Stefano Indraccolo

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. doi request reprint Insights into the regulation of tumor dormancy by angiogenesis in experimental tumors
    Stefano Indraccolo
    Istituto Oncologico Veneto IRCCS, Padua, Italy
    Adv Exp Med Biol 734:37-52. 2013
  2. ncbi request reprint Effects of CD2 locus control region sequences on gene expression by retroviral and lentiviral vectors
    S Indraccolo
    IST Viral and Molecular Oncology Section, the Department of Oncology and Surgical Sciences, University of Padua, Italy
    Blood 98:3607-17. 2001
  3. ncbi request reprint Gene therapy of ovarian cancer with IFN-alpha-producing fibroblasts: comparison of constitutive and inducible vectors
    S Indraccolo
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    Gene Ther 13:953-65. 2006
  4. pmc Interruption of tumor dormancy by a transient angiogenic burst within the tumor microenvironment
    Stefano Indraccolo
    Department of Oncology and Surgical Sciences, University of Padova, 35128 Padova, Italy
    Proc Natl Acad Sci U S A 103:4216-21. 2006
  5. ncbi request reprint Establishment and characterization of xenografts and cancer cell cultures derived from BRCA1 -/- epithelial ovarian cancers
    Stefano Indraccolo
    Istituto Oncologico Veneto, Padova, Italy
    Eur J Cancer 42:1475-83. 2006
  6. ncbi request reprint Dormant tumors awaken by a short-term angiogenic burst: the spike hypothesis
    Stefano Indraccolo
    Istituto Oncologico Veneto, Padova, Italy
    Cell Cycle 5:1751-5. 2006
  7. doi request reprint Interferon-alpha as angiogenesis inhibitor: learning from tumor models
    Stefano Indraccolo
    Istituto Oncologico Veneto, IRCCS, Padova, Italy
    Autoimmunity 43:244-7. 2010
  8. ncbi request reprint Ligand-driven activation of the notch pathway in T-ALL and solid tumors: why Not(ch)?
    Stefano Indraccolo
    Istituto Oncologico Veneto IRCCS, Padova, Italy
    Cell Cycle 9:80-5. 2010
  9. ncbi request reprint Concluding remarks
    Stefano Indraccolo
    Istituto Oncologico Veneto, Via Gattamelata, 64, I 35128 Padova, Italy
    Mol Aspects Med 28:167. 2007
  10. doi request reprint Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy
    Stefano Indraccolo
    Istituto Oncologico Veneto IRCCS, Padua, Italy
    Cancer Res 69:1314-23. 2009

Detail Information

Publications55

  1. doi request reprint Insights into the regulation of tumor dormancy by angiogenesis in experimental tumors
    Stefano Indraccolo
    Istituto Oncologico Veneto IRCCS, Padua, Italy
    Adv Exp Med Biol 734:37-52. 2013
    ..These functional links between activation of the LKB1/AMPK by anti-angiogenic therapy and tumor dormancy suggest a role for metabolism in the regulation of this phenomenon...
  2. ncbi request reprint Effects of CD2 locus control region sequences on gene expression by retroviral and lentiviral vectors
    S Indraccolo
    IST Viral and Molecular Oncology Section, the Department of Oncology and Surgical Sciences, University of Padua, Italy
    Blood 98:3607-17. 2001
    ..These findings suggest a potential application of this LCR to increase gene expression by retroviral and lentiviral vectors in T lymphocytes...
  3. ncbi request reprint Gene therapy of ovarian cancer with IFN-alpha-producing fibroblasts: comparison of constitutive and inducible vectors
    S Indraccolo
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    Gene Ther 13:953-65. 2006
    ..Overall, these findings indicate that intracavitary IFN-alpha gene therapy using engineered fibroblasts requires sustained production of IFN-alpha to achieve durable antitumor effects...
  4. pmc Interruption of tumor dormancy by a transient angiogenic burst within the tumor microenvironment
    Stefano Indraccolo
    Department of Oncology and Surgical Sciences, University of Padova, 35128 Padova, Italy
    Proc Natl Acad Sci U S A 103:4216-21. 2006
    ..These findings may emphasize that tumor angiogenesis is a process requiring a higher amount of angiogenic factors for its induction than maintenance...
  5. ncbi request reprint Establishment and characterization of xenografts and cancer cell cultures derived from BRCA1 -/- epithelial ovarian cancers
    Stefano Indraccolo
    Istituto Oncologico Veneto, Padova, Italy
    Eur J Cancer 42:1475-83. 2006
    ..The PD-OVCA1 and PD-OVCA2 ovarian cancer cell lines will provide a valuable tool for new experimental models for the study of BRCA1-associated tumour biology...
