what is still a matter of controversy is what the first-line therapy in these patients should be...
  18. doi Measurement of the thickness of the urethrovaginal space in women with or without vaginal orgasm
    Giovanni Luca Gravina
    Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    J Sex Med 5:610-8. 2008
    ..The physiology and anatomy of female sexual function are poorly understood. The differences in sexual function among women may be partly attributed to anatomical factors...
  19. doi Premature ejaculation results in female sexual distress: standardization and validation of a new diagnostic tool for sexual distress
    Erika Limoncin
    School of Sexology, Department of Clinical, Applied and Biotechnological Sciences, University of L Aquila, L Aquila, Italy
    J Urol 189:1830-5. 2013
    ..We measured premature ejaculation related female sexual distress using a new diagnostic tool, the Female Sexual Distress Scale-Revised-Premature Ejaculation questionnaire...
  20. pmc Hormonal therapy promotes hormone-resistant phenotype by increasing DNMT activity and expression in prostate cancer models
    Giovanni Luca Gravina
    Department of Experimental Medicine, Division of Radiotherapy and Radiobiology, University of L Aquila, Via Vetoio, Coppito 2, 67100 L Aquila, Italy
    Endocrinology 152:4550-61. 2011
    ..Our findings provide evidence of a relationship between the castration-resistant phenotype and DNMT expression and activity in human prostate cancer...
  21. doi The TORC1/TORC2 inhibitor, Palomid 529, reduces tumor growth and sensitizes to docetaxel and cisplatin in aggressive and hormone-refractory prostate cancer cells
    Giovanni Luca Gravina
    Laboratory of Radiobiology Division of Radiotherapy Oncology Endocrinology, Department of Experimental Medicine, University of L Aquila, Italy
    Endocr Relat Cancer 18:385-400. 2011
    ..Our results provide a rationale for combinatorial treatment using conventional chemotherapy and a Akt/mTOR inhibitor as promising therapeutic approach for the treatment of HRPC, a disease largely resistant to conventional therapies...
  22. pmc Strategies for imaging androgen receptor signaling pathway in prostate cancer: implications for hormonal manipulation and radiation treatment
    Gravina Giovanni Luca
    Department of Applied, Clinical and Biotechnological Sciences, Laboratory of Radiobiology and Division of Radiotherapy, University of L Aquila, Via Vetoio, Coppito 2, L Aquila, Italy Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Italy LIPOGEN LLC, Mount Laurel, NJ, USA
    Biomed Res Int 2013:460546. 2013
    ..This aim may be obtained by combining the anatomical properties of conventional imaging modalities with biological information to better predict tumor response to conventional treatments. ..
  23. ncbi Subclinical erectile dysfunction: proposal for a novel taxonomic category in sexual medicine
    Emmanuele A Jannini
    Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    J Sex Med 3:787-93; discussion 794. 2006
    ..In addition, we suggest research into biochemical markers to define this condition, which we have named subclinical erectile dysfunction...
  24. pmc Ontogenetic profile of the expression of thyroid hormone receptors in rat and human corpora cavernosa of the penis
    Eleonora Carosa
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    J Sex Med 7:1381-90. 2010
    ..In the last few years, various studies have underlined a correlation between thyroid function and male sexual function, hypothesizing a direct action of thyroid hormones on the penis...
  25. ncbi Platelet-derived growth factor regulation of type-5 phosphodiesterase in human and rat penile smooth muscle cells
    Eleonora Carosa
    Department of Biotechnological and Applied Clinical Sciences, University of L Aquila, L Aquila, Italy
    J Sex Med 11:1675-84. 2014
    ..The most abundant PDE present in corpora cavernosa is the electrolytic cGMP-specific phosphodiesterase type 5 (PDE5)...
  26. ncbi Antitumor effects of saffron-derived carotenoids in prostate cancer cell models
    Claudio Festuccia
    Laboratory of Radiobiology, Department of Biotechnological and Applied Clinical Sciences, University of L Aquila, 67100 L Aquila, Italy
    Biomed Res Int 2014:135048. 2014
    ..Our findings suggest that CR and CCT may be dietary phytochemicals with potential antitumor effects in biologically aggressive PCa cells. ..
