M Guazzi

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi Pulmonary hemodynamic and tidal volume changes during exercise in heart failure
    Piergiuseppe Agostoni
    Institute of Cardiology, Centro Cardiologico Monzino, IRCCS, University of Milan, Centro di Studio per le Ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Milan, Italy
    Ital Heart J 3:104-8. 2002
  2. doi Maximal dyspnea on exertion during cardiopulmonary exercise testing is related to poor prognosis and echocardiography with tissue Doppler imaging in heart failure
    Marco Guazzi
    Cardiopulmonary Laboratory, Cardiology Division, University of Milano, San Paolo Hospital, Milano, Italy
    Congest Heart Fail 15:277-83. 2009
  3. doi Worksite health and wellness in the European union
    Marco Guazzi
    Heart Failure Unit, Cardiology, University of Milano, IRCCS Policlinico San Donato, Milano, Italy Electronic address
    Prog Cardiovasc Dis 56:508-14. 2014
  4. doi Abnormalities in cardiopulmonary exercise testing ventilatory parameters in heart failure: pathophysiology and clinical usefulness
    Marco Guazzi
    Heart Failure Unit, Cardiology, IRCCS, San Donato University Hospital, Milan, Italy
    Curr Heart Fail Rep 11:80-7. 2014
  5. doi Pathophysiology of cardiorenal syndrome in decompensated heart failure: role of lung-right heart-kidney interaction
    M Guazzi
    Heart Failure Unit, Cardiology, IRCCS Policlinico San Donato, University of Milano, Milano, Italy Electronic address
    Int J Cardiol 169:379-84. 2013
  6. doi Pulmonary hypertension in left heart disease
    Marco Guazzi
    Heart Failure Unit, University of Milan, IRCCS Policlinico San Donato, Milan
    Eur Respir Rev 21:338-46. 2012
  7. doi Right ventricular pulmonary hypertension
    Marco Guazzi
    Heart Failure Unit, I R C C S, Policlinico San Donato, University of Milan, Milan, Italy
    Curr Heart Fail Rep 9:303-8. 2012
  8. ncbi Treatment for pulmonary hypertension of left heart disease
    Marco Guazzi
    Cardiopulmonary Unit, University of Milano, I R C C S, Policlinico San Donato, Piazza Malan, 2, 20097, Milano, Italy
    Curr Treat Options Cardiovasc Med 14:319-27. 2012
  9. doi Exercise oscillatory breathing and NT-proBNP levels in stable heart failure provide the strongest prediction of cardiac outcome when combining biomarkers with cardiopulmonary exercise testing
    Marco Guazzi
    Cardiology, I R C C S Policlinico San Donato, University of Milano, San Donato Milanese, Italy
    J Card Fail 18:313-20. 2012
  10. ncbi Exercise ventilation inefficiency and cardiovascular mortality in heart failure: the critical independent prognostic value of the arterial CO2 partial pressure
    Marco Guazzi
    Cardiopulmonary Laboratory, Cardiology Division, University of Milano, San Paolo Hospital, Via A Di Rudini, 8, 20142, Milano, Italy
    Eur Heart J 26:472-80. 2005

Detail Information

Publications106 found, 100 shown here

  1. ncbi Pulmonary hemodynamic and tidal volume changes during exercise in heart failure
    Piergiuseppe Agostoni
    Institute of Cardiology, Centro Cardiologico Monzino, IRCCS, University of Milan, Centro di Studio per le Ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Milan, Italy
    Ital Heart J 3:104-8. 2002
    ....
  2. doi Maximal dyspnea on exertion during cardiopulmonary exercise testing is related to poor prognosis and echocardiography with tissue Doppler imaging in heart failure
    Marco Guazzi
    Cardiopulmonary Laboratory, Cardiology Division, University of Milano, San Paolo Hospital, Milano, Italy
    Congest Heart Fail 15:277-83. 2009
    ..4; P<.001) and peak VO(2) (residual chi-square, 7.5; P=.006) added predictive value. These results suggest that increasing DOE reflects the degree of disease severity and adds prognostic value to established CPX variables...
  3. doi Worksite health and wellness in the European union
    Marco Guazzi
    Heart Failure Unit, Cardiology, University of Milano, IRCCS Policlinico San Donato, Milano, Italy Electronic address
    Prog Cardiovasc Dis 56:508-14. 2014
    ..This review will describe the current state of workplace health promotion in Europe and address future directions for this potentially important intervention strategy. ..
  4. doi Abnormalities in cardiopulmonary exercise testing ventilatory parameters in heart failure: pathophysiology and clinical usefulness
    Marco Guazzi
    Heart Failure Unit, Cardiology, IRCCS, San Donato University Hospital, Milan, Italy
    Curr Heart Fail Rep 11:80-7. 2014
    ..Overall, a refined prevalence definition and more comprehensive use of these markers in a clinical environment and in future interventional trials seem challenging for the years to come. ..
  5. doi Pathophysiology of cardiorenal syndrome in decompensated heart failure: role of lung-right heart-kidney interaction
    M Guazzi
    Heart Failure Unit, Cardiology, IRCCS Policlinico San Donato, University of Milano, Milano, Italy Electronic address
    Int J Cardiol 169:379-84. 2013
    ..The resultant CVP rise is transmitted to the renal veins, eventually drives CRS and leads to a positive feedback loop evolving towards HF refractoriness. ..
  6. doi Pulmonary hypertension in left heart disease
    Marco Guazzi
    Heart Failure Unit, University of Milan, IRCCS Policlinico San Donato, Milan
    Eur Respir Rev 21:338-46. 2012
    ..This review gives an overview of the pathophysiology and epidemiology of PH associated with left heart disease, and discusses the challenges associated with its management and treatment...
  7. doi Right ventricular pulmonary hypertension
    Marco Guazzi
    Heart Failure Unit, I R C C S, Policlinico San Donato, University of Milan, Milan, Italy
    Curr Heart Fail Rep 9:303-8. 2012
    ..The search for new therapeutic opportunities targeted on pulmonary vascular and right heart remodeling are an important challenge for the future...
