Alfonso Iorio

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. ncbi request reprint Seizures, headache and thrombocytopenia: diagnosis and treatment do not always come in a standard sequence
    A Iorio
    Medicina Interna e Vascolare Stroke Unit, Dipartimento di Medicina Interna, Ospedale S Maria della Misericordia, Perugia, Italy
    Intern Emerg Med 2:202-6. 2007
  2. ncbi request reprint Impaired endothelial antithrombotic activity following short-term interruption of continuous subcutaneous insulin infusion in type 1 diabetic patients
    Alfonso Iorio
    Section of Internal and Vascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Thromb Haemost 98:635-41. 2007
  3. doi request reprint Iatrogenic causes of an ICH: OAT therapy
    A Iorio
    Universita di Perugia, Sezione di Medicina Interna e Cardiovascolare, Stroke Unit, Dipartimento di Medicina Interna, Perugia, Italy
    Eur J Anaesthesiol Suppl 42:8-11. 2008
  4. ncbi request reprint Are placebo-controlled trials ethical in areas where current guidelines recommend therapy? No
    A Iorio
    Division of Internal and Cardiovascular Medicine and Stroke Unit, University of Perugia, Italy
    J Thromb Haemost 4:2133-6. 2006
  5. doi request reprint Italian Registry of Haemophilia and Allied Disorders. Objectives, methodology and data analysis
    A Iorio
    Hemophilia Centre, Internaland Vascular Medicine, University of Perugia, 06131 Perugia, Italy
    Haemophilia 14:444-53. 2008
  6. pmc The good use of plasma. A critical analysis of five international guidelines
    Alfonso Iorio
    Medicina Interna e Vascolare, Universita di Perugia, Italy
    Blood Transfus 6:18-24. 2008
  7. pmc Audit of the clinical use of fresh-frozen plasma in Umbria: study design and results of the pilot phase
    Alfonso Iorio
    SC di Medicina Interna and Vascolare, Dipartimento di Medicina Interna, Universita di Perugia, Italy
    Blood Transfus 6:211-9. 2008
  8. doi request reprint Clinical trials and haemophilia: does the Bayesian approach make the ideal and desirable good friends?
    A Iorio
    Internal and Vascular Medicine Haemophilia Centre, University of Perugia, Via G Dottori 1, Perugia 06129, Italy
    Haemophilia 15:900-3. 2009
  9. doi request reprint Objectives and methodology: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)
    Alfonso Iorio
    Internal and Vascular Medicine, University of Perugia, Perugia
    Thromb Res 124:e1-5. 2009
  10. ncbi request reprint Prevention of venous thromboembolism after major orthopedic surgery: summing up evidence about old and new antithrombotic agents
    A Iorio
    Sezione di Medicina Interna e Cardiovascolare, Universita di Perugia, Perugia, Italy
    J Thromb Haemost 2:1055-7. 2004

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Seizures, headache and thrombocytopenia: diagnosis and treatment do not always come in a standard sequence
    A Iorio
    Medicina Interna e Vascolare Stroke Unit, Dipartimento di Medicina Interna, Ospedale S Maria della Misericordia, Perugia, Italy
    Intern Emerg Med 2:202-6. 2007
  2. ncbi request reprint Impaired endothelial antithrombotic activity following short-term interruption of continuous subcutaneous insulin infusion in type 1 diabetic patients
    Alfonso Iorio
    Section of Internal and Vascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Thromb Haemost 98:635-41. 2007
    ..Thus, early detection of hyperketonemia in DM patients could contribute to the prevention of life-threatening vascular events...
  3. doi request reprint Iatrogenic causes of an ICH: OAT therapy
    A Iorio
    Universita di Perugia, Sezione di Medicina Interna e Cardiovascolare, Stroke Unit, Dipartimento di Medicina Interna, Perugia, Italy
    Eur J Anaesthesiol Suppl 42:8-11. 2008
    ..Patients who receive chronic oral anticoagulant treatment urgently require effective treatments for acute oral anticoagulant treatment-intracerebral haemorrhage, and therefore controlled clinical trials are needed...
