E Hirsch

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi request reprint PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects
    Enrico Patrucco
    Department of Genetics, Biology, and Biochemistry, University of Torino, Via Santena 5bis, Italy
    Cell 118:375-87. 2004
  2. doi request reprint Twice upon a time: PI3K's secret double life exposed
    Emilio Hirsch
    Molecular Biotechnology Center, Torino, Italy
    Trends Biochem Sci 34:244-8. 2009
  3. pmc Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma
    Carmine Vecchione
    Istituto di Ricovero e Cura a Carattere Scientifico, Neuromed, 86077 Pozzilli, Italy
    J Exp Med 201:1217-28. 2005
  4. pmc Targeting PI3K in Cancer: Any Good News?
    Miriam Martini
    Molecular Biotechnology Center, University of Turin Turin, Italy
    Front Oncol 3:108. 2013
  5. pmc Anchoring proteins as regulators of signaling pathways
    Alessia Perino
    Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy
    Circ Res 111:482-92. 2012
  6. ncbi request reprint CALming Down T Cell Acute Leukemia
    Emilio Hirsch
    Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy
    Cancer Cell 21:449-50. 2012
  7. pmc Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain
    Emilio Hirsch
    Dipartimento di Genetica, Biologia, e Biochimica, Universita di Torino, 10126 Torino, Italy
    J Cell Biol 157:481-92. 2002
  8. ncbi request reprint Resistance to thromboembolism in PI3Kgamma-deficient mice
    E Hirsch
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Via Santina 5 bis, 10126 Turin, Italy
    FASEB J 15:2019-21. 2001
  9. doi request reprint Taming the PI3K team to hold inflammation and cancer at bay
    Emilio Hirsch
    Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy
    Pharmacol Ther 118:192-205. 2008
  10. ncbi request reprint Phosphoinositide 3-kinases as a common platform for multi-hormone signaling
    Emilio Hirsch
    Dipartimento di Genetica, Biologia e Biochimica, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Turin 10126, Italy
    J Endocrinol 194:243-56. 2007

Detail Information

Publications84

  1. ncbi request reprint PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects
    Enrico Patrucco
    Department of Genetics, Biology, and Biochemistry, University of Torino, Via Santena 5bis, Italy
    Cell 118:375-87. 2004
    ....
  2. doi request reprint Twice upon a time: PI3K's secret double life exposed
    Emilio Hirsch
    Molecular Biotechnology Center, Torino, Italy
    Trends Biochem Sci 34:244-8. 2009
    ..We will discuss such findings, highlighting the crucial scaffold function of PI3Kgamma in cAMP homeostasis and PI3Kbeta in receptor recycling...
  3. pmc Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma
    Carmine Vecchione
    Istituto di Ricovero e Cura a Carattere Scientifico, Neuromed, 86077 Pozzilli, Italy
    J Exp Med 201:1217-28. 2005
    ..These data indicate that PI3Kgamma is a key transducer of the intracellular signals that are evoked by angiotensin II and suggest that blocking PI3Kgamma function might be exploited to improve therapeutic intervention on hypertension...
  4. pmc Targeting PI3K in Cancer: Any Good News?
    Miriam Martini
    Molecular Biotechnology Center, University of Turin Turin, Italy
    Front Oncol 3:108. 2013
    ..In this review we will discuss individual PIK3CA mutations as predictors of sensitivity and resistance to targeted therapies, leading to use of novel PI3K/mTOR/AKT inhibitors to a more "personalized" treatment...
  5. pmc Anchoring proteins as regulators of signaling pathways
    Alessia Perino
    Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy
    Circ Res 111:482-92. 2012
    ..In this review we will focus on the description of A-kinase anchoring protein function in the regulation of cardiac physiopathology...
  6. ncbi request reprint CALming Down T Cell Acute Leukemia
    Emilio Hirsch
    Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy
    Cancer Cell 21:449-50. 2012
    ..In this issue of Cancer Cell, Subramaniam et al. show that T-ALL can be tamed by inhibiting γ and δ PI3K isoforms...
