P Invernizzi

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi request reprint Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-conjugated species in patients with primary biliary cirrhosis
    P Invernizzi
    Division of Internal Medicine, Ospedale San Paolo School of Medicine, University of Milan, Italy
    Hepatology 29:320-7. 1999
  2. ncbi request reprint X monosomy in female systemic lupus erythematosus
    Pietro Invernizzi
    Division of Internal Medicine and Liver Unit, Department of Medicine, Surgery and Dentistry, San Paolo Hospital School of Medicine, University of Milan, Via di Rudini 8, 20142 Milan, Italy
    Ann N Y Acad Sci 1110:84-91. 2007
  3. ncbi request reprint The X chromosome in female-predominant autoimmune diseases
    Pietro Invernizzi
    Division of Internal Medicine and Liver Unit, San Paolo Hospital School of Medicine, University of Milan, Via di Rudini 8, 20142 Milan, Italy
    Ann N Y Acad Sci 1110:57-64. 2007
  4. ncbi request reprint X chromosome monosomy: a common mechanism for autoimmune diseases
    Pietro Invernizzi
    Division of Internal Medicine, Department of Medicine, Surgery and Dentistry, San Paolo School of Medicine, University of Milan, Italy
    J Immunol 175:575-8. 2005
  5. doi request reprint Skewing of X chromosome inactivation in autoimmunity
    Pietro Invernizzi
    Division of Internal Medicine and Liver Unit, San Paolo Hospital School of Medicine, University of Milan, Milan, Italy
    Autoimmunity 41:272-7. 2008
  6. ncbi request reprint Antinuclear antibodies in primary biliary cirrhosis
    Pietro Invernizzi
    Department of Medicine, Surgery and Dentistry, San Paolo School of Medicine, University of Milan, Italy
    Semin Liver Dis 25:298-310. 2005
  7. ncbi request reprint Frequency of monosomy X in women with primary biliary cirrhosis
    Pietro Invernizzi
    Department of Internal Medicine University of Milan, Via di Rudini 8, 20142 Milan, Italy
    Lancet 363:533-5. 2004
  8. ncbi request reprint X chromosome in autoimmune diseases
    Pietro Invernizzi
    Department of Internal Medicine, Istituto Clinico Humanitas IRCCS, University of Milan, Via Manzoni 56, 20089 Rozzano, Milan, Italy and Clinical Immunology, University of California, Davis, CA, USA
    Expert Rev Clin Immunol 4:591-7. 2008
  9. ncbi request reprint Presence of fetal DNA in maternal plasma decades after pregnancy
    Pietro Invernizzi
    Division of Internal Medicine, Department of Medicine, Surgery and Dentistry, San Paolo School of Medicine, University of Milan, Via di Rudini 8, 20142 Milan, Italy
    Hum Genet 110:587-91. 2002
  10. pmc Blood fetal microchimerism in primary biliary cirrhosis
    P Invernizzi
    Department of Medicine, Surgery and Dentistry, San Paolo School of Medicine, University of Milan, Milan, Italy
    Clin Exp Immunol 122:418-22. 2000

Detail Information

Publications68

  1. ncbi request reprint Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-conjugated species in patients with primary biliary cirrhosis
    P Invernizzi
    Division of Internal Medicine, Ospedale San Paolo School of Medicine, University of Milan, Italy
    Hepatology 29:320-7. 1999
    ..This comparative study suggests that tauroursodeoxycholate has significant advantages over ursodeoxycholate that may be of benefit for long-term therapy in PBC...
  2. ncbi request reprint X monosomy in female systemic lupus erythematosus
    Pietro Invernizzi
    Division of Internal Medicine and Liver Unit, Department of Medicine, Surgery and Dentistry, San Paolo Hospital School of Medicine, University of Milan, Via di Rudini 8, 20142 Milan, Italy
    Ann N Y Acad Sci 1110:84-91. 2007
    ..3960, SLE vs. HCs, Student's t-test), thus suggesting that a different mechanism of immune deregulation might be predominant in the female population of patients with SLE...