  4. ncbi request reprint Are placebo-controlled trials ethical in areas where current guidelines recommend therapy? No
    A Iorio
    Division of Internal and Cardiovascular Medicine and Stroke Unit, University of Perugia, Italy
    J Thromb Haemost 4:2133-6. 2006
  5. doi request reprint Italian Registry of Haemophilia and Allied Disorders. Objectives, methodology and data analysis
    A Iorio
    Hemophilia Centre, Internaland Vascular Medicine, University of Perugia, 06131 Perugia, Italy
    Haemophilia 14:444-53. 2008
    ..The Italian registry run by AICE adds to the list of the available national haemophilia registries and is intended to establish treatment guidelines and foster research projects in Italy...
  6. pmc The good use of plasma. A critical analysis of five international guidelines
    Alfonso Iorio
    Medicina Interna e Vascolare, Universita di Perugia, Italy
    Blood Transfus 6:18-24. 2008
    ..The aim of the present study was to analyse some of the existing guidelines on the good use of plasma, applying a scientifically validated method, as a preliminary step in the implementation of Regional guidelines...
  7. pmc Audit of the clinical use of fresh-frozen plasma in Umbria: study design and results of the pilot phase
    Alfonso Iorio
    SC di Medicina Interna and Vascolare, Dipartimento di Medicina Interna, Universita di Perugia, Italy
    Blood Transfus 6:211-9. 2008
    ..The literature, however, reports a high percentage of inappropriate requests for FFP. This article presents the results of a pilot study of clinical auditing of the use of FFP in the Region of Umbria (Italy)...
  8. doi request reprint Clinical trials and haemophilia: does the Bayesian approach make the ideal and desirable good friends?
    A Iorio
    Internal and Vascular Medicine Haemophilia Centre, University of Perugia, Via G Dottori 1, Perugia 06129, Italy
    Haemophilia 15:900-3. 2009
    ..Exemplifications of the advantages of the Bayesian approach will be given discussing some papers published in Haemophilia...
  9. doi request reprint Objectives and methodology: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)
    Alfonso Iorio
    Internal and Vascular Medicine, University of Perugia, Perugia
    Thromb Res 124:e1-5. 2009
    ....
  10. ncbi request reprint Prevention of venous thromboembolism after major orthopedic surgery: summing up evidence about old and new antithrombotic agents
    A Iorio
    Sezione di Medicina Interna e Cardiovascolare, Universita di Perugia, Perugia, Italy
    J Thromb Haemost 2:1055-7. 2004
  11. doi request reprint Bone mineral density in haemophilia patients. A meta-analysis
    Alfonso Iorio
    Hemophilia Centre Internal and Vascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Thromb Haemost 103:596-603. 2010
    ..This meta-analysis confirms the association between severe haemophilia and low BMD. Future studies should investigate fracture rates and interventions to prevent bone loss in persons with haemophilia...
  12. ncbi request reprint Applied pharmacoeconomics: considerations to drive the choice of a prophylactic antithrombotic regimen
    A Iorio
    Sezione di Medicina Interna e Cardiovascolare, Universita di Perugia, Perugia, Italy
    J Thromb Haemost 1:881-3. 2003
  13. doi request reprint Rate of inhibitor development in previously untreated hemophilia A patients treated with plasma-derived or recombinant factor VIII concentrates: a systematic review
    A Iorio
    Internal and Vascular Medicine and Hemophilia Centre, University of Perugia, Perugia, Italy
    J Thromb Haemost 8:1256-65. 2010
    ..Different rates of inhibitor development after either plasma-derived (pdFVIII) or recombinant (rFVIII) FVIII have been suggested. However, conflicting results are reported in the literature...
  14. doi request reprint Influenza vaccination and vitamin K antagonist treatment: a placebo-controlled, randomized, double-blind crossover study
    Alfonso Iorio
    Department of Internal and Cardiovascular Medicine, University of Perugia, 06100 Perugia, Italy
    Arch Intern Med 170:609-16. 2010
    ....