  7. pmc Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain
    Emilio Hirsch
    Dipartimento di Genetica, Biologia, e Biochimica, Universita di Torino, 10126 Torino, Italy
    J Cell Biol 157:481-92. 2002
    ..Altogether, our data provide the evidence for an epistatic interaction between the beta1 integrin cytoplasmic domain and Rac, and indicate that this anchorage-dependent signaling pathway is crucial for cell growth control...
  8. ncbi request reprint Resistance to thromboembolism in PI3Kgamma-deficient mice
    E Hirsch
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Via Santina 5 bis, 10126 Turin, Italy
    FASEB J 15:2019-21. 2001
    ..This result demonstrates an unsuspected, well-defined role for PI3Kgamma downstream of ADP and suggests that pharmacological targeting of PI3Kgamma has a potential use as antithrombotic therapy...
  9. doi request reprint Taming the PI3K team to hold inflammation and cancer at bay
    Emilio Hirsch
    Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy
    Pharmacol Ther 118:192-205. 2008
    ..This review will focus on these findings and on the ongoing efforts to tame this family of enzymes to beat inflammation and cancer...
  10. ncbi request reprint Phosphoinositide 3-kinases as a common platform for multi-hormone signaling
    Emilio Hirsch
    Dipartimento di Genetica, Biologia e Biochimica, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Turin 10126, Italy
    J Endocrinol 194:243-56. 2007
    ..This review will thus focus on the different pathways that converge on PI3K activation, with particular attention to the paradigmatic PI3K involvement in insulin signaling...
  11. ncbi request reprint Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing
    Emilio Hirsch
    Dipartimento di Genetica, Biologia e Biochimica, University of Torino, Via Santena 5bis, 10126 Torino, Italy
    Thromb Haemost 95:29-35. 2006
    ....
  12. pmc Defective dendrite elongation but normal fertility in mice lacking the Rho-like GTPase activator Dbl
    Emilio Hirsch
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, 10126 Turin, Italy
    Mol Cell Biol 22:3140-8. 2002
    ..However, in distinct populations of Dbl-null cortical pyramidal neurons, the length of dendrites was significantly reduced, suggesting a role for Dbl in dendrite elongation...
  13. ncbi request reprint Analysis of the murine phosphoinositide 3-kinase gamma gene
    E Hirsch
    Department of Genetics, Biology and Biochemistry, University of Torino, I 10126, Torino, Italy
    Gene 256:69-81. 2000
    ..This suggests that mouse models will provide reliable results in the assessments of novel PI3Kgamma inhibitors...
  14. ncbi request reprint Integrin function and regulation in development
    G Tarone
    Department of Genetics, Biology and Biochemistry, University of Torino, Italy
    Int J Dev Biol 44:725-31. 2000
    ..The important role of both alpha and beta integrin subunit cytoplasmic domains during development is further illustrated by the analysis of targeted mutations which we have generated by homologous recombination in mice...
  15. ncbi request reprint Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
    E Hirsch
    Department of Genetics, Biology and Biochemistry, University of Torino, Turin, Italy
    Science 287:1049-53. 2000
    ..These results demonstrate that PI3Kgamma is a crucial signaling molecule required for macrophage accumulation in inflammation...
  16. ncbi request reprint Ciliary neurotrophic factor constitutively expressed in the nervous system of transgenic mice protects embryonic dorsal root ganglion neurons from apoptosis
    E Tolosano
    Department of Genetics, Biology and Medical Chemistry, University of Turin, Italy
    Eur J Neurosci 8:521-9. 1996
    ..We discuss our results with regard to CNTF potentialities in vivo and the significance of programmed cell death during development...