  6. ncbi request reprint Dormant tumors awaken by a short-term angiogenic burst: the spike hypothesis
    Stefano Indraccolo
    Istituto Oncologico Veneto, Padova, Italy
    Cell Cycle 5:1751-5. 2006
    ..Here we discuss the implications of these observations on our view of tumor angiogenesis and on the therapeutic potential of angiogenesis inhibitors...
  7. doi request reprint Interferon-alpha as angiogenesis inhibitor: learning from tumor models
    Stefano Indraccolo
    Istituto Oncologico Veneto, IRCCS, Padova, Italy
    Autoimmunity 43:244-7. 2010
    ..Finally, as effective anti-angiogenic therapy with IFN-alpha demands sustained localized production of this cytokine, innovative strategies of targeted delivery of the IFN-alpha gene into tumors are discussed...
  8. ncbi request reprint Ligand-driven activation of the notch pathway in T-ALL and solid tumors: why Not(ch)?
    Stefano Indraccolo
    Istituto Oncologico Veneto IRCCS, Padova, Italy
    Cell Cycle 9:80-5. 2010
    ....
  9. ncbi request reprint Concluding remarks
    Stefano Indraccolo
    Istituto Oncologico Veneto, Via Gattamelata, 64, I 35128 Padova, Italy
    Mol Aspects Med 28:167. 2007
  10. doi request reprint Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy
    Stefano Indraccolo
    Istituto Oncologico Veneto IRCCS, Padua, Italy
    Cancer Res 69:1314-23. 2009
    ..Our results elucidate a novel mechanism by which a direct interplay between endothelial and tumor cells promotes survival and triggers tumor growth...
  11. ncbi request reprint Interferon-alpha gene therapy by lentiviral vectors contrasts ovarian cancer growth through angiogenesis inhibition
    Stefano Indraccolo
    Department of Oncology and Surgical Sciences, University of Padua, Italy
    Hum Gene Ther 16:957-70. 2005
    ....
  12. ncbi request reprint Undermining tumor angiogenesis by gene therapy: an emerging field
    S Indraccolo
    Istituto Nazionale per la Ricerca sul Cancro IST, Genua, Italy
    Curr Gene Ther 4:297-308. 2004
    ....
  13. ncbi request reprint Gene transfer in ovarian cancer cells: a comparison between retroviral and lentiviral vectors
    Stefano Indraccolo
    IST Viral and Molecular Oncology Section, Padova, Italy
    Cancer Res 62:6099-107. 2002
    ..These findings indicate that lentiviral vectors deserve attention in the design of future gene therapy approaches to ovarian cancer aimed at achieving long-term expression of therapeutic genes...
  14. doi request reprint Notch3 signalling promotes tumour growth in colorectal cancer
    Valentina Serafin
    Department of Oncology and Surgical Sciences, University of Padua, 35128 Padova, Italy
    J Pathol 224:448-60. 2011
    ..Altogether, these findings indicate that Notch3 can modulate the tumourigenic properties of CRC cells and contributes to sustained Notch activity in DLL4-expressing tumours...
  15. ncbi request reprint Expression from cell type-specific enhancer-modified retroviral vectors after transduction: influence of marker gene stability
    Stefano Indraccolo
    IST Viral and Molecular Oncology Section, Via Gattamelata, 64 35128, Padua, Italy
    Gene 283:199-208. 2002
    ..These findings indicate that enhancer replacement is a feasible and promising approach to address the function of cell type-specific regulatory elements in retroviral vectors carrying the EGFP gene...
  16. ncbi request reprint Alternatively spliced forms of Igalpha and Igbeta prevent B cell receptor expression on the cell surface
    Stefano Indraccolo
    Department of Oncology and Surgical Sciences, Interuniversity Center for Research on Cancer, University of Padova, Padova, Italy
    Eur J Immunol 32:1530-40. 2002
    ..These findings document a possible novel mechanism for controlling BCR expression in B cells, based on up-regulated synthesis of components devoid of transport function...
  17. ncbi request reprint Recruitment of human umbilical vein endothelial cells and human primary fibroblasts into experimental tumors growing in SCID mice
    Valeria Roni
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    Exp Cell Res 287:28-38. 2003
    ....