  3. ncbi request reprint The X chromosome in female-predominant autoimmune diseases
    Pietro Invernizzi
    Division of Internal Medicine and Liver Unit, San Paolo Hospital School of Medicine, University of Milan, Via di Rudini 8, 20142 Milan, Italy
    Ann N Y Acad Sci 1110:57-64. 2007
    ..Future studies will identify the X chromosome regions containing candidate genes for autoimmune susceptibility...
  4. ncbi request reprint X chromosome monosomy: a common mechanism for autoimmune diseases
    Pietro Invernizzi
    Division of Internal Medicine, Department of Medicine, Surgery and Dentistry, San Paolo School of Medicine, University of Milan, Italy
    J Immunol 175:575-8. 2005
    ..These data highlight the thesis that chromosome instability is common to women with SSc and AITD and that haploinsufficiency for X-linked genes may be a critical factor for the female predominance of autoimmune diseases...
  5. doi request reprint Skewing of X chromosome inactivation in autoimmunity
    Pietro Invernizzi
    Division of Internal Medicine and Liver Unit, San Paolo Hospital School of Medicine, University of Milan, Milan, Italy
    Autoimmunity 41:272-7. 2008
    ..Future efforts will help to identify specific X chromosome regions containing candidate genes for disease susceptibility...
  6. ncbi request reprint Antinuclear antibodies in primary biliary cirrhosis
    Pietro Invernizzi
    Department of Medicine, Surgery and Dentistry, San Paolo School of Medicine, University of Milan, Italy
    Semin Liver Dis 25:298-310. 2005
    ..In recent years, the clinical significance of ANA in PBC has been widely investigated and data indicate that, unlike AMAs, PBC-specific ANAs correlate with disease severity and may therefore be a marker of poor prognosis...
  7. ncbi request reprint Frequency of monosomy X in women with primary biliary cirrhosis
    Pietro Invernizzi
    Department of Internal Medicine University of Milan, Via di Rudini 8, 20142 Milan, Italy
    Lancet 363:533-5. 2004
    ..050 (95% CI 0.046-0.055) in women with PBC, 0.032 (0.028-0.036) in those with chronic hepatitis C, and 0.028 (0.025-0.032) in controls. We suggest that haploinsufficiency for specific X-linked genes leads to female susceptibility to PBC...
  8. ncbi request reprint X chromosome in autoimmune diseases
    Pietro Invernizzi
    Department of Internal Medicine, Istituto Clinico Humanitas IRCCS, University of Milan, Via Manzoni 56, 20089 Rozzano, Milan, Italy and Clinical Immunology, University of California, Davis, CA, USA
    Expert Rev Clin Immunol 4:591-7. 2008
    ..We believe that future high-throughput tools will help to identify specific clusters of genes on the sex chromosomes that are candidates for disease susceptibility or resistance...
  9. ncbi request reprint Presence of fetal DNA in maternal plasma decades after pregnancy
    Pietro Invernizzi
    Division of Internal Medicine, Department of Medicine, Surgery and Dentistry, San Paolo School of Medicine, University of Milan, Via di Rudini 8, 20142 Milan, Italy
    Hum Genet 110:587-91. 2002
    ..This finding has practical implications for non-invasive prenatal diagnoses based on maternal blood, and may be considered for possible pathophysiological correlations...
  10. pmc Blood fetal microchimerism in primary biliary cirrhosis
    P Invernizzi
    Department of Medicine, Surgery and Dentistry, San Paolo School of Medicine, University of Milan, Milan, Italy
    Clin Exp Immunol 122:418-22. 2000
    ..Overall, our data do not support the hypothesis that fetal microchimerism plays a significant role in the onset or progression of PBC...
  11. ncbi request reprint Peculiar HLA polymorphisms in Italian patients with primary biliary cirrhosis
    Pietro Invernizzi
    Department of Medicine, San Paolo Hospital Medical School, University of Milan, Via di Rudini 8, 20142 Milan, Italy
    J Hepatol 38:401-6. 2003
    ..Data concerning human leukocyte antigen (HLA) polymorphisms in PBC come from a limited number of geographical areas, from which the association with the HLA-DRB1*08 allele has been consistently reported...
