Grazia Graziani

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. pmc NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug
    Simona Caporali
    Laboratory of Molecular Oncology, Istituto Dermopatico dell Immacolata IRCCS, Rome, Italy
    J Transl Med 10:252. 2012
  2. doi request reprint Ipilimumab: a novel immunostimulatory monoclonal antibody for the treatment of cancer
    Grazia Graziani
    Pharmacology and Medical Oncology Section, Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Pharmacol Res 65:9-22. 2012
  3. ncbi request reprint Corticotropin-releasing hormone receptor-1 in human endometrial cancer
    Grazia Graziani
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Oncol Rep 15:375-9. 2006
  4. ncbi request reprint Clinical perspectives of PARP inhibitors
    Grazia Graziani
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy
    Pharmacol Res 52:109-18. 2005
  5. ncbi request reprint Valproic acid increases the stimulatory effect of estrogens on proliferation of human endometrial adenocarcinoma cells
    Grazia Graziani
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Endocrinology 144:2822-8. 2003
  6. ncbi request reprint Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Eur J Cancer 41:2948-57. 2005
  7. doi request reprint MSH3 expression does not influence the sensitivity of colon cancer HCT116 cell line to oxaliplatin and poly(ADP-ribose) polymerase (PARP) inhibitor as monotherapy or in combination
    Lucio Tentori
    Department of System Medicine, University of Rome, Tor Vergata, Via Montpellier 1, 00133, Rome, Italy
    Cancer Chemother Pharmacol 72:117-25. 2013
  8. ncbi request reprint Generation of an immortalized human endothelial cell line as a model of neovascular proliferating endothelial cells to assess chemosensitivity to anticancer drugs
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, I 00133 Rome, Italy
    Int J Oncol 27:525-35. 2005
  9. ncbi request reprint Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Clin Cancer Res 9:5370-9. 2003
  10. ncbi request reprint Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, Rome, Italy
    Eur J Cancer 43:2124-33. 2007

Collaborators

Detail Information

Publications45

  1. pmc NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug
    Simona Caporali
    Laboratory of Molecular Oncology, Istituto Dermopatico dell Immacolata IRCCS, Rome, Italy
    J Transl Med 10:252. 2012
    ..Here we investigated whether NF-κB is activated by TMZ and whether AKT is involved in this molecular event. We also evaluated the functional consequence of inhibiting NF-κB on tumor cell response to TMZ...
  2. doi request reprint Ipilimumab: a novel immunostimulatory monoclonal antibody for the treatment of cancer
    Grazia Graziani
    Pharmacology and Medical Oncology Section, Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Pharmacol Res 65:9-22. 2012
    ....
  3. ncbi request reprint Corticotropin-releasing hormone receptor-1 in human endometrial cancer
    Grazia Graziani
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Oncol Rep 15:375-9. 2006
    ..Two out of 4 cases (50%) expressing CRH-R1 mRNA had extrauterine spreading of the disease, whereas cases not expressing CRH-R1 mRNA were all FIGO stage I, 2 (p=0.015)...
  4. ncbi request reprint Clinical perspectives of PARP inhibitors
    Grazia Graziani
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy
    Pharmacol Res 52:109-18. 2005
    ..g. chronic use for the therapy of neurodegeneration and neuroinflammation, or diabetic complications) may be more challenging because of the unknown potential long-term side effects of PARP inhibitors...
  5. ncbi request reprint Valproic acid increases the stimulatory effect of estrogens on proliferation of human endometrial adenocarcinoma cells
    Grazia Graziani
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Endocrinology 144:2822-8. 2003
    ..Similar effects of VA on cell proliferation were also observed in an ERalpha-positive breast cancer cell line (MCF-7). These findings indicate that VA might favor proliferation of estrogen-dependent human tumors...
  6. ncbi request reprint Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Eur J Cancer 41:2948-57. 2005
    ..In conclusion, PARG inhibition represents an alternative strategy to enhance TMZ efficacy against melanoma in peripheral as well as at CNS site...