  18. ncbi request reprint Differential regulation of hypoxia-induced CXCR4 triggering during B-cell development and lymphomagenesis
    Erich Piovan
    Oncology Section, Department of Oncology and Surgical Sciences, University of Padova, Italy
    Cancer Res 67:8605-14. 2007
    ..The unresponsiveness of GC-derived lymphomatous B cells to CXCR4 triggering under hypoxia may have implications for the development and pathogenesis of GC-derived lymphoid tumors...
  19. pmc Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death
    Elena Favaro
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Padova, Italy
    Am J Pathol 173:1186-201. 2008
    ....
  20. doi request reprint The side population of ovarian cancer cells is a primary target of IFN-alpha antitumor effects
    Lidia Moserle
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    Cancer Res 68:5658-68. 2008
    ..These findings could have relevant clinical implications because they imply that tumors bearing large SP numbers, albeit rare, could be sensitive to IFN-alpha treatment...
  21. pmc Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma
    Massimiliano Cadamuro
    Department of Surgery, Oncology and Gastroenterology, University of Padova, Italy
    Hepatology 58:1042-53. 2013
    ..Targeting tumor or stroma interactions with inhibitors of the PDGF-D pathway may offer a novel therapeutic approach...
  22. ncbi request reprint Heterogeneous intracellular expression of B-cell receptor components in B-cell chronic lymphocytic leukaemia (B-CLL) cells and effects of CD79b gene transfer on surface immunoglobulin levels in a B-CLL-derived cell line
    Sonia Minuzzo
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    Br J Haematol 130:878-89. 2005
    ..These findings indicate that the phenotype of B-CLL cells in a subset of patients may depend primarily on poor CD79b expression, and suggest that upregulation of CD79b expression may correct the phenotype of these cells...
  23. doi request reprint Cellular interactions in the vascular niche: implications in the regulation of tumor dormancy
    Elena Favaro
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Padova, Italy
    APMIS 116:648-59. 2008
    ..In this review, we discuss the possible implications of this hypothesis for our understanding of the phenomenon of tumor dormancy...
  24. doi request reprint Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization
    Giorgia Nardo
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Padova, Italy
    Cancer Res 71:4214-25. 2011
    ..Taken together, our findings reveal functional links between the Warburg effect and the AMPK pathway with therapeutic responses to VEGF neutralization in tumor xenograft models...
  25. doi request reprint Antineoplastic activity of lentiviral vectors expressing interferon-alpha in a preclinical model of primary effusion lymphoma
    Maria Luisa Calabrò
    Immunology and Diagnostic Molecular Oncology, Istituto Oncologico Veneto, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy
    Blood 113:4525-33. 2009
    ....
  26. doi request reprint hTERT inhibition triggers Epstein-Barr virus lytic cycle and apoptosis in immortalized and transformed B cells: a basis for new therapies
    Silvia Giunco
    Department of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of Padova, Italy
    Clin Cancer Res 19:2036-47. 2013
    ..The possible therapeutic role of hTERT inhibition combined with antiviral drugs was investigated...
  27. doi request reprint Side population and cancer stem cells: therapeutic implications
    Lidia Moserle
    Department of Oncology and Surgical Sciences, University of Padova, Italy
    Cancer Lett 288:1-9. 2010
    ..These recent findings underscore the need of a more comprehensive view of the interactions between cytokines and key regulatory pathways in SP and CSC...
  28. doi request reprint Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150
    Margherita Ghisi
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    Blood 117:7053-62. 2011
    ..Overall, these findings suggest that control of the Notch pathway through miR-150 may have an important impact on T-cell development and physiology...
  29. doi request reprint Metabolic effects of anti-angiogenic therapy in tumors
    Elisabetta Zulato
    Istituto Oncologico Veneto IRCCS, Via Gattamelata, 64 35128 Padova, Italy
    Biochimie 94:925-31. 2012
    ..e. their dependency from glucose as primary energy substrate - might affect tumor responses to anti-VEGF treatment...
  30. doi request reprint Interferon-alpha counteracts the angiogenic switch and reduces tumor cell proliferation in a spontaneous model of prostatic cancer
    Luca Persano
    Oncology Section, Department of Oncology and Surgical Sciences, University of Padova, Padova I 35128, Italy
    Carcinogenesis 30:851-60. 2009
    ..Since the angiogenic switch also marks progression of human prostatic cancer, these results highlight the potential of angiogenesis inhibitors for the development of chemoprevention strategies in high-risk individuals...
  31. ncbi request reprint hTERT inhibits the Epstein-Barr virus lytic cycle and promotes the proliferation of primary B lymphocytes: implications for EBV-driven lymphomagenesis
    Liliana Terrin
    Department of Oncology and Surgical Sciences, Section of Oncology, University of Padova, Padova, Italy
    Int J Cancer 121:576-87. 2007
    ..These findings indicate that hTERT contributes by multiple mechanisms to the EBV-driven transformation of B lymphocytes and suggest that hTERT may constitute a therapeutic target for EBV-associated B cell lymphomas...