  17. ncbi request reprint Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease
    G Alloatti
    Dipartimento di Biologia Animale e dell Uomo e Istituto Nazionale per la Fisica della Materia, Universita di Torino, Turin, Italy
    Biochem Soc Trans 32:383-6. 2004
    ....
  18. ncbi request reprint Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice
    E Tolosano
    Department of Genetics, Biology and Biochemistry, University of Turin, Italy
    Blood 94:3906-14. 1999
    ..These data indicate that, although Hx is not crucial either for iron metabolism or as a protection against oxidative stress under physiologic conditions, it does play an important protective role after hemolytic processes...
  19. ncbi request reprint Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain
    M Brancaccio
    Department of Genetics, University of Torino, Torino 10126, Italy
    J Biol Chem 274:29282-8. 1999
    ....
  20. ncbi request reprint Alpha v integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development
    E Hirsch
    Dipartimento di Genetica, Biologia e Chimica Medica, Universita di Torino, Italy
    Dev Dyn 201:108-20. 1994
    ..Moreover, alpha v is likely to be involved in the myotendinous junction during embryonic life, suggesting a dual functional role of this integrin in muscle and nervous tissue...
  21. doi request reprint Targeting phosphoinositide 3-kinase gamma to fight inflammation and more
    Laura Barberis
    Molecular Biotechnology Center and Department of Genetics, Biology and Biochemistry, University of Torino, Via Nizza 52, 10126 Turin, Italy
    Thromb Haemost 99:279-85. 2008
    ..Development of inhibitors has already provided series of hits, whose efficacy is currently under scrutiny worldwide...
  22. ncbi request reprint Identification of the macromolecular complex responsible for PI3Kgamma-dependent regulation of cAMP levels
    A Perino
    Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 5bis, 10126 Torino, Italy
    Biochem Soc Trans 34:502-3. 2006
    ..PI3Kgamma regulates cardiac cAMP homoeostasis by forming a macromolecular complex containing PDE3B (phosphodiesterase 3B). In this complex, PI3Kgamma could regulate PDE3B activity through protein kinase A, a PDE activator...
  23. ncbi request reprint Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis
    F Di Cunto
    Department of Genetics, Biology and Biochemistry, University of Torino, Italy
    Neuron 28:115-27. 2000
    ..Our results indicate that Citron-K is essential for cytokinesis in vivo but only in specific neuronal precursors. Moreover, they suggest a novel molecular mechanism for a subset of human malformative syndromes of the CNS...
  24. doi request reprint Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin
    Laura Barberis
    Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Torino, Italy
    Eur J Immunol 39:1136-46. 2009
    ..These results define vimentin N-terminal phosphorylation and fiber reorganization as a target of chemokine-dependent PI3Kgamma signaling in leukocytes...
  25. pmc Plasma protein haptoglobin modulates renal iron loading
    Sharmila Fagoonee
    Department of Genetics, Biology and Biochemistry, University of Turin, Via Santena 5bis, 10126 Turin, Italy
    Am J Pathol 166:973-83. 2005
    ..These data demonstrate that haptoglobin crucially prevents glomerular filtration of hemoglobin and, consequently, renal iron loading during aging and following acute plasma heme-protein overload...
  26. doi request reprint Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues
    Antonella Roetto
    Department of Clinical and Biological Science, University of Torino, Turin, Italy
    Blood 115:3382-9. 2010
    ..Our results strengthen the function of hepatic alpha-Tfr2 in hepcidin activation, suggest a role for extrahepatic Tfr2 and indicate that beta-Tfr2 may specifically control spleen iron efflux...
  27. ncbi request reprint Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis
    Emanuela Tolosano
    Department of Genetics, Biology and Biochemistry, University of Turin and the San Giovanni Battista Hospital, Turin, Italy
    Blood 100:4201-8. 2002
    ..These data demonstrate that haptoglobin and hemopexin together are essential for protection from splenomegaly and liver fibrosis resulting from intravascular hemolysis...