  7. doi request reprint MSH3 expression does not influence the sensitivity of colon cancer HCT116 cell line to oxaliplatin and poly(ADP-ribose) polymerase (PARP) inhibitor as monotherapy or in combination
    Lucio Tentori
    Department of System Medicine, University of Rome, Tor Vergata, Via Montpellier 1, 00133, Rome, Italy
    Cancer Chemother Pharmacol 72:117-25. 2013
    ..We have investigated whether MSH3 transfection in MSH3-deficient colon cancer cells confers resistance to oxaliplatin or PARPi and whether their combination restores chemosensitivity...
  8. ncbi request reprint Generation of an immortalized human endothelial cell line as a model of neovascular proliferating endothelial cells to assess chemosensitivity to anticancer drugs
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, I 00133 Rome, Italy
    Int J Oncol 27:525-35. 2005
    ..In conclusion, the immortalized human endothelial line HUV-ST represents a suitable model for studying the efficacy of anti-neovascular therapy, mimicking proliferating neovascular endothelial cells associated to the tumor mass...
  9. ncbi request reprint Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Clin Cancer Res 9:5370-9. 2003
    ....
  10. ncbi request reprint Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, Rome, Italy
    Eur J Cancer 43:2124-33. 2007
    ..These results provide evidence for targeting PARP for anti-angiogenesis, adding novel therapeutic implications to the use of PARP inhibitors in cancer treatment...
  11. doi request reprint The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Eur J Cancer 47:1219-30. 2011
    ..These findings indicate that NBDHEX represents a good candidate for combination therapies including TMZ, offering new perspectives for the treatment of melanoma...
  12. ncbi request reprint Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, Rome 00133, Italy
    FASEB J 20:1709-11. 2006
    ..In conclusion, the PARP inhibitor represents a novel strategy to enhance the antitumor efficacy and reduce toxicity of chemotherapy in colon cancer...
  13. ncbi request reprint Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, I 00133 Rome, Italy
    Int J Oncol 26:415-22. 2005
    ..In conclusion, PARP-1 inhibitor GPI 15427 is efficacious as chemosensitizer for the treatment of tumors located at the CNS site when it is administered by oral route...
  14. ncbi request reprint Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Mol Pharmacol 63:192-202. 2003
    ..Moreover, the data presented here suggest that TMZ + PARP inhibitor combination is active against telomerase-suppressed and slowly growing tumors...
  15. doi request reprint Stable depletion of poly (ADP-ribose) polymerase-1 reduces in vivo melanoma growth and increases chemosensitivity
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, Rome, Italy
    Eur J Cancer 44:1302-14. 2008
    ..These results provide novel evidence for a direct role of PARP-1 in tumour aggressiveness and chemoresistance...
  16. ncbi request reprint The integrin antagonist cilengitide increases the antitumor activity of temozolomide against malignant melanoma
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, 00133 Rome, Italy
    Oncol Rep 19:1039-43. 2008
    ..In conclusion, this study proposes the use of cilengitide in combination with TMZ for the treatment of metastatic melanoma, thereby opening novel perspectives for the use of integrin inhibitors to enhance the efficacy of chemotherapy...
  17. ncbi request reprint Evidence that corticotropin-releasing hormone inhibits cell growth of human breast cancer cells via the activation of CRH-R1 receptor subtype
    Grazia Graziani
    Pharmacology and Medical Oncology Section, Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Mol Cell Endocrinol 264:44-9. 2007
    ....
  18. ncbi request reprint CRH inhibits cell growth of human endometrial adenocarcinoma cells via CRH-receptor 1-mediated activation of cAMP-PKA pathway
    Grazia Graziani
    Department of Neuroscience, University of Rome Tor Vergata, Italy
    Endocrinology 143:807-13. 2002
    ..Experiments with the PKA inhibitor 14-22 amide and forskolin, as well as the measurement of intracellular cAMP, suggested the downstream involvement of cAMP-PKA pathway in CRH-induced inhibition of Ishikawa cell growth...
  19. doi request reprint Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan
    Lucio Tentori
    Department of System Medicine, University of Rome Tor Vergata, I 00133 Rome, Italy
    Int J Oncol 43:210-8. 2013
    ..Remarkably, inhibition of PARP function by PARPi or by PARP-1 gene silencing always increased the antitumor activity of irinotecan, even in the presence of low PARP-1 expression...
  20. ncbi request reprint Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Glia 40:44-54. 2002
    ..Thus, a pharmacological strategy based on the interruption of N-methylpurine repair might represent a novel strategy to restore or increase glioma sensitivity to TZM...
