Research Topics
| Andrea GuiottoSummaryAffiliation: University of Padova Country: Italy Publications
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Detail Information
Publications
Synthesis and evaluation of neuroprotective alpha,beta-unsaturated aldehyde scavenger histidyl-containing analogues of carnosineAndrea Guiotto
Institute of Biomolecular Chemistry of CNR, Padova Unit, Via F Marzolo, 1, 35131 Padova, Italy
J Med Chem 48:6156-61. 2005..The cytoprotective efficacy of these compounds suggests their potential use as therapeutic agents for disorders that involve excessive membrane lipids peroxidation and HNE-mediated neuronal toxicity...- Carnosine and carnosine-related antioxidants: a reviewAndrea Guiotto
Institute of Biomolecular Chemistry of CNR Padova Unit, Italy
Curr Med Chem 12:2293-315. 2005.... - Efficient and chemoselective N-acylation of 10-amino-7-ethyl camptothecin with poly(ethylene glycol)Andrea Guiotto
Department of Pharmaceutical Sciences, University of Padova via F Marzolo, 5 35131 Padova, Italy
Bioorg Med Chem Lett 14:1803-5. 2004..The conjugate was tested against P388 murine leukemia cell lines and resulted equipotent to CPT-11, a camptothecin analogue already in clinical use... - Spatial conformation and topography of the tyrosine aromatic ring in substrate recognition by protein tyrosine kinasesPaolo Ruzza
Institute of Biomolecular Chemistry of CNR, Padova Unit, via F Marzolo 1, 35131 Padova, Italy
J Med Chem 49:1916-24. 2006.... - Synthesis, characterization, and preliminary in vivo tests of new poly(ethylene glycol) conjugates of the antitumor agent 10-amino-7-ethylcamptothecinAndrea Guiotto
Department of Pharmaceutical Sciences, University of Padova, Via F. Marzolo, 5, 35131 Padova, Italy
J Med Chem 47:1280-9. 2004..Pharmacokinetic studies indicated that 3 acts as a reservoir of 10-amino-7-ethylcamptothecin, as the mean residence time (MRT) is about 3-fold higher than that of the free drug... - Fluorescent, internally quenched, peptides for exploring the pH-dependent substrate specificity of cathepsin BPaolo Ruzza
Institute of Biomolecular Chemistry of CNR, Padua Unit, 35131 Padua, Italy
J Pept Sci 12:455-61. 2006..4, and are poorly hydrolyzed at pH 5.0. These findings provide new information for the rational design of cathepsin B-activated peptide-containing anticancer drugs... 
Mechanistic studies of amide bond scission during acidolytic deprotection of Pip containing peptideChiara Rubini
Institute of Biomolecular Chemistry of CNR, Padua Unit, 35131 Padua, Italy
J Pept Sci 14:989-97. 2008..The hydrolysis is proposed to proceed via an oxazolinium ion intermediate. This mechanism is supported by H/D exchange as observed by ESI-MS and NMR experiments...- Anchimeric assistance effect on regioselective hydrolysis of branched PEGs: a mechanistic investigationAndrea Guiotto
Dipartimento di Science Farmaceutiche, Via Marzolo, 5, 35131 Padova, Italy
Bioorg Med Chem 12:5031-7. 2004..Unexpected results reveal an anchimeric assistance of the Lys-AaA amide proton to the hydrolysis of the carbamoyl moiety joining mPEG to the alpha-amino group of lysine through the formation of an hydantoin system... - Tat cell-penetrating peptide has the characteristics of a poly(proline) II helix in aqueous solution and in SDS micellesPaolo Ruzza
Institute of Biomolecular Chemistry, Padova Unit, CNR, 35131 Padova, Italy
J Pept Sci 10:423-6. 2004..The CD spectrum of the Tat cell-penetrating peptide in SDS micellar solution was virtually unchanged from that in aqueous solution, and at low temperature it was close to that of a poly(proline) II helix... - Malondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogsAndrea Guiotto
Institute of Biomolecular Chemistry of CNR, Department of Chemical Sciences, University of Padua, Via F Marzolo, 1 35131 Padova, Italy
Bioorg Med Chem 15:6158-63. 2007..The data obtained indicate that this class of compounds maintains the activity profile of carnosine and is a suitable candidate for the treatment of disorders caused by oxidative stress... - 4-Fluoroproline derivative peptides: effect on PPII conformation and SH3 affinityPaolo Ruzza
Institute of Biomolecular Chemistry, Padua Unit, CNR, Via Marzolo1, 35131 Padua, Italy
J Pept Sci 12:462-71. 2006.... - Conformational constraints of tyrosine in protein tyrosine kinase substrates: Information about preferred bioactive side-chain orientationPaolo Ruzza
Institute of Biomolecular Chemistry, Padova Unit, CNR, Via Marzolo 1, 35131 Padua, Italy
Biopolymers 71:478-88. 2003..In contrast, these conformationally restricted tyrosine analogs were not tolerated by the Src-related tyrosine kinases Lyn and c-Fgr... - Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugatesAlessia Furin
Dipartimento di Scienze Farmaceutiche, Universita' degli Studi di Padova, Via F. Marzolo, 5-35100, Padua, Italy
Eur J Med Chem 38:739-49. 2003..The compound PEG(5000)-Nle-malonato-Pt-DACH (4) has been tested against L1210-implanted mice and showed and appreciable increase in cytotoxicity as compared to the reference standard Cl(2)PtDACH... - Neuroprotective actions of a histidine analogue in models of ischemic strokeSung Chun Tang
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
J Neurochem 101:729-36. 2007..These findings suggest a therapeutic potential for HNE-scavenging histidine analogues in the treatment of stroke and related neurodegenerative conditions... - PEGylation of the antimicrobial peptide nisin A: problems and perspectivesAndrea Guiotto
Dipartimento di Science Farmaceutiche, Padua, Italy
Farmaco 58:45-50. 2003..We report the synthesis of a PEG-nisin conjugate, and the microbiology assays against some bacterial cell lines... - An improved procedure for the synthesis of branched polyethylene glycols (PEGs) with the reporter dipeptide Met-betaAla for protein conjugationAndrea Guiotto
Dipartimento di Science Farmaceutiche, Via Marzolo 5, 35100 Padova, Italy
Bioorg Med Chem Lett 12:177-80. 2002....