  8. ncbi Treatment for pulmonary hypertension of left heart disease
    Marco Guazzi
    Cardiopulmonary Unit, University of Milano, I R C C S, Policlinico San Donato, Piazza Malan, 2, 20097, Milano, Italy
    Curr Treat Options Cardiovasc Med 14:319-27. 2012
    ....
  9. doi Exercise oscillatory breathing and NT-proBNP levels in stable heart failure provide the strongest prediction of cardiac outcome when combining biomarkers with cardiopulmonary exercise testing
    Marco Guazzi
    Cardiology, I R C C S Policlinico San Donato, University of Milano, San Donato Milanese, Italy
    J Card Fail 18:313-20. 2012
    ..We sought to refine cardiac events prediction by performing a combined analysis of NT-proBNP with markers of exercise ventilatory efficiency...
  10. ncbi Exercise ventilation inefficiency and cardiovascular mortality in heart failure: the critical independent prognostic value of the arterial CO2 partial pressure
    Marco Guazzi
    Cardiopulmonary Laboratory, Cardiology Division, University of Milano, San Paolo Hospital, Via A Di Rudini, 8, 20142, Milano, Italy
    Eur Heart J 26:472-80. 2005
    ..Ve/Vco(2) slope determinants are the dead space-tidal volume (Vd/Vt) ratio and the arterial CO(2) partial pressure (Paco(2)). We aimed at defining the respective prognostic role of these two variables...
  11. ncbi Insulin ameliorates exercise ventilatory efficiency and oxygen uptake in patients with heart failure-type 2 diabetes comorbidity
    Marco Guazzi
    Department of Medicine and Surgery, University of Milan, Cardiology Division, San Paolo Hospital, Milan, Italy
    J Am Coll Cardiol 42:1044-50. 2003
    ..This study sought to test whether insulin improves exercise ventilatory efficiency (VE/VCO2 slope) and oxygen uptake at peak exercise (peak VO2) in patients with type 2 diabetes-heart failure (HF) comorbidity...
  12. ncbi Exercise metaboreflex activation and endothelial function impairment in atrial fibrillation
    Marco Guazzi
    Endothelial Function and Cardiopulmonary Unit, Cardiology Division, Univ of Milano, San Paolo Hospital, Via A Di Rudini 8, 20142 Milan, Italy
    Am J Physiol Heart Circ Physiol 291:H2396-402. 2006
    ..In AF, a cause-effect link exists between ED dysfunction and metaboreflex activity. Ventilatory advantages of CV seem to be inversely related with the extension of the underlying ED oxidative impairment...
  13. ncbi Endothelial dysfunction and exercise performance in lone atrial fibrillation or associated with hypertension or diabetes: different results with cardioversion
    Marco Guazzi
    Cardiopulmonary Unit, Cardiology Division, University of Milan, San Paolo Hospital, Via A Di Rudini, 8, 20142 Milan, Italy
    Am J Physiol Heart Circ Physiol 291:H921-8. 2006
    ..Comorbidities that impair endothelial activity worsen endothelial dysfunction and exercise intolerance in AF. The advantages of CV appear to be inversely related to the extent of the underlying oxidative injury...
  14. ncbi Cardiopulmonary exercise testing in the clinical and prognostic assessment of diastolic heart failure
    Marco Guazzi
    Cardiopulmonary Laboratory, University of Milan, San Paolo Hospital, Milan, Italy
    J Am Coll Cardiol 46:1883-90. 2005
    ..This study sought to define the relative prognostic value of cardiopulmonary exercise testing (CPET) variables in heart failure (HF) patients with preserved versus reduced systolic function...
  15. ncbi The effects of phosphodiesterase-5 inhibition with sildenafil on pulmonary hemodynamics and diffusion capacity, exercise ventilatory efficiency, and oxygen uptake kinetics in chronic heart failure
    Marco Guazzi
    Cardiopulmonary Laboratory, Cardiology Division, University of Milan, San Paolo Hospital, Via A Di Rudini 8, 20142 Milan, Italy
    J Am Coll Cardiol 44:2339-48. 2004
    ..We sought to investigate the effects of sildenafil, a phosphodiesterase-5 (PDE(5)) inhibitor, on lung function and exercise performance in chronic heart failure (CHF)...
  16. ncbi Functional evaluation of patients with chronic pulmonary hypertension
    Marco Guazzi
    Laboratory of Cardiopulmonary Pathophysiology, University of Milan, Division of Cardiology, San Paolo Hospital, Milan, Italy
    Ital Heart J 6:789-94. 2005
    ..In this review we critically address the knowledge currently acquired on these techniques...
  17. ncbi Alveolar-capillary membrane conductance is the best pulmonary function correlate of exercise ventilation efficiency in heart failure patients
    Marco Guazzi
    Cardiopulmonary Laboratory, University of Milano, Cardiology Division, San Paolo Hospital, Via A Di Rudini, 8, 20142, Milano, Italy
    Eur J Heart Fail 7:1017-22. 2005
    ..In heart failure (HF), changes in lung mechanics and gas diffusion are limiting factors to exercise. Their contribution to an increased exercise ventilation to CO2 production (VE/VCO2) slope is undefined...
  18. ncbi Effects of orthostatic stress on forearm endothelial function in normal subjects and in patients with hypertension, diabetes, or both diseases
    Marco Guazzi
    Cardiopulmonary Laboratory, Cardiology Division, St Paolo Hospital, University of Milano, Milano, Italy
    Am J Hypertens 18:986-94. 2005
    ..It has not been clarified whether this is coupled with a modulating endothelial vasorelaxation and whether diseases causing endothelial dysfunction, such as diabetes and hypertension, may impair this counterregulatory mechanism...
  19. ncbi Effects of cardioversion of atrial fibrillation on endothelial function in hypertension or diabetes
    M Guazzi
    University of Milan, San Paolo Hospital, Milan, Italy
    Eur J Clin Invest 37:26-34. 2007
    ..As AF often complicates hypertension and diabetes (disorders associated with impaired endothelial function) the study probed whether these comorbidities to AF produced an additive effect and to what extent CV might be advantageous...
