P Gresele

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. pmc Loss of matrix metalloproteinase 2 in platelets reduces arterial thrombosis in vivo
    Stefania Momi
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia 06100, Italy
    J Exp Med 206:2365-79. 2009
  2. pmc Outside-in signalling generated by a constitutively activated integrin αIIbβ3 impairs proplatelet formation in human megakaryocytes
    Loredana Bury
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    PLoS ONE 7:e34449. 2012
  3. pmc Alteration of liver enzymes is a feature of the MYH9-related disease syndrome
    Alessandro Pecci
    Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
    PLoS ONE 7:e35986. 2012
  4. doi request reprint In vivo platelet activation and platelet hyperreactivity in abacavir-treated HIV-infected patients
    Emanuela Falcinelli
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via E dal Pozzo, Perugia, Italy
    Thromb Haemost 110:349-57. 2013
  5. doi request reprint Endothelial and platelet function alterations in HIV-infected patients
    P Gresele
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Thromb Res 129:301-8. 2012
  6. doi request reprint Effect on walking distance and atherosclerosis progression of a nitric oxide-donating agent in intermittent claudication
    Paolo Gresele
    Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
    J Vasc Surg 56:1622-8, 1628.e1-5. 2012
  7. ncbi request reprint NCX4016: a novel antithrombotic agent
    P Gresele
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via Enrico Dal Pozzo, 06126 Perugia, Italy
    Dig Liver Dis 35:S20-6. 2003
  8. pmc Dominant inheritance of a novel integrin beta3 mutation associated with a hereditary macrothrombocytopenia and platelet dysfunction in two Italian families
    Paolo Gresele
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via E dal Pozzo, Perugia, Italy
    Haematologica 94:663-9. 2009
  9. ncbi request reprint Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production
    Paolo Gresele
    Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, 06100 Perugia, Italy
    J Nutr 138:1602-8. 2008
  10. doi request reprint Patients with primary antiphospholipid antibody syndrome and without associated vascular risk factors present a normal endothelial function
    P Gresele
    Department of Internal Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Thromb Res 123:444-51. 2009

Collaborators

Detail Information

Publications64

  1. pmc Loss of matrix metalloproteinase 2 in platelets reduces arterial thrombosis in vivo
    Stefania Momi
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia 06100, Italy
    J Exp Med 206:2365-79. 2009
    ..These findings open new possibilities for the prevention of thrombosis by the development of MMP-2 inhibitors...
  2. pmc Outside-in signalling generated by a constitutively activated integrin αIIbβ3 impairs proplatelet formation in human megakaryocytes
    Loredana Bury
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    PLoS ONE 7:e34449. 2012
    ..The origin of thrombocytopenia in this condition remains unclear and this may represent an interesting natural model to get further insight into the role of the megakaryocyte fibrinogen receptor in megakaryopoiesis...
  3. pmc Alteration of liver enzymes is a feature of the MYH9-related disease syndrome
    Alessandro Pecci
    Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy
    PLoS ONE 7:e35986. 2012
    ..Our aim was to evaluate if the alteration of liver tests is a feature of the MYH9-RD and to define its clinical significance...
  4. doi request reprint In vivo platelet activation and platelet hyperreactivity in abacavir-treated HIV-infected patients
    Emanuela Falcinelli
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via E dal Pozzo, Perugia, Italy
    Thromb Haemost 110:349-57. 2013
    ..In conclusion, treatment with ABC enhances in vivo platelet activation and induces platelet hyperreactivity by blunting the inhibitory effects of NO on platelets. These effects may lead to an increase of ischaemic cardiovascular events. ..
  5. doi request reprint Endothelial and platelet function alterations in HIV-infected patients
    P Gresele
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Thromb Res 129:301-8. 2012
    ..Potential therapeutic implications are also discussed...
  6. doi request reprint Effect on walking distance and atherosclerosis progression of a nitric oxide-donating agent in intermittent claudication
    Paolo Gresele
    Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
    J Vasc Surg 56:1622-8, 1628.e1-5. 2012
    ....
  7. ncbi request reprint NCX4016: a novel antithrombotic agent
    P Gresele
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via Enrico Dal Pozzo, 06126 Perugia, Italy
    Dig Liver Dis 35:S20-6. 2003
    ..Nitroaspirin has shown a number of significant advantages over the presently available antiplatelet agents; however, only clinical studies will say whether nitroaspirin represents a step forward in antithrombotic treatment...
