L Guasti

Summary

Affiliation: University of Insubria
Country: Italy

Publications

  1. pmc Angiotensin II type 1 and type 2 receptor expression in circulating monocytes of diabetic and hypercholesterolemic patients over 3-month rosuvastatin treatment
    Franca Marino
    Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy
    Cardiovasc Diabetol 11:153. 2012
  2. ncbi request reprint Changes in pain perception during treatment with angiotensin converting enzyme-inhibitors and angiotensin II type 1 receptor blockade
    Luigina Guasti
    Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy
    J Hypertens 20:485-91. 2002
  3. ncbi request reprint Circadian blood pressure variability is associated with autonomic and baroreflex-mediated modulation of the sinoatrial node
    Luigina Guasti
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Acta Cardiol 60:319-24. 2005
  4. ncbi request reprint Mixed cranial nerve neuroma revealing itself as baroreflex failure
    Luigina Guasti
    Internal Medicine, Department of Clinical Medicine University of Insubria, Ospedale di Circolo Viale Borri 57, 21100 Varese, Italy
    Auton Neurosci 130:57-60. 2006
  5. ncbi request reprint Hypertension-related hypoalgesia, autonomic function and spontaneous baroreflex sensitivity
    Luigina Guasti
    Department of Clinical and Biological Sciences, University of Insubria, Ospedale di Circolo, Varese, Italy
    Auton Neurosci 99:127-33. 2002
  6. ncbi request reprint Simvastatin treatment modifies polymorphonuclear leukocyte function in high-risk individuals: a longitudinal study
    Luigina Guasti
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    J Hypertens 24:2423-30. 2006
  7. ncbi request reprint Changes in autonomic modulation to the heart and intracellular catecholamines. A longitudinal study in differentiated thyroid carcinoma during short-term hypothyroidism and thyroid hormone replacement
    L Guasti
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Horm Res 67:171-8. 2007
  8. pmc An unusual case presenting with hypertensive crisis
    L Guasti
    Department of Clinical Medicine, University of Insubria Ospedale di Circolo, Viale Borri 57, I 21100, Varese, Italy
    Intern Emerg Med 2:29-32. 2007
  9. ncbi request reprint Autonomic function and baroreflex sensitivity during angiotensin-converting enzyme inhibition or angiotensin II AT-1 receptor blockade in essential hypertensive patients
    L Guasti
    Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy
    Acta Cardiol 56:289-95. 2001
  10. ncbi request reprint Pain perception, blood pressure levels, and peripheral benzodiazepine receptors in patients followed for differentiated thyroid carcinoma: a longitudinal study in hypothyroidism and during hormone treatment
    Luigina Guasti
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Clin J Pain 23:518-23. 2007

Collaborators

Detail Information

Publications45

  1. pmc Angiotensin II type 1 and type 2 receptor expression in circulating monocytes of diabetic and hypercholesterolemic patients over 3-month rosuvastatin treatment
    Franca Marino
    Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy
    Cardiovasc Diabetol 11:153. 2012
    ..We sought to investigate the potential changes of AT1R-AT2R expression in human monocytes of type 2 diabetic- hypercholesterolemic patients and in hypercholesterolemic subjects, upon clinical treatment with rosuvastatin...
  2. ncbi request reprint Changes in pain perception during treatment with angiotensin converting enzyme-inhibitors and angiotensin II type 1 receptor blockade
    Luigina Guasti
    Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy
    J Hypertens 20:485-91. 2002
    ..The study was approved by the ethical committee of our Department...
  3. ncbi request reprint Circadian blood pressure variability is associated with autonomic and baroreflex-mediated modulation of the sinoatrial node
    Luigina Guasti
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Acta Cardiol 60:319-24. 2005
    ..The aim of this study was to investigate whether the nocturnal BP reduction was associated with the autonomic and baroreflex-mediated modulation of the sinoatrial node in normotensive and hypertensive subjects...
  4. ncbi request reprint Mixed cranial nerve neuroma revealing itself as baroreflex failure
    Luigina Guasti
    Internal Medicine, Department of Clinical Medicine University of Insubria, Ospedale di Circolo Viale Borri 57, 21100 Varese, Italy
    Auton Neurosci 130:57-60. 2006
    ..Given the clinical suspicion of baroreflex failure, even in the absence of iatrogenic clues, we propose that the patient's study should include neuroradiologic evaluation of the ponto-cerebellar angulus...