  32. ncbi request reprint Identification of genes selectively regulated by IFNs in endothelial cells
    Stefano Indraccolo
    Department of Oncology and Surgical Sciences, Istituto Oncologico Veneto, Via Gattemelata 64, I 35128 Padua, Italy
    J Immunol 178:1122-35. 2007
    ..Moreover, we suggest that quantitative differences in the magnitude of the transcriptional activation of IFN-responsive genes could form the basis for cell-specific transcriptional signatures...
  33. doi request reprint Vandetanib improves anti-tumor effects of L19mTNFalpha in xenograft models of esophageal cancer
    Marika Crescenzi
    Istituto Oncologico Veneto IRCCS, Padua, Italy
    Clin Cancer Res 17:447-58. 2011
    ....
  34. doi request reprint Hypoxia and HIF1alpha repress the differentiative effects of BMPs in high-grade glioma
    Francesca Pistollato
    Department of Pediatrics, University of Padova, Italy
    Stem Cells 27:7-17. 2009
    ....
  35. ncbi request reprint Angiogenesis meets immunology: cytokine gene therapy of cancer
    Sonia Minuzzo
    Department of Oncology and Surgical Sciences, University of Padova, Via Gattamelata 64, 35128 Padova, Italy
    Mol Aspects Med 28:59-86. 2007
    ..Therapeutic exploitation of this property may result in the design of novel approaches which, by maximizing immune-stimulating and anti-angiogenic effects, could possibly lead to starvation of established tumors in patients...
  36. ncbi request reprint Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation
    Erich Piovan
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padua, Via Gattamelata 64, Padua, I 35128, Italy
    Blood 105:931-9. 2005
    ..These studies demonstrate that CXCL12 expression may be associated with EBV infection and suggest that the CXCR4/CXCL12 axis may participate in the EBV-associated lymphomagenesis process in immunodeficient hosts...
  37. ncbi request reprint Anti-angiogenic gene therapy of cancer: current status and future prospects
    Luca Persano
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Via Gattamelata, 64, 35128 Padova, Italy
    Mol Aspects Med 28:87-114. 2007
    ....
  38. ncbi request reprint Gene therapy of cancer in the clinic: good news in sight from Asia?
    Elena Favaro
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, 35128 Padova, Italy
    Curr Opin Mol Ther 9:477-82. 2007
    ..In this regard, China has recently emerged as a country with growth potential in this sector and it may be the country where evidence of clinical efficacy of cancer gene therapy will first be achieved...
  39. ncbi request reprint RNA interference: implications for cancer treatment
    Massimo Masiero
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Via Gattamelata, 64, 35128 Padova, Italy
    Mol Aspects Med 28:143-66. 2007
    ..This review provides a brief overview of the RNAi mechanism and of its application in preclinical animal models of cancer...
  40. ncbi request reprint Prognostic and predictive implications of EGFR mutations, EGFR copy number and KRAS mutations in advanced stage lung adenocarcinoma
    Laura Bonanno
    Department of Medical Oncology 2, Istituto Oncologico Veneto IRCCS, 64, I 35128 Padua, Italy
    Anticancer Res 30:5121-8. 2010
    ....
  41. pmc Nuclear expression of S100A4 calcium-binding protein increases cholangiocarcinoma invasiveness and metastasization
    Luca Fabris
    Department of Surgical and Gastroenterological Sciences, University of Padova, Italy
    Hepatology 54:890-9. 2011
    ..Nuclear expression of S100A4 increases CCA cells invasiveness and metastasization, indicating that S100A4 may also represent a potential therapeutic target...
  42. ncbi request reprint Metabolic effects of antiangiogenic drugs in tumors: therapeutic implications
    Luigi Quintieri
    Dipartimento di Scienze del Farmaco, Universita di Padova, Padova, Italy
    Biochem Pharmacol 89:162-70. 2014
    ..Moreover, we discuss the hypothesis that anti-angiogenic therapy might foster metabolic evolution of tumors. The therapeutic implications of this hypothesis will be discussed further here. ..
  43. pmc Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia
    Erich Piovan
    Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA UOC Immunologia e Diagnostica Molecolare Oncologica, Istituto Oncologico Veneto IRCCS, Padova 35128, Italy Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Universita di Padova, Padova, Veneto 35128, Italy
    Cancer Cell 24:766-76. 2013
    ....
