Alessandro Giuffrè


Affiliation: University of Rome La Sapienza
Country: Italy


  1. Zuhra K, Sousa P, Paulini G, Lemos A, Kalme Z, Bisenieks I, et al. Screening Pyridine Derivatives against Human Hydrogen Sulfide-synthesizing Enzymes by Orthogonal Methods. Sci Rep. 2019;9:684 pubmed publisher
    ..This work, while presenting a robust methodological platform for screening putative inhibitors of the human H2S-synthesizing enzymes, highlights the importance of employing complementary methodologies in compound screenings. ..
  2. Borisov V, Forte E, Siletsky S, Sarti P, Giuffrè A. Cytochrome bd from Escherichia coli catalyzes peroxynitrite decomposition. Biochim Biophys Acta. 2015;1847:182-188 pubmed publisher
    ..To the best of our knowledge, this is the first time that the kinetics of ONOO(-) decomposition by a terminal oxidase has been investigated. These results strongly suggest a protective role of cytochrome bd against ONOO(-) damage. ..
  3. Vicente J, Colaço H, Sarti P, Leandro P, Giuffrè A. S-Adenosyl-l-methionine Modulates CO and NO• Binding to the Human H2S-generating Enzyme Cystathionine β-Synthase. J Biol Chem. 2016;291:572-81 pubmed publisher
    ..This further supports the notion that CBS regulation is a complex process, involving the concerted action of multiple physiologically relevant effectors. ..
  4. Mastronicola D, Falabella M, Forte E, Testa F, Sarti P, Giuffrè A. Antioxidant defence systems in the protozoan pathogen Giardia intestinalis. Mol Biochem Parasitol. 2016;206:56-66 pubmed publisher
    ..Here, we review current knowledge on the antioxidant defence systems in G. intestinalis, focusing on the progress made over the last decade in the field. The relevance of this research and future perspectives are discussed. ..
  5. Forte E, Borisov V, Vicente J, Giuffrè A. Cytochrome bd and Gaseous Ligands in Bacterial Physiology. Adv Microb Physiol. 2017;71:171-234 pubmed publisher
    ..This review aims to give an update on our current understanding of bd-type oxidases with a focus on their reactivity with gaseous ligands and its potential impact on bacterial physiology and human pathophysiology. ..