C Gotti

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi Heterogeneity and selective targeting of neuronal nicotinic acetylcholine receptor (nAChR) subtypes expressed on retinal afferents of the superior colliculus and lateral geniculate nucleus: identification of a new native nAChR subtype alpha3beta2(alpha5 o
    Cecilia Gotti
    CNR, Institute of Neuroscience, Section of Cellular and Molecular Pharmacology Center, Department of Medical Pharmacology, University of Milan, Italy
    Mol Pharmacol 68:1162-71. 2005
  2. doi Structural and functional diversity of native brain neuronal nicotinic receptors
    Cecilia Gotti
    Department of Medical Pharmacology, CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology, University of Milan, Milan, Italy
    Biochem Pharmacol 78:703-11. 2009
  3. ncbi Heterogeneity and complexity of native brain nicotinic receptors
    Cecilia Gotti
    CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology, Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Biochem Pharmacol 74:1102-11. 2007
  4. ncbi Brain neuronal nicotinic receptors as new targets for drug discovery
    C Gotti
    CNR, Institute of Neuroscience, Section of Cellular and Molecular Pharmacology, Department of Medical Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milano, Italy
    Curr Pharm Des 12:407-28. 2006
  5. ncbi Expression of nigrostriatal alpha 6-containing nicotinic acetylcholine receptors is selectively reduced, but not eliminated, by beta 3 subunit gene deletion
    Cecilia Gotti
    Consiglio Nazionale delle Ricerche, Institute of Neuroscience, Section of Cellular and Molecular Pharmacology Center, Department of Medical Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Mol Pharmacol 67:2007-15. 2005
  6. doi Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors
    Luca Pucci
    Consiglio Nazionale delle Ricerche, Istituto di Neuroscienze, Farmacologia Cellulare e Molecolare e Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Milan, Italy
    FASEB J 25:3775-89. 2011
  7. ncbi Neuronal nicotinic receptors: from structure to pathology
    C Gotti
    CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology Section, Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Prog Neurobiol 74:363-96. 2004
  8. ncbi Developmental expression of heteromeric nicotinic receptor subtypes in chick retina
    S Vailati
    National Research Council, Institute of Neuroscience, Section of Cellular and Molecular Pharmacology, Department of Medical Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Mol Pharmacol 63:1329-37. 2003
  9. ncbi Neuronal nicotinic receptors, important new players in brain function
    F Clementi
    Department of Medical Pharmacology, CNR Cellular and Molecular Pharmacology Center, University of Milan, Via Vanvitelli 32, 20129, Milan, Italy
    Eur J Pharmacol 393:3-10. 2000
  10. ncbi A functional alpha-bungarotoxin receptor is present in chick cerebellum: purification and characterization
    C Gotti
    CNR Center of Cytopharmacology, Department of Medical Pharmacology, University of Milan, Italy
    Neuroscience 50:117-27. 1992

Collaborators

Detail Information

Publications34

  1. ncbi Heterogeneity and selective targeting of neuronal nicotinic acetylcholine receptor (nAChR) subtypes expressed on retinal afferents of the superior colliculus and lateral geniculate nucleus: identification of a new native nAChR subtype alpha3beta2(alpha5 o
    Cecilia Gotti
    CNR, Institute of Neuroscience, Section of Cellular and Molecular Pharmacology Center, Department of Medical Pharmacology, University of Milan, Italy
    Mol Pharmacol 68:1162-71. 2005
    ....
  2. doi Structural and functional diversity of native brain neuronal nicotinic receptors
    Cecilia Gotti
    Department of Medical Pharmacology, CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology, University of Milan, Milan, Italy
    Biochem Pharmacol 78:703-11. 2009
    ..We also discuss recent findings concerning the effect of chronic nicotine on the expression of native subtypes...
  3. ncbi Heterogeneity and complexity of native brain nicotinic receptors
    Cecilia Gotti
    CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology, Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Biochem Pharmacol 74:1102-11. 2007
    ....
