Davide Grassi

Summary

Affiliation: University of L'Aquila
Country: Italy

Publications

  1. ncbi request reprint Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons
    Davide Grassi
    Department of Internal Medicine and Public Health, University of L Aquila, L Aquila, Italy
    Am J Clin Nutr 81:611-4. 2005
  2. ncbi request reprint Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives
    Davide Grassi
    Dipartimento Internal Medicine and Public Health, University of L Aquila, Piazzale Salvatore Tommasi 1, 67100 Coppito, L Aquila, Italy
    Hypertension 46:398-405. 2005
  3. ncbi request reprint C-reactive protein: interaction with the vascular endothelium and possible role in human atherosclerosis
    Claudio Ferri
    Department of Internal Medicine and Public Health, University of L Aquila, L Aquila, Italy
    Curr Pharm Des 13:1631-45. 2007
  4. ncbi request reprint Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate
    Davide Grassi
    Department of Internal Medicine and Public Health, University of L Aquila, 67100 L Aquila, Italy
    J Nutr 138:1671-6. 2008
  5. doi request reprint Black tea consumption dose-dependently improves flow-mediated dilation in healthy males
    Davide Grassi
    Department of Internal Medicine and Public Health, University of L Aquila, L Aquila, Italy
    J Hypertens 27:774-81. 2009
  6. doi request reprint Black tea lowers blood pressure and wave reflections in fasted and postprandial conditions in hypertensive patients: a randomised study
    Davide Grassi
    Department of Life, Health and Environmental Sciences, University of L Aquila, Viale San Salvatore, L Aquila 67100, Italy
    Nutrients 7:1037-51. 2015
  7. doi request reprint Hyperuricemia and cardiovascular risk
    Davide Grassi
    Department of Life, Health and Environmental Sciences, University of L Aquila, Viale S Salvatore, Delta 6 Medicina, 67100, Coppito L Aquila, Italy
    High Blood Press Cardiovasc Prev 21:235-42. 2014
  8. pmc Peripheral vascular dysfunction in migraine: a review
    Simona Sacco
    Department of Neurology and Regional Headache Center, University of L Aquila, Piazzale Salvatore Tommasi 1, L Aquila, 67100, Italy
    J Headache Pain 14:80. 2013
  9. doi request reprint Protective effects of flavanol-rich dark chocolate on endothelial function and wave reflection during acute hyperglycemia
    Davide Grassi
    University of L Aquila, Department of Internal Medicine and Public Health, Viale S Salvatore, Delta 6 Medicina, 67100 Coppito, L Aquila, Italy
    Hypertension 60:827-32. 2012
  10. pmc Flavonoids: antioxidants against atherosclerosis
    Davide Grassi
    Department of Internal Medicine and Public Health, University of L Aquila, L Aquila, 67100 Italy
    Nutrients 2:889-902. 2010

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons
    Davide Grassi
    Department of Internal Medicine and Public Health, University of L Aquila, L Aquila, Italy
    Am J Clin Nutr 81:611-4. 2005
    ..In turn, nitric oxide bioavailability deeply influences insulin-stimulated glucose uptake and vascular tone. Thus, flavanols may also exert positive metabolic and pressor effects...
  2. ncbi request reprint Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives
    Davide Grassi
    Dipartimento Internal Medicine and Public Health, University of L Aquila, Piazzale Salvatore Tommasi 1, 67100 Coppito, L Aquila, Italy
    Hypertension 46:398-405. 2005
    ..These results suggest that, while balancing total calorie intake, flavanols from cocoa products may provide some cardiovascular benefit if included as part of a healthy diet for patients with EH...
  3. ncbi request reprint C-reactive protein: interaction with the vascular endothelium and possible role in human atherosclerosis
    Claudio Ferri
    Department of Internal Medicine and Public Health, University of L Aquila, L Aquila, Italy
    Curr Pharm Des 13:1631-45. 2007
    ..Then, we have discussed how to measure circulating CRP and the more recent findings on the suggested role of circulating CRP as a novel cardiovascular risk factor...