  20. doi Phosphodiesterase 5 inhibition with sildenafil reverses exercise oscillatory breathing in chronic heart failure: a long-term cardiopulmonary exercise testing placebo-controlled study
    Marco Guazzi
    Cardiopulmonary Unit, University of Milano, San Paolo Hospital, Via A Di Rudini 8, Milan, Italy
    Eur J Heart Fail 14:82-90. 2012
    ..Accordingly, we performed a 1-year pilot trial with sildenafil in patients with HF and EOB...
  21. doi Regulation of alveolar gas conductance by NO in man, as based on studies with NO donors and inhibitors of NO production
    M Guazzi
    Cardiopulmonary Unit, University of Milan, San Paolo Hospital, Via A Di Rudini 8, Milan, Italy
    Acta Physiol (Oxf) 196:267-77. 2009
    ..Nitric oxide (NO) is a mediator of the pulmonary vessel tone and permeability. We hypothesized that it may also regulate the alveolar-capillary membrane gas conductance and lung diffusion capacity...
  22. doi Exercise oscillatory breathing in diastolic heart failure: prevalence and prognostic insights
    Marco Guazzi
    Cardiopulmonary Unit, University of Milano, San Paolo Hospital, Milano, Italy
    Eur Heart J 29:2751-9. 2008
    ..Exercise oscillatory breathing (EOB) is a powerful predictor of survival in patients with systolic HF. In diastolic HF, EOB prevalence and prognostic impact are unknown...
  23. ncbi Sildenafil and phosphodiesterase-5 inhibitors for heart failure
    Marco Guazzi
    Cardiopulmonary Unit, University of Milano, San Paolo Hospital, Via A Di Rudini, 8, 20142 Milano, Italy
    Curr Heart Fail Rep 5:110-4. 2008
    ..Despite promising initial data, larger controlled trials are necessary to define the safety, tolerability, and potential impact of PDE5 inhibitors on morbidity and mortality across the wide spectrum of patients with HF...
  24. doi Endothelial dysfunction and pathophysiological correlates in atrial fibrillation
    M Guazzi
    Cardiopulmonary Unit, University of Milan, Milan, Italy
    Heart 95:102-6. 2009
    ..This review focuses on the evidence of an association of AF with ED, the possible underlying mechanisms and the pathophysiological correlates...
  25. doi Evolving changes in lung interstitial fluid content after acute myocardial infarction: mechanisms and pathophysiological correlates
    Marco Guazzi
    Cardiopulmonary Unit, Cardiology Division, University of Milano, San Paolo Hospital, Via A Di Rudini 8, Milano 20142, Italy
    Am J Physiol Heart Circ Physiol 294:H1357-64. 2008
    ....
  26. ncbi Long-term use of sildenafil in the therapeutic management of heart failure
    Marco Guazzi
    Cardiopulmonary Unit, Cardiology Division, University of Milan, San Paolo Hospital, Milan, Italy
    J Am Coll Cardiol 50:2136-44. 2007
    ..This study sought to test the functional exercise capacity and endothelial function in a cohort of chronic heart failure (CHF) patients treated with chronic type 5 phosphodiesterase (PDE5) inhibitor...
  27. ncbi [Clinical use of phosphodiesterase-5 inhibitors in cardiopulmonary diseases: from experimental evidence to clinical application]
    Marco Guazzi
    Unità Cardiopolmonare, Ospedale San Paolo, Universita degli Studi, Milano
    G Ital Cardiol (Rome) 10:725-37. 2009
    ..Evidence currently available for considering PDE5 inhibition an additional therapeutic opportunity in cardiovascular disorders is provided...
  28. ncbi The role of PDE5-inhibitors in cardiopulmonary disorders: from basic evidence to clinical development
    Marco Guazzi
    Department of Medicine, Surgery and Dentistry, University of Milan, San Paolo Hospital, Milan, Italy
    Curr Med Chem 14:2181-91. 2007
    ..Evidence currently available for considering PDE5-inhibition an additional opportunity in the treatment of common cardiopulmonary disorders is here provided...
  29. ncbi Exercise oscillatory ventilation may predict sudden cardiac death in heart failure patients
    Marco Guazzi
    Cardiopulmonary Unit, Cardiology Division, University of Milano, San Paolo Hospital, Milano, Italy
    J Am Coll Cardiol 50:299-308. 2007
    ..The purpose of this study was to test the ability of cardiopulmonary exercise testing (CPET)-derived variables as sudden cardiac death (SCD) predictors...
  30. ncbi Endothelium-mediated modulation of ergoreflex and improvement in exercise ventilation by acute sildenafil in heart failure patients
    M Guazzi
    Cardiopulmonary Unit, Cardiology Division, University of Milano, San Paolo Hospital, Milano, Italy
    Clin Pharmacol Ther 83:336-41. 2008
    ..Phosphodiesterase-5 inhibition, by improving endothelial activity and muscle perfusion, modulates signaling and improves ventilatory and aerobic efficiencies, potentially indicating a novel pathway in the HF therapeutic management...
  31. ncbi Atorvastatin therapy improves exercise oxygen uptake kinetics in post-myocardial infarction patients
    M Guazzi
    Cardiopulmonary Unit, Cardiology Division, University of Milan, San Paolo Hospital, 20142 Milan, Italy
    Eur J Clin Invest 37:454-62. 2007
    ..We tested the hypothesis that statin therapy improves VO(2) exercise performance in normocholesterolaemic post-MI patients...
  32. doi Pulmonary hypertension with left-sided heart disease
    Marco Guazzi
    Cardiopulmonary Unit, University of Milan, San Paolo Hospital, Via A Di Rudini 8, 20142 Milan, Italy
    Nat Rev Cardiol 7:648-59. 2010
    ....