  12. ncbi request reprint Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis
    P Invernizzi
    Department of Medicine, Surgery and Dentistry, San Paolo School of Medicine, University of Milan, Italy
    J Hepatol 34:366-72. 2001
    ..Antibodies against nuclear pore complexes (NPCs) have been detected in primary biliary cirrhosis (PBC), but their clinical relevance is still unsettled...
  13. ncbi request reprint Ten-year combination treatment with colchicine and ursodeoxycholic acid for primary biliary cirrhosis: a double-blind, placebo-controlled trial on symptomatic patients
    P M Battezzati
    Department of Medicine, Surgery and Dentistry Ospedale San Paolo, School of Medicine San Paolo, University of Milan, Milan, Italy
    Aliment Pharmacol Ther 15:1427-34. 2001
    ..Combined medical treatment may provide further benefit to primary biliary cirrhosis (PBC) patients administered ursodeoxycholic acid (UDCA)...
  14. pmc Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: a multicenter study of 664 patients and 1992 healthy controls
    Pietro Invernizzi
    Department of Internal Medicine, Istituto Clinico Humanitas IRCCS, University of Milan, Milan, Italy
    Hepatology 48:1906-12. 2008
    ..We suggest that a large whole-genome approach is required to identify further genetic elements contributing to the loss of tolerance in this disease...
  15. pmc Hyperlipidaemic state and cardiovascular risk in primary biliary cirrhosis
    M Longo
    Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Italy
    Gut 51:265-9. 2002
    ..Primary biliary cirrhosis (PBC), a chronic cholestatic liver disease, is frequently associated with severe hypercholesterolaemia but the clinical significance of this finding is unclear...
  16. ncbi request reprint Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis
    Yasuhiko Kimura
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA, USA
    Hepatology 41:55-63. 2005
    ..In conclusion, genetic polymorphisms of CYP 2D6 and 2E1, PXR, and MDR1 do not appear to play a role in the onset of PBC...
  17. doi request reprint Acute liver and renal failure during treatment with buprenorphine at therapeutic dose
    M Zuin
    Department of Medicine, Division of Internal Medicine, San Paolo School of Medicine, University of Milan, Milan, Italy
    Dig Liver Dis 41:e8-e10. 2009
    ..In conclusion, we surmise that buprenorphine at suggested doses can induce liver and kidney failure in susceptible individuals, possibly through direct mitochondrial toxicity...
  18. ncbi request reprint Genes and (auto)immunity in primary biliary cirrhosis
    C Selmi
    Division of Internal Medicine, San Paolo School of Medicine, University of Milan, Milan, Italy
    Genes Immun 6:543-56. 2005
    ....
  19. pmc Etiopathogenesis of primary biliary cirrhosis
    Ana Lleo
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis School of Medicine, Davis, CA 95616, USA
    World J Gastroenterol 14:3328-37. 2008
    ..In this article, we critically review the available evidence on etiopathogenesis of PBC and present interpretations of complex data, new developments and theories, and nominate directions for future research...
  20. pmc Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis
    Ana Lleo
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA, USA
    Hepatology 52:987-98. 2010
    ..They further emphasize the critical role of the innate immune system in the perpetuation of this autoimmune disease...
  21. ncbi request reprint Fetal microchimerism in normal and embryo transfer bovine pregnancies
    L Turin
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Universita di Milano, Via Celoria 10, 20133, Milano, Italy
    Vet Res Commun 31:205-7. 2007
  22. ncbi request reprint Bovine fetal microchimerism in normal and embryo transfer pregnancies and its implications for biotechnology applications in cattle
    Lauretta Turin
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Universita degli Studi di Milano, Milano, Italy
    Biotechnol J 2:486-91. 2007
    ....
