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Genomes and GenesSpecies | P GreseleSummaryAffiliation: University of Perugia Country: Italy Publications
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Publications
Endothelial and platelet function alterations in HIV-infected patientsP Gresele
Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
Thromb Res 129:301-8. 2012..Potential therapeutic implications are also discussed...- Effect on walking distance and atherosclerosis progression of a nitric oxide-donating agent in intermittent claudicationPaolo Gresele
Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
J Vasc Surg 56:1622-8, 1628.e1-5. 2012.... 
Prevention by NCX 4016, a nitric oxide-donating aspirin, but not by aspirin, of the acute endothelial dysfunction induced by exercise in patients with intermittent claudicationPaolo Gresele
Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Via Enrico Dal Pozzo, I 06126 Perugia, Italy
Thromb Haemost 97:444-50. 2007..Maximal treadmill exercise induces a systemic arterial endothelial dysfunction in patients with intermittent claudication. A nitric oxide-donating aspirin, but not aspirin, prevents effort-induced endothelial dysfunction...
Hyperglycemia-induced platelet activation in type 2 diabetes is resistant to aspirin but not to a nitric oxide-donating agentPaolo Gresele
Section of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
Diabetes Care 33:1262-8. 2010..Our aim was to assess comparatively the effect of aspirin, a nitric oxide-donating agent (NCX 4016), their combination, or placebo on platelet activation induced by acute hyperglycemia in type 2 diabetes...- NCX4016: a novel antithrombotic agentP Gresele
Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via Enrico Dal Pozzo, 06126 Perugia, Italy
Dig Liver Dis 35:S20-6. 2003..Nitroaspirin has shown a number of significant advantages over the presently available antiplatelet agents; however, only clinical studies will say whether nitroaspirin represents a step forward in antithrombotic treatment... - Endothelium, venous thromboembolism and ischaemic cardiovascular eventsPaolo Gresele
Department of Internal Medicine Division of Internal and Cardiovascular Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
Thromb Haemost 103:56-61. 2010.... - Dominant inheritance of a novel integrin beta3 mutation associated with a hereditary macrothrombocytopenia and platelet dysfunction in two Italian familiesPaolo Gresele
Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via E dal Pozzo, Perugia, Italy
Haematologica 94:663-9. 2009..Although large heterogeneity has been described for Glanzmann's thrombasthenia, no family has so far been described as having an autosomal dominant form of this disease... - Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide productionPaolo Gresele
Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, 06100 Perugia, Italy
J Nutr 138:1602-8. 2008..This activity may contribute to the beneficial effects of moderate wine intake on ischemic cardiovascular disease... - Patients with primary antiphospholipid antibody syndrome and without associated vascular risk factors present a normal endothelial functionP Gresele
Department of Internal Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
Thromb Res 123:444-51. 2009..Endothelial dysfunction is an early event in the natural history of atherosclerosis. Aim of our study was to compare endothelial function of patients with PAPS and no associated risk factors with that of age- and sex-matched controls... - Potentiation and priming of platelet activation: a potential target for antiplatelet therapyPaolo Gresele
Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via Enrico Dal Pozzo, Perugia, Italy
Trends Pharmacol Sci 29:352-60. 2008..Here, we review the present knowledge on some molecules acting as potentiators or primers of platelet activation and discuss their possible pharmacologic modulation for antithrombotic purposes... - TAFI deficiency in liver cirrhosis: relation with plasma fibrinolysis and survivalPaolo Gresele
Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
Thromb Res 121:763-8. 2008..We evaluated the relationship of TAFI level with plasma fibrinolysis and survival in cirrhotic patients... - Pharmacologic profile and therapeutic potential of NCX 4016, a nitric oxide-releasing aspirin, for cardiovascular disordersPaolo Gresele
Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
Cardiovasc Drug Rev 24:148-68. 2006..Also, the long-term tolerability of NCX 4016, as well as its possible effectiveness in preventing ischemic cardiovascular events and progression of atherosclerosis, should be explored... - Effects of resveratrol and other wine polyphenols on vascular function: an updatePaolo Gresele
Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, 06126 Perugia, Italy
J Nutr Biochem 22:201-11. 2011..In this overview, the in vitro and in vivo evidence on the activity of resveratrol on vascular function and circulating blood cells, with a special emphasis on blood platelets, is thoroughly presented... - Acute, short-term hyperglycemia enhances shear stress-induced platelet activation in patients with type II diabetes mellitusPaolo Gresele
Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via E dal Pozzo, snc 06126, Perugia, Italy
J Am Coll Cardiol 41:1013-20. 2003..The aim of our study was to assess whether acute, short-term hyperglycemia affects platelet reactivity in patients with Type II diabetes mellitus (T2DM)... - Activated human protein C prevents thrombin-induced thromboembolism in mice. Evidence that activated protein c reduces intravascular fibrin accumulation through the inhibition of additional thrombin generationP Gresele
Institute of Internal and Vascular Medicine, University of Perugia, 06126 Perugia, Italy
J Clin Invest 101:667-76. 1998.... - Anti-platelet therapy: phosphodiesterase inhibitorsPaolo Gresele
Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy
Br J Clin Pharmacol 72:634-46. 2011..This review focuses on the effect of PDE2, PDE3 and PDE5 inhibitors on platelet function and on the evidence for an antithrombotic action of some of them, and in particular of dipyridamole and cilostazol... - Novel approaches to the treatment of thrombosisPaolo Gresele
Division of Internal and Cardiovascular Medicine, Dept of Internal Medicine, University of Perugia, Via E dal Pozzo, I 06126, Perugia, Italy
Trends Pharmacol Sci 23:25-32. 2002..Several achievements are anticipated from the development of new antithrombotics, including a further reduction of cardiovascular mortality and unwanted bleeding, and easier patient management... - Platelets release matrix metalloproteinase-2 in the coronary circulation of patients with acute coronary syndromes: possible role in sustained platelet activationPaolo Gresele
Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
Eur Heart J 32:316-25. 2011.... - Critical limb ischemiaPaolo Gresele
Dipartimento di Medicina Interna, Sezione di Medicina Interna e Cardiovascolare, Universita di Perugia, Via E dal Pozzo, Perugia, Italy
Intern Emerg Med 6:129-34. 2011..Finally, the evaluation of the risk, benefit and optimal timing of revascularization lesions or the decision about amputation and its extension is a complex decision that requires a multidisciplinary approach... - Cloricromene inhibits leukotriene formation by human polymorphonuclear leucocytes by suppressing arachidonate release from membrane phospholipidsP Gresele
Institute of Internal and Vascular Medicine, University of Perugia, Italy
Biochem Pharmacol 45:123-30. 1993.... - Effect of cloricromene on intermittent claudication. A randomized, double-blind, placebo-controlled trial in patients treated with aspirin: effect on claudication distance and quality of life. CRAMPS Investigator Group. Cloricromene Randomized ArteriopathP Gresele
Institute of Internal and Vascular Medicine, University of Perugia, Italy
Vasc Med 5:83-9. 2000..An improvement of 40-60 m in the ICD on a standardized treadmill test does not translate into a self-perceived improvement in the quality of life as assessed by the SF-36 questionnaire... - Cloricromene inhibits G-protein-mediated activation of phospholipase A2 in human plateletsM Stasi
Istituto di Biochimica e Chimica Medica, Universita di Perugia, Italy
J Lipid Mediat 7:253-67. 1993.... - Low molecular weight heparins prevent thrombin-induced thrombo-embolism in mice despite low anti-thrombin activity. Evidence that the inhibition of feed-back activation of thrombin generation confers safety advantages over direct thrombin inhibitionS Momi
Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy
Haematologica 86:297-302. 2001.... - Treatment of intermittent claudication with mesoglycan--a placebo-controlled, double-blind studyG G Nenci