  28. ncbi request reprint Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment
    Erica L Martin
    Department of Anesthesiology and Critical Care, University of Turin, Ospedale S Giovanni Battista Molinette, Turin, Italy
    Am J Respir Crit Care Med 182:762-73. 2010
    ..Leukocyte recruitment, required to limit bacterial spread, depends on phosphoinositide-3 kinase γ (PI3Kγ) signaling in vitro; however, the role of this enzyme in polymicrobial sepsis has remained unclear...
  29. doi request reprint PI3K inhibition in inflammation: Toward tailored therapies for specific diseases
    Alessandra Ghigo
    Molecular Biotechnology Center, University of Torino, Italy
    Bioessays 32:185-96. 2010
    ....
  30. ncbi request reprint PI3K in cancer-stroma interactions: bad in seed and ugly in soil
    E Hirsch
    Department of Molecular Biotechnology and Health Sciences Center for Molecular Biotechnology, University of Torino, Torino, Italy
    Oncogene 33:3083-90. 2014
    ....
  31. doi request reprint PI3K keeps the balance between metabolism and cancer
    L Braccini
    Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Torino, Italy
    Adv Biol Regul 52:389-405. 2012
    ..In this review, we will thus discuss the current concepts of tumor metabolism and the opportunity of PI3K-targeted therapies to exploit the "sweet tooth" of cancer cells...
  32. ncbi request reprint Specific expression in brain and liver driven by the hemopexin promoter in transgenic mice
    E Tolosano
    Department of Genetics, Biology and Medical Chemistry, University of Turin, Italy
    Biochem Biophys Res Commun 218:694-703. 1996
    ....
  33. ncbi request reprint Present and future of PI3K pathway inhibition in cancer: perspectives and limitations
    E Ciraolo
    Department of Genetics, Biology and Biochemistry, Molecular Biotecnology Center, University of Torino, Torino, Italy
    Curr Med Chem 18:2674-85. 2011
    ..We will also review the preclinical studies documenting the major effects of systemic PI3K inhibition on non-cancer tissues, which have shed light on potential side effects, caveats and limitations for PI3K blockade in patients...
  34. ncbi request reprint Expression of beta 1 integrin complexes on the surface of unfertilized mouse oocyte
    G Tarone
    Dipartimento di Genetica, Biologia e Chimica Medica, Universita di Torino, Italy
    Development 117:1369-75. 1993
    ..These data demonstrate for the first time the expression of three beta 1 integrin complexes in unfertilized mouse oocytes. Such proteins may have a role in sperm-egg interaction or during very early steps of embryogenesis...
  35. pmc Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility
    Elisa Ciraolo
    Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy
    Mol Biol Cell 21:704-11. 2010
    ..These data establish that activation of the p110beta PI3K isoform by c-Kit is required during spermatogenesis, thus opening the way to new treatments for c-Kit positive testicular cancers...
  36. doi request reprint Phosphoinositide 3-kinase signalling in the vascular system
    Fulvio Morello
    Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy
    Cardiovasc Res 82:261-71. 2009
    ....
  37. pmc Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma
    Carlotta Costa
    Dipartimento di Genetica, Biologia e Biochimica, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy
    Proc Natl Acad Sci U S A 104:14354-9. 2007
    ....
  38. ncbi request reprint Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility
    Giuseppe Alloatti
    Dipartimento di Biologia Animale e dell Uomo e Istituto Nazionale per la Fisica della Materia, Universita di Torino, 10123 Torino, Italy
    Cardiovasc Res 60:242-9. 2003
    ..We thus investigated whether the GPCR-activated phosphoisositide 3-kinase gamma (PI3Kgamma) could play a role in the cardiac response to PAF...
  39. pmc Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis
    Enrico Lupia
    Dipartimento di Fisiopatologia Clinica, Universita di Torino, Via Genova 3, 10126 Torino, Italy
    Am J Pathol 165:2003-11. 2004
    ..Our results thus suggest that inhibition of PI3K gamma may be of therapeutic value in acute pancreatitis...
