Emilio Hirsch


Affiliation: University of Turin
Country: Italy


  1. Hirsch E, Braccini L, Ciraolo E, Morello F, Perino A. Twice upon a time: PI3K's secret double life exposed. Trends Biochem Sci. 2009;34:244-8 pubmed publisher
    ..We will discuss such findings, highlighting the crucial scaffold function of PI3Kgamma in cAMP homeostasis and PI3Kbeta in receptor recycling. ..
  2. Campa C, Germena G, Ciraolo E, Copperi F, Sapienza A, Franco I, et al. Rac signal adaptation controls neutrophil mobilization from the bone marrow. Sci Signal. 2016;9:ra124 pubmed publisher
    ..Furthermore, our findings might help to find new modes of intervention to treat conditions characterized by excessively low or high circulating neutrophils. ..
  3. De Santis M, Gulluni F, Campa C, Martini M, Hirsch E. Targeting PI3K signaling in cancer: Challenges and advances. Biochim Biophys Acta Rev Cancer. 2019;1871:361-366 pubmed publisher
    ..In addition, we will focus on the recent emergence of class II and III PI3K inhibitors, which helped to define their class I non-redundant role. ..
  4. Margaria J, Ratto E, Gozzelino L, Li H, Hirsch E. Class II PI3Ks at the Intersection between Signal Transduction and Membrane Trafficking. Biomolecules. 2019;9: pubmed publisher
    ..This review focuses on the recent developments regarding the coordination of membrane trafficking and intracellular signaling of class II PI3Ks through the confined phosphorylation of inositol phospholipids. ..
  5. Gulluni F, De Santis M, Margaria J, Martini M, Hirsch E. Class II PI3K Functions in Cell Biology and Disease. Trends Cell Biol. 2019;29:339-359 pubmed publisher
    ..Here, we focus on the cellular functions of class II PI3Ks in different cell systems and underline the emerging importance of these enzymes in various physiological and pathological contexts. ..
  6. Hirsch E, Barberis L, Brancaccio M, Azzolino O, Xu D, Kyriakis J, et al. Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain. J Cell Biol. 2002;157:481-92 pubmed
    ..Altogether, our data provide the evidence for an epistatic interaction between the beta1 integrin cytoplasmic domain and Rac, and indicate that this anchorage-dependent signaling pathway is crucial for cell growth control. ..
  7. Zamboni V, Jones R, Umbach A, Ammoni A, Passafaro M, Hirsch E, et al. Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities. Int J Mol Sci. 2018;19: pubmed publisher
    ..Here we review all knowledge in support of this possibility. ..
  8. Zamboni V, Armentano M, Berto G, Ciraolo E, Ghigo A, Garzotto D, et al. Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics. Sci Rep. 2018;8:7254 pubmed publisher
  9. Campa C, Margaria J, Derle A, Del Giudice M, De Santis M, Gozzelino L, et al. Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes. Nat Chem Biol. 2018;14:801-810 pubmed publisher
    ..Our findings thus define that delivery of recycling cargo toward the ERC requires spatial and sequential coupling of Rab11 activity with PtdIns(3)P turnover. ..

