Laura Gramantieri

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi request reprint Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma
    Laura Gramantieri
    Center for Applied Biomedical Research CRBA, University of Bologna and St Orsola Malpighi University Hospital, Bologna, Italy
    Liver Int 27:997-1007. 2007
  2. doi request reprint MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells
    Francesca Fornari
    Dipartimento di Medicina Clinica e CRBA, Policlinico S Orsola Malpighi, Bologna, Italy
    Cancer Res 69:5761-7. 2009
  3. ncbi request reprint MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells
    Francesca Fornari
    Centro di Ricerca Biomedica Applicata e Dipartimento di Medicina Interna, Policlinico S Orsola Malpighi e Università di Bologna, Bologna, Italy
    Cancer Res 70:5184-93. 2010
  4. ncbi request reprint GADD45-alpha expression in cirrhosis and hepatocellular carcinoma: relationship with DNA repair and proliferation
    Laura Gramantieri
    Center for Applied Biomedical Research CRBA, Saint Orsola Malpighi University Hospital, University of Bologna, 40138 Bologna, Italy
    Hum Pathol 36:1154-62. 2005
  5. doi request reprint CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma
    Catia Giovannini
    Center for Applied Biomedical Research, S Orsola Malpighi University Hospital, Bologna, Italy
    Am J Pathol 181:413-22. 2012
  6. pmc MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality
    Laura Gramantieri
    Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Bologna, Italy
    Clin Cancer Res 15:5073-81. 2009
  7. ncbi request reprint Human hepatocellular carcinoma expresses specific PCNA isoforms: an in vivo and in vitro evaluation
    Annamaria Venturi
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Lab Invest 88:995-1007. 2008
  8. doi request reprint MicroRNA involvement in hepatocellular carcinoma
    Laura Gramantieri
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    J Cell Mol Med 12:2189-204. 2008
  9. ncbi request reprint Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma
    Laura Gramantieri
    Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Bologna, Italy
    Cancer Res 67:6092-9. 2007
  10. doi request reprint Selective ablation of Notch3 in HCC enhances doxorubicin's death promoting effect by a p53 dependent mechanism
    Catia Giovannini
    Center for Applied Biomedical Research CRBA, S Orsola Malpighi University Hospital, Bologna, Italy
    J Hepatol 50:969-79. 2009

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma
    Laura Gramantieri
    Center for Applied Biomedical Research CRBA, University of Bologna and St Orsola Malpighi University Hospital, Bologna, Italy
    Liver Int 27:997-1007. 2007
    ..Notch signalling is altered in several solid tumours and it plays a role in growth inhibition and apoptosis of hepatocellular carcinoma (HCC)-derived cell lines, bile duct development and hepatocyte regeneration...
  2. doi request reprint MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells
    Francesca Fornari
    Dipartimento di Medicina Clinica e CRBA, Policlinico S Orsola Malpighi, Bologna, Italy
    Cancer Res 69:5761-7. 2009
    ..Our findings establish a basis toward the development of combined chemo- and miRNA-based therapy for HCC treatment...
  3. ncbi request reprint MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells
    Francesca Fornari
    Centro di Ricerca Biomedica Applicata e Dipartimento di Medicina Interna, Policlinico S Orsola Malpighi e Università di Bologna, Bologna, Italy
    Cancer Res 70:5184-93. 2010
    ..These results suggest that tactics to regulate mTOR and c-Met by elevating levels of miR-199a-3p may have therapeutic benefits in highly lethal cancers such as HCC...
  4. ncbi request reprint GADD45-alpha expression in cirrhosis and hepatocellular carcinoma: relationship with DNA repair and proliferation
    Laura Gramantieri
    Center for Applied Biomedical Research CRBA, Saint Orsola Malpighi University Hospital, University of Bologna, 40138 Bologna, Italy
    Hum Pathol 36:1154-62. 2005
    ..GADD45-alpha protein levels were higher in HCCs with DNA-bound CDKN1A and PCNA, suggesting a possible role in DNA repair...
  5. doi request reprint CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma
    Catia Giovannini
    Center for Applied Biomedical Research, S Orsola Malpighi University Hospital, Bologna, Italy
    Am J Pathol 181:413-22. 2012
    ..In addition, reduced Hes1 protein expression is accompanied by a shorter time to recurrence after curative resection, suggesting that Hes1 may represent a biomarker for prediction of patients with poor prognosis...
  6. pmc MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality
    Laura Gramantieri
    Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Bologna, Italy
    Clin Cancer Res 15:5073-81. 2009
    ..Deregulated cell proliferation and apoptosis play a major role in hepatocellular carcinoma (HCC). MicroRNAs participate in the modulation of key molecules linked to hepatocarcinogenesis...
  7. ncbi request reprint Human hepatocellular carcinoma expresses specific PCNA isoforms: an in vivo and in vitro evaluation
    Annamaria Venturi
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Lab Invest 88:995-1007. 2008
    ..We conclude that human hepatocellular carcinoma expresses specific PCNA isoforms compared to those found in cirrhosis, implicating a role for PCNA functional alterations in hepatocarcinogenesis...