  5. ncbi request reprint Hypertension-related hypoalgesia, autonomic function and spontaneous baroreflex sensitivity
    Luigina Guasti
    Department of Clinical and Biological Sciences, University of Insubria, Ospedale di Circolo, Varese, Italy
    Auton Neurosci 99:127-33. 2002
    ..This study has sought to investigate whether the spontaneous baroreflex sensitivity and the autonomic nervous system balance are related to hypertension-associated hypoalgesia...
  6. ncbi request reprint Simvastatin treatment modifies polymorphonuclear leukocyte function in high-risk individuals: a longitudinal study
    Luigina Guasti
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    J Hypertens 24:2423-30. 2006
    ....
  7. ncbi request reprint Changes in autonomic modulation to the heart and intracellular catecholamines. A longitudinal study in differentiated thyroid carcinoma during short-term hypothyroidism and thyroid hormone replacement
    L Guasti
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Horm Res 67:171-8. 2007
    ..The effects of thyroid deprivation on the autonomic modulation to the heart remain controversial...
  8. pmc An unusual case presenting with hypertensive crisis
    L Guasti
    Department of Clinical Medicine, University of Insubria Ospedale di Circolo, Viale Borri 57, I 21100, Varese, Italy
    Intern Emerg Med 2:29-32. 2007
  9. ncbi request reprint Autonomic function and baroreflex sensitivity during angiotensin-converting enzyme inhibition or angiotensin II AT-1 receptor blockade in essential hypertensive patients
    L Guasti
    Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy
    Acta Cardiol 56:289-95. 2001
    ..The influence of ACE-inhibition and angiotensin II ATI receptor blockade on the autonomic function and baroreflex sensitivity was investigated in hypertension...
  10. ncbi request reprint Pain perception, blood pressure levels, and peripheral benzodiazepine receptors in patients followed for differentiated thyroid carcinoma: a longitudinal study in hypothyroidism and during hormone treatment
    Luigina Guasti
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Clin J Pain 23:518-23. 2007
    ..Moreover, a few experimental studies show that peripheral benzodiazepine receptors (PBRs), which may be altered in hypothyroidism, seem to be related with pain perception...
  11. doi request reprint Prolonged statin-associated reduction in neutrophil reactive oxygen species and angiotensin II type 1 receptor expression: 1-year follow-up
    Luigina Guasti
    Department of Clinical Medicine, University of Insubria, Viale Borri 57, Varese 21100, Italy
    Eur Heart J 29:1118-26. 2008
    ..Our study investigated reactive oxygen species (ROS) generation and angiotensin II type 1 receptor (AT(1)-R) expression in primed polymorphonuclear leukocytes (PMNs) of dyslipidaemic subjects over prolonged statin treatment...
  12. doi request reprint Cytokine production from peripheral blood mononuclear cells and polymorphonuclear leukocytes in patients studied for suspected obstructive sleep apnea
    Luigina Guasti
    Research Center on Dyslipidemia, Department of Clinical Medicine, University of Insubria, Viale Borri 57, Varese, 21100, Italy
    Sleep Breath 15:3-11. 2011
    ..We sought to determine cellular tumor necrosis factor-alpha (TNF-α) production from peripheral blood mononuclear cells (PBMCs) and interleukin (IL)-8 release from neutrophils (PMNs) in patients studied for suspected OSA...
  13. doi request reprint Lack of relationship between cardiovascular reactivity to mental stress and autonomic modulation of the sinoatrial node in normotensive and hypertensive male subjects
    Luigina Guasti
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Int J Psychophysiol 71:258-63. 2009
    ..Thus, the cardiovascular response to a mental stimulus appears to prevail over the baseline pattern of cardiovascular regulation independently of the presence or absence of the hypertensive disease...
  14. doi request reprint Components of arterial systolic pressure and RR-interval oscillation spectra in a case of baroreflex failure, a human open-loop model of vascular control
    L Guasti
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    J Hum Hypertens 24:417-26. 2010
    ..The synchronization in LF band is a hallmark of integrity of baroreflex arc whose impairment unmasks lower frequency rhythms in SAP and RR whose fluctuations oscillate independently...
