Affiliation: University of Bologna
- gamma-Linolenic acid supplementation can affect cancer cell proliferation via modification of fatty acid compositionS Hrelia
Department of Biochemistry G Moruzzi, University of Bologna, Italy
Biochem Biophys Res Commun 225:441-7. 1996..The highest cytostatic effect was reached when GLA was not transformed into its metabolites, suggesting that the GLA toxicity to tumor cells is not dependent on metabolites but is due to GLA itself...
- Nutritional interventions to counteract oxidative stress in cardiac cellsSilvana Hrelia
Nutrition Research Center, Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio, 48 Bologna, Italy
Ital J Biochem 53:157-63. 2004..The protective effect of the polyphenolic components of green tea in the prevention/counteraction of cell damage induced in the heart by doxorubicin or hypoxia/reoxygenation has been discussed...
- Doxorubicin induces early lipid peroxidation associated with changes in glucose transport in cultured cardiomyocytesSilvana Hrelia
Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, I 40126 Bologna, Italy
Biochim Biophys Acta 1567:150-6. 2002..The regulation of nutrient transport mechanisms in cardiomyocytes may be considered an early event in the development of the cardiotoxic effects of the anthracycline...
- Green tea extracts can counteract the modification of fatty acid composition induced by doxorubicin in cultured cardiomyocytesS Hrelia
Nutrition Research Center, Department of Biochemistry G Moruzzi University of Bologna, Italy
Prostaglandins Leukot Essent Fatty Acids 66:519-24. 2002..These differences could be ascribed to the different total catechin content and to qualitative differences among the tea extracts, determined by HPLC analysis...
- Role of gamma-linolenic acid in counteracting doxorubicin-induced damage in cultured rat cardiomyocytesS Hrelia
Dipartimento di Biochimica G Moruzzi, University of Bologna, Bologna, Italy
Prostaglandins Leukot Essent Fatty Acids 64:139-45. 2001..HUFA biosynthesis plays a role in counteracting doxorubicin toxicity, but it cannot completely overcome the depletion of these fatty acids; serum and exogenous gamma-linolenate are critical in filling the decreased HUFA pool...
- Role of quercetin in modulating rat cardiomyocyte gene expression profileC Angeloni
Department of Biochemistry, G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
Am J Physiol Heart Circ Physiol 294:H1233-43. 2008..Results showed distinct temporal changes in gene expression induced by quercetin and a strong upregulation of phase 2 enzymes, highlighting quercetin ability to act also with an indirect antioxidant mechanism...
- Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stressC Angeloni
Department of Biochemistry G Moruzzi, Nutrition Research Centre, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
Biochimie 89:73-82. 2007....
- Essential fatty acid metabolism in long term primary cultures of rat cardiomyocytes: a beneficial effect of n-6:n-3 fatty acids supplementationP L Biagi
Department of Biochemistry G Moruzzi, Bologna, Italy
Mech Ageing Dev 107:181-95. 1999..I. observed with senescence, but only the n-6:n-3 (2:1) was able to do so by increasing the cellular content of the fatty acids which are precursors of anti-aggregation eicosanoids without altering the n-6:n-3 fatty acid ratio...
- Green tea modulation of inducible nitric oxide synthase in hypoxic/reoxygenated cardiomyocytesG Agnetti
Department of Biochemistry G Moruzzi, Centro Studi e Ricerche sul Metabolismo Cardiaco, University of Bologna, Via Irnerio, 48 4016 Bologna, Italy
Biochimie 87:457-60. 2005..It is necessary to verify in humans the relationship between the modulation of NO production and green tea dietary consumption...
- Synthesis and antiproliferative activity of some thiazolylbenzimidazole-4,7-dionesL Garuti
Department of Pharmaceutical Science, University of Bologna, Via Belmeloro 6, I 40126, Bologna, Italy
Bioorg Med Chem Lett 11:3147-9. 2001..The importance of the methoxy group on the quinone moiety is confirmed and the function at 4-position of the thiazole ring plays a determining role for the activity...
- Antioxidant effectiveness of organically and non-organically grown red oranges in cell culture systemsA Tarozzi
Dept of Pharmacology, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy
Eur J Nutr 45:152-8. 2006..Consumers consider plant food products from organic origin healthier than the corresponding conventional plant foods. Clear experimental evidence supporting this assumption is still lacking...
- Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatmentA Minarini
Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
Neuropharmacology 62:997-1003. 2012..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
- Protective effects of cyanidin-3-O-beta-glucopyranoside against UVA-induced oxidative stress in human keratinocytesAndrea Tarozzi
International Centre for Applied Cosmetological Research, Department of Pharmacology, University of Bologna, Bologna, Italy
Photochem Photobiol 81:623-9. 2005..These encouraging in vitro results support further research into C-3-G (and other anthocyanins) as novel agents for skin photoprotection...