  33. ncbi Exercise oscillatory breathing and increased ventilation to carbon dioxide production slope in heart failure: an unfavorable combination with high prognostic value
    Marco Guazzi
    Cardiopulmonary Unit, University of Milano, Milano, Italy
    Am Heart J 153:859-67. 2007
    ..Recently, the occurrence of exercise oscillatory breathing (EOB) has emerged as an additional strong indicator of survival...
  34. doi Development of a cardiopulmonary exercise prognostic score for optimizing risk stratification in heart failure: the (P)e(R)i(O)dic (B)reathing during (E)xercise (PROBE) study
    Marco Guazzi
    Cardiopulmonary Unit, University of Milano, Milano, Italy
    J Card Fail 16:799-805. 2010
    ....
  35. doi PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study
    Marco Guazzi
    Cardiopulmonary Unit and Department of Cardiology, University of Milano, San Paolo Hospital, Via A Di Rudini 8, Milan, Italy
    Circ Heart Fail 4:8-17. 2011
    ..In a cohort of systolic HF patients, we tested the effects of PDE5 inhibition (sildenafil) on LV ejection fraction, diastolic function, cardiac geometry, and clinical status...
  36. doi Pulmonary hypertension in heart failure with preserved ejection fraction: a target of phosphodiesterase-5 inhibition in a 1-year study
    Marco Guazzi
    Cardiopulmonary Unit, University of Milan, San Paolo Hospital, Via A Di Rudini 8, 20142 Milan, Italy
    Circulation 124:164-74. 2011
    ..The prognosis worsens with pulmonary hypertension and right ventricular (RV) failure development. We targeted pulmonary hypertension and RV burden with the phosphodiesterase-5 inhibitor sildenafil...
  37. ncbi Exercise hyperventilation, dyspnea sensation, and ergoreflex activation in lone atrial fibrillation
    Marco Guazzi
    Cardiopulmonary Laboratory, Cardiology Division, Univ of Milano, San Paolo Hospital, Via A Di Rudini, 8 20144 Milano, Italy
    Am J Physiol Heart Circ Physiol 287:H2899-905. 2004
    ..In subjects with lone atrial fibrillation, an impairment in ventilatory efficiency appears to be involved in the pathophysiology of exercise limitation, and to be primarily related with a demodulated peripheral control of ventilation...
  38. ncbi Improvement of alveolar-capillary membrane diffusing capacity with exercise training in chronic heart failure
    Marco Guazzi
    Cardiopulmonary Laboratory, Cardiology Division, University of Milan, San Paolo Hospital, Via A Di Rudini, 8, 20142 Milan, Italy
    J Appl Physiol (1985) 97:1866-73. 2004
    ..Results document, for the first time, that training improves DlCO in CHF, and this effect may contribute to enhancement of exercise performance...
  39. doi Six-minute walk test and cardiopulmonary exercise testing in patients with chronic heart failure: a comparative analysis on clinical and prognostic insights
    Marco Guazzi
    Cardiopulmonary Unit, University of Milano, Italy
    Circ Heart Fail 2:549-55. 2009
    ..A comprehensive comparison on clinical and prognostic validity of the 2 techniques has not been performed and is the aim of the present investigation...
  40. ncbi Normalization for peak oxygen uptake increases the prognostic power of the ventilatory response to exercise in patients with chronic heart failure
    Marco Guazzi
    Istituto di Cardiologia, Universita degli Studi di Milano, Milan, Italy
    Am Heart J 146:542-8. 2003
    ..We hypothesized that the prognostic value of a high VE/VCO2 slope may be improved by normalization for peak VO2 (VE/VCO2/VO2)...
  41. ncbi Alveolar-capillary membrane dysfunction in heart failure: evidence of a pathophysiologic role
    Marco Guazzi
    Department of Medicine and Surgery, University of Milan, Cardiopulmonary Laboratory, Cardiology Division, San Paolo Hospital, Via A Di Rudini 8, 20142 Milan, Italy
    Chest 124:1090-102. 2003
    ..This article reviews the putative mechanisms involved in the impairment in gas diffusion in CHF patients and provides a link between physiologic changes and clinical findings...
  42. pmc Sildenafil reduces L-NAME-induced severe hypertension and worsening of myocardial ischaemia-reperfusion damage in the rat
    G Rossoni
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Milan, Italy
    Br J Pharmacol 150:567-76. 2007
    ..We investigated whether sildenafil counteracts the cardiovascular alterations induced by N -nitro-L-arginine methyl ester (L-NAME) in the rat...
  43. ncbi Cardiomegaly as a possible cause of lung dysfunction in patients with heart failure
    P Agostoni
    Centro Cardiologico, Fondazione Monzino, IRCCS, Istituto di Cardiologia dell Universita degli Studi, Milan, Italy
    Am Heart J 140:e24. 2000
    ..Our hypothesis is that an enlarged heart may compete for space with the lungs, causing a restrictive pattern that is often seen in patients with chronic heart failure...
  44. ncbi The influence of diastolic and systolic function on exercise performance in heart failure due to dilated cardiomyopathy or ischemic heart disease
    M Pepi
    Istituto di Cardiologia dell Universita degli Studi, Centro Cardiologico Fondazione Monzino, IRCCS, Milan, Italy
    Eur J Heart Fail 1:161-7. 1999
    ..Peripheral adaptations and ventricular abnormalities influence physical performance in chronic heart failure. However, the role of the heart in determining exercise capacity has not been completely elucidated...
  45. pmc Does lung diffusion impairment affect exercise capacity in patients with heart failure?
    P G Agostoni
    Centro Cardiologico Monzino, IRCCS, Institute of Cardiology, University of Milan, Milan, Italy
    Heart 88:453-9. 2002
    ..To determine whether there is a relation between impairment of lung diffusion and reduced exercise capacity in chronic heart failure...
