Betti Giusti

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. doi request reprint Gene expression profiling of peripheral blood in patients with abdominal aortic aneurysm
    B Giusti
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Eur J Vasc Endovasc Surg 38:104-12. 2009
  2. ncbi request reprint Role of glycoprotein Ia gene polymorphisms in determining platelet function in myocardial infarction patients undergoing percutaneous coronary intervention on dual antiplatelet treatment
    Betti Giusti
    Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, DENOthe, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Atherosclerosis 196:341-8. 2008
  3. pmc Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility
    Betti Giusti
    Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, DENOthe, University of Florence, Florence, Italy
    PLoS ONE 2:e495. 2007
  4. pmc Gene expression profile of rat left ventricles reveals persisting changes following chronic mild exercise protocol: implications for cardioprotection
    Betti Giusti
    Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, DENOthe, University of Florence, Florence, Italy
    BMC Genomics 10:342. 2009
  5. doi request reprint Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis
    Betti Giusti
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Am J Cardiol 103:806-11. 2009
  6. doi request reprint Relation of CYP2C19 loss-of-function polymorphism to the occurrence of stent thrombosis
    Betti Giusti
    University of Florence and SOD Atherothrombotic Diseases, Department of Medical and Surgical Critical Care, AOU Careggi, Viale Morgagni 85, 50134 Florence, Italy
    Expert Opin Drug Metab Toxicol 6:393-407. 2010
  7. doi request reprint Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism
    Betti Giusti
    Department of Medical and Surgical Critical Care, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Thromb Haemost 104:231-42. 2010
  8. ncbi request reprint Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients
    Betti Giusti
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Pharmacogenet Genomics 17:1057-64. 2007
  9. doi request reprint High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism
    Betti Giusti
    Department of Medical and Surgical Critical Care, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    Biochem Genet 46:406-23. 2008
  10. doi request reprint High on-treatment platelet reactivity by more than one agonist predicts 12-month follow-up cardiovascular death and non-fatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting
    Rossella Marcucci
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Thromb Haemost 104:279-86. 2010

Detail Information

Publications56

  1. doi request reprint Gene expression profiling of peripheral blood in patients with abdominal aortic aneurysm
    B Giusti
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Eur J Vasc Endovasc Surg 38:104-12. 2009
    ..Abdominal aortic aneurysm (AAA) pathogenesis remains poorly understood. This study investigated the gene expression profile of peripheral blood from patients with AAA using microarray technology...
  2. ncbi request reprint Role of glycoprotein Ia gene polymorphisms in determining platelet function in myocardial infarction patients undergoing percutaneous coronary intervention on dual antiplatelet treatment
    Betti Giusti
    Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, DENOthe, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Atherosclerosis 196:341-8. 2008
    ....
  3. pmc Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility
    Betti Giusti
    Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, DENOthe, University of Florence, Florence, Italy
    PLoS ONE 2:e495. 2007
    ..Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF...
  4. pmc Gene expression profile of rat left ventricles reveals persisting changes following chronic mild exercise protocol: implications for cardioprotection
    Betti Giusti
    Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, DENOthe, University of Florence, Florence, Italy
    BMC Genomics 10:342. 2009
    ..Cardioprotection was investigated by ischemia/reperfusion experiments (n = 10 trained vs. n = 10 control rats)...
  5. doi request reprint Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis
    Betti Giusti
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Am J Cardiol 103:806-11. 2009
    ..These findings could impact on the future design of pharmacogenetic antiaggregant strategies...
  6. doi request reprint Relation of CYP2C19 loss-of-function polymorphism to the occurrence of stent thrombosis
    Betti Giusti
    University of Florence and SOD Atherothrombotic Diseases, Department of Medical and Surgical Critical Care, AOU Careggi, Viale Morgagni 85, 50134 Florence, Italy
    Expert Opin Drug Metab Toxicol 6:393-407. 2010
    ..Recently, CYP2C19*2 polymorphism (G681A nucleotide substitution) has been shown to be associated with decreased metabolisation of clopidogrel, poor antiaggregant effect and increased adverse cardiovascular events...