- New polyphenolic beta-lactams with antioxidant activityGianfranco Cainelli
Dipartimento di Chimica G Ciamician, Universita di Bologna, Via Selmi 2, I 40126 Bologna, Italy
Chem Biodivers 5:811-29. 2008..The results were discussed with regard to mechanism and correlated with structural parameters...
- Neuroprotective effects of anthocyanins and their in vivo metabolites in SH-SY5Y cellsAndrea Tarozzi
Department of Pharmacology, Alma Mater Studiorum University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
Neurosci Lett 424:36-40. 2007..These in vitro findings should encourage further research in animal models of neurological diseases to explore the potential neuroprotective effects of compounds generated during in vivo metabolism of anthocyanins...
- Green tea modulates alpha(1)-adrenergic stimulated glucose transport in cultured rat cardiomyocytesCristina Angeloni
Department of Biochemistry G Moruzzi, Via Irnerio 48, University of Bologna, 40126 Bologna, Italy
J Agric Food Chem 55:7553-8. 2007....
- Relevance of apple consumption for protection against oxidative damage induced by hydrogen peroxide in human lymphocytesFrancesca Maffei
Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
Br J Nutr 97:921-7. 2007..88, P <0.05). These findings suggest that the consumption of whole apple provides a useful dietary source of active scavengers to protect cells and tissue from oxidative stress and related DNA injury...
- Green tea protects cytoskeleton from oxidative injury in cardiomyocytesEleonora Pagnotta
Department of Biochemistry G Moruzzi, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
J Agric Food Chem 54:10159-63. 2006..GTE supplementation increases cytosolic antioxidant activity and shows protective effects on cardiomyocyte cytoarchitecture and viability...
- Selenium supplementation can protect cultured rat cardiomyocytes from hypoxia/reoxygenation damageAlessandra Bordoni
Nutrition Research Center, Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, Italy
J Agric Food Chem 51:1736-40. 2003..According to these data Se supplementation represents another possibility to counteract oxidative damage in the myocardium...
- Differential antiproliferative activity of new benzimidazole-4,7-dionesLaura Garuti
Department of Pharmaceutical Science, University of Bologna, Via Belmeloro 6, Bologna 40126, Italy
Farmaco 59:663-8. 2004..Both the substituents in the quinone ring and the position of the nitrogen atom in the pyridine moiety play a crucial role for the biological activity...
- Susceptibility to hypoxia/reoxygenation of aged rat cardiomyocytes and its modulation by selenium supplementationAlessandra Bordoni
Nutrition Research Center, Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
J Agric Food Chem 53:490-4. 2005..The observed ability of selenium supplementation to protect aged cardiomyocytes from hypoxia/reoxygenation damage underlines the importance of an optimal selenium dietary intake, particularly in the elderly...
- Hypoxia/reoxygenation alters essential fatty acids metabolism in cultured rat cardiomyocytes: protection by antioxidantsAlessandra Bordoni
Centro Ricerche sulla Nutrizione, Dipartimento di Biochimica, G Moruzzi, Alma Mater Studiorum, Via Irnerio, 48, 40126 Bologna, Italy
Nutr Metab Cardiovasc Dis 15:166-73. 2005..Furthermore, the effectiveness of antioxidants like alpha-tocopherol and a green tea extract in counteracting H/R damage towards HUFA biosynthesis was tested...
- Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase CdeltaAnna Ghelli
Dipart di Biologia Ev Sp, Via Irnerio 42, Universita di Bologna, Bologna, Italy
Biochem J 366:187-93. 2002..In conclusion, in CFNPE9o(-) cells, SPP interacts with a membrane receptor linked to a G(i) type of G-protein, leading to activation of PLD, probably the PLD1 isoform, by a signalling pathway involving Src and PKCdelta...
- HPLC-F analysis of melatonin and resveratrol isomers in wine using an SPE procedureLaura Mercolini
Laboratory of Pharmaco Toxicological Analysis, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Alma Mater Studiorum University of Bologna, Bologna, Italy
J Sep Sci 31:1007-14. 2008..Thus, the method seems to be suitable for the analysis of MLT and resveratrol isomers in wine samples. Moreover, wine total polyphenol content and antioxidant activity were evaluated...
- High-protein-PUFA supplementation, red blood cell membranes, and plasma antioxidant activity in volleyball athletesMarco Malaguti
Dept of Biochemistry, University of Bologna, Italy
Int J Sport Nutr Exerc Metab 18:301-12. 2008..Adherence to the Mediterranean diet seems to be the better choice...