Research Topics
Genomes and GenesSpecies | Laura GramantieriSummaryAffiliation: University of Bologna Country: Italy Publications
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Detail Information
Publications
Aberrant Notch3 and Notch4 expression in human hepatocellular carcinomaLaura Gramantieri
Center for Applied Biomedical Research CRBA, University of Bologna and St Orsola Malpighi University Hospital, Bologna, Italy
Liver Int 27:997-1007. 2007..Notch signalling is altered in several solid tumours and it plays a role in growth inhibition and apoptosis of hepatocellular carcinoma (HCC)-derived cell lines, bile duct development and hepatocyte regeneration...
MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cellsFrancesca Fornari
Dipartimento di Medicina Clinica e CRBA, Policlinico S Orsola Malpighi, Bologna, Italy
Cancer Res 69:5761-7. 2009..Our findings establish a basis toward the development of combined chemo- and miRNA-based therapy for HCC treatment...- MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cellsFrancesca Fornari
Centro di Ricerca Biomedica Applicata e Dipartimento di Medicina Interna, Policlinico S Orsola Malpighi e Università di Bologna, Bologna, Italy
Cancer Res 70:5184-93. 2010..These results suggest that tactics to regulate mTOR and c-Met by elevating levels of miR-199a-3p may have therapeutic benefits in highly lethal cancers such as HCC... - GADD45-alpha expression in cirrhosis and hepatocellular carcinoma: relationship with DNA repair and proliferationLaura Gramantieri
Center for Applied Biomedical Research CRBA, Saint Orsola Malpighi University Hospital, University of Bologna, 40138 Bologna, Italy
Hum Pathol 36:1154-62. 2005..GADD45-alpha protein levels were higher in HCCs with DNA-bound CDKN1A and PCNA, suggesting a possible role in DNA repair... - CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinomaCatia Giovannini
Center for Applied Biomedical Research, S Orsola Malpighi University Hospital, Bologna, Italy
Am J Pathol 181:413-22. 2012..In addition, reduced Hes1 protein expression is accompanied by a shorter time to recurrence after curative resection, suggesting that Hes1 may represent a biomarker for prediction of patients with poor prognosis... - MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocalityLaura Gramantieri
Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Bologna, Italy
Clin Cancer Res 15:5073-81. 2009..Deregulated cell proliferation and apoptosis play a major role in hepatocellular carcinoma (HCC). MicroRNAs participate in the modulation of key molecules linked to hepatocarcinogenesis... - Human hepatocellular carcinoma expresses specific PCNA isoforms: an in vivo and in vitro evaluationAnnamaria Venturi
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Lab Invest 88:995-1007. 2008..We conclude that human hepatocellular carcinoma expresses specific PCNA isoforms compared to those found in cirrhosis, implicating a role for PCNA functional alterations in hepatocarcinogenesis... - MicroRNA involvement in hepatocellular carcinomaLaura Gramantieri
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
J Cell Mol Med 12:2189-204. 2008..These findings suggest that miRNAs could become novel molecular targets for HCC treatment. The demonstration of in vivo efficacy and safety of anti-miRNA compounds has opened the way to their use in clinical trials... - Selective ablation of Notch3 in HCC enhances doxorubicin's death promoting effect by a p53 dependent mechanismCatia Giovannini
Center for Applied Biomedical Research CRBA, S Orsola Malpighi University Hospital, Bologna, Italy
J Hepatol 50:969-79. 2009..We previously reported aberrant Notch3 and Notch4 up-regulation in HCC and we have extended these observations to include Notch1... - Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinomaLaura Gramantieri
Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Bologna, Italy
Cancer Res 67:6092-9. 2007..These results indicate that cyclin G1 is a target of miR-122a and expand our knowledge of the molecular alterations involved in HCC pathogenesis and of the role of miRNAs in human cancer... - In human hepatocellular carcinoma in cirrhosis proliferating cell nuclear antigen (PCNA) is involved in cell proliferation and cooperates with P21 in DNA repairLaura Gramantieri
Center for Applied Biomedical Research CRBA, University of Bologna and St Orsola Malpighi University Hospital, Bologna, Italy
J Hepatol 39:997-1003. 2003..During DNA-synthesis and repair the only active PCNA fraction is tightly bound to DNA. Similarly, during DNA-repair, a fraction of p21 colocalizes with PCNA in a detergent-insoluble form... - Checkpoint effectors CDKN1A and Gadd45 correlate with oxidative DNA damage in human prostate carcinomaCatia Giovannini
Center for Applied Biomedical Research CRBA, S Orsola Malpighi University Hospital, Via Massarenti 9, 40138 Bologna, Italy
Anticancer Res 24:3955-60. 2004..Although cellular oxidative stress is a major cause of DNA damage, it is still not clear to what degree it affects genetic instability and malignant progression in established prostate carcinoma (PCa)... - Serum albumin-bound proteomic signature for early detection and staging of hepatocarcinoma: sample variability and data classificationCarlo M Camaggi
Dipartimento di Chimica Organica, Universita di Bologna, Bologna, Italy
Clin Chem Lab Med 48:1319-26. 2010..However, published procedures have been criticized for the lack of data about analytical reproducibility, and the use of inadequate data processing... - Notch3 intracellular domain accumulates in HepG2 cell lineCatia Giovannini
Department of Internal Medicine and Gastroenterology, University of Bologna and S Orsola Malpighi University Hospital, 40138 Bologna, Italy
Anticancer Res 26:2123-7. 2006..The expression and the functional role of some major components of the Notch signaling pathway in human hepatocellular carcinoma (HCC) are poorly characterized... - From liver cirrhosis to HCCLuigi Bolondi
Department of Digestive Diseases and Internal Medicine, University of Bologna Policlinico S Orsola Malpighi Bologna, Via Albertoni 15, Bologna, Italy
Intern Emerg Med 6:93-8. 2011.... - Hepatocellular carcinoma: epidemiology and clinical aspectsRoberto Mazzanti
Department of Oncology, Azienda Ospedaliero Universitaria Careggi, Istituto Toscano Tumori, University of Florence, Florence, Italy
Mol Aspects Med 29:130-43. 2008..In this review authors report the most recent findings on the pathogenesis of liver cancer and on therapeutic approaches, included those emerging from the most recent literature... - Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomasGeorge A Calin
Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
Cancer Cell 12:215-29. 2007..Our findings argue that ncRNAs and interaction between noncoding genes are involved in tumorigenesis to a greater extent than previously thought... - Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancerElena Miotto
Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy
Cancer Res 64:8156-9. 2004..Our results indicate that CDH4 may act as a tumor suppressor gene in human gastrointestinal tumors and can potentially be used as an early diagnostic marker for gastrointestinal tumorigenesis... - Liver metastases from rectal carcinoma: disease progression during chemotherapy despite loss of arterial-phase hypervascularity on real-time contrast-enhanced harmonic sonography at low acoustic energyFabio Piscaglia
Division of Internal Medicine, University of Bologna, Azienda Ospedaliera S. Orsola-Malpighi, Via Albertoni 15, 40138 Bologna, Italy
J Clin Ultrasound 31:387-91. 2003..In this case, changes in arterial perfusion over time did not parallel the response of liver metastases to chemotherapy...