  40. ncbi request reprint Phosphoinositide 3-kinase gamma controls autonomic regulation of the mouse heart through Gi-independent downregulation of cAMP level
    Giuseppe Alloatti
    Dipartimento di Biologia Animale e dell Uomo, Universita di Torino, 10123 Torino, Italy
    FEBS Lett 579:133-40. 2005
    ..Consistently, cAMP level of PI3Kgamma-null ventricles was always higher than wild-type controls. Thus, PI3Kgamma controls the cardiac function by reducing cAMP concentration independently of Gi-mediated signaling...
  41. ncbi request reprint Lack of phosphoinositide 3-kinase-gamma attenuates ventilator-induced lung injury
    Vincenzo Lionetti
    Dipartimento di Anestesiologia e Rianimazione, Ospedale S Giovanni Battista Molinette, Universita di Torino, Torino, Italy
    Crit Care Med 34:134-41. 2006
    ..The G protein-sensitive phosphoinositide-3-kinase gamma (PI3Kgamma) regulates several cellular functions including inflammation and cell survival. We explored the role of PI3Kgamma on ventilator-induced lung injury...
  42. ncbi request reprint Isoform selective phosphoinositide 3-kinase gamma and delta inhibitors and their therapeutic potential
    Alessandra Ghigo
    Molecular Biotechnology Center, University of Torino, Torino, Italy
    Recent Pat Inflamm Allergy Drug Discov 2:1-10. 2008
    ..Here, we describe recently published patent specifications disclosing new PI3K inhibitors, with a main focus on compounds displaying some selectivity for PI3Kdelta and gamma isoforms and their potential therapeutic applications...
  43. ncbi request reprint Phosphoinositide 3-kinasegamma (PI3Kgamma) controls L-type calcium current (ICa,L) through its positive modulation of type-3 phosphodiesterase (PDE3)
    Andrea Marcantoni
    Dipartimento di Neuroscienze, Universita degli Studi di Torino, Torino, Italy
    J Cell Physiol 206:329-36. 2006
    ..As observed in PI3Kgamma-/- neonatal cardiomyocytes, cells lacking PI3Kgamma are more sensitive to stimulation of beta2-adrenergic receptors...
  44. doi request reprint Dissection of the interplay between class I PI3Ks and Rac signaling in phagocytic functions
    Carlotta Costa
    Department of Genetics, Biology, and Biochemistry, Molecular Biotechnology Center, University of Turin, Italy
    ScientificWorldJournal 10:1826-39. 2010
    ....
  45. ncbi request reprint Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload
    Mara Brancaccio
    Department of Genetics, Biology, and Biochemistry, Turin University, 10126 Turin, Italy
    Nat Med 9:68-75. 2003
    ..Thus, melusin prevents cardiac dilation during chronic pressure overload by specifically sensing mechanical stress...
  46. pmc The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation
    Chiara Ambrogio
    Department of Biomedical Sciences and Human Oncology, Center for Experimental Research and Medical Studies, University of Torino, Turin, Italy
    Cancer Res 68:8899-907. 2008
    ..Thus, our data open perspectives for new therapeutic strategies by revealing a mechanism of regulation of ALCL cell growth through Cdc42...
  47. doi request reprint Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis
    Roberta Ferretti
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, 10126 Torino, Italy
    Dev Cell 18:486-95. 2010
    ..In addition, tumor tissue array histochemical analysis revealed that morgana is underexpressed in a large fraction of breast and lung human cancers. Thus, morgana/chp-1 appears to prevent both centrosome amplification and tumorigenesis...
  48. ncbi request reprint Tissue-specific KO of ECM proteins
    Mara Brancaccio
    Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy
    Methods Mol Biol 522:15-50. 2009
    ..This chapter will thus focus on the recent advances in gene-targeting technology with a special eye on the study of genes involved in cell adhesion and migration...