  15. ncbi request reprint Global link between heart rate and blood pressure oscillations at rest and during mental arousal in normotensive and hypertensive subjects
    Luigina Guasti
    Dept of Clinical Medicine, University of Insubria, Viale Borri 57, Varese 21100, Italy
    Auton Neurosci 120:80-7. 2005
    ..As a secondary endpoint, we evaluated the potential changes of the components of heart rate and blood pressure variability during stress...
  16. ncbi request reprint Microalbuminuria in never-treated hypertensives: lack of relationship to hyperinsulinemia and genetic predisposition to hypertension
    A M Grandi
    Department of Clinical and Biological Sciences, Faculty of Medicine, University of Insubria, Varese, Italy
    Am J Hypertens 13:353-8. 2000
    ....
  17. ncbi request reprint Obesity and left ventricular diastolic function: noninvasive study in normotensives and newly diagnosed never-treated hypertensives
    A M Grandi
    Internal Medicine, Department of Clinical and Biological Sciences, Faculty of Medicine, University of Insubria, Varese, Italy
    Int J Obes Relat Metab Disord 24:954-8. 2000
    ..To evaluate the influence of obesity, per se or associated with hypertension, on left ventricular (LV) diastolic function...
  18. ncbi request reprint Microalbuminuria as a marker of preclinical diastolic dysfunction in never-treated essential hypertensives
    A M Grandi
    Department of Clinical and Biological Sciences, Faculty of Medicine, University of Insubria, Varese, Italy
    Am J Hypertens 14:644-8. 2001
    ..This relation, independent from increased BP or LV mass, strengthens the role of microalbuminuria as an early and reliable marker of preclinical cardiac involvement...
  19. ncbi request reprint Autonomic function and baroreflex sensitivity during a normal ovulatory cycle in humans
    L Guasti
    Chair of Internal Medicine, University of Insubria, Varese, Italy
    Acta Cardiol 54:209-13. 1999
    ..On the contrary, the baroreceptor function seems to be scarcely influenced by the two phases of the menstrual cycle...
  20. ncbi request reprint Ambulatory blood pressure, nocturnal blood pressure reduction and plasma catecholamines
    L Guasti
    Chair of Internal Medicine, University of Pavia, Varese, Italy
    Acta Cardiol 52:485-94. 1997
    ..The correlation between dopamine and nocturnal blood pressure fall seems to indicate that the impairment of dopaminergic system may influence the 24-hour blood pressure profile, affecting the nocturnal blood pressure reduction...
  21. ncbi request reprint Left ventricular changes in isolated office hypertension: a blood pressure-matched comparison with normotension and sustained hypertension
    A M Grandi
    Department of Clinical and Biological Sciences, Faculty of Medicine, University of Insubria, Varese, Italy
    Arch Intern Med 161:2677-81. 2001
    ..The 3 groups were matched not only by age, sex, and body mass index but also by clinic blood pressure (BP) (IO hypertensives and sustained hypertensives) and daytime BP (IO hypertensives and normotensives)...
  22. doi request reprint Left ventricular remodeling in patients with metabolic syndrome: influence of gender
    E Nicolini
    Ospedale di Circolo Fondazione Macchi, Varese, Italy
    Nutr Metab Cardiovasc Dis 23:771-5. 2013
    ..The study was aimed to evaluate the influence of gender on left ventricular (LV) remodeling in metabolic syndrome (MetS)...
  23. ncbi request reprint Thyroid hormone and thyrotropin regulate intracellular free calcium concentrations in human polymorphonuclear leukocytes: in vivo and in vitro studies
    F Marino
    Department of Clinical Medicine, University of Insubria, Via Ottorino Rossi n 9, 21100 Varese VA Italy
    Int J Immunopathol Pharmacol 19:149-60. 2006
    ..T3, rT3, and TRIAC had no effect. In conclusion, this study provides evidence for a direct relationship between thyroid status and (Ca++)i homeostasis in human PMNs, mainly related to direct actions of TSH and T4 on these cells...
  24. ncbi request reprint Relationship between left ventricular diastolic function and atrial natriuretic factor in never-treated mild hypertensives
    A M Grandi
    Department of Clinical and Biological Sciences, II Faculty of Medicine, University of Pavia, Varese, Italy
    Am J Hypertens 10:946-50. 1997
    ....