  4. ncbi Brain neuronal nicotinic receptors as new targets for drug discovery
    C Gotti
    CNR, Institute of Neuroscience, Section of Cellular and Molecular Pharmacology, Department of Medical Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milano, Italy
    Curr Pharm Des 12:407-28. 2006
    ....
  5. ncbi Expression of nigrostriatal alpha 6-containing nicotinic acetylcholine receptors is selectively reduced, but not eliminated, by beta 3 subunit gene deletion
    Cecilia Gotti
    Consiglio Nazionale delle Ricerche, Institute of Neuroscience, Section of Cellular and Molecular Pharmacology Center, Department of Medical Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Mol Pharmacol 67:2007-15. 2005
    ..However, beta3 subunit expression is not essential for the expression of alpha6*, high-affinity alpha-CtxMII binding nAChRs...
  6. doi Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors
    Luca Pucci
    Consiglio Nazionale delle Ricerche, Istituto di Neuroscienze, Farmacologia Cellulare e Molecolare e Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Milan, Italy
    FASEB J 25:3775-89. 2011
    ..5-fold lower potency. Thus, MII[E11R] and RDP-MII[E11R] are potent antagonists showing a degree of α6β2* vs. α3β2* selectivity in vivo...
  7. ncbi Neuronal nicotinic receptors: from structure to pathology
    C Gotti
    CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology Section, Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Prog Neurobiol 74:363-96. 2004
    ..Finally, the role of NAChRs in disease will be considered in some details...
  8. ncbi Developmental expression of heteromeric nicotinic receptor subtypes in chick retina
    S Vailati
    National Research Council, Institute of Neuroscience, Section of Cellular and Molecular Pharmacology, Department of Medical Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Mol Pharmacol 63:1329-37. 2003
    ..These results indicate that there is an increase in receptor heterogeneity and complexity in chick retina during development that is also maintained in adulthood...
  9. ncbi Neuronal nicotinic receptors, important new players in brain function
    F Clementi
    Department of Medical Pharmacology, CNR Cellular and Molecular Pharmacology Center, University of Milan, Via Vanvitelli 32, 20129, Milan, Italy
    Eur J Pharmacol 393:3-10. 2000
    ....
  10. ncbi A functional alpha-bungarotoxin receptor is present in chick cerebellum: purification and characterization
    C Gotti
    CNR Center of Cytopharmacology, Department of Medical Pharmacology, University of Milan, Italy
    Neuroscience 50:117-27. 1992
    ....
  11. doi Nicotinic acetylcholine receptors in the mesolimbic pathway: primary role of ventral tegmental area alpha6beta2* receptors in mediating systemic nicotine effects on dopamine release, locomotion, and reinforcement
    Cecilia Gotti
    Department of Medical Pharmacology, Consiglio Nazionale delle Ricerche, Institute of Neuroscience, Cellular and Molecular Pharmacology Center, University of Milan, 20129 Milan, Italy
    J Neurosci 30:5311-25. 2010
    ....
  12. doi Partial deletion of the nicotinic cholinergic receptor alpha 4 or beta 2 subunit genes changes the acetylcholine sensitivity of receptor-mediated 86Rb+ efflux in cortex and thalamus and alters relative expression of alpha 4 and beta 2 subunits
    Cecilia Gotti
    Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, Institute of Neuroscience, Cellular and Molecular Pharmacology, Consiglio Nazionale delle Ricerche, University of Milan, Milan, Italy
    Mol Pharmacol 73:1796-807. 2008
    ..These results strongly suggest that alpha4beta2-nAChR with different stoichiometry are expressed in native tissue...
  13. ncbi Anti-neuronal nicotinic receptor antibodies in MG patients with thymoma
    C Gotti
    CNR Cellular and Molecular Pharmacology Center, Department of Medical Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milano, Italy
    J Neuroimmunol 113:142-5. 2001
    ..Our data suggest that there is no correlation between the presence of anti-alpha 3 antibodies and thymoma...
  14. ncbi Nicotinic acetylcholine receptor subtypes expression during rat retina development and their regulation by visual experience
    Milena Moretti
    CNR, Institute of Neuroscience, Section of Cellular and Molecular Pharmacology, Department of Medical Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milano, Italy
    Mol Pharmacol 66:85-96. 2004
    ..These receptors have a specific distribution, and their expression is finely regulated during development and by visual experience...