  7. doi request reprint Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism
    Betti Giusti
    Department of Medical and Surgical Critical Care, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Thromb Haemost 104:231-42. 2010
    ..This study identifies significant genetic associations between premature ischaemic stroke and haplotypes in BHMT, CBS, FOLH1, MTR, PON2, TCN2 and TYMS genes involved in methionine metabolism...
  8. ncbi request reprint Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients
    Betti Giusti
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Pharmacogenet Genomics 17:1057-64. 2007
    ....
  9. doi request reprint High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism
    Betti Giusti
    Department of Medical and Surgical Critical Care, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    Biochem Genet 46:406-23. 2008
    ..2% concordance. We also performed a haplotype analysis. This approach could represent a useful tool to investigate the genotype-phenotype correlation and the association of these genes with hyperhomocysteinemia and correlated diseases...
  10. doi request reprint High on-treatment platelet reactivity by more than one agonist predicts 12-month follow-up cardiovascular death and non-fatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting
    Rossella Marcucci
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Thromb Haemost 104:279-86. 2010
    ..Isolated platelet hyperreactivity to only one agonist has not a predictive value for clinical recurrences...
  11. doi request reprint High on-treatment platelet reactivity by ADP and increased risk of MACE in good clopidogrel metabolizers
    Rossella Marcucci
    Department of Medical and Surgical Critical Care, Centre for the Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Viale Morgagni 85, Florence, Italy
    Platelets 23:586-93. 2012
    ..Therefore, both phenotype and genotype are clinically relevant for the evaluation of the antiplatelet effect of clopidogrel and for the prognostic stratification of ACS patients...
  12. ncbi request reprint Thrombotic events in high risk patients are predicted by evaluating different pathways of platelet function
    Anna Maria Gori
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Thromb Haemost 100:1136-45. 2008
    ..This prospective study documents that the evaluation of platelet reactivity addressed to identify patients at risk of thrombotic events on dual antiplatelet treatment has to be carried out by methods able to explore different pathways...
  13. pmc A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patients
    Betti Giusti
    Department of Medical and Surgical Critical Care DENOTHE, University of Florence, Florence, Italy
    Arthritis Res Ther 8:R115. 2006
    ..These observations indicate that microvascular endothelial cells of patients with SSc show abnormalities in a variety of genes that are able to account for defective angiogenesis...
  14. doi request reprint Comparison of methods for monitoring residual platelet reactivity after clopidogrel by point-of-care tests on whole blood in high-risk patients
    Rita Paniccia
    Department of Medical and Surgical Critical Care, Thrombosis Center, University of Florence, Florence, Italy
    Thromb Haemost 104:287-92. 2010
    ..MEA might represent a reliable method and valid alternative in comparison with other available platelet function assays. It might help to guide antiplatelet therapy and thus improve clinical outcome of high-risk CAD patients...
  15. doi request reprint Polymorphisms of genes involved in extracellular matrix remodeling and abdominal aortic aneurysm
    Claudia Saracini
    Department of Medical and Surgical Critical Care, University of Florence, Atherothrombotic Diseases Center, Florence, Italy
    J Vasc Surg 55:171-179.e2. 2012
    ..Abdominal aortic aneurysm (AAA) has a multifactorial etiology and the relevance of genetic factors is getting increasing interest, in particular those related to the destructive remodeling of extracellular matrix...
  16. doi request reprint High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PCI
    Guido Parodi
    Department of Cardiology, Careggi Hospital, Florence, Italy
    JAMA 306:1215-23. 2011
    ..High residual platelet reactivity (HRPR) in patients receiving clopidogrel has been associated with high risk of ischemic events after percutaneous coronary intervention (PCI)...
  17. doi request reprint Low-density lipoprotein receptor-related protein 5 gene polymorphisms and genetic susceptibility to abdominal aortic aneurysm
    Silvia Galora
    Department of Medical and Surgical Critical Care, University of Florence, Atherothrombotic Diseases Center AOU Careggi, Florence, Italy
    J Vasc Surg 58:1062-8.e1. 2013
    ..The aim of this study was to evaluate the role of polymorphisms in LRP5 gene in determining genetic susceptibility to AAA...