  15. ncbi request reprint Thrombophilia and cerebral vein thrombosis
    Alfonso Iorio
    Stroke Unit and Division of Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Via Dottori, Sant Andrea delle Fratte, Perugia, Italy
    Front Neurol Neurosci 23:55-76. 2008
    ..38 for factor V Leiden mutation, 9.27 for Prothrombin G20210A mutation, 32 for antiphospholipid syndrome and 4.07 for hyperhomocysteinemia. Some simple but critical rules are finally given to help when testing for thrombophilia...
  16. doi request reprint Small intestinal bacterial overgrowth and warfarin dose requirement variability
    Vittorio Giuliano
    Gastrointestinal and Hepatology Section, Department of Clinical and Experimental Medicine, Ospedale S Maria della Misericordia, and Department of Biochemistry Science and Molecular Biotechnologies, University of Perugia, Italy
    Thromb Res 126:12-7. 2010
    ..Larger studies are needed to confirm these preliminary data and to evaluate the effects of SIBO decontamination on warfarin dosage...
  17. pmc Replacement therapy with recombinant factor IX. A multicentre evaluation of current dosing practices in Italy
    Alessandra Rocca
    Haemophilia Centre of Perugia, Internal and Vascular Medicine, Via G Dottori 1, Perugia, Italy
    Blood Transfus 9:60-9. 2011
    ..In clinical practice, a conversion (augmentation) factor is suggested to calculate the necessary doses of rFIX. The aim of this study was to assess the range of values for the conversion factor in usual clinical practice in Italy...
  18. ncbi request reprint Fibrinogenolysis and thrombin generation after reduced dose bolus or conventional rt-PA for pulmonary embolism. The Coagulation Project Investigators of the Bolus Alteplase Pulmonary Embolism Group
    G Agnelli
    Istituto di Medicina Interna e Medicina Vascolare, Universita di Perugia, Italy
    Blood Coagul Fibrinolysis 8:216-22. 1997
    ..0%) in Group B suffered major or other important bleeding. Our results indicate that the administration of weight-adjusted reduced-dose rt-PA bolus produces less impairment of blood coagulation than the FDA approved regimen...
  19. ncbi request reprint Influenza vaccination in patients on long-term anticoagulant therapy
    A M Iorio
    Department of Hygiene, University of Perugia, Via del Giochetto, 06100 Perugia, Italy
    Vaccine 24:6624-8. 2006
    ....
  20. ncbi request reprint Three months versus one year of oral anticoagulant therapy for idiopathic deep venous thrombosis. Warfarin Optimal Duration Italian Trial Investigators
    G Agnelli
    Dipartimento di Medicina Interna, Universita di Perugia, Italy
    N Engl J Med 345:165-9. 2001
    ..Whether this benefit persists after anticoagulant therapy is discontinued is controversial...
  21. ncbi request reprint Low-molecular-weight heparin for the long-term treatment of symptomatic venous thromboembolism: meta-analysis of the randomized comparisons with oral anticoagulants
    A Iorio
    Sezione de Medicina Interna e Cardiovasculare, Universita di Perugia, Perugia, Italy
    J Thromb Haemost 1:1906-13. 2003
    ....
  22. doi request reprint Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor: a systematic review
    Alfonso Iorio
    Department of Internal Medicine, University of Perugia, Italy
    Arch Intern Med 170:1710-6. 2010
    ..We aimed to determine the risk of recurrence for symptomatic venous thromboembolism (VTE) provoked by different transient risk factors...
  23. ncbi request reprint Low-molecular-weight and unfractionated heparin for prevention of venous thromboembolism in neurosurgery: a meta-analysis
    A Iorio
    Laboratorio di Analisi Chimico Cliniche, Azienda Ospedaliera Santa Maria Nuova, Reggio Emilia, Perugia, Italy
    Arch Intern Med 160:2327-32. 2000
    ..We performed a meta-analysis of controlled randomized trials on the efficacy and safety of heparin in the prophylaxis of venous thromboembolism in neurosurgery...
