Paola Grimaldi

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi request reprint Molecular genetics of male infertility: stem cell factor/c-kit system
    Paola Grimaldi
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Universita degli Studi di Roma, Italy
    Am J Reprod Immunol 48:27-33. 2002
  2. ncbi request reprint Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population
    Francesca Lolicato
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy
    Dev Biol 313:725-38. 2008
  3. pmc Microgravity promotes differentiation and meiotic entry of postnatal mouse male germ cells
    Manuela Pellegrini
    Department of Public Health and Cellular Biology, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 5:e9064. 2010
  4. ncbi request reprint Cyclic adenosine monophosphate (cAMP) stimulation of the kit ligand promoter in sertoli cells requires an Sp1-binding region, a canonical TATA box, and a cAMP-induced factor binding to an immediately downstream GC-rich element
    Paola Grimaldi
    Department of Public Health and Cell Biology, Section of Anatomy, University of Rome Tor Vergata, 00133 Rome, Italy
    Biol Reprod 69:1979-88. 2003
  5. pmc The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis
    Paola Grimaldi
    Department of Public Health and Cellular Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    Proc Natl Acad Sci U S A 106:11131-6. 2009
  6. ncbi request reprint ATRA and KL promote differentiation toward the meiotic program of male germ cells
    Manuela Pellegrini
    Department of Public Health and Cellular Biology, University of Rome Tor Vergata, Rome
    Cell Cycle 7:3878-88. 2008
  7. pmc Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cells
    Claudia Compagnucci
    Department of Biomedicine and Prevention, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 8:e54271. 2013
  8. ncbi request reprint Transcriptome analysis of differentiating spermatogonia stimulated with kit ligand
    Pellegrino Rossi
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Universita degli Studi di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Gene Expr Patterns 8:58-70. 2008
  9. ncbi request reprint Analysis of the gene expression profile of mouse male meiotic germ cells
    Pellegrino Rossi
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Sezione di Anatomia, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Gene Expr Patterns 4:267-81. 2004
  10. ncbi request reprint Developmental expression of BMP4/ALK3/SMAD5 signaling pathway in the mouse testis: a potential role of BMP4 in spermatogonia differentiation
    Manuela Pellegrini
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Sezione di Anatomia, Universita di Roma Tor Vergata, Rome, Italy
    J Cell Sci 116:3363-72. 2003

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Molecular genetics of male infertility: stem cell factor/c-kit system
    Paola Grimaldi
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Universita degli Studi di Roma, Italy
    Am J Reprod Immunol 48:27-33. 2002
    ..In mice, mutations in the c-kit gene and in the gene encoding stem cell factor (SCF) cause pleiotropic defects among which sterility. A possible involvement of the SCF/c-kit system in human spermatogenesis was investigated...
  2. ncbi request reprint Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population
    Francesca Lolicato
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy
    Dev Biol 313:725-38. 2008
    ..These results allow to conclude that, in the prepuberal testis, Nanos3 is important to maintain undifferentiated spermatogonia via the regulation of their cell cycle...
  3. pmc Microgravity promotes differentiation and meiotic entry of postnatal mouse male germ cells
    Manuela Pellegrini
    Department of Public Health and Cellular Biology, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 5:e9064. 2010
    ..In conclusion, SM is an artificial environmental condition which promotes postnatal male germ cell differentiation and might provide a tool to study the molecular mechanisms underlying the switch from mitosis to meiosis in mammals...
  4. ncbi request reprint Cyclic adenosine monophosphate (cAMP) stimulation of the kit ligand promoter in sertoli cells requires an Sp1-binding region, a canonical TATA box, and a cAMP-induced factor binding to an immediately downstream GC-rich element
    Paola Grimaldi
    Department of Public Health and Cell Biology, Section of Anatomy, University of Rome Tor Vergata, 00133 Rome, Italy
    Biol Reprod 69:1979-88. 2003
    ....
  5. pmc The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis
    Paola Grimaldi
    Department of Public Health and Cellular Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    Proc Natl Acad Sci U S A 106:11131-6. 2009
    ....
  6. ncbi request reprint ATRA and KL promote differentiation toward the meiotic program of male germ cells
    Manuela Pellegrini
    Department of Public Health and Cellular Biology, University of Rome Tor Vergata, Rome
    Cell Cycle 7:3878-88. 2008
    ..These data suggest that RA may control the timing of meiosis by influencing both the somatic and the germ cell compartment of the postnatal testis through the activation of the KL/Kit system...
  7. pmc Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cells
    Claudia Compagnucci
    Department of Biomedicine and Prevention, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 8:e54271. 2013
    ..These results highlight the role of CB(1) in the regulation of NSC fate and suggest that its activation may represent a pro-neuronal differentiation signal...
  8. ncbi request reprint Transcriptome analysis of differentiating spermatogonia stimulated with kit ligand
    Pellegrino Rossi
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Universita degli Studi di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Gene Expr Patterns 8:58-70. 2008
    ....
  9. ncbi request reprint Analysis of the gene expression profile of mouse male meiotic germ cells
    Pellegrino Rossi
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Sezione di Anatomia, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Gene Expr Patterns 4:267-81. 2004
    ..These studies will help to delineate the global patterns of gene expression characterizing male germ cell differentiation for a better understanding of regulation of spermatogenesis in mammals...
  10. ncbi request reprint Developmental expression of BMP4/ALK3/SMAD5 signaling pathway in the mouse testis: a potential role of BMP4 in spermatogonia differentiation
    Manuela Pellegrini
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Sezione di Anatomia, Universita di Roma Tor Vergata, Rome, Italy
    J Cell Sci 116:3363-72. 2003
    ..As a result of the latter event, Kit-negative spermatogonia acquire sensitivity to Stem Cell Factor...
  11. doi request reprint Modulation of the endocannabinoid-degrading enzyme fatty acid amide hydrolase by follicle-stimulating hormone
    Paola Grimaldi
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome, Italy
    Vitam Horm 81:231-61. 2009
    ..Taken together, these data identify FAAH as the only target of FSH among the elements of the endocannabinoid system, with a critical impact on Sertoli cell proliferation, and thus spermatogenesis and male reproduction...
  12. doi request reprint The faah gene is the first direct target of estrogen in the testis: role of histone demethylase LSD1
    Paola Grimaldi
    Department of Public Health and Cellular Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    Cell Mol Life Sci 69:4177-90. 2012
    ..Finally, FAAH silencing abolished E(2) protection against apoptosis induced by the FAAH substrate anandamide. Taken together, our results identify FAAH as the first direct target of E(2)...