  8. doi request reprint MicroRNA involvement in hepatocellular carcinoma
    Laura Gramantieri
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    J Cell Mol Med 12:2189-204. 2008
    ..These findings suggest that miRNAs could become novel molecular targets for HCC treatment. The demonstration of in vivo efficacy and safety of anti-miRNA compounds has opened the way to their use in clinical trials...
  9. ncbi request reprint Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma
    Laura Gramantieri
    Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Bologna, Italy
    Cancer Res 67:6092-9. 2007
    ..These results indicate that cyclin G1 is a target of miR-122a and expand our knowledge of the molecular alterations involved in HCC pathogenesis and of the role of miRNAs in human cancer...
  10. doi request reprint Selective ablation of Notch3 in HCC enhances doxorubicin's death promoting effect by a p53 dependent mechanism
    Catia Giovannini
    Center for Applied Biomedical Research CRBA, S Orsola Malpighi University Hospital, Bologna, Italy
    J Hepatol 50:969-79. 2009
    ..We previously reported aberrant Notch3 and Notch4 up-regulation in HCC and we have extended these observations to include Notch1...
  11. ncbi request reprint In human hepatocellular carcinoma in cirrhosis proliferating cell nuclear antigen (PCNA) is involved in cell proliferation and cooperates with P21 in DNA repair
    Laura Gramantieri
    Center for Applied Biomedical Research CRBA, University of Bologna and St Orsola Malpighi University Hospital, Bologna, Italy
    J Hepatol 39:997-1003. 2003
    ..During DNA-synthesis and repair the only active PCNA fraction is tightly bound to DNA. Similarly, during DNA-repair, a fraction of p21 colocalizes with PCNA in a detergent-insoluble form...
  12. ncbi request reprint Checkpoint effectors CDKN1A and Gadd45 correlate with oxidative DNA damage in human prostate carcinoma
    Catia Giovannini
    Center for Applied Biomedical Research CRBA, S Orsola Malpighi University Hospital, Via Massarenti 9, 40138 Bologna, Italy
    Anticancer Res 24:3955-60. 2004
    ..Although cellular oxidative stress is a major cause of DNA damage, it is still not clear to what degree it affects genetic instability and malignant progression in established prostate carcinoma (PCa)...
  13. doi request reprint Serum albumin-bound proteomic signature for early detection and staging of hepatocarcinoma: sample variability and data classification
    Carlo M Camaggi
    Dipartimento di Chimica Organica, Universita di Bologna, Bologna, Italy
    Clin Chem Lab Med 48:1319-26. 2010
    ..However, published procedures have been criticized for the lack of data about analytical reproducibility, and the use of inadequate data processing...
  14. ncbi request reprint Notch3 intracellular domain accumulates in HepG2 cell line
    Catia Giovannini
    Department of Internal Medicine and Gastroenterology, University of Bologna and S Orsola Malpighi University Hospital, 40138 Bologna, Italy
    Anticancer Res 26:2123-7. 2006
    ..The expression and the functional role of some major components of the Notch signaling pathway in human hepatocellular carcinoma (HCC) are poorly characterized...
  15. pmc Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3b phosphorylation and p21 down-regulation in hepatocellular carcinoma
    Catia Giovannini
    Center for Applied Biomedical Research CRBA, S Orsola Malpighi University Hospital, Bologna, Italy
    Oncotarget 4:1618-31. 2013
    ..Notch3 inhibition in combination with sorafenib can be a promising strategy for treatment of HCC. ..
  16. doi request reprint From liver cirrhosis to HCC
    Luigi Bolondi
    Department of Digestive Diseases and Internal Medicine, University of Bologna Policlinico S Orsola Malpighi Bologna, Via Albertoni 15, Bologna, Italy
    Intern Emerg Med 6:93-8. 2011
    ....
  17. ncbi request reprint Hepatocellular carcinoma: epidemiology and clinical aspects
    Roberto Mazzanti
    Department of Oncology, Azienda Ospedaliero Universitaria Careggi, Istituto Toscano Tumori, University of Florence, Florence, Italy
    Mol Aspects Med 29:130-43. 2008
    ..In this review authors report the most recent findings on the pathogenesis of liver cancer and on therapeutic approaches, included those emerging from the most recent literature...
  18. ncbi request reprint Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas
    George A Calin
    Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 12:215-29. 2007
    ..Our findings argue that ncRNAs and interaction between noncoding genes are involved in tumorigenesis to a greater extent than previously thought...
  19. ncbi request reprint Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer
    Elena Miotto
    Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy
    Cancer Res 64:8156-9. 2004
    ..Our results indicate that CDH4 may act as a tumor suppressor gene in human gastrointestinal tumors and can potentially be used as an early diagnostic marker for gastrointestinal tumorigenesis...
  20. ncbi request reprint Liver metastases from rectal carcinoma: disease progression during chemotherapy despite loss of arterial-phase hypervascularity on real-time contrast-enhanced harmonic sonography at low acoustic energy
    Fabio Piscaglia
    Division of Internal Medicine, University of Bologna, Azienda Ospedaliera S Orsola Malpighi, Via Albertoni 15, 40138 Bologna, Italy
    J Clin Ultrasound 31:387-91. 2003
    ..In this case, changes in arterial perfusion over time did not parallel the response of liver metastases to chemotherapy...