  18. doi request reprint eNOS gene influences platelet phenotype in acute coronary syndrome patients on dual antiplatelet treatment
    Cinzia Fatini
    Department of Medical and Surgical Critical Care, Department of Heart and Vessels, Azienda Ospedaliero Universitaria Careggi, University of Florence, 50134 Florence, Italy
    Platelets 20:548-54. 2009
    ..02). This study evidences a role for eNOS gene in moderately, but significantly, modulating platelet phenotype in a high-risk population on dual antiplatelet treatment...
  19. ncbi request reprint Hyperhomocysteinemia and vitamin B6 deficiency: new risk markers for nonvalvular atrial fibrillation?
    Rossella Marcucci
    Department of Medical and Surgical Critical Care, University of Florence, Florence Italy
    Am Heart J 148:456-61. 2004
    ..Furthermore, the role of these variables in the occurrence of ischemic events was investigated...
  20. ncbi request reprint COL6A1 genomic deletions in Bethlem myopathy and Ullrich muscular dystrophy
    Guglielmina Pepe
    Department of Medical and Surgical Critical Care and Center for the Study of Molecular and Clinical Level of Chronic, Degenerative, and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy
    Ann Neurol 59:190-5. 2006
    ..Our studies identify a deletion-prone region in COL6A1 and suggest that similar mutations can lead to congenital muscle disorders of different clinical severity...
  21. ncbi request reprint Genetic determinants of fasting and post-methionine hyperhomocysteinemia in patients with retinal vein occlusion
    Rossella Marcucci
    Dipartimento di Area Critica Medico Chirurgica, Sez di Clinica Medica Generale e Cliniche Specialistiche, University of Florence, Viale Morgagni, 85, 50134 Florence, Italy
    Thromb Res 110:7-12. 2003
    ..Moreover, scarce information is available on the usefulness of measuring homocysteine also after methionine loading to increase the diagnostic efficacy of hyperhomocysteinemia in RVO patients...
  22. doi request reprint Clopidogrel non-responsiveness and risk of cardiovascular morbidity. An updated meta-analysis
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Thromb Haemost 103:841-8. 2010
    ....
  23. doi request reprint Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: a 12-month follow-up
    Rossella Marcucci
    Department of Medical and Surgical Critical Care and Center for Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy
    Circulation 119:237-42. 2009
    ....
  24. ncbi request reprint Phenotypic variability of cardiovascular manifestations in Marfan Syndrome. Possible role of hyperhomocysteinemia and C677T MTHFR gene polymorphism
    Betti Giusti
    Dipartimento di Area Critica Medico Chirurgica, University of Florence, Florence, Italy
    Eur Heart J 24:2038-45. 2003
    ....
  25. doi request reprint Hepatitis C virus RNA localization in human carotid plaques
    Maria Boddi
    Clinica Medica Generale e Cardiologia, Department of Medical and Surgical Critical Care, University of Florence, Italy
    J Clin Virol 47:72-5. 2010
    ..Hepatitis C virus (HCV) infection has certain characteristics that enable it to play an important role in atherosclerosis. Some studies report its association with an increased risk of carotid artery plaque...
  26. ncbi request reprint Fish intake and LPA 93C>T polymorphism: gene-environment interaction in modulating lipoprotein (a) concentrations
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
    Atherosclerosis 195:e147-54. 2007
    ..In conclusion, this study reported a significant interaction of daily fish intake and LPA 93C>T polymorphism in decreasing Lp(a) concentrations...
  27. doi request reprint MMP9 variation after thrombolysis is associated with hemorrhagic transformation of lesion and death
    Domenico Inzitari
    From the Stroke and Neurology Unit, Careggi University Hospital, Florence, Italy D I, p n, M N, V P, B P, G P Department of Experimental and Clinical Medicine, Thrombosis Centre, University of Florence, Florence, Italy B G, A M G, A A, R A Neurology Unit, Ospedale di Circolo e Fondazione Macchi, University of Insubria, Varese, Italy G B SSO Stroke Unit, U O Neurologia d O, DAI di Neuroscienze, Azienda Ospedaliera Integrata, Verona, Italy P B U O Neurologia, G Jazzolino Hospital, Vibo Valentia, Italy D C Neurology Unit, Valduce General Hospital, Como, Italy M G Neurology Unit, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy A N Neurology Unit, Misericordia e Dolce Hospital, Prato, Germany
    Stroke 44:2901-3. 2013
    ..Tissue-type plasminogen activator (tPA) enhances such effects. This study aimed to expand clinical evidence in this connection...
