Research Topics
| Gaetano IapichinoSummaryAffiliation: University of Milan Country: Italy Publications
| Collaborators
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Detail Information
Publications
The use of analgesic drugs in postoperative patients: the neglected problem of pain control in intensive care units. An observational, prospective, multicenter study in 128 Italian intensive care unitsGuido Bertolini
GiViTI Coordinating Center, Laboratory of Clinical Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Centro di Ricerche Cliniche per le Malattie Rare Aldo e Cele Daccò, 24020 RANICA Bergamo, Italy
Eur J Clin Pharmacol 58:73-7. 2002..The use of analgesic drugs in patients admitted to Italian intensive care units (ICUs) was assessed...- Intensive care of patients requiring open abdomen treatment: a case-series analysisP Spanu
Servizio di Anestesia e Rianimazione Polo Universitario San Paolo, Milano, Italy
Minerva Anestesiol 79:349-59. 2013..The gut can be used for nutrition (even without gastrointestinal continuity), and long-term light sedation (mainly enteral) with minimal impact on perfusion, ventilation and gut motility... 
Implications of ICU triage decisions on patient mortality: a cost-effectiveness analysisDavid L Edbrooke
Medical and Economics Research Centre Sheffield, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, Glossop Road, Sheffield S10 2JF, UK
Crit Care 15:R56. 2011....- Measuring complexity/level of care and appropriateness of resource use in intensive care unitsG Iapichino
Istituto di Ricerche Farmacologiche Mario Negri
Minerva Anestesiol 66:541-7. 2000..Thus, a higher attention to improve the efficiency of the use of ICU resources is indispensable. The objective of this study was the development of a simple and reliable tool for the evaluation of the appropriateness of ICU utilization... - Effectiveness and efficiency of intensive care medicine: variable costs in different diagnosis groupsG Iapichino
Istituto di Anestesiologia e Rianimazione dell Università degli Studi di Milano, Azienda Ospedaliera Polo Universitario San Paolo, Milano, Italy
Acta Anaesthesiol Scand 48:820-6. 2004..To propose strategies aimed at reducing costs and improving efficiency in each patient group... - Time course of endogenous nitric oxide inhibitors in severe sepsis in humansG Iapichino
Department of Anesthesiology, Intensive Therapy and Dermatologic Sciences, University of Milan, Italy
Minerva Anestesiol 76:325-33. 2010..We investigated plasma ADMA and SDMA levels during ICU stay to reveal the time course of endogenous NO inhibition in patients with sepsis... - Evaluating daily nursing use and needs in the intensive care unit: a method to assess the rate and appropriateness of ICU resource useG Iapichino
Istituto di Anestesiologia e Rianimazione dell Università degli Studi di Milano, Azienda Ospedaliera Polo Universitario San Paolo, Via A Di Rudini 8, 20142 Milano, Italy
Health Policy 73:228-34. 2005..We designed a tool to measure the rate and appropriateness of intensive care unit (ICU) nursing coverage as a proxy for the use of resources... - Metabolic support of the critically ill: 2008 updateG Iapichino
Institute of Anesthesia and Intensive Care, University of Milan, Milan, Italy
Minerva Anestesiol 74:709-13. 2008.... 