  49. pmc Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development
    Elisa Ciraolo
    Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy
    Sci Signal 1:ra3. 2008
    ..These findings indicate an unexpected role for p110beta catalytic activity in diabetes and cancer, opening potential avenues for therapeutic intervention...
  50. doi request reprint PI3K kinase and scaffold functions in heart
    Federico Damilano
    Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy
    Ann N Y Acad Sci 1188:39-45. 2010
    ..This review will thus focus on the effects of these multiple signaling events, with particular emphasis on their involvement in cardiac hypertrophy and failure...
  51. ncbi request reprint Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation
    Hong Ji
    Merck Serono S A, Geneva Research Center, Geneva, Switzerland
    Blood 110:2940-7. 2007
    ..Thus, the pathology in the p110gammadelta-deficient mice is likely to be secondary to a developmental block in the thymus that leads to lymphopenia-associated inflammatory responses...
  52. ncbi request reprint Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function
    Muriel Laffargue
    Institute of Biochemistry, Department of Medicine, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
    Immunity 16:441-51. 2002
    ..PI3Kgamma thus relays inflammatory signals through various G(i)-coupled receptors and is central to mast cell function...
  53. ncbi request reprint Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
    Michael A Crackower
    IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences, c o Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Cell 110:737-49. 2002
    ..These data show that PTEN has an important in vivo role in cardiomyocyte hypertrophy and GPCR signaling and identify a function for the PTEN-PI3Kgamma pathway in the modulation of heart muscle contractility...
  54. ncbi request reprint A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B
    Paolo Lova
    Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    J Biol Chem 278:131-8. 2003
    ....
  55. ncbi request reprint Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio
    Luis Rodríguez-Borlado
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Universidad Autonoma, Cantoblanco, Madrid, Spain
    J Immunol 170:4475-82. 2003
    ..These observations underscore the contribution of PI3K in T cell development, as well as its implication in determining the CD4(+)/CD8(+) T cell differentiation ratio in vivo...
  56. pmc Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice
    Annalisa Del Prete
    Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
    EMBO J 23:3505-15. 2004
    ..Thus, PI3Kgamma plays a nonredundant role in DC trafficking and in the activation of specific immunity. Therefore, PI3Kgamma may be considered a new target to control exaggerated immune reactions...
  57. pmc Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family
    Cecilia Garlanda
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Proc Natl Acad Sci U S A 101:3522-6. 2004
    ..Thus, TIR8 represents a negative pathway of regulation of the IL-1 receptor/TLR system, expressed in epithelial cells and DC, crucial for tuning inflammation in the gastrointestinal tract...
  58. ncbi request reprint Fetal lungs of tenascin-C-deficient mice grow well, but branch poorly in organ culture
    Matthias Roth-Kleiner
    Institute of Anatomy, University of Bern, Buehlstrasse 26, CH 3000 Bern 9, Switzerland
    Am J Respir Cell Mol Biol 30:360-6. 2004
    ..Because TNC is predominantly expressed at the growing tip of the future airways, we hypothesize that TNC promotes the penetration into the surrounding mesenchyme and the branching of the growing airways...
  59. ncbi request reprint Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1
    Gareth E Jones
    Randall Centre, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, UK
    Exp Cell Res 290:120-31. 2003
    ..These results indicate that the initial actin reorganization induced by either a GPCR or tyrosine kinase receptor agonist is not dependent on PI3Kgamma, whereas PI3Kgamma is needed for optimal migration of macrophages to either agonist...
  60. ncbi request reprint Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases
    Matthew J Thomas
    Novartis Institutes for BioMedical Research, Horsham, UK
    Eur J Immunol 35:1283-91. 2005
    ..These data resolve the complexities of chemokine-induced neutrophilia and PI3K signaling and define the gamma isoform as a promising target for new therapeutics to treat airway inflammatory diseases...