  46. ncbi Effects of simulated altitude-induced hypoxia on exercise capacity in patients with chronic heart failure
    P Agostoni
    Centro Cardiologico, Fondazione Monzino IRCCS, Istituto di Cardiologia dell Universita di Milano, Centro di Studio per le Ricerche Cardiovascolari del CNR, Milan, Italy
    Am J Med 109:450-5. 2000
    ..Patients with stable heart failure often wish to spend time at altitudes above those of their residence. However, it is not known whether they can safely tolerate ascent to high altitudes or what its effects on work capacity may be...
  47. ncbi How the left and right sides of the heart, as well as pulmonary venous drainage, adapt to an increasing degree of head-up tilting in hypertrophic cardiomyopathy: differences from the normal heart
    M Guazzi
    Istituto di Cardiologia dell Universita degli Studi, Centro Cardiologico, IRCCS, Centro di Studio Ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Milano, Italy
    J Am Coll Cardiol 36:185-93. 2000
    ..We aimed to assess the differences in the adaptive response of patients with hypertrophic cardiomyopathy (HCM) compared with normal subjects, as well as any association with increased susceptibility to the test...
  48. ncbi Angiotensin-converting enzyme inhibition restores the diffusing capacity for carbon monoxide in patients with chronic heart failure by improving the molecular diffusion across the alveolar capillary membrane
    M Guazzi
    Istituto di Cardiologia dell Universita degli Studi, Centro di Studio per le Ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Fondazione Monzino, I R C C S, Via C Parea 4, 20138 Milan, Italy
    Clin Sci (Lond) 96:17-22. 1999
    ....
  49. ncbi Oxygen consumption
    P G Agostoni
    Istituto di Cardiologia, Universita degli Studi, Centro Cardiologico Fondazione Monzino, IRCCS, Milano
    Cardiologia 44:987-92. 1999
    ..We specifically describe changes in VO2 during simulated altitude; we also contemplate mechanisms governing oxygen diffusion from capillary bed to mitochondria and critical capillary PO2 concept...
  50. ncbi Synergistic efficacy of enalapril and losartan on exercise performance and oxygen consumption at peak exercise in congestive heart failure
    M Guazzi
    Istituto di Cardiologia dell Universita degli Studi, Centro di Studio per le Ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Fondazione Monzino, I R C C S, Milan, Italy
    Am J Cardiol 84:1038-43. 1999
    ..Thus, lorsartan and enalapril similarly increased peak VO2 in CHF patients, but mediators of this effect were, at least in part, different therapeutic targets that may be synergistic when the 2 drugs are combined...
  51. ncbi Pulmonary function, cardiac function, and exercise capacity in a follow-up of patients with congestive heart failure treated with carvedilol
    M Guazzi
    Istituto di Cardiologia dell Universita degli Studi, Centro di Studio per le Ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Fondazione Monzino, IRCCS, Milano, Italy
    Am Heart J 138:460-7. 1999
    ..This study was aimed at investigating the pulmonary response to changes in LV performance produced by carvedilol in patients with chronic heart failure...
  52. ncbi The behaviour of the flow-mediated brachial artery vasodilatation during orthostatic stress in normal man
    M Guazzi
    Department of Medicine and Surgery, Cardiopulmonary Laboratory, University of Milan, Cardiology Division, St Paolo Hospital, Milan, Italy
    Acta Physiol Scand 182:353-60. 2004
    ..This subject deserves investigation for two main reasons: humans spend the larger part of their life in the upright position; this position has significant effects on neural vascular regulation...
  53. ncbi Insulin improves alveolar-capillary membrane gas conductance in type 2 diabetes
    Marco Guazzi
    Institute of Cardiology, University of Milan, Milan, Italy
    Diabetes Care 25:1802-6. 2002
    ..An influence of insulin, per se, on the alveolar-capillary membrane conductance is unexplored. We aimed at testing this possibility...
  54. ncbi Effect of non-insulin-dependent diabetes mellitus on pulmonary function and exercise tolerance in chronic congestive heart failure
    Marco Guazzi
    Istituto di Cardiologia dell Universita degli Studi, Centro di Studio per le Ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Centro Cardiologico, I R C C S, Milan, Italy
    Am J Cardiol 89:191-7. 2002
    ..Thus, coexistence of NIDDM makes pulmonary dysfunction worse in CHF, and significantly enhances exercise intolerance...
  55. doi Tricuspid annular plane systolic excursion and pulmonary arterial systolic pressure relationship in heart failure: an index of right ventricular contractile function and prognosis
    M Guazzi
    Heart Failure Unit, Department of Cardiology, University of Milano, Istituto Di Ricovero e Cura a Carattere Scientifico IRCCSPoliclinico San Donato, Milano, Italy
    Am J Physiol Heart Circ Physiol 305:H1373-81. 2013
    ..The TAPSE vs. PASP relationship as a possible index of the length-force relationship may be a step forward for a more efficient RV function evaluation and is not affected by the quality of LV dysfunction...
  56. ncbi Modulation of alveolar-capillary sodium handling as a mechanism of protection of gas transfer by enalapril, and not by losartan, in chronic heart failure
    M Guazzi
    Istituto di Cardiologia dell Universita degli Studi, Centro di Studio per le Ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, IRCCS, Milano, Italy
    J Am Coll Cardiol 37:398-406. 2001
    ..We sought to compare the protective efficacy of enalapril and losartan on lung diffusion in chronic heart failure (CHF)...
  57. ncbi Lack of improvement of lung diffusing capacity following fluid withdrawal by ultrafiltration in chronic heart failure
    P G Agostoni
    Istituto di Cardiologia dell Universita degli Studi, Centro Cardiologico IRCCS, Centro di Studio per le Ricerche Cardiovascolari del CNR, Milan, Italy
    J Am Coll Cardiol 36:1600-4. 2000
    ..We sought to investigate the possibility that lung diffusing capacity reduction observed in chronic heart failure is reversible in the short term...
  58. ncbi Effects of acute angiotensin-converting enzyme inhibition on diastolic ventricular interaction in the dilated heart
    Mauro Pepi
    Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia dell Universita degli Studi, Milan, Italy
    Clin Cardiol 26:424-30. 2003
    ..The normal and dilated heart behaves as a single functional unit during preload reduction: volume unloading in the setting of diastolic ventricular interaction allows for increased left ventricular (LV) filling...