Tight glycemic control does not affect asymmetric-dimethylarginine in septic patientsGaetano Iapichino
Istituto di Anestesiologia e Rianimazione, Universita degli Studi di Milano, Via A Di Rudini 8, 20142 Milan, Italy
Intensive Care Med 34:1843-50. 2008..We investigated whether preventing hyperglycemia in septic patients affected the plasma concentration of asymmetric-dimethylarginine and if this was associated with clinical benefit...- Metabolic treatment of critically ill patients: energy balance and substrate disposalG Iapichino
Department of Anesthesiology and Intensive Care, San Paolo Hospital, University of Milan, Milan, Italy
Minerva Anestesiol 72:533-41. 2006..Composition of dietary intake can be usefully different for each pathology, and also for different periods of the same pathology, because critically ill patients have a variety of metabolic needs during their stay in ICU... - Metabolic treatment of critically ill patients: energy expenditure and energy supplyG Iapichino
Department of Anesthesiology and Intensive Care, San Paolo Hospital, University of Milan, Milan, Italy
Minerva Anestesiol 72:559-65. 2006..Then, this review would lead the decision making process beginning from biochemistry and bioenergetics, until the metabolic strategy practically usable at the bedside of patients during the whole critical phase of their pathology... - Reasons for refusal of admission to intensive care and impact on mortalityGaetano Iapichino
Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Università degli Studi di Milano UO Anestesia e Rianimazione, Azienda Ospedaliera Polo Universitario San Paolo, Via A Di Rudini 8, 20142 Milan, Italy
Intensive Care Med 36:1772-9. 2010..To identify factors influencing triage decisions and investigate whether admission to the intensive care unit (ICU) could reduce mortality compared with treatment on the ward... - Nutrition given to critically ill patients during high level/complex care (on Italian ICUs)G Iapichino
Istituto di Anestesiologia e Rianimazione dell Università degli Studi di Milano Azienda Ospedaliera, Polo Universitario San Paolo, Milan, Italy
Clin Nutr 23:409-16. 2004..Within a prospective study on costs in 45 Italian intensive units we reviewed nutrition support practice given during critical illness... - Volume of activity and occupancy rate in intensive care units. Association with mortalityGaetano Iapichino
Istituto di Anestesiologia e Rianimazione, Universita di Milano, Azienda Ospedaliera Polo Universitario San Paolo, Via A Di Rudini 8, 20142 Milan, Italy
Intensive Care Med 30:290-7. 2004..We examined the relationship between the volume of activity of intensive care units (ICUs) and mortality by a measure of risk-adjusted volume of activity specific for ICUs... - Daily classification of the level of care. A method to describe clinical course of illness, use of resources and quality of intensive care assistanceG Iapichino
Servizio di Anestesia e Rianimazione, Ospedale Universitario San Paolo, Milano, Italy
Intensive Care Med 27:131-6. 2001..To develop a simple and comparable clinical method able to distinguish between higher and lower complexities of care in the ICU... - Description of trends in the course of illness of critically ill patients. Markers of intensive care organization and performanceG Iapichino
Cattedra di Anestesiologia e Rianimazione dell Università di Milano, Azienda Ospedaliera Polo Universitario San Paolo, Milan, Italy
Intensive Care Med 28:985-9. 2002..To identify objective trends of the course of illness that might be used as benchmarks in the auditing of the organization/performance of Intensive Care Units (ICU)... - Proposal of a flexible structural-organizing model for the Intensive Care UnitsG Iapichino
Institute of Anaesthesiology and Intensive Care Medicine, Polo Universitario San Paolo, University of Milan, Milan, Italy
Minerva Anestesiol 73:501-6. 2007.... - Daily monitoring of biomarkers of sepsis in complicated long-term ICU-patients: can it support treatment decisions?G Iapichino
Department of Anesthesiology, San Paolo University Hospital, University of Milan, Milan, Italy