  61. doi request reprint Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes
    Anne Fougerat
    INSERM U563, Département Lipoprotéines et Médiateurs Lipidiques, Toulouse Purpan, BP 3028, 31024 Toulouse Cedex 3, France
    Circulation 117:1310-7. 2008
    ..These properties and the expression of PI3Kgamma in the cardiovascular system suggest that PI3Kgamma plays a role in atherosclerosis...
  62. ncbi request reprint Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
    Alison M Condliffe
    The Inositide Laboratory, Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK
    Blood 106:1432-40. 2005
    ..These results start to define which PI3K isoforms are responsible for modulating neutrophil responsiveness to infection and inflammation...
  63. ncbi request reprint Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
    Montserrat Camps
    Serono Pharmaceutical Research Institute, Serono International S A, 14, Chemin des Aulx, 1228 Plan les Ouates, Geneva, Switzerland
    Nat Med 11:936-43. 2005
    ..Our results identify selective PI3Kgamma inhibitors as potential therapeutic molecules for the treatment of chronic inflammatory disorders such as rheumatoid arthritis...
  64. ncbi request reprint Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion
    Domingo F Barber
    Department of Immunology and Oncology, and Animal Facility, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    J Immunol 176:589-93. 2006
    ..These results validate the PI3Kgamma isoform as a target for systemic lupus erythematosus treatment...
  65. ncbi request reprint Signal transduction in inflammation. Perspective clues from the leukocyte-endothelium interface
    Emilio Hirsch
    Thromb Haemost 95:3-4. 2006
  66. ncbi request reprint PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis
    G John Ferguson
    The Babraham Institute, Cambridge, CB22 3AT, UK
    Nat Cell Biol 9:86-91. 2007
    ....
  67. ncbi request reprint Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition
    Barbara Frossi
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Udine, Italy
    J Immunol 178:2549-55. 2007
    ..The findings also demonstrate the dominance of the Fyn/p38 MAPK pathway in driving IL-4 production...
  68. ncbi request reprint Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection
    Ulrich A Maus
    Laboratory for Experimental Lung Research, Hannover School of Medicine, Hannover, Germany
    Am J Respir Crit Care Med 175:958-66. 2007
    ..However, interfering with PI3Kgamma signaling might increase the risk of bacterial infections in humans...
  69. pmc A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress
    César Nombela-Arrieta
    Theodor Kocher Institute, University of Bern, CH 3012 Bern, Switzerland
    J Exp Med 204:497-510. 2007
    ..In summary, our data support a central role for DOCK2, and to a lesser extent T cell-expressed PI3Kgamma, for signal transduction during interstitial lymphocyte migration and S1P-mediated egress...
  70. ncbi request reprint CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer
    Fabien Garcon
    Laboratory of Lymphocyte Signaling and Development, Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom
    Blood 111:1464-71. 2008
    ..Consistent with this, CD28 and p110delta double-deficient mice were severely immune compromised. We therefore suggest that combined pharmaceutic targeting of p110delta activity and CD28 costimulation has potent therapeutic potential...
  71. ncbi request reprint Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration
    Cornelia Weiss-Haljiti
    Serono Pharmaceutical Research Institute, Serono International S A, 14 Chemin des Aulx, CH 1228 Plan les Ouates, Geneva, Switzerland
    J Biol Chem 279:43273-84. 2004
    ..Our results thus demonstrate a chemokine-specific signaling pathway in which Gi and PI3Kgamma coordinate to drive Rac1 and PAK2 activation that eventually controls the chemotactic response...
  72. ncbi request reprint The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion
    Nayoung Kim
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom
    Blood 110:3202-8. 2007
    ..These results provide genetic evidence that p110delta is the dominant PI3K isoform for cytokine secretion by NK cells and suggest that PI3Ks cooperate during NK-cell development and cytotoxicity...