  8. pmc Dominant inheritance of a novel integrin beta3 mutation associated with a hereditary macrothrombocytopenia and platelet dysfunction in two Italian families
    Paolo Gresele
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via E dal Pozzo, Perugia, Italy
    Haematologica 94:663-9. 2009
    ..Although large heterogeneity has been described for Glanzmann's thrombasthenia, no family has so far been described as having an autosomal dominant form of this disease...
  9. ncbi request reprint Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production
    Paolo Gresele
    Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, 06100 Perugia, Italy
    J Nutr 138:1602-8. 2008
    ..This activity may contribute to the beneficial effects of moderate wine intake on ischemic cardiovascular disease...
  10. doi request reprint Patients with primary antiphospholipid antibody syndrome and without associated vascular risk factors present a normal endothelial function
    P Gresele
    Department of Internal Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Thromb Res 123:444-51. 2009
    ..Endothelial dysfunction is an early event in the natural history of atherosclerosis. Aim of our study was to compare endothelial function of patients with PAPS and no associated risk factors with that of age- and sex-matched controls...
  11. ncbi request reprint Pharmacologic profile and therapeutic potential of NCX 4016, a nitric oxide-releasing aspirin, for cardiovascular disorders
    Paolo Gresele
    Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
    Cardiovasc Drug Rev 24:148-68. 2006
    ..Also, the long-term tolerability of NCX 4016, as well as its possible effectiveness in preventing ischemic cardiovascular events and progression of atherosclerosis, should be explored...
  12. ncbi request reprint TAFI deficiency in liver cirrhosis: relation with plasma fibrinolysis and survival
    Paolo Gresele
    Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Thromb Res 121:763-8. 2008
    ..We evaluated the relationship of TAFI level with plasma fibrinolysis and survival in cirrhotic patients...
  13. doi request reprint Potentiation and priming of platelet activation: a potential target for antiplatelet therapy
    Paolo Gresele
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via Enrico Dal Pozzo, Perugia, Italy
    Trends Pharmacol Sci 29:352-60. 2008
    ..Here, we review the present knowledge on some molecules acting as potentiators or primers of platelet activation and discuss their possible pharmacologic modulation for antithrombotic purposes...
  14. ncbi request reprint Prevention by NCX 4016, a nitric oxide-donating aspirin, but not by aspirin, of the acute endothelial dysfunction induced by exercise in patients with intermittent claudication
    Paolo Gresele
    Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Via Enrico Dal Pozzo, I 06126 Perugia, Italy
    Thromb Haemost 97:444-50. 2007
    ..Maximal treadmill exercise induces a systemic arterial endothelial dysfunction in patients with intermittent claudication. A nitric oxide-donating aspirin, but not aspirin, prevents effort-induced endothelial dysfunction...
  15. doi request reprint Endothelium, venous thromboembolism and ischaemic cardiovascular events
    Paolo Gresele
    Department of Internal Medicine Division of Internal and Cardiovascular Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Thromb Haemost 103:56-61. 2010
    ....
  16. pmc Hyperglycemia-induced platelet activation in type 2 diabetes is resistant to aspirin but not to a nitric oxide-donating agent
    Paolo Gresele
    Section of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Care 33:1262-8. 2010
    ..Our aim was to assess comparatively the effect of aspirin, a nitric oxide-donating agent (NCX 4016), their combination, or placebo on platelet activation induced by acute hyperglycemia in type 2 diabetes...
  17. doi request reprint Platelets release matrix metalloproteinase-2 in the coronary circulation of patients with acute coronary syndromes: possible role in sustained platelet activation
    Paolo Gresele
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Eur Heart J 32:316-25. 2011
    ....
  18. pmc Activated human protein C prevents thrombin-induced thromboembolism in mice. Evidence that activated protein c reduces intravascular fibrin accumulation through the inhibition of additional thrombin generation
    P Gresele
    Institute of Internal and Vascular Medicine, University of Perugia, 06126 Perugia, Italy
    J Clin Invest 101:667-76. 1998
    ....
  19. pmc Anti-platelet therapy: phosphodiesterase inhibitors
    Paolo Gresele
    Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy
    Br J Clin Pharmacol 72:634-46. 2011
    ..This review focuses on the effect of PDE2, PDE3 and PDE5 inhibitors on platelet function and on the evidence for an antithrombotic action of some of them, and in particular of dipyridamole and cilostazol...
