Andrea Guiotto

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi request reprint Synthesis and evaluation of neuroprotective alpha,beta-unsaturated aldehyde scavenger histidyl-containing analogues of carnosine
    Andrea Guiotto
    Institute of Biomolecular Chemistry of CNR, Padova Unit, Via F Marzolo, 1, 35131 Padova, Italy
    J Med Chem 48:6156-61. 2005
  2. ncbi request reprint Carnosine and carnosine-related antioxidants: a review
    Andrea Guiotto
    Institute of Biomolecular Chemistry of CNR Padova Unit, Italy
    Curr Med Chem 12:2293-315. 2005
  3. ncbi request reprint Efficient and chemoselective N-acylation of 10-amino-7-ethyl camptothecin with poly(ethylene glycol)
    Andrea Guiotto
    Department of Pharmaceutical Sciences, University of Padova via F Marzolo, 5 35131 Padova, Italy
    Bioorg Med Chem Lett 14:1803-5. 2004
  4. ncbi request reprint Synthesis, characterization, and preliminary in vivo tests of new poly(ethylene glycol) conjugates of the antitumor agent 10-amino-7-ethylcamptothecin
    Andrea Guiotto
    Department of Pharmaceutical Sciences, University of Padova, Via F Marzolo, 5, 35131 Padova, Italy
    J Med Chem 47:1280-9. 2004
  5. ncbi request reprint Spatial conformation and topography of the tyrosine aromatic ring in substrate recognition by protein tyrosine kinases
    Paolo Ruzza
    Institute of Biomolecular Chemistry of CNR, Padova Unit, via F Marzolo 1, 35131 Padova, Italy
    J Med Chem 49:1916-24. 2006
  6. ncbi request reprint Fluorescent, internally quenched, peptides for exploring the pH-dependent substrate specificity of cathepsin B
    Paolo Ruzza
    Institute of Biomolecular Chemistry of CNR, Padua Unit, 35131 Padua, Italy
    J Pept Sci 12:455-61. 2006
  7. doi request reprint Mechanistic studies of amide bond scission during acidolytic deprotection of Pip containing peptide
    Chiara Rubini
    Institute of Biomolecular Chemistry of CNR, Padua Unit, 35131 Padua, Italy
    J Pept Sci 14:989-97. 2008
  8. ncbi request reprint Anchimeric assistance effect on regioselective hydrolysis of branched PEGs: a mechanistic investigation
    Andrea Guiotto
    Dipartimento di Science Farmaceutiche, Via Marzolo, 5, 35131 Padova, Italy
    Bioorg Med Chem 12:5031-7. 2004
  9. ncbi request reprint Conformational constraints of tyrosine in protein tyrosine kinase substrates: Information about preferred bioactive side-chain orientation
    Paolo Ruzza
    Institute of Biomolecular Chemistry, Padova Unit, CNR, Via Marzolo 1, 35131 Padua, Italy
    Biopolymers 71:478-88. 2003
  10. ncbi request reprint Tat cell-penetrating peptide has the characteristics of a poly(proline) II helix in aqueous solution and in SDS micelles
    Paolo Ruzza
    Institute of Biomolecular Chemistry, Padova Unit, CNR, 35131 Padova, Italy
    J Pept Sci 10:423-6. 2004

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Synthesis and evaluation of neuroprotective alpha,beta-unsaturated aldehyde scavenger histidyl-containing analogues of carnosine
    Andrea Guiotto
    Institute of Biomolecular Chemistry of CNR, Padova Unit, Via F Marzolo, 1, 35131 Padova, Italy
    J Med Chem 48:6156-61. 2005
    ..The cytoprotective efficacy of these compounds suggests their potential use as therapeutic agents for disorders that involve excessive membrane lipids peroxidation and HNE-mediated neuronal toxicity...
  2. ncbi request reprint Carnosine and carnosine-related antioxidants: a review
    Andrea Guiotto
    Institute of Biomolecular Chemistry of CNR Padova Unit, Italy
    Curr Med Chem 12:2293-315. 2005
    ....
  3. ncbi request reprint Efficient and chemoselective N-acylation of 10-amino-7-ethyl camptothecin with poly(ethylene glycol)
    Andrea Guiotto
    Department of Pharmaceutical Sciences, University of Padova via F Marzolo, 5 35131 Padova, Italy
    Bioorg Med Chem Lett 14:1803-5. 2004
    ..The conjugate was tested against P388 murine leukemia cell lines and resulted equipotent to CPT-11, a camptothecin analogue already in clinical use...
  4. ncbi request reprint Synthesis, characterization, and preliminary in vivo tests of new poly(ethylene glycol) conjugates of the antitumor agent 10-amino-7-ethylcamptothecin
    Andrea Guiotto
    Department of Pharmaceutical Sciences, University of Padova, Via F Marzolo, 5, 35131 Padova, Italy
    J Med Chem 47:1280-9. 2004
    ..Pharmacokinetic studies indicated that 3 acts as a reservoir of 10-amino-7-ethylcamptothecin, as the mean residence time (MRT) is about 3-fold higher than that of the free drug...