  59. doi Heart rate recovery and tissue Doppler echocardiography in heart failure
    Marco Guazzi
    Cardiopulmonary Laboratory, Cardiology Division, University of Milano, San Paolo Hospital, Milano, Italy
    Clin Cardiol 33:E61-4. 2010
    ..Previous research has demonstrated the prognostic value of echocardiography with tissue Doppler imaging (TDI) in the heart failure (HF) population. Heart rate recovery (HRR) has also recently shown promise as a prognostic marker...
  60. ncbi Diabetes worsens pulmonary diffusion in heart failure, and insulin counteracts this effect
    Marco Guazzi
    Istituto di Cardiologia dell Universita degli Studi, Milan, Italy
    Am J Respir Crit Care Med 166:978-82. 2002
    ....
  61. ncbi Decrease by ACE-inhibition of the excessive alveolar-capillary membrane resistance to gas transfer in chronic heart failure
    M Guazzi
    Istituto di Cardiologia, Universita degli Studi, Milano
    Cardiologia 43:625-30. 1998
    ....
  62. doi Echocardiography with Tissue Doppler Imaging and cardiopulmonary exercise testing in patients with heart failure: a correlative and prognostic analysis
    Marco Guazzi
    University of Milano, San Paolo Hospital, Cardiopulmonary Laboratory, Cardiology Division, Milano, Italy
    Int J Cardiol 143:323-9. 2010
    ..peak oxygen consumption (VO2). The present investigation undertakes a more thorough correlative and prognostic assessment...
  63. ncbi Alveolar--capillary membrane gas conductance: a novel prognostic indicator in chronic heart failure
    M Guazzi
    Centro Cardiologico, I R C C S, Centro di Studio Ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Istituto di Cardiologia dell Università, Milan, Italy
    Eur Heart J 23:467-76. 2002
    ..We aimed to evaluate the prognostic value of lung function tests in a population of patients with stable chronic heart failure...
  64. ncbi Aspirin worsens exercise performance and pulmonary gas exchange in patients with heart failure who are taking angiotensin-converting enzyme inhibitors
    M Guazzi
    Istituto di Cardiologie dellUniversità degli Studi, Centro di Studio per le Ricerhe Cardiovascolari del Consiglio Nazionale delle Ricerche, Fondazione Monzine, IRCCS, Milan, Italy
    Am Heart J 138:254-60. 1999
    ..This suggests the possibility that aspirin may disturb the pulmonary function and exercise ability in CHF, at least in those patients who are taking ACE inhibitors. This study was aimed at probing this hypothesis...
  65. ncbi Exercise intolerance in rats with hypertensive heart disease is associated with impaired diastolic relaxation
    M Guazzi
    Institute of Cardiology, University of Milan, Milan, Italy
    Hypertension 37:204-8. 2001
    ..However, studies in which LV function is assessed during exercise are needed to conclusively define the roles of systolic and diastolic dysfunction in causing exercise intolerance...
  66. pmc Influence of ACE-inhibition on salt-mediated worsening of pulmonary gas exchange in heart failure
    M Guazzi
    Istituto di Cardiologia dell Universita degli Studi, Centro Ricerche Cardiovascolari del CNR, Centro Cardiologico, I R C C S, Milano, Italy
    Br J Clin Pharmacol 51:482-7. 2001
    ..We investigated whether enalapril can readjust the capillary permeability to sodium...
  67. ncbi Impedance to gas transfer across the alveolar-capillary membrane in chronic cardiac failure
    M Guazzi
    Institute of Cardiology, University of Milan, Italy
    Ital Heart J 1:169-73. 2000
    ..The evidence relating to the pathophysiological and clinical significance of the impairment in lung diffusion capacity in patients with chronic heart failure, as well as the response to treatment are the main subjects of this review...
  68. ncbi Influences of sildenafil on lung function and hemodynamics in patients with chronic heart failure
    Marco Guazzi
    Cardiopulmonary Laboratory, Cardiology Division, and Respiratory Unit, University of Milan, Italy
    Clin Pharmacol Ther 76:371-8. 2004
    ..Whether enhancement of NO availability is beneficial with regard to these functions has not been explored. Phosphodiesterase 5 inhibitors, such as sildenafil, may provide a tool with which to test this possibility...
  69. ncbi Exercise ventilation inefficiency in heart failure: pathophysiological and clinical significance
    Gabriele Tumminello
    Cardiopulmonary Unit, Cardiology Division, University of Milano, San Paolo Hospital, Milano, Italy
    Eur Heart J 28:673-8. 2007
    ..The precise mechanisms sustaining exercise periodic breathing are not fully defined but ventilatory and metabo-haemodynamic hypotheses have been proposed...
  70. doi Cardiopulmonary exercise testing variables reflect the degree of diastolic dysfunction in patients with heart failure-normal ejection fraction
    Marco Guazzi
    Cardiology Division, University of Milano, San Paolo Hospital, Milan, Italy
    J Cardiopulm Rehabil Prev 30:165-72. 2010
    ..The purpose of the present investigation was to perform a comparative analysis between echocardiography with TDI and CPX in patients with HF and normal ejection fraction (NEF)...
  71. doi Phosphodiesterase-5 inhibition abolishes neuron apoptosis induced by chronic hypoxia independently of hypoxia-inducible factor-1alpha signaling
    Anna Caretti
    University of Milan, San Paolo Hospital, via di Rudinì 8 I 20142 Milan, Italy
    Exp Biol Med (Maywood) 233:1222-30. 2008
    ..0002) and P-p38 (P = 0.004). We conclude that upregulating the NO/cGMP pathway by PDE-5 inhibition during hypoxia reduces neuron apoptosis, regardless of HIF-1alpha, through an interaction involving ERK1/2 and p38...