  4. ncbi request reprint Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate
    Davide Grassi
    Department of Internal Medicine and Public Health, University of L Aquila, 67100 L Aquila, Italy
    J Nutr 138:1671-6. 2008
    ..These findings suggest flavanol-rich, low-energy cocoa food products may have a positive impact on CVD risk factors...
  5. doi request reprint Black tea consumption dose-dependently improves flow-mediated dilation in healthy males
    Davide Grassi
    Department of Internal Medicine and Public Health, University of L Aquila, L Aquila, Italy
    J Hypertens 27:774-81. 2009
    ..Further, no study has evaluated the dose-response curve. Our study aimed to test the effects of various doses of black tea on vascular function, BP and insulin resistance...
  6. doi request reprint Black tea lowers blood pressure and wave reflections in fasted and postprandial conditions in hypertensive patients: a randomised study
    Davide Grassi
    Department of Life, Health and Environmental Sciences, University of L Aquila, Viale San Salvatore, L Aquila 67100, Italy
    Nutrients 7:1037-51. 2015
    ..Considering lipemia-induced impairment of arterial function may occur frequently during the day, our findings suggest regular consumption of black tea may be relevant for cardiovascular protection...
  7. doi request reprint Hyperuricemia and cardiovascular risk
    Davide Grassi
    Department of Life, Health and Environmental Sciences, University of L Aquila, Viale S Salvatore, Delta 6 Medicina, 67100, Coppito L Aquila, Italy
    High Blood Press Cardiovasc Prev 21:235-42. 2014
    ..We review the evidence stating the relationship between hyperuricemia and the development of comorbid conditions contributing to cardiovascular risk and disease. ..
  8. pmc Peripheral vascular dysfunction in migraine: a review
    Simona Sacco
    Department of Neurology and Regional Headache Center, University of L Aquila, Piazzale Salvatore Tommasi 1, L Aquila, 67100, Italy
    J Headache Pain 14:80. 2013
    ..However, further targeted research is needed to understand whether altered arterial function explains the increased risk of vascular disease among patients with migraine. ..
  9. doi request reprint Protective effects of flavanol-rich dark chocolate on endothelial function and wave reflection during acute hyperglycemia
    Davide Grassi
    University of L Aquila, Department of Internal Medicine and Public Health, Viale S Salvatore, Delta 6 Medicina, 67100 Coppito, L Aquila, Italy
    Hypertension 60:827-32. 2012
    ..These results suggest cocoa flavanols may contribute to vascular health by reducing the postprandial impairment of arterial function associated with the pathogenesis of atherosclerosis...
  10. pmc Flavonoids: antioxidants against atherosclerosis
    Davide Grassi
    Department of Internal Medicine and Public Health, University of L Aquila, L Aquila, 67100 Italy
    Nutrients 2:889-902. 2010
    ..Dietary flavonoids represent a range of polyphenolic compounds naturally occurring in plant foods. Flavonoids are potentially involved in cardiovascular prevention mainly by decreasing oxidative stress and increasing NO bioavailability...
  11. ncbi request reprint Cardiovascular risk and endothelial dysfunction: the preferential route for atherosclerosis
    Davide Grassi
    Department of Internal Medicine and Public Health, University of L Aquila, Viale S Salvatore, Delta 6 Medicina, 67100 Coppito L Aquila, Italy
    Curr Pharm Biotechnol 12:1343-53. 2011
    ..The concepts of "endothelial dysfunction" and "endothelial activation" referring to different alterations in endothelial phenotype, may contribute to the development and clinical expression of atherosclerosis...
  12. ncbi request reprint Oxidative stress and endothelial dysfunction: say NO to cigarette smoking!
    Davide Grassi
    Department of Internal Medicine and Public Health, University of L Aquila, Viale S Salvatore, Delta 6 Medicina, 67100 Coppito AQ, Italy
    Curr Pharm Des 16:2539-50. 2010
    ....
  13. doi request reprint Blood pressure and cardiovascular risk: what about cocoa and chocolate?
    Davide Grassi
    Department of Internal Medicine and Public Health, University of L Aquila, L Aquila, Italy
    Arch Biochem Biophys 501:112-5. 2010
    ..This paper summarizes new findings concerning cocoa effects on cardiovascular health focusing on putative mechanisms of action and nutritional and "pharmacological" viewpoints. Cocoa consumption could play a pivotal role in human health...