  28. ncbi request reprint The antiangiogenic tissue kallikrein pattern of endothelial cells in systemic sclerosis
    Betti Giusti
    Department of Experimental Pathology and Oncology, University of Florence, Viale G M Morgagni 50, 50134 Florence, Italy
    Arthritis Rheum 52:3618-28. 2005
    ....
  29. doi request reprint Pharmacogenetics of clopidogrel: comparison between a standard and a rapid genetic testing
    Claudia Saracini
    Department of Medical and Surgical Critical Care, University of Florence Atherothrombotic Diseases Center, AOU Careggi, Florence, Italy
    Genet Test Mol Biomarkers 16:500-3. 2012
    ..One hundred acute coronary syndrome patients were genotyped for CYP2C19*2,*3,*4,*5, and *17 polymorphisms with two platforms: Verigene(®) and the TaqMan(®) system...
  30. ncbi request reprint Improvement of low-density microelectronic array technology to characterize 14 mutations/single-nucleotide polymorphisms from several human genes on a large scale
    Sabrina Frusconi
    Unita Operativa Citogenetica e Genetica, Azienda Ospedaliera Careggi, Florence, Italy
    Clin Chem 50:775-7. 2004
  31. doi request reprint Bone marrow-derived progenitor cells in the early phase of ischemic stroke: relation with stroke severity and discharge outcome
    Francesca Cesari
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy
    J Cereb Blood Flow Metab 29:1983-90. 2009
    ..We report an association between the number of CPCs measured in the early phase after stroke presentation, neurologic severity, and discharge outcome...
  32. ncbi request reprint Increased plasma levels of lipoprotein(a) and the risk of idiopathic and recurrent venous thromboembolism
    Rossella Marcucci
    Dipartimento Area Critica Medico Chirurgica, Clinica Medica Generale e Cardiologia, Florence, Italy
    Am J Med 115:601-5. 2003
    ..Elevated lipoprotein(a) [Lp(a)] levels are a recognized risk factor for cardiovascular disease; however, little is known about their effects on venous thromboembolism...
  33. ncbi request reprint Using a calibration experiment to assess gene-specific information: full Bayesian and empirical Bayesian models for two-channel microarray data
    Marta Blangiardo
    Department of Statistics G Parenti, University of Florence and Biostatistic Unit CSPO, Florence, Italy
    Bioinformatics 22:50-7. 2006
    ..In this case it is possible to estimate the gene-specific variance, to be incorporated in comparative experiments on the same tissue, cellular line or species...
  34. pmc Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice
    Francesca Margheri
    Department of Experimental Pathology and Oncology, University of Florence, 50134 Florence, Italy
    Neoplasia 11:1106-15. 2009
    ..The extent of tumor necrosis suggested an antiangiogenesis-dependent inhibition of tumor development...
  35. ncbi request reprint Is ectopia lentis in some cases a mild phenotypic expression of Marfan syndrome? Need for a long-term follow-up
    Guglielmina Pepe
    Department of Medical and Surgical Critical Care, University of Florence, Regional Marfan Centre, Florence, Centre of Research, Transfer, High Education DENOTHE, University of Florence, Italy
    Mol Vis 13:2242-7. 2007
    ..Ectopia lentis (EL) and Marfan syndrome (MFS) are considered two distinct clinical entities. We performed genetic and clinical studies to investigate whether EL is actually distinct from MFS or if it is a mild phenotypic expression of it...
  36. doi request reprint Improvement in ACE I/D polymorphism detection
    Paola Bolli
    Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, DENOthe, University of Florence, Italy
    J Renin Angiotensin Aldosterone Syst 12:129-32. 2011
    ..Our experiments provide evidence that, by using the Nanogen stepdown method, the DD mistyping was markedly decreased, thus representing a useful tool suitable for performing large-scale screening or research...
  37. pmc Desmoglein-2-integrin Beta-8 interaction regulates actin assembly in endothelial cells: deregulation in systemic sclerosis
    Betti Giusti
    Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
    PLoS ONE 8:e68117. 2013
    ..Here we investigated the role of desmoglein-2 in human N-MVECs and SSc-MVECs angiogenesis...