  73. pmc Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions
    Paolo Madeddu
    Bristol Heart Institute, University of Bristol, Upper Maudlin Street, Bristol, BS2 8HW, UK
    Arterioscler Thromb Vasc Biol 28:68-76. 2008
    ..We evaluated whether phosphatidylinositol 3-kinase gamma (PI3Kgamma) plays a role in reparative neovascularization and endothelial progenitor cell (EPC) function...
  74. pmc Phosphoinositide 3-kinase gamma participates in T cell receptor-induced T cell activation
    Isabela Alcázar
    Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Madrid 28049, Spain
    J Exp Med 204:2977-87. 2007
    ....
  75. pmc p130Cas mediates the transforming properties of the anaplastic lymphoma kinase
    Chiara Ambrogio
    Center for Experimental Research and Medical Studies and Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Blood 106:3907-16. 2005
    ....
  76. ncbi request reprint Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase
    Louise M C Webb
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, Cambridge, United Kingdom
    J Immunol 175:2783-7. 2005
    ..This work demonstrates that PI3K activity is critical for T cell development and depends on the combined function of p110gamma and p110delta...
  77. ncbi request reprint Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
    Cecilia Garlanda
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Nature 420:182-6. 2002
    ..Thus, the long pentraxin Ptx3 is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents, in particular to the opportunistic fungal pathogen Aspergillus fumigatus...
  78. pmc The RhoA-associated protein Citron-N controls dendritic spine maintenance by interacting with spine-associated Golgi compartments
    Paola Camera
    Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino 10126, Italy
    EMBO Rep 9:384-92. 2008
    ..We suggest that CIT-N might function as a scaffold protein in spine organization through its ability to bind to Golgi membranes and by affecting actin remodelling...
  79. ncbi request reprint PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization
    Antonietta Salustri
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome 00133, Italy
    Development 131:1577-86. 2004
    ..Thus, PTX3 is a structural constituent of the cumulus oophorus extracellular matrix essential for female fertility...
  80. ncbi request reprint Integrin signalling: the tug-of-war in heart hypertrophy
    Mara Brancaccio
    Department of Genetics, Biology, and Biochemistry, Turin University, Italy
    Cardiovasc Res 70:422-33. 2006
    ..Better understanding of the functional role of the initiator elements is of key importance to developing novel strategies to control cardiac hypertrophy and prevent heart failure...
  81. ncbi request reprint Magnetically enriched bone marrow-derived macrophages loaded in vitro with iron oxide can migrate to inflammation sites in mice
    Jorg Hamm
    Department of Genetics, Biology and Biochemistry and CERMS, University of Turin, Turin, Italy
    NMR Biomed 21:120-8. 2008
    ..Furthermore, by using genetically modified mice as BMDM donors, it should be possible to study the role of individual genes in macrophage recruitment...
  82. ncbi request reprint Selective Rac-1 inhibition protects from diabetes-induced vascular injury
    Carmine Vecchione
    Department of AngioCardioNeurology, IRCCS Neuromed, Localita Camerelle, 86077 Pozzilli, Italy
    Circ Res 98:218-25. 2006
    ..Our study demonstrates that Rac-1 plays a crucial role in diabetes-induced vascular injury, and it could be a target of novel therapeutic approaches to reduce vascular risk in diabetes mellitus...
  83. ncbi request reprint CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells
    Paola Cappello
    Center for Experimental Research and Medical Studies, San Giovanni Battista Hospital, Turin, Italy
    J Immunol 177:6143-51. 2006
    ..Our findings indicate that induction of MoDC maturation is an important property of CCL16 and suggest that chemokines may not only organize the migration of MoDCs, but also directly regulate their ability to prime T cell responses...
  84. ncbi request reprint Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence
    Giulio Selvetella
    Department of AngioCardioNeurology, I R C C S Neuromed, La Sapienza University of Rome, 86077 Pozzilli IS, Italy
    Cardiovasc Res 63:373-80. 2004
    ..Delinealing intracellular signaling pathways involved in the different aspects of cardiac hypertrophy will permit future improvements in the signaling that controls beneficial growth...