  72. ncbi Monitoring gas exchange during a constant work rate exercise in patients with left ventricular dysfunction treated with carvedilol
    M Guazzi
    Istituto di Cardiologia dell Universita degli Studi, Centro di Studio per le Richerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Milan, Italy
    Am J Cardiol 85:660-4, A10. 2000
    ..Persistence of respiratory incompetence may prevent improvement in submaximal oxygen uptake kinetics...
  73. doi Alveolar gas diffusion abnormalities in heart failure
    Marco Guazzi
    Cardiopulmonary Unit, University of Milano, San Paolo Hospital, Milano, Italy
    J Card Fail 14:695-702. 2008
    ..This review focuses on the current knowledge of these topics...
  74. ncbi [Cardiocirculatory effects of insulin in patients with heart failure]
    Gabriele Tumminello
    Laboratorio di Fisiopatologia Cardiopolmonare, Dipartimento di Medicina e Chirurgia, Universita degli Studi, Ospedale San Paolo, Milano
    Ital Heart J Suppl 4:368-74. 2003
    ..The present review focuses on the pathophysiological mechanisms underlying the insulin benefits, and emphasizes the hormone therapeutic applicability in a CHF setting...
  75. ncbi The impact of pharmacotherapy on the cardiopulmonary exercise test response in patients with heart failure: a mini review
    Marco Guazzi
    Cardiopulmonary Laboratory, Cardiology Division, University of Milano, San Paolo Hospital, Milano, Italy
    Curr Vasc Pharmacol 7:557-69. 2009
    ..Summarize the present body of evidence addressing the change in CPX in response to different pharmacologic interventions including beta-blockade, renin-angiotensin-aldosterone axis inhibition and sildenafil...
  76. ncbi Alveolar-capillary membrane dysfunction in chronic heart failure: pathophysiology and therapeutic implications
    M Guazzi
    Istituto di Cardiologia dell Universita degli Studi, Centro di Studio per le Ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Centro Cardiologico, I R C C S, Milan, Italy
    Clin Sci (Lond) 98:633-41. 2000
    ..This review examines the pathophysiological and clinical significance of assessing lung diffusion capacity in patients with CHF...
  77. ncbi Angiotensin-converting enzyme inhibition facilitates alveolar-capillary gas transfer and improves ventilation-perfusion coupling in patients with left ventricular dysfunction
    M Guazzi
    Istituto di Cardiologia dell Universita degli Studi, Centro di Studio per le Ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Fondazione Monzino, IRCCS
    Clin Pharmacol Ther 65:319-27. 1999
    ..Because the angiotensin-converting enzyme (ACE) is highly concentrated in the vascular endothelium of the lungs, we examined whether ACE inhibitors may influence the pulmonary function in patients with congestive heart failure...
  78. ncbi Aspirin-angiotensin-converting enzyme inhibitor coadministration and mortality in patients with heart failure: a dose-related adverse effect of aspirin
    Marco Guazzi
    Istituto di Cardiologia, Universita degli Studi di Milano, Milan, Italy
    Arch Intern Med 163:1574-9. 2003
    ..Two major unresolved issues in patients with CHF are whether these agents together can affect mortality and whether the interaction is related with the dose of aspirin. We aimed at exploring these possibilities...
  79. doi Permanent atrial fibrillation affects exercise capacity in chronic heart failure patients
    Piergiuseppe Agostoni
    Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia, Universita di Milano, Via Parea 4, 20138 Milano, Italy
    Eur Heart J 29:2367-72. 2008
    ..The influence of permanent atrial fibrillation on exercise tolerance and cardio-respiratory function during exercise in heart failure (HF) is unknown...
  80. ncbi Asymmetric dimethylarginine (ADMA) induces vascular endothelium impairment and aggravates post-ischemic ventricular dysfunction in rats
    Vito De Gennaro Colonna
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Via Vanvitelli 32, Italy
    Eur J Pharmacol 557:178-85. 2007
    ..The increased plasma levels of ADMA presumably cause endothelial dysfunction because of a deficiency in NO production, which also appears involved in the aggravation of myocardial ischemia-reperfusion injury...
  81. ncbi Oxygen transport in blood at high altitude: role of the hemoglobin-oxygen affinity and impact of the phenomena related to hemoglobin allosterism and red cell function
    Michele Samaja
    Dipartimento di Medicina, Chirurgia e Odontoiatria, Ospedale San Paolo, Universita di Milano, Via di Rudini 8, 20142 Milan, Italy
    Eur J Appl Physiol 90:351-9. 2003
    ....
  82. doi Effect of enalapril on exercise cardiopulmonary performance in chronic obstructive pulmonary disease: A pilot study
    Fabiano Di Marco
    Clinica di Malattie dell Apparato Respiratorio, Ospedale San Paolo, Università degli Studi di, 20142 Milano, Italy
    Pulm Pharmacol Ther 23:159-64. 2010
    ..Secondary outcomes were exercise variables evaluated by the cardiopulmonary exercise test, and pulmonary function according to ACE genotyping...
  83. ncbi Carvedilol reduces the inappropriate increase of ventilation during exercise in heart failure patients
    Piergiuseppe Agostoni
    Centro Cardiologico, Monzino, Istituto di Ricovero e Cura a Carattere Scientifico, Istituto di Cardiologia, Universita di Milano, Via Parea 4, 20138 Milan, Italy
    Chest 122:2062-7. 2002
    ....
  84. doi Effects of treatment strategy on endothelial function
    L Tomasoni
    IRCCS Galeazzi Orthopedic Institute, Department of Health Technologies, Universita di Milano, Milan, Italy
    Autoimmun Rev 9:840-4. 2010
    ..This review focuses on the ancillary effects of hypertensive drugs and HMGCoA-reductase inhibitors that go beyond lowering blood pressure and cholesterol levels...
  85. ncbi Impaired brachial artery endothelial flow-mediated dilation and orthostatic stress in hemodialysis patients
    M Gallieni
    Nephrology and Dialysis Unit, San Paolo Hospital, University of Milan, Milan Italy
    Int J Artif Organs 31:34-42. 2008
    ..We assessed endothelial function via brachial artery flow-mediated dilation (BAFMD), an index of endothelial-dependent vasodilation...