  15. doi A comparative study of the effects of the intravenous self-administration or subcutaneous minipump infusion of nicotine on the expression of brain neuronal nicotinic receptor subtypes
    Milena Moretti
    Consiglio Nazionale delle Ricerche, Neuroscience Institute Milano, Cellular and Molecular Pharmacology, Department of Medical Pharmacology, University of Milan, Milan, Italy
    Mol Pharmacol 78:287-96. 2010
    ..These results show that nicotine has an area-specific effect on receptor subtypes, regardless of its administration route, but the effect is quantitatively greater in the case of MP administration...
  16. pmc Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells
    Loredana Riganti
    CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology, Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Br J Pharmacol 146:1096-109. 2005
    ....
  17. ncbi Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic receptor subtypes
    Eric Carbonnelle
    CNR, Institute of Neuroscience, Section of Cellular and Molecular Pharmacology, Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Eur J Pharmacol 471:85-96. 2003
    ..Adding chemical groups of a different class or size to the basic nitrogen of cytisine leads to compounds that lose full agonist activity on the alpha 3 beta 4 and alpha 7 subtypes...
  18. ncbi Regulation of neuronal nicotinic receptor traffic and expression
    Annalisa Gaimarri
    CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology Center, Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Brain Res Rev 55:134-43. 2007
    ..We will particularly focus on the possible mechanisms involved in the up-regulation of nAChRs...
  19. ncbi Brain nicotinic acetylcholine receptors: native subtypes and their relevance
    Cecilia Gotti
    CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology, Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milan, 20129 Milan, Italy
    Trends Pharmacol Sci 27:482-91. 2006
    ....
  20. ncbi Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation
    Cecilia Gotti
    CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology Section, Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Italy
    Neurobiol Dis 23:481-9. 2006
    ..05). This study demonstrates distinct combinations of subunits contributing to heteromeric nicotinic receptor binding in the human brain that are area/pathway specific and differentially affected by neurodegeneration...
  21. ncbi Extremely low-frequency electromagnetic field (ELF-EMF) does not affect the expression of alpha3, alpha5 and alpha7 nicotinic receptor subunit genes in SH-SY5Y neuroblastoma cell line
    Ruth Adele Antonini
    Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Toxicol Lett 164:268-77. 2006
    ....
  22. ncbi Expression of mutant beta2 nicotinic receptors during development is crucial for epileptogenesis
    Irene Manfredi
    San Raffaele Scientific Institute, Milan, Italy
    Hum Mol Genet 18:1075-88. 2009
    ..Our data indicate that mutant nicotinic receptors are responsible for abnormal formation of neuronal circuits and/or long-lasting alteration of network assembly in the developing brain, thus leading to epilepsy...
  23. ncbi Subunit composition of nicotinic receptors in monkey striatum: effect of treatments with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or L-DOPA
    Maryka Quik
    The Parkinson s Institute, 1170 Morse Ave, Sunnyvale, CA 94089 1605, USA
    Mol Pharmacol 67:32-41. 2005
    ..Overall, these results suggest that drugs targeting non-alpha7 nicotinic receptors may be useful in the treatment of disorders characterized by nigrostriatal dopaminergic damage, such as Parkinson's disease...
  24. ncbi Alpha7 but not alpha4 AChR subunit expression is regulated by light in developing primary visual cortex
    Eugenio Aztiria
    International School for Advanced Studies ISAS SISSA, 34014 Trieste, Italy
    J Comp Neurol 480:378-91. 2004
    ....
  25. ncbi Design, synthesis, and preliminary pharmacological evaluation of new quinoline derivatives as nicotinic ligands
    Luca Guandalini
    Laboratory of Design, Synthesis and Study of Biologically Active Heterocycles HeteroBioLab, Department of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, I 50019 Sesto Fiorentino, Italy
    J Med Chem 50:4993-5002. 2007
    ..5-10.4 A, interact with the alpha4beta2* nicotinic receptor with Ki in the microM range; compound 3c shows preference for the alpha7* subtype...