  23. ncbi request reprint Genetic variants of endothelial nitric oxide synthase in patients with primary biliary cirrhosis: association with disease severity
    Carlo Selmi
    Division of Internal Medicine, Department of Medicine, Surgery and Dentistry, University of Milan, Division of Clinical Chemistry and Microbiology, San Paolo Hospital, Milan, Italy
    J Gastroenterol Hepatol 18:1150-5. 2003
    ....
  24. ncbi request reprint T-cell receptor polymorphism in primary biliary cirrhosis
    Carlo Selmi
    Divisione di Medicina Interna, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi, Polo San Paolo di Milano
    Ann Ital Med Int 18:149-53. 2003
    ..1 +/- 1.2 vs 5.7 +/- 1.2 in non-heterozygous). Our data suggest that TCR constant beta-2 polymorphism does not play a key role in modulating the multifactorial etiopathogenesis of primary biliary cirrhosis...
  25. doi request reprint Experimental evidence on the immunopathogenesis of primary biliary cirrhosis
    Carlo Selmi
    Department of Translational Medicine, Universita degli Studi di Milano, Milan, Italy
    Cell Mol Immunol 7:1-10. 2010
    ..Most recently, several murine models have been reported, including genetically determined models as well as models induced by immunization with xenobiotics and bacteria...
  26. ncbi request reprint From bases to basis: linking genetics to causation in primary biliary cirrhosis
    Pietro Invernizzi
    Division of Internal Medicine, Department of Medicine, Surgery and Dentistry, San Paolo School of Medicine, University of Milan, Italy
    Clin Gastroenterol Hepatol 3:401-10. 2005
    ....
  27. doi request reprint New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity
    Stefania Recalcati
    Institute of General Pathology, University of Milan, Via Mangiagalli 31, 20133 Milan, Italy
    J Autoimmun 30:84-9. 2008
    ....
  28. doi request reprint The genetics of human autoimmune disease
    Pietro Invernizzi
    Division of Internal Medicine and Hepatobiliary Immunopathology Unit, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA, USA
    J Autoimmun 33:290-9. 2009
    ..In addition, a role for sex chromosomes in the development of autoimmune diseases has also been suggested. This review will focus on the recent discoveries related to genetics of autoimmunity...
  29. pmc Clinical features and management of primary biliary cirrhosis
    Andrea Crosignani
    Dipartimento di Medicina Interna, Polo Universitario, Ospedale San Paolo, Via di Rudini 8, Milano 20142, Italy
    World J Gastroenterol 14:3313-27. 2008
    ....
  30. doi request reprint Female predominance and X chromosome defects in autoimmune diseases
    Pietro Invernizzi
    Division of Internal Medicine and Hepatobiliary Immunopathology Unit, IRCCS Istituto Clinico Humanitas, Milan, Italy
    J Autoimmun 33:12-6. 2009
    ..Taken together, sex chromosome changes might constitute the common trait of the susceptibility to autoimmune diseases...
  31. ncbi request reprint Primary biliary cirrhosis: does X mark the spot?
    Carlo Selmi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, TB 192 One Shields Ave, Davis, CA 95616, USA
    Autoimmun Rev 3:493-9. 2004
    ..Such observations appear independent from the degree of cholestasis and specific for PBC. In this review we discuss the implications of these findings and their immunological implications...
  32. pmc Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis
    P Invernizzi
    Department of Medicine, Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Genes Immun 13:461-8. 2012
    ..No signal was observed in the HLA class 1 or class 3 regions. These findings better define the association of PBC with HLA and specifically support the role of classical HLA-DRB1 and DPB1 genes and alleles in susceptibility to PBC...
  33. ncbi request reprint Primary biliary cirrhosis: solving the enigma
    Alessia Giorgini
    Division of Internal Medicine, Department of Medicine, Surgery and Dentistry, San Paolo School of Medicine, University of Milan, Milan, Italy
    Ann N Y Acad Sci 1051:185-93. 2005
    ..In this review, available data and current theories regarding the immunomediated pathogenesis of PBC will be described...