  24. ncbi request reprint Safety and efficacy of ximelagatran: meta-analysis of the controlled randomized trials for the prophylaxis or treatment of venous thromboembolism
    A Iorio
    Division of Internal and Cardiovascular Medicine, Dept of Internal Medicine, University of Perugia, Italy
    Curr Pharm Des 11:3893-918. 2005
    ..Aim of the study was to evaluate safety and efficacy of ximelagatran in a meta-analysis of prophylaxis and/or treatment randomized controlled trials...
  25. ncbi request reprint Low-molecular-weight heparin and cancer survival: review of the literature and pooled analysis of 1,726 patients treated for at least three months
    Serenella Conti
    Sezione di Medicina Interna e Cardiovascolare, Universita di Perugia, Perugia, Italy
    Pathophysiol Haemost Thromb 33:197-201. 2003
    ..However, the biological rationale of this effect for a short treatment with LMWH remains unclear. We wanted to check if similar results were achieved in cancer patients treated with LMWH for a longer period of time...
  26. ncbi request reprint Performance comparison of three assay methods used in fasting and postmethionine load plasma homocysteine determinations from patients with vascular disease
    Evangelia Mourvaki
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy
    Am J Clin Pathol 124:675-81. 2005
    ..Differences among tHcy values must be taken into account when these methods will be used interchangeably for diagnosis and monitoring of treatment...
  27. ncbi request reprint Successful treatment with rFVIIa of spontaneous intracerebral hemorrhage in a patient with mechanical prosthetic heart valves
    S Conti
    Sezione di Medicina Interna e Cardiovascolare, University of Perugia, Via Enrico Dal Pozzo, 06123 Perugia, Italy
    Clin Lab Haematol 27:283-5. 2005
    ..Neurological examination at 3 months follow-up visit was completely normal. To our knowledge, this is the first report of the safe and successful use of rFVIIa to treat ICH in a patient on oral anticoagulants for prosthetic heart valves...
  28. doi request reprint Clinical validation of a new algorithm for computerized dosing of vitamin K antagonist therapy: a retrospective simulation study
    Michela Basileo
    Department of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
    Intern Emerg Med 8:55-63. 2013
    ..In conclusion, the new algorithm proved to consistently overlap with the manual method. The algorithm is useful but must be tested in a multi-center, prospective, interventional study...
  29. ncbi request reprint D-dimer testing to determine the duration of anticoagulation therapy
    Gualtiero Palareti
    Department of Angiology and Blood Coagulation, S Orsola Malpighi University Hospital, Bologna, Italy
    N Engl J Med 355:1780-9. 2006
    ..The optimal duration of oral anticoagulation in patients with idiopathic venous thromboembolism is uncertain. Testing of D-dimer levels may play a role in the assessment of the need for prolonged anticoagulation...
  30. ncbi request reprint Factor V Leiden and prothrombin gene G20210A mutations in Italian patients with Behçet's disease and deep vein thrombosis
    Mauro Silingardi
    Ospedale di Reggio Emilia, Regio Emilia, Italy
    Arthritis Rheum 51:177-83. 2004
    ..To evaluate the frequency and type of vascular lesions and to study the association of factor V gene G1691A (Leiden) and prothrombin gene G20210A polymorphisms with venous thrombosis in Italian patients with Behçet's disease (BD)...
  31. ncbi request reprint Intracranial bleeding: epidemiology and relationships with antithrombotic treatment in 241 cerebral hemorrhages in Reggio Emilia
    Alberto Nicolini
    Unità Tromboembolismo Venoso, Centro Emostasi e Trombosi, Dipartimento Area Medica 1, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy
    Haematologica 87:948-56. 2002
    ..The aim of this study was to determine the incidence of intracranial bleeding in the population of Reggio Emilia and to investigate the potential effect of AC and AP drugs...
  32. doi request reprint Safety and efficacy of sucrose-formulated full-length recombinant factor VIII: experience in the standard clinical setting
    Roberto Musso
    Azienda Ospedale Vittorio Emanuele, Ospedale Ferrarotto, Catania, Italy
    Thromb Haemost 99:52-8. 2008
    ..Furthermore, these findings are consistent with those of previous phase III clinical studies with rFVIII-FS, particularly with regard to its efficacy and low incidence of inhibitor formation...