  26. ncbi Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum
    Michele Zoli
    Department of Biomedical Sciences, Section of Physiology, University of Modena and Reggio Emilia, 41100 Modena, Italy
    J Neurosci 22:8785-9. 2002
    ..The identification of the nAChRs expressed on striatal dopaminergic terminals opens up the possibility of developing selective nAChR ligands active on dopaminergic systems and associated diseases, such as Parkinson's disease...
  27. ncbi Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice
    Nicolas Champtiaux
    Laboratoire de Neurobiologie Moléculaire, Centre National de la Recherche Scientifique Unité de Recherche Associée 2182 Récepteurs et Cognition, Institut Pasteur, 75724 Paris Cedex 15, France
    J Neurosci 23:7820-9. 2003
    ....
  28. ncbi Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures
    Davide Franceschini
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Brain Res Mol Brain Res 98:29-40. 2002
    ..These findings indicate that alpha7 may not be necessary for the mechanisms underlying nicotine-induced seizures...
  29. ncbi Nicotinic acetylcholine receptor subtypes in the rat sympathetic ganglion: pharmacological characterization, subcellular distribution and effect of pre- and postganglionic nerve crush
    Arianna Del Signore
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita La Sapienza, Rome, Italy
    J Neuropathol Exp Neurol 63:138-50. 2004
    ..This observation and the lack of any effect of preganglionic nerve crush on the number of nicotinic receptors suggest that the peripheral targets affect the organization of intraganglionic synapses in adult SCG...
  30. ncbi Synthesis and alpha4beta2 nicotinic affinity of unichiral 5-(2-pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes
    Marco Pallavicini
    Istituto di Chimica Farmaceutica e Tossicologica, Universita di Milano, Viale Abruzzi 42, I 20131 Milano, Italy
    Bioorg Med Chem Lett 16:5610-5. 2006
    ..Interestingly, both the synthesized pyrrolidinylbenzodioxanes exhibit analogous affinity at alpha(2) adrenergic receptor resembling the behaviour of some known alpha(2)-AR ligands recently proved to possess neuronal nicotinic affinity...
  31. ncbi Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization
    Chiara Fiorentini
    Section of Pharmacology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, 25124 Brescia, Italy
    Mol Pharmacol 74:59-69. 2008
    ..These data give a novel insight into how D1R and D3R may function in an integrated way, providing a molecular mechanism by which to converge D1R- and D3R-related dysfunctions...
  32. ncbi Dystrophin stabilizes alpha 3- but not alpha 7-containing nicotinic acetylcholine receptor subtypes at the postsynaptic apparatus in the mouse superior cervical ganglion
    Arianna Del Signore
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita La Sapienza, 0185 Roma, Italy
    Neurobiol Dis 10:54-66. 2002
    ..Conversely, dystrophin is not involved in the stabilization of the alpha7-containing nAChRs, as the percentage of alpha7-immunopositive synapses is similar in both wild-type and mdx mouse SCG...
  33. ncbi Synthesis and alpha4beta2 nicotinic affinity of 2-pyrrolidinylmethoxyimines and prolinal oxime ethers
    Marco Pallavicini
    Istituto di Chimica Farmaceutica e Tossicologica, Universita di Milano, Viale Abruzzi 42, I 20131 Milano, Italy
    Bioorg Med Chem Lett 14:5827-30. 2004
    ....
  34. ncbi A noncompetitive, sequential mechanism for inhibition of rat alpha4beta2 neuronal nicotinic acetylcholine receptors by carbamate pesticides
    Chantal J G M Smulders
    Institute for Risk Assessment Sciences, Utrecht University, NL 3508 TD Utrecht, The Netherlands
    Toxicol Sci 82:219-27. 2004
    ..The time- and concentration-dependent inhibition of nAChR-mediated ion current by fenoxycarb is accounted for by a two-step mechanism involving a rapid blocked state and a sequential more stably blocked or desensitized state...