  38. ncbi request reprint High levels of homocysteine, lipoprotein (a) and plasminogen activator inhibitor-1 are present in patients with abdominal aortic aneurysm
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Thromb Haemost 94:1094-8. 2005
    ..13; p = 0.005). In conclusion, a significant association between abnormal levels of some metabolic parameters related to thrombosis such as Hcy, Lp(a) and PAI-1 and AAA has been observed...
  39. ncbi request reprint Dominant and recessive COL6A1 mutations in Ullrich scleroatonic muscular dystrophy
    Betti Giusti
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Ann Neurol 58:400-10. 2005
    ....
  40. doi request reprint Platelet and leukocyte ROS production and lipoperoxidation are associated with high platelet reactivity in Non-ST elevation myocardial infarction (NSTEMI) patients on dual antiplatelet treatment
    Matteo Becatti
    Department of Experimental and Clinical Medicine, University of Florence, Italy Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy
    Atherosclerosis 231:392-400. 2013
    ..Several studies have shown that reactive oxygen species (ROS) may be involved in modulating platelet function...
  41. ncbi request reprint A homozygous COL6A2 intron mutation causes in-frame triple-helical deletion and nonsense-mediated mRNA decay in a patient with Ullrich congenital muscular dystrophy
    Laura Lucarini
    Department of Medical and Surgical Critical Care and Center of Research, Transfer and High Education, MCIDNENT, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Hum Genet 117:460-6. 2005
    ..Our results underscore the importance of multifaceted analyses in the accurate molecular diagnosis and interpretation of genotype-phenotype correlations of UCMD...
  42. pmc Determinants to optimize response to clopidogrel in acute coronary syndrome
    Betti Giusti
    Department of Medical and Surgical Critical Care, University of Florence, SOD Atherothrombotic Diseases, AOU Careggi, Florence, Italy
    Pharmgenomics Pers Med 3:33-50. 2010
    ....
  43. ncbi request reprint Association between homocysteine, vitamin B(6) concentrations and inflammation
    Anna Maria Gori
    Department of Medical and Surgical Critical Care, University of Florence, DeNOTHE Centre for the Study at Molecular and Clinical Level of Chronic, University of Florence, Florence, Italy
    Clin Chem Lab Med 45:1728-36. 2007
    ..This association, independent of the leading factor, may explain, at least in part, why subjects with high concentrations of Hcy and low concentrations of vitamin B(6) have a high risk of developing cardiovascular diseases...
  44. doi request reprint Antiplatelets in acute coronary syndrome: personal perspectives
    Rossella Marcucci
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Expert Rev Cardiovasc Ther 10:1487-96. 2012
    ....
  45. doi request reprint Genetic polymorphisms of antioxidant enzymes in preterm infants
    Chiara Poggi
    Department of Medical and Surgical Critical Care, Neonatology Section, Careggi University Hospital, Florence, Italy
    J Matern Fetal Neonatal Med 25:131-4. 2012
    ..Evidence is growing about the associations between single nucleotide polymorphisms (SNPs) in genes involved in OS or antioxidant response and the occurrence of neonatal morbidities...
  46. doi request reprint Bone marrow-derived progenitor cells in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Francesca Pescini
    Department of Neurological and Psychiatric Sciences, Thrombosis Center, University of Florence, Florence, Italy
    Stroke 41:218-23. 2010
    ..No data are available about these cells in CADASIL. Our objective in this study was to evaluate endothelial progenitor cells and CPCs role in CADASIL...
  47. ncbi request reprint HCV infection facilitates asymptomatic carotid atherosclerosis: preliminary report of HCV RNA localization in human carotid plaques
    Maria Boddi
    Clinica Medica Generale e Cardiologia, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Dig Liver Dis 39:S55-60. 2007
    ..We aimed to investigate whether (a) HCV infection can facilitate asymptomatic carotid lesions and (b) the presence of HCV RNA sequences can be shown in plaque tissues...