  25. ncbi request reprint Longitudinal changes of insulin sensitivity in essential hypertension: influence of blood pressure control and familial predisposition to hypertension
    A M Grandi
    Department of Clinical and Biological Sciences, Faculty of Medicine, University of Insubria, 21100 Varese, Italy
    J Clin Endocrinol Metab 86:3027-31. 2001
    ..A persistently high BP has a negative influence on insulin sensitivity in F+ and F-; this influence is greater when high BP is associated with a familial predisposition to hypertension...
  26. ncbi request reprint One-year antihypertensive treatment with amlodipine: effects on 24-hour blood pressure and left ventricular anatomy and function
    M Bignotti
    Department of Internal Medicine and Medical Therapy, University of Pavia, Ospedale di Circolo, Varese, Italy
    Acta Cardiol 50:135-42. 1995
    ..Amlodipine is able to induce regression of left ventricular diastolic function and no changes of systolic function...
  27. ncbi request reprint Angiotensin II type 1 receptor expression on human leukocyte subsets: a flow cytometric and RT-PCR study
    Emanuela Rasini
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Regul Pept 134:69-74. 2006
    ....
  28. ncbi request reprint Relation of extent of nocturnal blood pressure decrease to cardiovascular remodeling in never-treated patients with essential hypertension
    Anna M Grandi
    Internal Medicine, Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy
    Am J Cardiol 89:1193-6. 2002
    ....
  29. doi request reprint Pulmonary embolism severity index accurately predicts long-term mortality rate in patients hospitalized for acute pulmonary embolism
    F Dentali
    Department of Clinical Medicine, Insubria University, Varese, Italy
    J Thromb Haemost 11:2103-10. 2013
    ..PESI score has been validated in studies with a relatively short-term follow-up and its accuracy in predicting long-term prognosis has never been established...
  30. doi request reprint Left ventricular remodelling in asymptomatic HIV infection on chronic HAART: comparison between hypertensive and normotensive subjects with and without HIV infection
    A M Grandi
    Department of Clinical Medicine, University of Insubria, Ospedale di Circolo, Varese, Italy
    J Hum Hypertens 26:570-6. 2012
    ..Asymptomatic HIV infection and chronic HAART are associated with myocardial hypertrophy and preclinical diastolic dysfunction, independently of BP values...
  31. ncbi request reprint Masked hypertension in type 2 diabetes mellitus. Relationship with left-ventricular structure and function
    Chiara Marchesi
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Am J Hypertens 20:1079-84. 2007
    ..To evaluate in type 2 diabetes mellitus the relationship between masked hypertension (MH) and left ventricular (LV) morpho-functional characteristics...
  32. ncbi request reprint Angiotensin II type 1 receptor expression in polymorphonuclear leukocytes from high-risk subjects: changes after treatment with simvastatin
    Franca Marino
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    J Cardiovasc Pharmacol 49:299-305. 2007
    ..In conclusion, simvastatin induces downregulation of AT1R expression, interferes with Ang II activity in PMNs, and contributes to the antiinflammatory profile of statins that can explain the therapeutic effects of these drugs...
  33. doi request reprint Angiotensin type 1 receptor expression and interleukin-8 production in polymorphonuclear leukocytes of patients with peripheral arterial disease
    Franca Marino
    Department of Clinical Medicine, Section of Experimental and Clinical Pharmacology, University of Insubria, Varese VA, Italy
    J Cardiovasc Pharmacol 54:520-5. 2009
    ..In PAD patients, femoral endarterectomy is associated with reduction of AT1R expression however with no apparent effect on IL-8 production. The relevance of such effects for cardiovascular protection deserves consideration...
  34. doi request reprint Simvastatin treatment in subjects at high cardiovascular risk modulates AT1R expression on circulating monocytes and T lymphocytes
    Franca Marino
    Section of Experimental and Clinical Pharmacology, Department of Clinical Medicine, University of Insubria, Varese, Italy
    J Hypertens 26:1147-55. 2008
    ..Angiotensin II, through the activation of angiotensin II type 1 receptors, plays a crucial role in atherosclerosis. Statins may interfere with the effects of angiotensin II...
  35. ncbi request reprint Family history of hypertension influences left ventricular diastolic function during chronic antihypertensive therapy
    Anna M Grandi
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Am J Hypertens 20:410-5. 2007
    ..This study was aimed to evaluate whether genetic predisposition to hypertension can also influence left ventricular (LV) changes during antihypertensive treatment...