  20. ncbi request reprint Novel approaches to the treatment of thrombosis
    Paolo Gresele
    Division of Internal and Cardiovascular Medicine, Dept of Internal Medicine, University of Perugia, Via E dal Pozzo, I 06126, Perugia, Italy
    Trends Pharmacol Sci 23:25-32. 2002
    ..Several achievements are anticipated from the development of new antithrombotics, including a further reduction of cardiovascular mortality and unwanted bleeding, and easier patient management...
  21. doi request reprint Critical limb ischemia
    Paolo Gresele
    Dipartimento di Medicina Interna, Sezione di Medicina Interna e Cardiovascolare, Universita di Perugia, Via E dal Pozzo, Perugia, Italy
    Intern Emerg Med 6:129-34. 2011
    ..Finally, the evaluation of the risk, benefit and optimal timing of revascularization lesions or the decision about amputation and its extension is a complex decision that requires a multidisciplinary approach...
  22. doi request reprint Effects of resveratrol and other wine polyphenols on vascular function: an update
    Paolo Gresele
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, 06126 Perugia, Italy
    J Nutr Biochem 22:201-11. 2011
    ..In this overview, the in vitro and in vivo evidence on the activity of resveratrol on vascular function and circulating blood cells, with a special emphasis on blood platelets, is thoroughly presented...
  23. ncbi request reprint Acute, short-term hyperglycemia enhances shear stress-induced platelet activation in patients with type II diabetes mellitus
    Paolo Gresele
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via E dal Pozzo, snc 06126, Perugia, Italy
    J Am Coll Cardiol 41:1013-20. 2003
    ..The aim of our study was to assess whether acute, short-term hyperglycemia affects platelet reactivity in patients with Type II diabetes mellitus (T2DM)...
  24. ncbi request reprint Cloricromene inhibits leukotriene formation by human polymorphonuclear leucocytes by suppressing arachidonate release from membrane phospholipids
    P Gresele
    Institute of Internal and Vascular Medicine, University of Perugia, Italy
    Biochem Pharmacol 45:123-30. 1993
    ....
  25. ncbi request reprint Effect of cloricromene on intermittent claudication. A randomized, double-blind, placebo-controlled trial in patients treated with aspirin: effect on claudication distance and quality of life. CRAMPS Investigator Group. Cloricromene Randomized Arteriopath
    P Gresele
    Institute of Internal and Vascular Medicine, University of Perugia, Italy
    Vasc Med 5:83-9. 2000
    ..An improvement of 40-60 m in the ICD on a standardized treadmill test does not translate into a self-perceived improvement in the quality of life as assessed by the SF-36 questionnaire...
  26. ncbi request reprint Cloricromene inhibits G-protein-mediated activation of phospholipase A2 in human platelets
    M Stasi
    Istituto di Biochimica e Chimica Medica, Universita di Perugia, Italy
    J Lipid Mediat 7:253-67. 1993
    ....
  27. ncbi request reprint Low molecular weight heparins prevent thrombin-induced thrombo-embolism in mice despite low anti-thrombin activity. Evidence that the inhibition of feed-back activation of thrombin generation confers safety advantages over direct thrombin inhibition
    S Momi
    Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy
    Haematologica 86:297-302. 2001
    ....
  28. doi request reprint Incomplete inhibition of platelet function as assessed by the platelet function analyzer (PFA-100) identifies a subset of cardiovascular patients with high residual platelet response while on aspirin
    M Crescente
    Department of Internal Medicine, University of Perugia, Italy
    Platelets 22:179-87. 2011
    ....
  29. ncbi request reprint Treatment of intermittent claudication with mesoglycan--a placebo-controlled, double-blind study
    G G Nenci
    Institute of Internal and Cardiovascular Medicine, University of Perugia, Italy
    Thromb Haemost 86:1181-7. 2001
    ..To assess the effect of treatment with mesoglycan, a sulphated polysaccharide compound, on the walking capacity of patients with stage II peripheral arterial disease...
  30. doi request reprint A new case of acquired Glanzmann's thrombasthenia: diagnostic value of flow cytometry
    S Giannini
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Cytometry B Clin Cytom 74:194-9. 2008
    ..Its diagnosis requires several laboratory assays and mixing tests, which are complex and time consuming. We describe here a new case of aGT and compare different tests for the detection of GPIIb/IIIa-blocking autoantibodies...