  14. ncbi request reprint Flavonoids, vascular function and cardiovascular protection
    Davide Grassi
    Department of Internal Medicine and Public Health, University of L Aquila, Coppito, Italy
    Curr Pharm Des 15:1072-84. 2009
    ....
  15. doi request reprint Tea, flavonoids, and cardiovascular health: endothelial protection
    Davide Grassi
    Department of Life, Health, and Environmental Sciences, University of L Aquila, L Aquila, Italy DG, GD, PDG, MDF, EF, PC, and CF and University Sapienza II Faculty of Medicine, Rome, Italy LF
    Am J Clin Nutr 98:1660S-1666S. 2013
    ....
  16. ncbi request reprint Tea, flavonoids, and nitric oxide-mediated vascular reactivity
    Davide Grassi
    Department of Internal Medicine and Public Health, University of L Aquila, 67100 L Aquila, Italy
    J Nutr 138:1554S-1560S. 2008
    ..Thus, because tea is a popular beverage worldwide, and several studies have shown that it is protective against CVD, further studies are needed to determine the role of tea in primary and secondary cardiovascular prevention...
  17. doi request reprint Protective effects of dark chocolate on endothelial function and diabetes
    Davide Grassi
    Department of Life, Health and Environmental Sciences, University of L Aquila, L Aquila, Italy
    Curr Opin Clin Nutr Metab Care 16:662-8. 2013
    ..This could be of clinical relevance and may suggest the mechanistic explanation for the reduced risk of cardiovascular events reported in the different studies after cocoa intake...
  18. doi request reprint Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study
    Giovambattista Desideri
    University of L Aquila, Department of Life, Health, and Environmental Sciences, Viale S Salvatore, Delta 6 Medicina, 67100 Coppito, L Aquila, Italy
    Hypertension 60:794-801. 2012
    ..This effect appears mediated in part by an improvement in insulin sensitivity...
  19. pmc Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway
    Giovambattista Desideri
    Department of Internal Medicine and Public Health, University of L Aquila, Piazzale S Tommasi 1, 67100 Coppito, L Aquila, Italy
    Mediators Inflamm 2008:305087. 2008
    ..In conclusion, among the four tested ACE-I, zofenoprilat was more effective in improving endothelin-1/nitric oxide balance in HUVECs likely because of its greater antioxidant properties...
  20. ncbi request reprint Enhanced plasma soluble CD40 ligand levels in essential hypertensive patients with blunted nocturnal blood pressure decrease
    Giovambattista Desideri
    Department of Internal Medicine and Public Health, University of L Aquila, Piazzale Salvatore Tommasi 1, 67100 Coppito, L Aquila, Italy
    Am J Hypertens 20:70-6; discussion 77. 2007
    ..Therefore, we evaluated the relationship between circulating sCD40L levels, circadian BP profile, and early carotid atherosclerosis in essential hypertensives...
  21. doi request reprint Soluble CD40 ligand is predictive of combined cardiovascular morbidity and mortality in patients on haemodialysis at a relatively short-term follow-up
    Giovambattista Desideri
    Department of Internal Medicine and Public Health, University of L Aquila, L Aquila, Italy
    Nephrol Dial Transplant 26:2983-8. 2011
    ....
  22. ncbi request reprint Cardiovascular risk and cardiometabolic protection: role of glitazones
    Luisa Petrazzi
    Department of Internal Medicine and Public Health, University of L Aquila, L Aquila Italy
    J Nephrol 21:826-35. 2008
    ..Additional large-scale trials are awaited to clarify the of role TZDs in cardiovascular outcomes...
  23. doi request reprint Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study-a randomized controlled trial
    Daniela Mastroiacovo
    From the Geriatric Unit DM, AR, LP, RR, MCL, and GD and the Alzheimer s Unit MCL and GD, SS Filippo e Nicola Hospital, L Aquila, Italy Mars, Inc, McLean, VA CK U the Department of Life, Health, and Environmental Sciences, University of L Aquila, L Aquila, Italy DG, sn, CM, CF, and GD and Complesso Integrato Columbus, Rome, Italy RB
    Am J Clin Nutr 101:538-48. 2015
    ..Recent evidence has indicated that flavanol consumption may have many health benefits in humans, including improved cognitive activities...