Minerva Anestesiol 76:814-23. 2010..The ACCP-SCCM criteria are difficult to apply for such patients, and objective, validated biomarkers would be of great use in this setting... - Determinants of post-intensive care mortality in high-level treated critically ill patientsGaetano Iapichino
Istituto di Anestesiologia e Rianimazione, Universita di Milano, Azienda Ospedaliera Polo Universitario San Paolo, Via A Di Rudini 8, 20142 Milan, Italy
Intensive Care Med 29:1751-6. 2003..To assess the predictive ability of preillness and illness variables, impact of care, and discharge variables on the post-intensive care mortality... - Use of sedative and analgesic drugs in the first week of ICU stay in high-level-of-careG Iapichino
Department of Anesthesiology and Resuscitation, University of Milan, San Paolo Hospital, Milan, Italy
Minerva Anestesiol 69:765-70, 771-4. 2003..The aim of this study was to update the current practice of pharmacological sedation and analgesia in Italian intensive care units... - Tight glycemic control may favor fibrinolysis in patients with sepsisMonica Savioli
Dipartimento di Anestesia, UO di Anestesia e Rianimazione, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Milan, Italy
Crit Care Med 37:424-31. 2009..To investigate whether tight glycemic control, in patients with sepsis, may restore a normal fibrinolysis by lowering plasminogen activator inhibitor (PAI)-1 levels... - Noninvasive CPAP With Face Mask: Comparison Among New Air-Entrainment Masks and the Boussignac ValveGiovanni Mistraletti
Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Universita degli Studi di Milano, Polo Universitario San Paolo, Milan, Italy
Respir Care 58:305-12. 2013..The performances of 2 noninvasive CPAP systems (high flow and low flow air-entrainment masks) were compared to the Boussignac valve in 3 different scenarios... - Sedation in the critically ill ventilated patient: possible role of enteral drugsMarco Cigada
Istituto di Anestesiologia e Rianimazione dell Università degli Studi di Milano, Azienda Ospedaliera Polo Universitario San Paolo, Italy
Intensive Care Med 31:482-6. 2005..Sedation by the enteral route is unusual in intensive medicine. We analysed the feasibility/efficacy of long-term enteral sedation in ventilated critically ill patients... - Conscious sedation in the critically ill ventilated patientMarco Cigada
Istituto di Anestesiologia e Rianimazione, Universita degli Studi di Milano, Azienda Ospedaliera San Paolo di Milano, 20142 Milano, Italy
J Crit Care 23:349-53. 2008..We analyzed if a level 2 on the Ramsay Scale (ie, awake, cooperative, oriented, tranquil patient) is suitable for an invasive therapeutic approach... - Severe water intoxication secondary to the concomitant intake of non-steroidal anti-inflammatory drugs and desmopressin: a case report and review of the literatureElisa Verrua
Department of Clinical Sciences and Community Health, University of Milan, Endocrinology and Diabetology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
Hormones (Athens) 12:135-41. 2013..Risks and benefits of co-treatment should be carefully considered and therapeutic alternatives to NSAIDs should be recommended to patients with central DI in order to improve DDAVP safety... - Variable costs of ICU patients: a multicenter prospective studyCarlotta Rossi
Centro di Ricerche Cliniche per le Malattie Rare Aldo e Cele Dacc, Istituto di Ricerche Farmacologiche Mario Negri, Ranica, Italy
Intensive Care Med 32:545-52. 2006..CONCLUSIONS: Cost of treatment in an ICU varies widely for different types of patients. Strategies are needed to contain the major determinants of high costs and low cost-efficiency... - Early enteral immunonutrition in patients with severe sepsis: results of an interim analysis of a randomized multicentre clinical trialGuido Bertolini
GiViTI Coordinating Center, Istituto di Ricerche Farmacologiche Mario Negri, Centro di Ricerche Cliniche per le Malattie Rare Aldo e Cele Daccò, Ranica, Bergamo, Italy
Intensive Care Med 29:834-40. 2003..We report the results of a planned interim analysis on patients with severe sepsis which was undertaken earlier than planned once a meta-analysis suggested excess mortality in patients with severe sepsis given enteral immunonutrition... - Actigraphic monitoring in critically ill patients: preliminary results toward an "observation-guided sedation"Giovanni Mistraletti