  34. ncbi request reprint The X chromosome and systemic sclerosis
    Carlo Selmi
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, California 95616, USA
    Curr Opin Rheumatol 18:601-5. 2006
    ..e. monosomy rates and inactivation patterns) in autoimmunity. We will review herein the most recent data on the role of the X chromosome in systemic sclerosis onset and discuss the potential implications...
  35. pmc The consequences of apoptosis in autoimmunity
    Ana Lleo
    Division of Rheumatology, University of California, Davis, CA, USA
    J Autoimmun 31:257-62. 2008
    ..We herein review the known mechanisms for regulating the uptake of the products of apoptosis in the development of autoimmunity...
  36. doi request reprint Impaired indoleamine 2,3-dioxygenase production contributes to the development of autoimmunity in primary biliary cirrhosis
    Sabine Oertelt-Prigione
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Autoimmunity 41:92-9. 2008
    ..In conclusion, we submit that an impaired IDO induction characterizes PBC and might represent a contributing factor in disease pathogenesis in association with several specific defects in the target tissue...
  37. pmc Autophagy: highlighting a novel player in the autoimmunity scenario
    Ana Lleo
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    J Autoimmun 29:61-8. 2007
    ..We review herein the role of autophagy in immune function and its possible contribution to breakdown of tolerance and development of autoimmunity...
  38. ncbi request reprint The enigma of primary biliary cirrhosis
    Carlo Selmi
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA, USA
    Clin Rev Allergy Immunol 28:73-81. 2005
    ....
  39. ncbi request reprint Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis
    Kentaro Kikuchi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Genome and Biomedical Sciences Facility, 451 E Health Sciences Drive, Suite 6510, Davis, CA 95616, USA
    J Autoimmun 24:347-52. 2005
    ..Interestingly, however, despite the functional association, there is no difference in the distribution of TLR9 genotypes between patients and controls. Our data emphasize the importance of dissecting the innate immune response in PBC...
  40. doi request reprint Future directions in genetic for autoimmune diseases
    Pietro Invernizzi
    Division of Internal Medicine and Hepatobiliary Immunopathology Unit, IRCCS Istituto Clinico Humanitas, Milan, Italy
    J Autoimmun 33:1-2. 2009
    ..In addition, a number of evidences suggest a role of X chromosome gene dosage in autoimmunity. Based on these findings, sex chromosome defects might be the common trait of the susceptibility to autoimmune diseases...
  41. doi request reprint Definition of human autoimmunity--autoantibodies versus autoimmune disease
    Ana Lleo
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Autoimmun Rev 9:A259-66. 2010
    ..This review discusses the clinical significance of autoantibodies, their pathogenic mechanisms in autoimmune diseases and, finally, illustrates the technology available for appropriate autoantibody detection...
  42. ncbi request reprint Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium
    Carlo Selmi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Hepatology 38:1250-7. 2003
    ..aromaticivorans is a candidate for the induction of PBC...
  43. doi request reprint Serum autoantibodies: a road map for the clinical hepatologist
    Francesca Meda
    Division of Internal Medicine and Liver Unit, San Paolo Hospital School of Medicine, University of Milan, Milan, Italy
    Autoimmunity 41:27-34. 2008
    ..The target of this review article is therefore, to illustrate the current knowledge and available experimental evidence to guide the diagnostic and prognostic decision making in autoimmune and viral chronic liver diseases...
  44. ncbi request reprint Genetics and geoepidemiology of primary biliary cirrhosis: following the footprints to disease etiology
    Carlo Selmi
    Division of Internal Medicine, San Paolo School of Medicine, University of Milan, Italy
    Semin Liver Dis 25:265-80. 2005
    ..We also submit possible interpretations of data, new developments and theories, and attempt to indicate directions for future research efforts...
  45. pmc Apotopes and the biliary specificity of primary biliary cirrhosis
    Ana Lleo
    Division of Rheumatology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 49:871-9. 2009
    ....
  46. pmc Quality of life and everyday activities in patients with primary biliary cirrhosis
    Carlo Selmi
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA 95616, USA
    Hepatology 46:1836-43. 2007
    ..Nevertheless, patients with PBC suffer significantly more than controls from a variety of symptoms that are beyond the immediate impact of liver failure and affect their lifestyle, personal relationships, and work activities...