  24. pmc Chronic hyperuricemia, uric acid deposit and cardiovascular risk
    Davide Grassi
    University of L Aquila Department of Internal Medicine and Public Health San Salvatore Hospital Italy
    Curr Pharm Des 19:2432-8. 2013
    ..The value of uric acid as a biomarker and as a potential therapeutic target for tailored old and novel "cardiometabolic" treatments will be also discussed...
  25. ncbi request reprint Cognitive decline as a consequence of essential hypertension
    Davide Grassi
    Department of Internal Medicine and Public Health, University of L Aquila, L Aquila, Italy
    Curr Pharm Des 17:3032-8. 2011
    ..New randomized controlled trials are needed to definitively clarify clinical advantages and specifically elucidate the relationship between anti-hypertensive treatments and cognitive function or dementia...
  26. doi request reprint Angiotensin-converting-enzyme inhibition counteracts angiotensin II-mediated endothelial cell dysfunction by modulating the p38/SirT1 axis
    Francesco Marampon
    aDepartment of Applied Clinical Sciences and Biotechnology, University of L Aquila bDepartment MeSVA, University of L Aquila, L Aquila, Italy cDepartment of Molecular Immunology, Virology, and Medical Genetics, The Ohio State University, Columbus, Ohio, USA dPreclinical Development Department, Menarini Ricerche, Firenze, Italy Francesco Marampon and Giovanni L Gravina contributed equally to the writing of this article
    J Hypertens 31:1972-83. 2013
    ..We have studied the chain of events induced by angiotensin-converting-enzyme (ACE) activation in vascular umbilical vein endothelial cells (HUVECs) by using an ACE inhibitor such as zofenoprilat...
  27. doi request reprint Cocoa consumption dose-dependently improves flow-mediated dilation and arterial stiffness decreasing blood pressure in healthy individuals
    Davide Grassi
    aDepartment of Life, Health and Environmental Science, University of L Aquila, L Aquila, Italy bBarry Callebaut, Lebbeke Wieze, Belgium
    J Hypertens 33:294-303. 2015
    ..Cocoa flavonoids exert beneficial vascular effects and reduce the risk of cardiovascular morbidity and mortality. Nevertheless, the involved mechanisms have not been clarified and no study has yet focused on the dose-response effects...
  28. doi request reprint Endothelium/nitric oxide mechanism mediates vasorelaxation and counteracts vasoconstriction induced by low concentration of flavanols
    Annalisa Aggio
    Department of Internal Medicine and Public Health, University of L Aquila, Viale S Salvatore, Delta 6 Medicina, 67100, Coppito, AQ, Italy
    Eur J Nutr 52:263-72. 2013
    ..The aim of our study was to investigate the effects of two flavanols at different doses on arterial functional state...
  29. doi request reprint Enhanced proatherogenic inflammation after recombinant human TSH administration in patients monitored for thyroid cancer remnant
    Giovambattista Desideri
    Department of Internal Medicine and Public Health, University of L Aquila, Italy
    Clin Endocrinol (Oxf) 71:429-33. 2009
    ..To evaluate the effect of recombinant human TSH (rhTSH) on biomarkers of vascular endothelial cell and platelet activation in patients monitored for thyroid carcinoma remnant...
  30. doi request reprint Therapeutic approaches to chronic hyperuricemia and gout
    Davide Grassi
    Department of Life, Health and Environmental Sciences, University of L Aquila, Viale S Salvatore, Delta 6 Medicina, 67100, Coppito, L Aquila, Italy
    High Blood Press Cardiovasc Prev 21:243-50. 2014
    ..Associated comorbidities and cardiovascular risk factors should be also addressed as an important part of the management of chronic hyperuricemia and gout. ..
  31. ncbi request reprint Cocoa beans, endothelial function and aging: an unexpected friendship?
    Claudio Ferri
    J Hypertens 24:1471-4. 2006