  21. doi request reprint Common fragile sites in colon cancer cell lines: role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1
    Patrizia Vernole
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy
    Mutat Res 712:40-8. 2011
    ..Our results indicate that MMR modulates colon cancer sensitivity to chromosomal breaks and CFS induced by APC and RAD51 silencing...
  22. ncbi request reprint Role of the mismatch repair system and p53 in the clastogenicity and cytotoxicity induced by bleomycin
    Patrizia Vernole
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Via Montpellier 1, Rome 00133, Italy
    Mutat Res 594:63-77. 2006
    ..Moreover, inactivation of MMR confers resistance to the cytotoxic activity of the anticancer agent in cells expressing either wild-type or mutant p53...
  23. ncbi request reprint N3-methyladenine induces early poly(ADP-ribosylation), reduction of nuclear factor-kappa B DNA binding ability, and nuclear up-regulation of telomerase activity
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Mol Pharmacol 67:572-81. 2005
    ..Moreover, the results underline the central and paradoxical role of PARP-1 in cell death induced by N3-methyladenine: effector of necrosis and coordinator of methylpurine repair...
  24. ncbi request reprint Chemopotentiation by PARP inhibitors in cancer therapy
    Lucio Tentori
    Department of Neuroscience, University of Rome, Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Pharmacol Res 52:25-33. 2005
    ..The aim of this article is to provide a brief overview of the recent literature on preclinical studies with the specific and potent inhibitors newly synthesized...
  25. pmc Exogenous control of the expression of Group I CD1 molecules competent for presentation of microbial nonpeptide antigens to human T lymphocytes
    Angelo Aquino
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Clin Dev Immunol 2011:790460. 2011
    ....
  26. doi request reprint Inhibition of homologous recombination by treatment with BVDU (brivudin) or by RAD51 silencing increases chromosomal damage induced by bleomycin in mismatch repair-deficient tumour cells
    Patrizia Vernole
    Department of Public Health and Cellular Biology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Mutat Res 664:39-47. 2009
    ..In MMR-deficient cells, BVDU attenuates the repair of BLM-induced DSBs and this is likely to occur via inhibition of HR...
  27. ncbi request reprint Apoptotic and genotoxic effects of a methyl sulfonate ester that selectively generates N3-methyladenine and poly(ADP-ribose) polymerase inhibitors in normal peripheral blood lymphocytes
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Cancer Chemother Pharmacol 49:217-24. 2002
    ..However, tumor cells with high MPG activity can be rendered susceptible to Me-Lex using poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors...
  28. ncbi request reprint Recent approaches to improve the antitumor efficacy of temozolomide
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Curr Med Chem 16:245-57. 2009
    ....
  29. pmc Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition
    Francesca Cavallo
    Department of Biomedicine and Prevention, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 7:e51563. 2012
    ....
  30. doi request reprint Challenging resistance mechanisms to therapies for metastatic melanoma
    Lucio Tentori
    Department of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Trends Pharmacol Sci 34:656-66. 2013
    ..This review discusses the implications of simultaneously targeting key regulators of melanoma cell proliferation/survival and immune responses to counteract resistance. ..
  31. ncbi request reprint Pharmacological strategies to increase the antitumor activity of methylating agents
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133, Italy
    Curr Med Chem 9:1285-301. 2002
    ..The potential use of N3-methyladenine selective agents in the case of tumors tolerant to O6-methylguanine will be also discussed...
  32. ncbi request reprint Stem cell factor activates telomerase in mouse mitotic spermatogonia and in primordial germ cells
    Susanna Dolci
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Sezione di Anatomia, Rome, Italy
    J Cell Sci 115:1643-9. 2002
    ..Our data suggest that the induction of telomerase by Kitl may contribute to the self-renewing potential of male germ cells and of PGCs...
  33. ncbi request reprint Detection of circulating tumor cells is improved by drug-induced antigen up-regulation: preclinical and clinical studies
    Laura Bonmassar
    Laboratory of Molecular Oncology, Istituto Dermopatico dell Immacolata IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy
    Anticancer Res 30:4721-30. 2010
    ..Therefore, immunomagnetic capture combined with exposure to ST provides a feasible and sensitive technique for the detection of functionally-active CTCs responsive to ST-mediated CEA up-regulation...