  86. doi Six months of Sildenafil therapy improves heart rate recovery in patients with heart failure
    Marco Guazzi
    University of Milano, San Paolo Hospital, Cardiopulmonary Laboratory, Cardiology Division, University of Milano, San Paolo Hospital, Milano, Italy
    Int J Cardiol 136:341-3. 2009
    ..A plausible mechanism for the improvement of HRR is the previously demonstrated impact Sildenafil has on arterial stiffness and therefore baroreceptor function...
  87. ncbi Comparison of the prognostic value of cardiopulmonary exercise testing between male and female patients with heart failure
    Marco Guazzi
    University of Milano, San Paolo Hospital, Cardiology Division, Italy
    Int J Cardiol 113:395-400. 2006
    ..Studies investigating the prognostic value of CPX in individuals with HF have consistently examined predominantly male groups. The purpose of the present study was to examine the prognostic value of CPX in a female HF group...
  88. ncbi Cardiac and renal dysfunction in chronic heart failure: relation to neurohumoral activation and prognosis
    G Marenzi
    IRCCS, Institute of Cardiology, University of Milan, Italy
    Am J Med Sci 321:359-66. 2001
    ..We investigated the relationship between both cardiac and renal dysfunction and neurohumoral activation, and their possible influence on prognosis...
  89. ncbi The added prognostic value of ventilatory efficiency to the Weber classification system in patients with heart failure
    Marco Guazzi
    University of Milano, San Paolo Hospital Cardiopulmonary Laboratory, Cardiology Division University of Milano, San Paolo Hospital Milano, Italy
    Int J Cardiol 129:86-92. 2008
    ..The purpose of the current study was to assess the added prognostic value of the minute ventilation/carbon dioxide production (VE/VCO(2)) slope to the Weber classification system in patients diagnosed with heart failure (HF)...
  90. ncbi Prognostic characteristics of cardiopulmonary exercise testing in heart failure: comparing American and European models
    Ross Arena
    Department of Physical Therapy, Virginia Commonwealth University, Health Sciences Campus, Richmond, Virginia, USA
    Eur J Cardiovasc Prev Rehabil 12:562-7. 2005
    ..The purpose of the present study was to compare the prognostic characteristics of peak oxygen consumption (VO2) and the minute ventilation-carbon dioxide production (VE/VCO2) slope between two independent heart failure groups...
  91. ncbi Prognostic value of heart rate recovery in patients with heart failure
    Ross Arena
    Department of Physical Therapy, Virginia Commonwealth University, Health Sciences Campus, Richmond, VA 23298 0224, USA
    Am Heart J 151:851.e7-13. 2006
    ..We sought to assess the prognostic utility of heart rate recovery (HRR) in patients with HF...
  92. ncbi [Alveolar-capillary dysfunction in heart failure]
    Stefano De Vita
    Istituto di Cardiologia Università degli Studi Via Parea, 4 20138 Milano
    Ital Heart J Suppl 3:1022-6. 2002
    ..This review examines the current knowledge on this topic...
  93. ncbi Prognostic value of end-tidal carbon dioxide during exercise testing in heart failure
    Ross Arena
    Department of Physical Therapy, Box 980224, Virginia Commonwealth University, Health Sciences Campus, Richmond, Virginia 23298 0224, United States
    Int J Cardiol 117:103-8. 2007
    ....
  94. ncbi Letter by Guazzi regarding article "Sleep and exertional periodic breathing in chronic heart failure: prognostic importance and interdependence"
    Marco Guazzi
    Circulation 114:e53; author reply e54. 2006
  95. ncbi Increased mechanoreceptor/metaboreceptor stimulation explains the exaggerated exercise pressor reflex seen in heart failure
    Marco Guazzi
    J Appl Physiol 102:498; author reply 504-5. 2007
  96. ncbi Letter by Guazzi and Reina regarding article, "Aspirin use and outcomes in a community-based cohort of 7352 patients discharged after first hospitalization for heart failure"
    Marco Guazzi
    Circulation 115:e54; author reply e55. 2007
  97. ncbi The prognostic value of ventilatory efficiency with beta-blocker therapy in heart failure
    Ross A Arena
    Department of Physical Therapy, Virginia Commonwealth University, Richmond, VA 23298 0224, USA
    Med Sci Sports Exerc 39:213-9. 2007
    ..The impact this pharmacological approach has on the prognostic information gained from cardiopulmonary exercise testing (CPX) is, however, unclear...
  98. doi The ventilatory classification system effectively predicts hospitalization in patients with heart failure
    Ross Arena
    Department of Physical Therapy, Physiology, and Internal Medicine, Virginia Commonwealth University, Health Sciences Campus, Richmond, VA 23298, USA
    J Cardiopulm Rehabil Prev 28:195-8. 2008
    ....
  99. doi Prognostic value of timing and duration characteristics of exercise oscillatory ventilation in patients with heart failure
    Ross Arena
    Department of Physical Therapy, Virginia Commonwealth University, Health Sciences Campus, Richmond, Virginia 23298 0224, USA
    J Heart Lung Transplant 27:341-7. 2008
    ..The purpose of this investigation was to examine the prognostic value of the largest ventilatory oscillation characteristics in HF patients...
  100. doi Relation of the prognostic value of ventilatory efficiency to body mass index in patients with heart failure
    Paul Chase
    LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina, USA
    Am J Cardiol 101:348-52. 2008
    ..In conclusion, the findings of the present study indicate that VE/VCO2 slope maintains prognostic value irrespective of BMI in patients with HF...
  101. doi Prognostic usefulness of dyspnea versus fatigue as reason for exercise test termination in patients with heart failure
    Paul Chase
    LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina, USA
    Am J Cardiol 102:879-82. 2008
    ..02). In conclusion, these results indicate that patients with HF terminating an exercise test primarily because of dyspnea have an increased incidence of cardiac-related events and poorer CPX markers than those limited by fatigue...