More Information


  1. Campa C, Franco I, Hirsch E. PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction. FEBS Lett. 2015;589:1552-8 pubmed publisher
    ..This review focuses on the latest discoveries regarding PI3K-C2α function in vesicle trafficking and its impact on cell biology and mammalian embryonic development. ..
  2. Franco I, Margaria J, De Santis M, Ranghino A, Monteyne D, Chiaravalli M, et al. Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation. J Am Soc Nephrol. 2016;27:1135-44 pubmed publisher
    ..These results indicate that PI3K-C2α is required for the transport of ciliary components such as polycystin-2, and partial loss of this enzyme is sufficient to exacerbate the pathogenesis of cystic kidney disease. ..
  3. Galli U, Ciraolo E, Massarotti A, Margaria J, Sorba G, Hirsch E, et al. The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors. Molecules. 2015;20:17275-87 pubmed publisher
    ..Compound 9b is a selective inhibitor against the PI3Kα isoform, maintaining a good inhibitory activity. Docking studies were also performed in order to rationalize its profile of selectivity. ..
  4. Beretta M, Bauer M, Hirsch E. PI3K signaling in the pathogenesis of obesity: The cause and the cure. Adv Biol Regul. 2015;58:1-15 pubmed publisher
    ..This integrated view of PI3K functions may ultimately help to develop new therapeutic interventions for the treatment of obesity. ..
  5. Movsesian M, Ahmad F, Hirsch E. Functions of PDE3 Isoforms in Cardiac Muscle. J Cardiovasc Dev Dis. 2018;5: pubmed publisher
  6. Li M, Hirsch E. Akt activation by PHLPP1 ablation prevents pathological hypertrophy by promoting angiogenesis. Cardiovasc Res. 2015;105:129-30 pubmed publisher
  7. Ghigo A, Li M, Hirsch E. New signal transduction paradigms in anthracycline-induced cardiotoxicity. Biochim Biophys Acta. 2016;1863:1916-25 pubmed publisher
    ..This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel. ..
  8. De Santis M, Sala V, Martini M, Ferrero G, Hirsch E. PI3K Signaling in Tissue Hyper-Proliferation: From Overgrowth Syndromes to Kidney Cysts. Cancers (Basel). 2017;9: pubmed publisher
    ..In particular, we discuss the most recent findings on how the same pathway may lead to different biological effects, due to the convergence and cooperation of different signaling cascades. ..
  9. Sala V, Margaria J, Murabito A, Morello F, Ghigo A, Hirsch E. Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF). Curr Heart Fail Rep. 2017;14:187-196 pubmed publisher
    ..Finally, we will discuss the potential of repurposing and/or developing new PDE and PI3K inhibitors for HFpEF therapy. ..
  10. request reprint
    Hirsch E, Bosco O, Tropel P, Laffargue M, Calvez R, Altruda F, et al. Resistance to thromboembolism in PI3Kgamma-deficient mice. FASEB J. 2001;15:2019-21 pubmed
    ..This result demonstrates an unsuspected, well-defined role for PI3Kgamma downstream of ADP and suggests that pharmacological targeting of PI3Kgamma has a potential use as antithrombotic therapy. ..
  11. Campa C, Hirsch E. Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking. Adv Biol Regul. 2017;63:132-139 pubmed publisher
    ..This review focuses on the latest advances regarding the mechanisms that ensure the compartmentalized regulation of Rab11 function through its interaction with phosphoinositides. ..
  12. Gulluni F, Martini M, De Santis M, Campa C, Ghigo A, Margaria J, et al. Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2? Scaffolding Function. Cancer Cell. 2017;32:444-459.e7 pubmed publisher
    ..As a consequence of altered spindle, loss of PI3K-C2? increases sensitivity to taxane-based therapy in pre-clinical models and in neoadjuvant settings. ..
  13. Ghigo A, Laffargue M, Li M, Hirsch E. PI3K and Calcium Signaling in Cardiovascular Disease. Circ Res. 2017;121:282-292 pubmed publisher
    ..This review explores the emerging molecular mechanisms linking Ca2+ and PI3K signaling in health and disease. ..
  14. Franco I, Gulluni F, Campa C, Costa C, Margaria J, Ciraolo E, et al. PI3K class II ? controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function. Dev Cell. 2014;28:647-58 pubmed publisher
    ..Thus, PI3K-C2? regulates the formation of a PtdIns3P pool at the PRE required for Rab11 and Shh pathway activation. ..
  15. request reprint
    Hirsch E, Costa C, Ciraolo E. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. J Endocrinol. 2007;194:243-56 pubmed
    ..This review will thus focus on the different pathways that converge on PI3K activation, with particular attention to the paradigmatic PI3K involvement in insulin signaling. ..
  16. Hirsch E, Pozzato M, Vercelli A, Barberis L, Azzolino O, Russo C, et al. Defective dendrite elongation but normal fertility in mice lacking the Rho-like GTPase activator Dbl. Mol Cell Biol. 2002;22:3140-8 pubmed
    ..However, in distinct populations of Dbl-null cortical pyramidal neurons, the length of dendrites was significantly reduced, suggesting a role for Dbl in dendrite elongation. ..