  44. ncbi request reprint Human immunodeficiency virus type 1 Tat protein modulates cell cycle and apoptosis in Epstein-Barr virus-immortalized B cells
    Eva Colombrino
    Department of Oncology and Surgical Sciences, Section of Oncology, University of Padova, Padua, Italy
    Exp Cell Res 295:539-48. 2004
    ....
  45. doi request reprint M30 neoepitope expression in epithelial cancer: quantification of apoptosis in circulating tumor cells by CellSearch analysis
    Elisabetta Rossi
    Oncology Section, Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    Clin Cancer Res 16:5233-43. 2010
    ..This study aimed to detect the M30 neoepitope on circulating tumor cells (CTC) as a tool for quantifying apoptotic CTC throughout disease course and treatment...
  46. doi request reprint Protein profiles in human ovarian cancer cell lines correspond to their metabolic activity and to metabolic profiles of respective tumor xenografts
    Christian Fabian
    Institute of Physiology and Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz, Germany
    FEBS J 279:882-91. 2012
    ..This model system could be useful for systematic studies on therapeutic intervention by manipulation of tumor glycolysis and associated pathways...
  47. ncbi request reprint Antiangiogenic therapy against experimental glioblastoma using genetically engineered cells producing interferon-alpha, angiostatin, or endostatin
    Sophie De Bouard
    INSERM U 421, Neuroplasticity and Therapeutics, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil, France
    Hum Gene Ther 14:883-95. 2003
    ..These data point to the local delivery of IFN-alpha(1) using cell vectors as a potent tool for the inhibition of tumor-induced angiogenesis...
  48. doi request reprint Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis
    Michele De Palma
    Angiogenesis and Tumor Targeting Research Unit, San Raffaele Institute, 20132 Milano, Italy
    Cancer Cell 14:299-311. 2008
    ..These results illustrate the therapeutic potential of gene- and cell-based IFN-alpha delivery and should allow the development of IFN treatments that more effectively treat cancer...
  49. ncbi request reprint Encapsulated cells producing retroviral vectors for in vivo gene transfer
    Robert M Saller
    Institute of Molecular Virology, GSF Research Centre for Environment and Health, Oberschleissheim, Germany
    J Gene Med 4:150-60. 2002
    ..To circumvent this problem, retroviral vector packaging cells that permanently produce recombinant retroviral vector particles have been encapsulated...
  50. ncbi request reprint Retroviral vectors for high-level transgene expression in T lymphocytes
    Boris Engels
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin, Germany
    Hum Gene Ther 14:1155-68. 2003
    ..In summary, MP71 vectors are useful tools for stable, high-level gene expression in T lymphocytes, for example, in the expression of T cell receptor genes...
  51. ncbi request reprint Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis
    Marco Rusnati
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
    Blood 104:92-9. 2004
    ..PTX3/FGF2 interaction may modulate angiogenesis in various physiopathologic conditions driven by inflammation, innate immunity, and/or neoplastic transformation...
  52. ncbi request reprint The involvement of stromal derived factor 1alpha in homing and progression of multiple myeloma in the 5TMM model
    Eline Menu
    Department of Hematology and Immunology, Vrije Universiteit Brussel, Brussels, Belgium
    Haematologica 91:605-12. 2006
    ..Stromal cell derived factor 1a (SDF1alpha) or CXCL12 is known to play an important role as a chemokine for hematopoietic progenitor cells and human MM cells. We studied the effects of SDF1a in the 5TMM murine model...
  53. ncbi request reprint Molecular mechanisms of action of angiopreventive anti-oxidants on endothelial cells: microarray gene expression analyses
    Ulrich Pfeffer
    Functional Genomics Unit, National Cancer Research Institute, Genova, Italy
    Mutat Res 591:198-211. 2005
    ..Down-regulation of the TNFalpha responsive pro-metastatic, pro-inflammatory genes, urokinase plasminogen activator and selectin E, further implies anti-metastatic effects for these drugs...
  54. ncbi request reprint Genes in the cure of cancer
    Stefano Indraccolo
    Mol Aspects Med 28:1-3. 2007
  55. ncbi request reprint Use of retroviral vectors for the analysis of SIV/HIV-specific CD8 T cell responses
    Donatella R M Negri
    Laboratory of Virology, Retrovirus Division, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    J Immunol Methods 291:153-63. 2004
    ..Thus, this method represents an alternative tool for the analysis of CTL responses during vaccination protocols in those animal models where little information is available on MHC class I alleles or CTL epitopes...