  47. ncbi request reprint Soluble CD40L in plasma of patients with primary biliary cirrhosis
    Sabine Oertelt
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Ann N Y Acad Sci 1051:205-10. 2005
    ..24). We concluded that PBC patients do not exhibit higher plasma concentrations of sCD40L than age-matched controls, a finding common to several autoimmune diseases. Further investigation of the CD40-CD40L system is strongly encouraged...
  48. ncbi request reprint Interpreting serological tests in diagnosing autoimmune liver diseases
    Pietro Invernizzi
    Division of Internal Medicine and Liver Unit, San Paolo Hospital School of Medicine, University of Milan, Milan, Italy
    Semin Liver Dis 27:161-72. 2007
    ..We review herein the numerous ALD screening tests available in routine and specialized laboratories and comment on their significance in clinical practice...
  49. ncbi request reprint Decreased serum leptin levels in primary biliary cirrhosis: a link between metabolism and autoimmunity?
    Roman Rieger
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Ann N Y Acad Sci 1051:211-7. 2005
    ..However, further studies are warranted to further characterize the functions of leptin during the natural history of autoimmunity...
  50. ncbi request reprint A sensitive bead assay for antimitochondrial antibodies: Chipping away at AMA-negative primary biliary cirrhosis
    Sabine Oertelt
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 45:659-65. 2007
    ..CONCLUSION: The development of this assay reflects the potential for automated detection with rapid and reliable assaying and further highlights the diminished number of truly AMA-negative PBC patients...
  51. ncbi request reprint Epidemiology and pathogenesis of primary biliary cirrhosis
    Carlo Selmi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, School of Medicine, Davis, CA 95616, USA
    J Clin Gastroenterol 38:264-71. 2004
    ..In this review, the available data regarding the epidemiology and pathogenesis of primary biliary cirrhosis will be described and discussed...
  52. doi request reprint Geoepidemiology of autoimmune liver diseases
    Pietro Invernizzi
    Division of Internal Medicine and Hepatobiliary Immunopathology Unit, IRCCS Istituto Clinico Humanitas, Via A Manzoni 113, 20089 Rozzano, Milan, Italy
    J Autoimmun 34:J300-6. 2010
    ..In particular, we will discuss the major underlying immunomolecular mechanisms of development, the genetic influences, the growing number of immuno-serological diagnostic markers, and the increasingly effective therapeutic possibilities...
  53. ncbi request reprint Preferential X chromosome loss but random inactivation characterize primary biliary cirrhosis
    Monica Miozzo
    Medical Genetics Unit, San Paolo Hospital School of Medicine, University of Milan, Milan, Italy
    Hepatology 46:456-62. 2007
    ....
  54. ncbi request reprint Genes and goals: an approach to microarray analysis in autoimmunity
    Sabine Oertelt
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, School of Medicine, 451 E Health Sciences Drive, Suite 6510, Davis, California 95616, USA
    Autoimmun Rev 4:414-22. 2005
    ..We also emphasize how, once potential chromosome regions or pathways are identified, specific array design will be a powerful resource when used on large and representative populations...
  55. ncbi request reprint Characterization of the antibodies to p62 nucleoporin in primary biliary cirrhosis using human recombinant antigen
    Jozefa Wesierska-Gadek
    Cell Cycle Regulation Group, Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria
    J Cell Biochem 104:27-37. 2008
    ....
  56. ncbi request reprint Estrogen receptors in cholangiocytes and the progression of primary biliary cirrhosis
    Domenico Alvaro
    Division of Gastroenterology, Department of Clinical Medicine, University of Rome, La Sapienza, via R Rossellini 51, 00137 Rome, Italy
    J Hepatol 41:905-12. 2004
    ..Estrogen receptors (ER) in cholangiocytes of primary biliary cirrhosis (PBC) patients and their relationship with cell proliferation and death were evaluated...