  34. ncbi request reprint PARP-1 inhibition to treat cancer, ischemia, inflammation
    Grazia Graziani
    Department of Neuroscience, Pharmacology Section, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Pharmacol Res 52:1-4. 2005
  35. ncbi request reprint Doping with growth hormone/IGF-1, anabolic steroids or erythropoietin: is there a cancer risk?
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Pharmacol Res 55:359-69. 2007
    ..Anyway, athletes should be made aware that long-term treatment with doping agents might increase the risk of developing cancer...
  36. pmc Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant
    Paola Fiorani
    Department of Biology, University of Rome Tor Vergata, CNR National Research Council, INFM National Institute for the Physics of Matter, Rome 00133, Italy
    Nucleic Acids Res 37:6849-58. 2009
    ..Taken together these results indicate the existence of a long range communication between the linker domain and the active site region and points out the crucial role of the linker in the modulation of the catalytic activity...
  37. pmc Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide
    Lucio Tentori
    Department of System Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    BMC Cancer 14:151. 2014
    ..PARPi are also investigated as monotherapy for tumors with deficiency of homologous recombination (HR). We have investigated whether PARPi may restore GSC sensitivity to TMZ or may be effective as monotherapy...
  38. ncbi request reprint Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site
    Lucio Tentori
    Department of Neuroscience, University of Rome Tor Vergata, Via di Tor Vergata 135, 00133 Rome, Italy
    Blood 99:2241-4. 2002
    ..Treatment with TZM alone was ineffective. This is the first report exploring in vivo the combination of TZM with PARP inhibitor for intracerebral neoplasias...
  39. ncbi request reprint BCG-infected adherent mononuclear cells release cytokines that regulate group 1 CD1 molecule expression
    Salvatore Pasquale Prete
    Department of Neuroscience, School of Medicine, University of Rome Tor Vergata, Rome, Italy
    Int Immunopharmacol 7:321-32. 2007
    ..It cannot be excluded that this mechanism could play a role in the limited efficiency of BCG vaccination...
  40. ncbi request reprint Pharmacological modulation of carcinoembryonic antigen in human cancer cells: studies with staurosporine
    Salvatore P Prete
    Department of Neuroscience, University of Rome, Tor Vergata, Italy
    Int Immunopharmacol 2:641-51. 2002
    ..This appears to be of potential clinical interest for the development of new immunotherapeutic or diagnostic approaches based on the pharmacological modulation of this antigenic marker...
  41. ncbi request reprint Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors
    Lucio Tentori
    Pharmacology Section, Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Pharmacol Res 45:73-85. 2002
    ..Moreover, the discovery of novel functions for the multiple members of the PARP family might lead in the future to additional clinical indications for PARP inhibitors...
  42. ncbi request reprint Treatment of peripheral blood with staurosporine increases detection of circulating carcinoembryonic antigen positive tumor cells
    Angelo Aquino
    Int J Cancer 100:119-21. 2002
  43. ncbi request reprint Primary cultures of microglial cells for testing toxicity of anticancer drugs
    Mauro Vairano
    Institute of Pharmacology, Catholic University Medical School, Largo Francesco Vito 1, Rome 00168, Italy
    Toxicol Lett 148:91-4. 2004
    ..TMZ has no effect at concentrations of clinical interest, whereas MTX significantly increases cell metabolism at 30 microM, a phenomenon possibly reflecting MTX neurotoxicity observed in patients...
  44. ncbi request reprint Valproic acid activity in androgen-sensitive and -insensitive human prostate cancer cells
    Fortunata Iacopino
    Institute of Histology and Embryology, Faculty of Medicine, Catholic University of the Sacred Heart, 00168 Rome, Italy
    Int J Oncol 32:1293-303. 2008
    ....
  45. ncbi request reprint Correspondence re: DC Lev et al., Dacarbazine causes transcriptional up-regulation of interleukin 8 and vascular endothelial growth factor in melanoma cells: a possible escape mechanism from chemotherapy. Mol Cancer Ther, 2003;2(8):753-63
    Lucio Tentori
    Mol Cancer Ther 3:383; author reply 383-4. 2004