  27. ncbi The psychosexual profile of sexual assistants: an internet-based explorative study
    Erika Limoncin
    Department of Clinical and Applied Sciences and Biotechnologies, School of Sexology, University of L Aquila, L Aquila, Italy
    PLoS ONE 9:e98413. 2014
    ..In this study, we investigate whether a rigorous selection and training process on the part of specialised organisations may reduce the risk of training subjects with an atypical sexual interest and behaviours resembling prostitution...
  28. ncbi Type V phosphodiesterase inhibitor treatments for erectile dysfunction increase testosterone levels
    Eleonora Carosa
    Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    Clin Endocrinol (Oxf) 61:382-6. 2004
    ..In this paper we studied the effect of different type V phosphodiesterase (PDE5) inhibitor treatments for ED on the reversibility of this endocrine pattern...
  29. doi Health-related characteristics and unmet needs of men with erectile dysfunction: a survey in five European countries
    Emmanuele A Jannini
    School of Sexology, Department of Clinical and Applied Sciences and Biotechnologies, University of L Aquila, L Aquila, Italy
    J Sex Med 11:40-50. 2014
    ..Data suggest that ED is still an underdiagnosed and undertreated condition. In addition, it seems that men with ED are unsatisfied about their relationship with their physician and with the available drugs...
  30. ncbi Possible correlation between type 1 diabetes mellitus and female sexual dysfunction: case report and literature review
    Antonella Bultrini
    Course of Endocrinology and Sexual Medicine at the Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    J Sex Med 1:337-40. 2004
    ..As support to the hypothesis of a potential diabetes-related arousal dysfunction caused by a decrease in vaginal lubrication of women with Type 1 diabetes mellitus, we describe the following case report...
  31. ncbi 5-Azacitidine restores and amplifies the bicalutamide response on preclinical models of androgen receptor expressing or deficient prostate tumors
    Giovanni Luca Gravina
    Division of Radiotherapy, Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    Prostate 70:1166-78. 2010
    ..This study tested the hypothesis that 5-Aza may restore and enhance the responsiveness of HRPC cells to anti-hormonal therapy on Androgen receptor (AR) expressing (22rv1) and AR-deficient (PC3) cells...
  32. ncbi Ontogenetic profile and thyroid hormone regulation of type-1 and type-8 glucose transporters in rat Sertoli cells
    Eleonora Carosa
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, 67100 L Aquila, Italy
    Int J Androl 28:99-106. 2005
    ..Our data demonstrate that GLUT1 and GLUT8 are both expressed in prepubertal testis, but only GLUT1 is regulated by T(3). In addition, we found that the effect of T(3) cannot be attributed to its action on GLUT1 promoter...
  33. doi Clinical correlates of erectile dysfunction and premature ejaculation in men with couple infertility
    Francesco Lotti
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 9:2698-707. 2012
    ..The frequency and the clinical characteristics of erectile dysfunction (ED) and premature ejaculation (PE) in infertile men have been poorly investigated...
  34. doi Evaluation of premature ejaculation
    Emmanuele A Jannini
    Department of Experimental Medicine, School of Sexology, University of L Aquila, L Aquila, Italy
    J Sex Med 8:328-34. 2011
    ..Because diagnosis informs treatment decisions that have an impact on clinical outcomes, the ability to diagnose PE accurately is vital to the successful management of this condition...
  35. ncbi Ejaculatory disorders: epidemiology and current approaches to definition, classification and subtyping
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, Coppito, Bldg 2, Room A2 54, 67100 L Aquila, Italy
    World J Urol 23:68-75. 2005
    ..This will soon demolish the barriers to seeking help perceived by patients suffering ejaculatory disorders...
  36. ncbi Use and abuse of Rigiscan in the diagnosis of erectile dysfunction
    Emmanuele A Jannini
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    J Sex Med 6:1820-9. 2009
    ..Shall we continue to consider these tools as a diagnostic gold standard in ED diagnosis?..
  37. ncbi New perspectives in the pharmacotherapy of erectile dysfunction
    Emmanuele A Jannini
    Department of Experimental Medicine, Course of Medical Sexology, University of L Aquila, 67100 L Aquila, Italy
    IDrugs 6:1165-72. 2003
    ..New treatments and more effective drugs are expected in the near future because of the rapid expansion of research into erection regulation mechanisms and epidemiological studies...