  57. ncbi request reprint Presence of fetal DNA in maternal plasma decades after pregnancy: further comments
    Pietro Invernizzi
    Hum Genet 111:576. 2002
  58. ncbi request reprint Correlation of initial autoantibody profile and clinical outcome in primary biliary cirrhosis
    Jozefa Wesierska-Gadek
    First Department of Internal Medicine, Institute of Cancer Research, Vienna Medical University, Vienna, Austria
    Hepatology 43:1135-44. 2006
    ..5%, P = .019). Anti-NPC antibodies remained stable or slightly increased over the period of observation. In condusion, anti-NPC identifies patients likely to experience an unfavorable clinical course and more rapid disease progression...
  59. ncbi request reprint Characterization of autoantibodies against components of the nuclear pore complexes: high frequency of anti-p62 nucleoporin antibodies
    Jozefa Wesierska-Gadek
    Cell Cycle Regulation Group, Div Institute of Cancer Research, Department of Medicine I, Vienna Medical University, Austria
    Ann N Y Acad Sci 1109:519-30. 2007
    ..Considering the recently reported clinical significance of ANAs in PBC, the prognostic value of the anti-NPC antibodies and their correlation with severity and progression of the disease is under evaluation...
  60. pmc Geographic clusters of primary biliary cirrhosis
    Saif Abu-Mouch
    Hepatology Clinic, Hillel Yaffe Medical Center, Hadera, Israel
    Clin Dev Immunol 10:127-31. 2003
    ..Although these data are anedoctal, the study of a large number of such clusters may provide a tool to estimate the roles of genetics and environment in the induction of autoimmunity...
  61. ncbi request reprint Antimitochondrial antibodies and reactivity to N. aromaticivorans proteins in Icelandic patients with primary biliary cirrhosis and their relatives
    Sigurdur Olafsson
    Department of Internal Medicine, Landspitali University Hospital, Reykjavik, Iceland
    Am J Gastroenterol 99:2143-6. 2004
    ..aromaticivorans might be the trigger of autoimmunity in PBC. No data are available on the specificity and crossreactivity of AMA in a genetically homogenous group of patients, such as the Icelandic population...
  62. ncbi request reprint Tamoxifen in treatment of primary biliary cirrhosis
    Pietro Invernizzi
    Hepatology 39:1175-6. 2004
  63. pmc Autoimmune liver diseases
    Pietro Invernizzi
    World J Gastroenterol 14:3290-1. 2008
    ....
  64. ncbi request reprint Effect of anti-carbonic anhydrase antibodies on carbonic anhydrases I and II
    Francesco Botre
    Controllo e Gestione delle Merci e del oro Impatto sull Ambiente Department, La Sapienza University of Rome, Via del Castro Laurenziano 9, 00161 Rome, Italy
    Clin Chem 49:1221-3. 2003
  65. ncbi request reprint Lack of immunological or molecular evidence for a role of mouse mammary tumor retrovirus in primary biliary cirrhosis
    Carlo Selmi
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, 95616, USA
    Gastroenterology 127:493-501. 2004
    ..Recent observations, including a pilot clinical trial, have suggested that a human mouse mammary tumor virus (MMTV) causes primary biliary cirrhosis (PBC). We attempted to confirm such data...
  66. ncbi request reprint Primary biliary cirrhosis in monozygotic and dizygotic twins: genetics, epigenetics, and environment
    Carlo Selmi
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, 95616, USA
    Gastroenterology 127:485-92. 2004
    ..Accordingly, we evaluated the concordance of PBC in a genetically defined population of twin sets and evaluated the clinical characteristics between concordant subjects...
  67. pmc The genetic basis of primary biliary cirrhosis: premises, not promises
    Pietro Invernizzi
    Gastroenterology 135:1044-7. 2008
  68. pmc Autoimmune liver serology: current diagnostic and clinical challenges
    Dimitrios P Bogdanos
    Institute of Liver Studies, King s College London School of Medicine, London SE5 9RS, UK
    World J Gastroenterol 14:3374-87. 2008
    ....