Istituto di Anestesiologia e Rianimazione, Universita degli Studi di Milano, Azienda Ospedaliera San Paolo Polo Universitario, 20142 Milano, Italy
J Crit Care 24:563-7. 2009..The aim of this study is to evaluate continuous wrist actigraphy (measurement of limb movements) in intensive care unit patients as a neurologic status monitoring... - Pharmacokinetics of orally administered melatonin in critically ill patientsGiovanni Mistraletti
Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Universita degli Studi di Milano, Milano, Italy
J Pineal Res 48:142-7. 2010.... - Noninvasive CPAP With Face Mask: Comparison Among New Air-Entrainment Masks and the Boussignac ValveGiovanni Mistraletti
Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Universita degli Studi di Milano, Polo Universitario San Paolo, Milan, Italy
Respir Care 58:305-12. 2013..The performances of 2 noninvasive CPAP systems (high flow and low flow air-entrainment masks) were compared to the Boussignac valve in 3 different scenarios... - Bias reduction in repeated-measures observational studies by the use of propensity score: the case of enteral sedation for critically ill patientsMichele Umbrello
Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Universita degli Studi di Milano, Milan, Italy
J Crit Care 27:662-72. 2012..Few studies addressed the specific issue of a PS correction of repeated-measures designs... - Scoring system for the selection of high-risk patients in the intensive care unitGaetano Iapichino
Istituto di Anestesiologia e Rianimazione, , Italy
Crit Care Med 34:1039-43. 2006..CONCLUSION: All three indicator variables select high-risk patients, the Severity/Intensity-of-care MIX being the most robust. These stratification criteria can improve case-mix selection for clinical and organizational studies... - Impact of antibiotics on the gut microbiota of critically ill patientsGaetano Iapichino
Istituto di Anestesiologia e Rianimazione, Universita degli Studi, Polo San Paolo, Via di Rudini 8, I 20142 Milano, Italy
J Med Microbiol 57:1007-14. 2008..A statistically significant link between these two ecological traits and the use of clindamycin was also found... - Evaluation of oxidative stress in serum of critically ill patients by a commercial assay and gas chromatography-mass spectrometryGiuliana Cighetti
Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, Milan, Italy
Clin Chem 51:1515-7. 2005 - Daily classification of complexity/level of intensive medical care. Does it allow the monitoring of the managerial process in ICU?G Iapichino
Chair of Anaesthesiology and Resuscitation, San Paolo Hospital, University of Milan, Milan, Italy
Minerva Anestesiol 68:71-5. 2002 - Performance determinants and flexible ICU organisationG Iapichino
Istituto di Anestesiologia e Rianimazione dell Università degli Studi di Milano, Azienda Ospedaliera, Polo Universitario San Paolo, Milano, Italy
Minerva Anestesiol 71:273-80. 2005.... - Pulse and systolic pressure variation assessment in partially assisted ventilatory supportMatteo Zaniboni
Istituto di Anestesiologia e Rianimazione, Universita degli Studi, Polo San Paolo, Via di Rudinì, Milan, Italy
J Clin Monit Comput 22:355-9. 2008..We tested if PPV and SPV during flow triggered synchronized intermittent mechanical ventilation (SIMV) could be as accurate as in controlled MV... - Short-term noninvasive pressure support ventilation prevents ICU admittance in patients with acute cardiogenic pulmonary edemaMatteo Giacomini
, Azienda Ospedaliera, Polo Universitario Ospedale San Paolo, Milan, Italy
Chest 123:2057-61. 2003..A 15-min weaning test can identify patients who will not need further invasive ventilatory support. COPD and hypotension at baseline are negative predictive criteria... - The Competency-Based Training in Intensive Care Medicine in Europe (CoBaTrICE) Italian collaborative: national results from the Picker surveyF Rubulotta
Department of Anesthesiology and Intensive Care, University Hospital Polyclinic, University of Catania, Catania, Italy