  5. ncbi request reprint Spatial conformation and topography of the tyrosine aromatic ring in substrate recognition by protein tyrosine kinases
    Paolo Ruzza
    Institute of Biomolecular Chemistry of CNR, Padova Unit, via F Marzolo 1, 35131 Padova, Italy
    J Med Chem 49:1916-24. 2006
    ....
  6. ncbi request reprint Fluorescent, internally quenched, peptides for exploring the pH-dependent substrate specificity of cathepsin B
    Paolo Ruzza
    Institute of Biomolecular Chemistry of CNR, Padua Unit, 35131 Padua, Italy
    J Pept Sci 12:455-61. 2006
    ..4, and are poorly hydrolyzed at pH 5.0. These findings provide new information for the rational design of cathepsin B-activated peptide-containing anticancer drugs...
  7. doi request reprint Mechanistic studies of amide bond scission during acidolytic deprotection of Pip containing peptide
    Chiara Rubini
    Institute of Biomolecular Chemistry of CNR, Padua Unit, 35131 Padua, Italy
    J Pept Sci 14:989-97. 2008
    ..The hydrolysis is proposed to proceed via an oxazolinium ion intermediate. This mechanism is supported by H/D exchange as observed by ESI-MS and NMR experiments...
  8. ncbi request reprint Anchimeric assistance effect on regioselective hydrolysis of branched PEGs: a mechanistic investigation
    Andrea Guiotto
    Dipartimento di Science Farmaceutiche, Via Marzolo, 5, 35131 Padova, Italy
    Bioorg Med Chem 12:5031-7. 2004
    ..Unexpected results reveal an anchimeric assistance of the Lys-AaA amide proton to the hydrolysis of the carbamoyl moiety joining mPEG to the alpha-amino group of lysine through the formation of an hydantoin system...
  9. ncbi request reprint Conformational constraints of tyrosine in protein tyrosine kinase substrates: Information about preferred bioactive side-chain orientation
    Paolo Ruzza
    Institute of Biomolecular Chemistry, Padova Unit, CNR, Via Marzolo 1, 35131 Padua, Italy
    Biopolymers 71:478-88. 2003
    ..In contrast, these conformationally restricted tyrosine analogs were not tolerated by the Src-related tyrosine kinases Lyn and c-Fgr...
  10. ncbi request reprint Tat cell-penetrating peptide has the characteristics of a poly(proline) II helix in aqueous solution and in SDS micelles
    Paolo Ruzza
    Institute of Biomolecular Chemistry, Padova Unit, CNR, 35131 Padova, Italy
    J Pept Sci 10:423-6. 2004
    ..The CD spectrum of the Tat cell-penetrating peptide in SDS micellar solution was virtually unchanged from that in aqueous solution, and at low temperature it was close to that of a poly(proline) II helix...
  11. ncbi request reprint Malondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogs
    Andrea Guiotto
    Institute of Biomolecular Chemistry of CNR, Department of Chemical Sciences, University of Padua, Via F Marzolo, 1 35131 Padova, Italy
    Bioorg Med Chem 15:6158-63. 2007
    ..The data obtained indicate that this class of compounds maintains the activity profile of carnosine and is a suitable candidate for the treatment of disorders caused by oxidative stress...
  12. ncbi request reprint 4-Fluoroproline derivative peptides: effect on PPII conformation and SH3 affinity
    Paolo Ruzza
    Institute of Biomolecular Chemistry, Padua Unit, CNR, Via Marzolo1, 35131 Padua, Italy
    J Pept Sci 12:462-71. 2006
    ....
  13. ncbi request reprint Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugates
    Alessia Furin
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Padova, Via F Marzolo, 5 35100, Padua, Italy
    Eur J Med Chem 38:739-49. 2003
    ..The compound PEG(5000)-Nle-malonato-Pt-DACH (4) has been tested against L1210-implanted mice and showed and appreciable increase in cytotoxicity as compared to the reference standard Cl(2)PtDACH...
  14. ncbi request reprint Neuroprotective actions of a histidine analogue in models of ischemic stroke
    Sung Chun Tang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurochem 101:729-36. 2007
    ..These findings suggest a therapeutic potential for HNE-scavenging histidine analogues in the treatment of stroke and related neurodegenerative conditions...
  15. ncbi request reprint PEGylation of the antimicrobial peptide nisin A: problems and perspectives
    Andrea Guiotto
    Dipartimento di Science Farmaceutiche, Padua, Italy
    Farmaco 58:45-50. 2003
    ..We report the synthesis of a PEG-nisin conjugate, and the microbiology assays against some bacterial cell lines...
  16. ncbi request reprint An improved procedure for the synthesis of branched polyethylene glycols (PEGs) with the reporter dipeptide Met-betaAla for protein conjugation
    Andrea Guiotto
    Dipartimento di Science Farmaceutiche, Via Marzolo 5, 35100 Padova, Italy
    Bioorg Med Chem Lett 12:177-80. 2002
    ....