  31. ncbi request reprint Intraplatelet signaling mechanisms of the priming effect of matrix metalloproteinase-2 on platelet aggregation
    E Falcinelli
    Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
    J Thromb Haemost 3:2526-35. 2005
    ..We explored the signal transduction mechanisms activated by MMP-2 in human blood platelets...
  32. pmc Inhibition of PAF synthesis by stimulated human polymorphonuclear leucocytes with cloricromene, an inhibitor of phospholipase A2 activation
    E Ribaldi
    Institute of Internal and Vascular Medicine, University of Perugia, Italy
    Br J Pharmacol 118:1351-8. 1996
    ....
  33. ncbi request reprint Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016)
    Teresa Corazzi
    Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Via Enrico Dal Pozzo, 06126, Perugia, Italy
    J Pharmacol Exp Ther 315:1331-7. 2005
    ....
  34. ncbi request reprint Platelets release active matrix metalloproteinase-2 in vivo in humans at a site of vascular injury: lack of inhibition by aspirin
    Emanuela Falcinelli
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Br J Haematol 138:221-30. 2007
    ..In conclusion, MMP-2 is released from platelets in vivo in humans at a localised site of vessel wall damage in amounts sufficient to potentiate platelet aggregation; aspirin does not reduce this release...
  35. ncbi request reprint Salicylates inhibit T cell adhesion on endothelium under nonstatic conditions: induction of L-selectin shedding by a tyrosine kinase-dependent mechanism
    R Gerli
    Section of Internal Medicine, Center for the Study of Rheumatic Diseases, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    J Immunol 166:832-40. 2001
    ..These results suggest that salicylates interfere not only with integrin activation, but also with the L-selectin-mediated first steps of T cell binding to endothelium...
  36. ncbi request reprint Nitric oxide and its antithrombotic action in the cardiovascular system
    Gustavo Reichenbach
    Department of Chemistry, Universita, Perugia, Italy
    Curr Drug Targets Cardiovasc Haematol Disord 5:65-74. 2005
    ..Another section examines the drugs that increase the endogenous production of NO and modulate its activities. The last part is dedicated to the novel antithrombotic agent Nitroaspirin. Methods for NO detection will also be examined...
  37. ncbi request reprint Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic study
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Perugia, Italy
    Gastroenterology 124:600-7. 2003
    ..NCX-4016 is a nitric oxide-releasing derivative of aspirin with antiplatelet activity. The aim of this study was to investigate the effect of NCX-4016 on gastrointestinal mucosa and platelet functions in healthy human volunteers...
  38. ncbi request reprint Matrix metalloproteinase-2 of human carotid atherosclerotic plaques promotes platelet activation. Correlation with ischaemic events
    M Lenti
    Paolo Gresele, MD, PhD, Dept of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy, Tel 39 075 5783989, Fax 39 075 5716083, E mail
    Thromb Haemost 111:1089-101. 2014
    ....
  39. doi request reprint Platelet and endothelial activation in catastrophic and quiescent antiphospholipid syndrome
    A Bontadi
    Reumatologia, Policlinico Universitario, Via Giustiniani 2, Padua, Italy
    Thromb Haemost 109:901-8. 2013
    ..In addition, sP-sel and von Willebrand factor activity were significantly higher during catastrophic than in quiescent phase...
  40. ncbi request reprint Thromboxane synthase inhibitors suppress more effectively the aggregation of thromboxane receptor-desensitized than that of normal platelets: role of adenylylcyclase up-regulation
    R Vezza
    Institute of Internal and Vascular Medicine, University of Perugia, Italy
    J Pharmacol Exp Ther 275:1497-505. 1995
    ..This can be of relevance in the treatment of thrombotic disorders in which an in vivo desensitization of platelet TxA2 receptors takes place...
  41. ncbi request reprint Detrimental effects of high-dose dexamethasone in severe, refractory, HIV-related thrombocytopenia
    M Marroni
    Department of Experimental Medicine and Biochemical Science, University of Perugia, Italy
    Ann Pharmacother 34:1139-41. 2000
    ..To report a case of HIV-related thrombocytopenia in which high-dose dexamethasone was ineffective and immunologically detrimental...