Institute of Internal and Cardiovascular Medicine, University of Perugia, Italy
Thromb Haemost 86:1181-7. 2001..To assess the effect of treatment with mesoglycan, a sulphated polysaccharide compound, on the walking capacity of patients with stage II peripheral arterial disease... - A new case of acquired Glanzmann's thrombasthenia: diagnostic value of flow cytometryS Giannini
Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
Cytometry B Clin Cytom 74:194-9. 2008..Its diagnosis requires several laboratory assays and mixing tests, which are complex and time consuming. We describe here a new case of aGT and compare different tests for the detection of GPIIb/IIIa-blocking autoantibodies... - Intraplatelet signaling mechanisms of the priming effect of matrix metalloproteinase-2 on platelet aggregationE Falcinelli
Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
J Thromb Haemost 3:2526-35. 2005..Platelet-released MMP-2 may contribute to platelet activation in vivo... - Incomplete inhibition of platelet function as assessed by the platelet function analyzer (PFA-100) identifies a subset of cardiovascular patients with high residual platelet response while on aspirinM Crescente
Department of Internal Medicine, University of Perugia, Italy
Platelets 22:179-87. 2011.... - Inhibition of PAF synthesis by stimulated human polymorphonuclear leucocytes with cloricromene, an inhibitor of phospholipase A2 activationE Ribaldi
Institute of Internal and Vascular Medicine, University of Perugia, Italy
Br J Pharmacol 118:1351-8. 1996.... - Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016)Teresa Corazzi
Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Via Enrico Dal Pozzo, 06126, Perugia, Italy
J Pharmacol Exp Ther 315:1331-7. 2005.... - Platelets release active matrix metalloproteinase-2 in vivo in humans at a site of vascular injury: lack of inhibition by aspirinEmanuela Falcinelli
Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
Br J Haematol 138:221-30. 2007..In conclusion, MMP-2 is released from platelets in vivo in humans at a localised site of vessel wall damage in amounts sufficient to potentiate platelet aggregation; aspirin does not reduce this release... - Nitric oxide and its antithrombotic action in the cardiovascular systemGustavo Reichenbach
Department of Chemistry, Universita, Perugia, Italy
Curr Drug Targets Cardiovasc Haematol Disord 5:65-74. 2005..Another section examines the drugs that increase the endogenous production of NO and modulate its activities. The last part is dedicated to the novel antithrombotic agent Nitroaspirin. Methods for NO detection will also be examined... - Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic studyStefano Fiorucci
Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Perugia, Italy
Gastroenterology 124:600-7. 2003..NCX-4016 is a nitric oxide-releasing derivative of aspirin with antiplatelet activity. The aim of this study was to investigate the effect of NCX-4016 on gastrointestinal mucosa and platelet functions in healthy human volunteers... - Salicylates inhibit T cell adhesion on endothelium under nonstatic conditions: induction of L-selectin shedding by a tyrosine kinase-dependent mechanismR Gerli
Section of Internal Medicine, Center for the Study of Rheumatic Diseases, Department of Clinical and Experimental Medicine, University of Perugia, Italy
J Immunol 166:832-40. 2001..These results suggest that salicylates interfere not only with integrin activation, but also with the L-selectin-mediated first steps of T cell binding to endothelium... - Thromboxane synthase inhibitors suppress more effectively the aggregation of thromboxane receptor-desensitized than that of normal platelets: role of adenylylcyclase up-regulationR Vezza
Institute of Internal and Vascular Medicine, University of Perugia, Italy
J Pharmacol Exp Ther 275:1497-505. 1995..This can be of relevance in the treatment of thrombotic disorders in which an in vivo desensitization of platelet TxA2 receptors takes place... - Detrimental effects of high-dose dexamethasone in severe, refractory, HIV-related thrombocytopeniaM Marroni
Department of Experimental Medicine and Biochemical Science, University of Perugia, Italy
Ann Pharmacother 34:1139-41. 2000..To report a case of HIV-related thrombocytopenia in which high-dose dexamethasone was ineffective and immunologically detrimental... - Loss of matrix metalloproteinase 2 in platelets reduces arterial thrombosis in vivoStefania Momi
Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia 06100, Italy
J Exp Med 206:2365-79. 2009..These findings open new possibilities for the prevention of thrombosis by the development of MMP-2 inhibitors... - Binding and release of cytochrome c in brain mitochondria is influenced by membrane potential and hydrophobic interactions with cardiolipinL Piccotti
Laboratory of Biochemistry, Department of Internal Medicine, University of Perugia, 06122, Perugia, Italy
J Membr Biol 198:43-53. 2004..The delta psi(m) decrease is ascribed to a selected mitochondrial population containing the incorporated cytochrome c... - Endothelial dysfunction in patients with spontaneous venous thromboembolismRino Migliacci
Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
Haematologica 92:812-8. 2007..Endothelial dysfunction is an early marker of atherosclerosis and has predictive value for ischemic events. We have evaluated endothelial function in patients with a history of spontaneous venous thromboembolism... - Laboratory diagnosis and monitoring of desmopressin treatment of von Willebrand's disease by flow cytometrySilvia Giannini
Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
Haematologica 92:1647-54. 2007..The diagnosis of VWD requires several laboratory tests. The aim of our study was to validate a flow cytometric test for the diagnosis of VWD and for monitoring the effects of desmopressin therapy... - HIV type 1 infection, and not short-term HAART, induces endothelial dysfunctionDaniela Francisci
Division of Infectious Diseases, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia 06126, Italy
AIDS 23:589-96. 2009..Our aim was to assess whether patients with chronic HIV infection present endothelial dysfunction and whether this is the consequence of infection or of HAART... - Effect of nitric oxide-donating agents on human monocyte cyclooxygenase-2Teresa Corazzi
Section of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via Enrico Dal Pozzo, 06126, Perugia, Italy
Biochem Biophys Res Commun 311:897-903. 2003..In conclusion, Nitroaspirin inhibits monocyte COX-2 activity by a cGMP-dependent mechanism. This might represent an advantage over aspirin, given the possible detrimental role of COX-2 in cardiovascular disease... - Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related diseaseAlessandro Pecci
Department of Internal Medicine, University of Pavia and Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Policlinico San Matteo Foundation, Pavia, Italy
Hum Mutat 29:409-17. 2008..These findings are relevant not only to patients' clinical management but also to the elucidation of the pathogenesis of the disease... - NCX 6560, a nitric oxide-releasing derivative of atorvastatin, inhibits cholesterol biosynthesis and shows anti-inflammatory and anti-thrombotic propertiesStefania Momi
Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
Eur J Pharmacol 570:115-24. 2007..05 vs vehicle) and in eNOS-/- mice (-21%, P<0.05 vs vehicle). In conclusion, NCX 6560 exerts greater lipid-lowering, anti-thrombotic and anti-inflammatory effects than atorvastatin, due to a large extent to NO release... - Defective platelet beta-N-acetyl hexosaminidase content and release in chronic myeloproliferative disordersCarla Emiliani
Department of Biochemical Sciences and Molecular Biotechnologies, University of Perugia, Perugia, Italy
Platelets 17:20-9. 2006.... - Interaction with damaged vessel wall in vivo in humans induces platelets to express CD40L resulting in endothelial activation with no effect of aspirin intakeSilvia Giannini
Div of Internal and Cardiovascular Medicine, Dept of Internal Medicine, Univ of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
Am J Physiol Heart Circ Physiol 300:H2072-9. 2011..We concluded that CD40L expressed by platelets in vivo in humans upon contact with a damaged vessel wall activates endothelium; aspirin treatment does not inhibit this mechanism... - Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammationSimon C Pitchford
Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Via E dal Pozzo, 06126 Italy
Blood 105:2074-81. 2005..P-selectin expression on the surfaces of platelets is a major requirement for pulmonary eosinophil and lymphocyte recruitment, allowing circulating platelets to bind to and stimulate leukocytes for endothelial attachment... - Allergen induces the migration of platelets to lung tissue in allergic asthmaSimon C Pitchford
Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Via E dal Pozzo, I 06126 Perugia, Italy
Am J Respir Crit Care Med 177:604-12. 2008..No studies, however, have explored the direct migration of platelets to lungs... - Matrix metalloproteinases and peripheral arterial diseaseChiara Busti
Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via E dal Pozzo, 06126, Perugia, Italy
Intern Emerg Med 5:13-25. 2010..In perspective, pharmacologic targeting of the expression or activity of MMPs may represent a novel, attractive approach for the treatment of peripheral arterial disease... - Diagnosis of platelet-type von Willebrand disease by flow cytometrySilvia Giannini
Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
Haematologica 95:1021-4. 2010..Genetic analysis revealed a heterozygous point mutation in codon 239 of the GPIbalpha gene leading to a methionine to valine substitution (M239V). Flow cytometry represents a useful tool for the diagnosis of PT-VWD... - Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human plateletsRoberta Vezza
Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, USA
Thromb Haemost 87:114-21. 2002..These data show that endoperoxides and TXA2 mediate their effects on platelets acting on both, and the same, receptor isoform(s)... - Deficiency of thrombin activatable fibrinolysis inhibitor in cirrhosis is associated with increased plasma fibrinolysisMario Colucci
Department of Biomedical Sciences, Section of General Pathology, University of Bari, Bari, Italy
Hepatology 38:230-7. 2003..Impairment of the antifibrinolytic TAFI pathway might contribute to bleeding associated with this disease... - Endothelial dysfunction in patients with kidney failure and vascular risk factors: acute effects of hemodialysisRino Migliacci
Division of General Medicine, Civic Hospital, Cortona (AR, Italy
Ital Heart J 5:371-7. 2004..Endothelial dysfunction may contribute to the progression of atherosclerosis in patients with kidney failure and vascular risk factors... - Inherited thrombocytopenias: a proposed diagnostic algorithm from the Italian Gruppo di Studio delle PiastrineCarlo L Balduini
Dipartimento di Medicina Interna, IRCCS Policlinico San Matteo, Universita di Pavia, Italy
Haematologica 88:582-92. 2003..However, diagnosis of these disorders is often difficult and requires competences that are limited to specialized centers. We, therefore, suspect that inherited thrombocytopenias are underreported because their diagnosis is often missed... - Significant potentiation of anticoagulation by flu-vaccine during the season 2001-2002Ugo Paliani
Haematologica 88:599-600. 2003 - Interactions between thrombophilic genetic mutations and clinical bleeding in patients on chronic oral anticoagulant treatmentLuigi Castori
Haematologica 90:1720-2. 2005..4%) and four (2.5%), respectively, among 156 matched patients with no bleeding while on OAT (odds ratio 3.1+/-1.6, p=0.026). In patients on chronic OAT, FV Leiden is a risk factor for moderate-severe bleeding... - Ankle-brachial index measured by palpation for the diagnosis of peripheral arterial diseaseRino Migliacci
Division of Internal Medicine, Ospedale della Valdichiana S Margherita, USL 8, Arezzo, Italy
Fam Pract 25:228-32. 2008.... - Platelets are essential for leukocyte recruitment in allergic inflammationSimon C Pitchford
Sackler Institute of Pulmonary Pharmacology, GKT School of Biomedical Sciences, King's College London, London
J Allergy Clin Immunol 112:109-18. 2003..CONCLUSION: These results suggest that platelet participation in cell recruitment occurs at the level of the circulation and might involve the priming of leukocytes for subsequent adhesion and transmigration into tissues... - Picotamide versus aspirin in diabetic patients with peripheral arterial disease: has David defeated Goliath?Paolo Gresele
Eur Heart J 25:1769-71. 2004 - Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammationSimon C Pitchford
Sackler Institute of Pulmonary Pharmacology, 5th Fl, Hodgkin Bldg, Guy s Campus, King s College London, London SE1 1UL, United Kingdom
Blood 103:639-47. 2004..Neither platelet depletion nor dexamethasone administration inhibited chronic AHR; thus, mechanisms other than inflammation and airway remodeling may be involved in the pathogenesis of chronic AHR...