  48. doi request reprint Atrial septal defect closure and de novo migraine: Exclusive ticlopidine efficacy
    Silvia Benemei
    Department of Preclinical and Clinical Pharmacology, Headache Centre, University of Florence and Careggi University Hospital, Viale Pieraccini 6, Florence, Italy
    Cephalalgia 32:1144-6. 2012
    ....
  49. doi request reprint Genetic polymorphisms of antioxidant enzymes as risk factors for oxidative stress-associated complications in preterm infants
    Betti Giusti
    Department of Medical and Surgical Critical Care, University of Florence, Atherothrombotic Diseases Centre, Careggi University Hospital of Florence, Florence, Italy
    Free Radic Res 46:1130-9. 2012
    ..Different SOD2 polymorphisms are associated per se with a lower gestational age and/or birth weight, and haplotypes of SOD1, SOD3 and CAT genes may be independent protecting or risk markers for prematurity complications...
  50. ncbi request reprint Evaluation of a new point-of-care celite-activated clotting time analyzer in different clinical settings. The i-STAT celite-activated clotting time test
    Rita Paniccia
    Dipartimento di Area Critica Medico Chirurgica, Sezione di Clinica Medica Generale e Cliniche Specialistiche, Centro di Riferimento Regionale per la Trombosi, Florence, Italy
    Anesthesiology 99:54-9. 2003
    ..Recently, a new device, the i-STAT system, has been introduced to measure ACT. The aim of this study was to correlate the performances of these two systems and to compare ACT values with heparin levels...
  51. doi request reprint Stent-related defects in patients presenting with stent thrombosis: differences at optical coherence tomography between subacute and late/very late thrombosis in the Mechanism Of Stent Thrombosis (MOST) study
    Guido Parodi
    Department of Cardiology, Careggi Hospital, Florence, Italy
    EuroIntervention 9:936-44. 2013
    ..High platelet reactivity also seems a necessary cofactor for both subacute and late/very late ST. Clinical Trial Registration: http://www.clinicaltrials.gov unique identifier NCT01410539. ..
  52. ncbi request reprint Plasma and serum levels of D-dimer and their correlations with other hemostatic parameters in pregnancy
    Rita Paniccia
    Dipartimento di Area Critica Medico Chirurgica, Sezione di Clinica Medica Generale e Cliniche Specialistiche, University of Florence, Viale Morgagni, 85, 50134, Italy
    Thromb Res 105:257-62. 2002
    ....
  53. ncbi request reprint LPA +93C>T and +121G>A polymorphisms detection by electronic microchip technology
    Elena Sticchi
    Fondazione Don Carlo Gnocchi, ONLUS, S Maria degli Ulivi IRCCS, Firenze, Italy
    Mol Genet Metab 91:79-84. 2007
    ..In particular, this Technology allows the analysis of polymorphisms at the LPA locus, able to modulate the levels of Lp(a), a relevant marker of atherosclerosis...
  54. doi request reprint Use of donor bone marrow mesenchymal stem cells for treatment of skin allograft rejection in a preclinical rat model
    Paolo Sbano
    Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Siena, Italy
    Arch Dermatol Res 300:115-24. 2008
    ..Results of our study in a rat tissue transplantation model demonstrated a possible immunogenic role for donor (allogeneic) MSC, confirming the need of adequate preclinical experimentation before clinical use...
  55. ncbi request reprint Novel COL6A1 splicing mutation in a family affected by mild Bethlem myopathy
    Olga Camacho Vanegas
    Department of Internal Medicine, University of Rome Tor Vergata, Via Tor Vergata 135, 00133 Roma, Italy
    Muscle Nerve 25:513-9. 2002
    ..In addition, we demonstrated that lymphocytes can be used for the first mutation screening analysis of patients with Bethlem myopathy...
  56. ncbi request reprint Ullrich myopathy phenotype with secondary ColVI defect identified by confocal imaging and electron microscopy analysis
    Stefania Petrini
    Unit of Molecular Medicine, Department of Laboratory Medicine, Bambino Gesù Paediatric Hospital IRCCS, Piazza S Onofrio 4, 00165 Rome, Italy
    Neuromuscul Disord 17:587-96. 2007
    ..We describe how confocal microscopy and rotary-shadowing electron microscopy may be useful to identify a secondary ColVI defect...