  42. ncbi request reprint Binding and release of cytochrome c in brain mitochondria is influenced by membrane potential and hydrophobic interactions with cardiolipin
    L Piccotti
    Laboratory of Biochemistry, Department of Internal Medicine, University of Perugia, 06122, Perugia, Italy
    J Membr Biol 198:43-53. 2004
    ..The delta psi(m) decrease is ascribed to a selected mitochondrial population containing the incorporated cytochrome c...
  43. ncbi request reprint Defective platelet beta-N-acetyl hexosaminidase content and release in chronic myeloproliferative disorders
    Carla Emiliani
    Department of Biochemical Sciences and Molecular Biotechnologies, University of Perugia, Perugia, Italy
    Platelets 17:20-9. 2006
    ..Platelets contain and release upon activation also lysosomes, and in particular beta-N-acetylhexosaminidase (Hex). We have assessed whether the content and in vivo release of Hex of platelets from MPD patients is altered...
  44. ncbi request reprint NCX 6560, a nitric oxide-releasing derivative of atorvastatin, inhibits cholesterol biosynthesis and shows anti-inflammatory and anti-thrombotic properties
    Stefania Momi
    Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
    Eur J Pharmacol 570:115-24. 2007
    ..05 vs vehicle) and in eNOS-/- mice (-21%, P<0.05 vs vehicle). In conclusion, NCX 6560 exerts greater lipid-lowering, anti-thrombotic and anti-inflammatory effects than atorvastatin, due to a large extent to NO release...
  45. ncbi request reprint Laboratory diagnosis and monitoring of desmopressin treatment of von Willebrand's disease by flow cytometry
    Silvia Giannini
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Haematologica 92:1647-54. 2007
    ..The diagnosis of VWD requires several laboratory tests. The aim of our study was to validate a flow cytometric test for the diagnosis of VWD and for monitoring the effects of desmopressin therapy...
  46. doi request reprint HIV type 1 infection, and not short-term HAART, induces endothelial dysfunction
    Daniela Francisci
    Division of Infectious Diseases, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia 06126, Italy
    AIDS 23:589-96. 2009
    ..Our aim was to assess whether patients with chronic HIV infection present endothelial dysfunction and whether this is the consequence of infection or of HAART...
  47. ncbi request reprint Effect of nitric oxide-donating agents on human monocyte cyclooxygenase-2
    Teresa Corazzi
    Section of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via Enrico Dal Pozzo, 06126, Perugia, Italy
    Biochem Biophys Res Commun 311:897-903. 2003
    ..In conclusion, Nitroaspirin inhibits monocyte COX-2 activity by a cGMP-dependent mechanism. This might represent an advantage over aspirin, given the possible detrimental role of COX-2 in cardiovascular disease...
  48. ncbi request reprint Endothelial dysfunction in patients with spontaneous venous thromboembolism
    Rino Migliacci
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Haematologica 92:812-8. 2007
    ..Endothelial dysfunction is an early marker of atherosclerosis and has predictive value for ischemic events. We have evaluated endothelial function in patients with a history of spontaneous venous thromboembolism...
  49. ncbi request reprint Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease
    Alessandro Pecci
    Department of Internal Medicine, University of Pavia and Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Policlinico San Matteo Foundation, Pavia, Italy
    Hum Mutat 29:409-17. 2008
    ..These findings are relevant not only to patients' clinical management but also to the elucidation of the pathogenesis of the disease...
  50. doi request reprint Interaction with damaged vessel wall in vivo in humans induces platelets to express CD40L resulting in endothelial activation with no effect of aspirin intake
    Silvia Giannini
    Div of Internal and Cardiovascular Medicine, Dept of Internal Medicine, Univ of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Am J Physiol Heart Circ Physiol 300:H2072-9. 2011
    ..We concluded that CD40L expressed by platelets in vivo in humans upon contact with a damaged vessel wall activates endothelium; aspirin treatment does not inhibit this mechanism...
  51. doi request reprint Matrix metalloproteinases and peripheral arterial disease
    Chiara Busti
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via E dal Pozzo, 06126, Perugia, Italy
    Intern Emerg Med 5:13-25. 2010
    ..In perspective, pharmacologic targeting of the expression or activity of MMPs may represent a novel, attractive approach for the treatment of peripheral arterial disease...
  52. ncbi request reprint Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation
    Simon C Pitchford
    Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Via E dal Pozzo, 06126 Italy
    Blood 105:2074-81. 2005
    ..P-selectin expression on the surfaces of platelets is a major requirement for pulmonary eosinophil and lymphocyte recruitment, allowing circulating platelets to bind to and stimulate leukocytes for endothelial attachment...