  36. ncbi request reprint Aldosterone antagonist improves diastolic function in essential hypertension
    Anna M Grandi
    Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy
    Hypertension 40:647-52. 2002
    ..This improvement, not accounted for by changes in blood pressure and left ventricular mass, can be therefore ascribed to a direct action of the drug on the myocardium...
  37. ncbi request reprint Natriuretic peptides as markers of preclinical cardiac disease in obesity
    A M Grandi
    University of Insubria, Varese, Italy
    Eur J Clin Invest 34:342-8. 2004
    ..Aim of the study was to evaluate the role of atrial (ANP) and brain natriuretic peptides (BNP) as markers of preclinical cardiac disease in obesity...
  38. doi request reprint Diagnostic accuracy of lung ultrasound for pulmonary embolism: a systematic review and meta-analysis
    A Squizzato
    Research Center on Thromboembolic Disorders and Antithrombotic Therapies, Department of Clinical and Experimental Medicine, University of Insubria, Viale Borri 57, Varese, Italy
    J Thromb Haemost 11:1269-78. 2013
    ..Among alternative imaging tests, lung ultrasound is the most promising technique. We aimed to systematically assess the diagnostic accuracy of lung ultrasound for PE diagnosis...
  39. doi request reprint Effects of dual blockade of Renin-Angiotensin system on concentric left ventricular hypertrophy in essential hypertension: a randomized, controlled pilot study
    Anna M Grandi
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Am J Hypertens 21:231-7. 2008
    ....
  40. ncbi request reprint Angiotensin-converting enzyme inhibitors influence left ventricular mass and function independently of the antihypertensive effect
    Anna Maria Grandi
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    J Cardiovasc Pharmacol 48:207-11. 2006
    ..In conclusion, our clinical study shows that ACE inhibitors can induce LV hypertrophy regression and improvement of diastolic function also in the absence of any antihypertensive effect...
  41. ncbi request reprint Metabolic syndrome and morphofunctional characteristics of the left ventricle in clinically hypertensive nondiabetic subjects
    Anna M Grandi
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Am J Hypertens 19:199-205. 2006
    ..The study was aimed to evaluate the impact of the metabolic syndrome on left ventricular (LV) structure and function in nondiabetic patients, never treated with antihypertensive or lipid-lowering drugs...
  42. ncbi request reprint Isolated office hypertension: a 3-year follow-up study
    Anna M Grandi
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Blood Press 14:298-305. 2005
    ..In conclusion, IO hypertensive patients show a high rate of progression towards sustained hypertension. Basal LV hypertrophy and/or preclinical diastolic dysfunction were the only markers of a greater risk of becoming hypertensives...
  43. ncbi request reprint Thyroid hormone regulation of cell migration and oxidative metabolism in polymorphonuclear leukocytes: clinical evidence in thyroidectomized subjects on thyroxine replacement therapy
    Franca Marino
    Department of Clinical Medicine, Section of Experimental and Clinical Pharmacology, University of Insubria, Via Ottorino Rossi n 9, 21100 Varese VA, Italy
    Life Sci 78:1071-7. 2006
    ..The present results document the existence of a correlation between thyroid status and oxidative metabolism of human PMNs, which is however unlikely to depend upon a direct action of thyroid hormones on these cells...
  44. ncbi request reprint Effect of glycemic control on left ventricular diastolic function in type 1 diabetes mellitus
    Anna M Grandi
    Department of Clinical Medicine, University of Insubria, Insubria, Italy
    Am J Cardiol 97:71-6. 2006
    ..Therefore, diastolic dysfunction can be prevented or reversed, at least partly, by tight glycemic control...
  45. ncbi request reprint Changes in plasma lipids during renin-angiotensin system blockade by combination therapy (enalapril plus valsartan) in patients with diabetes and hypertension
    Giovanni Gaudio
    Department of Biometry and Clinical Epidemiology, IRCCS Policlinico S Matteo, Pavia, Italy
    J Cardiovasc Pharmacol 45:362-6. 2005
    ..Thus, the greater degree of renin-angiotensin system blockade or specific pharmacodynamic effects of valsartan could account for the changes in plasma lipid profile observed in this study...