Minerva Anestesiol 75:117-24. 2009..The CoBaTrICE Project has performed a survey, in collaboration with the Picker institute, United Kingdom, to identify desirable characteristics of Intensive Care Unit (ICU) specialists, as expressed by patients and their relatives... - Effects of recombinant human activated protein C on the fibrinolytic system of patients undergoing conventional or tight glycemic controlF Polli
Institute of Anesthesia and Intensive Care, University of Milan, Milan, Italy
Minerva Anestesiol 75:417-26. 2009..Our aim was to evaluate the effects on the fibrinolytic system after the administration of rh-APC in septic patients undergoing conventional or TGC... - Severe water intoxication secondary to the concomitant intake of non-steroidal anti-inflammatory drugs and desmopressin: a case report and review of the literatureElisa Verrua
Department of Clinical Sciences and Community Health, University of Milan, Endocrinology and Diabetology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
Hormones (Athens) 12:135-41. 2012..Risks and benefits of co-treatment should be carefully considered and therapeutic alternatives to NSAIDs should be recommended to patients with central DI in order to improve DDAVP safety... - Early enteral immunonutrition vs. parenteral nutrition in critically ill patients without severe sepsis: a randomized clinical trialD Radrizzani
Istituto di Ricerche Farmacologiche Mario Negri, GiViTI Scientific Committee, 24020 Ranica, Italy
Intensive Care Med 32:1191-8. 2006..Parenteral nutrition in these patients should be abandoned, at least when enteral nutrition can be administered, even at an initial low caloric content... - Sleep and delirium in the intensive care unitG Mistraletti
Department of Anesthesiology and Reanimation, University of Milan, Milan, Italy
Minerva Anestesiol 74:329-33. 2008..Further studies are needed on the effects of strategies to promote sleep and on the evaluation of better sleep in clinical outcomes, particularly on the development of delirium... - [The assessment of nursing workload]A Guccione
Istituto di Anestesiologia e Rianimazione, , Polo Universitario Ospedale San Paolo, Milano, Italy
Minerva Anestesiol 70:411-6. 2004..These scores represent the instruments to assess the correct use of ICU resources... - Vardenafil and weaning from inhaled nitric oxide: effect on pulmonary hypertension in ARDSM Giacomini
Anesthesia and Intensive Care Department, Cardiology Department and Pneumology Unit, Milan University, San Paolo Hospital, Milan, Italy
Anaesth Intensive Care 35:91-3. 2007.... - Nursing activities scoreDinis Reis Miranda
University Hospital Groningen, The Netherlands
Crit Care Med 31:374-82. 2003.... - SAPS 3--From evaluation of the patient to evaluation of the intensive care unit. Part 2: Development of a prognostic model for hospital mortality at ICU admissionRui P Moreno
Unidade de Cuidados Intensivos Polivalente, Hospital de St António dos Capuchos, Centro Hospitalar de Lisboa zona central, Lisbon, Portugal
Intensive Care Med 31:1345-55. 2005..To develop a model to assess severity of illness and predict vital status at hospital discharge based on ICU admission data... - SAPS 3--From evaluation of the patient to evaluation of the intensive care unit. Part 1: Objectives, methods and cohort descriptionPhilipp G H Metnitz
Dept of Anesthesiology and General Intensive Care, University Hospital of Vienna, Vienna, Austria
Intensive Care Med 31:1336-44. 2005..Objective of the SAPS 3 study was to collect data about risk factors and outcomes in a heterogeneous cohort of intensive care unit (ICU) patients, in order to develop a new, improved model for risk adjustment... - Treating hyperglycemia improves skeletal muscle protein metabolism in cancer patients after major surgeryGianni Biolo
Division of Internal Medicine, Department of Clinical, Morphological and Technological Sciences, University of Trieste, Trieste, Italy
Crit Care Med 36:1768-75. 2008..We compared the effects of insulin-mediated euglycemia and moderate hyperglycemia on kinetics of protein and selected amino acids in skeletal muscle of female cancer patients after major surgery... - On-line measurement of systolic pressure variation and pulse pressure variation on a multiparametric monitorMichele Umbrello
Intensive Care Med 34:386-7. 2008