  53. ncbi request reprint Allergen induces the migration of platelets to lung tissue in allergic asthma
    Simon C Pitchford
    Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Via E dal Pozzo, I 06126 Perugia, Italy
    Am J Respir Crit Care Med 177:604-12. 2008
    ..No studies, however, have explored the direct migration of platelets to lungs...
  54. pmc Diagnosis of platelet-type von Willebrand disease by flow cytometry
    Silvia Giannini
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Haematologica 95:1021-4. 2010
    ..Genetic analysis revealed a heterozygous point mutation in codon 239 of the GPIbalpha gene leading to a methionine to valine substitution (M239V). Flow cytometry represents a useful tool for the diagnosis of PT-VWD...
  55. ncbi request reprint Deficiency of thrombin activatable fibrinolysis inhibitor in cirrhosis is associated with increased plasma fibrinolysis
    Mario Colucci
    Department of Biomedical Sciences, Section of General Pathology, University of Bari, Bari, Italy
    Hepatology 38:230-7. 2003
    ..Impairment of the antifibrinolytic TAFI pathway might contribute to bleeding associated with this disease...
  56. ncbi request reprint Endothelial dysfunction in patients with kidney failure and vascular risk factors: acute effects of hemodialysis
    Rino Migliacci
    Division of General Medicine, Civic Hospital, Cortona AR, Italy
    Ital Heart J 5:371-7. 2004
    ..The aim of this study was to evaluate the acute effects of hemodialysis on endothelial dysfunction in patients with kidney failure and associated vascular risk factors and to assess the role of endothelium-toxic substances...
  57. ncbi request reprint Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets
    Roberta Vezza
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, USA
    Thromb Haemost 87:114-21. 2002
    ..These data show that endoperoxides and TXA2 mediate their effects on platelets acting on both, and the same, receptor isoform(s)...
  58. ncbi request reprint Interactions between thrombophilic genetic mutations and clinical bleeding in patients on chronic oral anticoagulant treatment
    Luigi Castori
    Haematologica 90:1720-2. 2005
    ..4%) and four (2.5%), respectively, among 156 matched patients with no bleeding while on OAT (odds ratio 3.1+/-1.6, p=0.026). In patients on chronic OAT, FV Leiden is a risk factor for moderate-severe bleeding...
  59. ncbi request reprint Picotamide versus aspirin in diabetic patients with peripheral arterial disease: has David defeated Goliath?
    Paolo Gresele
    Eur Heart J 25:1769-71. 2004
  60. ncbi request reprint Inherited thrombocytopenias: a proposed diagnostic algorithm from the Italian Gruppo di Studio delle Piastrine
    Carlo L Balduini
    Dipartimento di Medicina Interna, IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Haematologica 88:582-92. 2003
    ..However, diagnosis of these disorders is often difficult and requires competences that are limited to specialized centers. We, therefore, suspect that inherited thrombocytopenias are underreported because their diagnosis is often missed...
  61. ncbi request reprint Significant potentiation of anticoagulation by flu-vaccine during the season 2001-2002
    Ugo Paliani
    Haematologica 88:599-600. 2003
  62. ncbi request reprint Platelets are essential for leukocyte recruitment in allergic inflammation
    Simon C Pitchford
    Sackler Institute of Pulmonary Pharmacology, GKT School of Biomedical Sciences, King s College London, London
    J Allergy Clin Immunol 112:109-18. 2003
    ..However, platelet-leukocyte interactions have been demonstrated in cardiovascular disease, culminating in enhanced leukocyte recruitment...
  63. doi request reprint Ankle-brachial index measured by palpation for the diagnosis of peripheral arterial disease
    Rino Migliacci
    Division of Internal Medicine, Ospedale della Valdichiana S Margherita, USL 8, Arezzo, Italy
    Fam Pract 25:228-32. 2008
    ....
  64. ncbi request reprint Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation
    Simon C Pitchford
    Sackler Institute of Pulmonary Pharmacology, 5th Fl, Hodgkin Bldg, Guy s Campus, King s College London, London SE1 1UL, United Kingdom
    Blood 103:639-47. 2004
    ..Neither platelet depletion nor dexamethasone administration inhibited chronic AHR; thus, mechanisms other than inflammation and airway remodeling may be involved in the pathogenesis of chronic AHR...