Antonio Girolami

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi request reprint Proposal of a flow chart for thrombosis-free oral contraceptive therapy
    Antonio Girolami
    University of Padua Medical School, Department of Medical and Surgical Sciences, Padua, Italy
    Clin Appl Thromb Hemost 9:33-7. 2003
  2. ncbi request reprint Discrepant ratios of arterial versus venous thrombosis in hemophilia A as compared with hemophilia B
    Antonio Girolami
    Department of Medical and Surgical Sciences, Padua University, Via Ospedale, 105, 35128, Padua, Italy
    J Thromb Thrombolysis 37:293-7. 2014
  3. doi request reprint Discrepant ratios of arterial vs. venous thrombosis in hemophilias A and B as compared to FVII deficiency
    Antonio Girolami
    Department of Medicine, University of Padua, Medical School, Padua, Italy
    Eur J Haematol 91:152-6. 2013
  4. doi request reprint Occurrence of thrombosis in congenital thrombocytopenic disorders: a critical annotation of the literature
    Antonio Girolami
    Department of Medicine, University of Padua Medical School, Padua, Italy
    Blood Coagul Fibrinolysis 24:18-22. 2013
  5. doi request reprint Congenital FVII deficiency and pulmonary embolism: a critical appraisal of all reported cases
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua, Medical School, Padua, Italy
    Clin Appl Thromb Hemost 19:55-9. 2013
  6. doi request reprint Homozygous FVII deficiencies with different reactivity towards tissue thromboplastins of different origin
    A Girolami
    Department of Medical and Surgical Sciences and Northeastern Italy Association for the Study of Coagulation Disorders, University of Padua Medical School, Padua, Italy
    Hematology 17:350-4. 2012
  7. doi request reprint Recombinant FVIIa concentrate-associated thrombotic events in congenital bleeding disorders other than hemophilias
    Antonio Girolami
    Department of Medicine, University of Padua, Medical School, Padua, Italy
    Hematology 17:346-9. 2012
  8. doi request reprint Myocardial infarction in two cousins heterozygous for ASN41HIS autosomal dominant variant of Bernard-Soulier syndrome
    Antonio Girolami
    Department of Medical and Surgical Sciences, Padua University, Via Ospedale 105, 35128, Padua, Italy
    J Thromb Thrombolysis 34:513-7. 2012
  9. doi request reprint Rare and unusual bleeding manifestations in congenital bleeding disorders: an annotated review
    Antonio Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
    Clin Appl Thromb Hemost 18:121-7. 2012
  10. doi request reprint A cluster of factor XI-deficient patients due to a new mutation (Ile 436 Lys) in northeastern Italy
    Antonio Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Eur J Haematol 88:229-36. 2012

Detail Information

Publications137 found, 100 shown here

  1. ncbi request reprint Proposal of a flow chart for thrombosis-free oral contraceptive therapy
    Antonio Girolami
    University of Padua Medical School, Department of Medical and Surgical Sciences, Padua, Italy
    Clin Appl Thromb Hemost 9:33-7. 2003
    ..In case of doubt the thrombotic event should be considered as idiopathic. The two flow charts are not intended to eliminate the OCT-related VTE but represent only an attempt to decrease the prevalence of this complication...
  2. ncbi request reprint Discrepant ratios of arterial versus venous thrombosis in hemophilia A as compared with hemophilia B
    Antonio Girolami
    Department of Medical and Surgical Sciences, Padua University, Via Ospedale, 105, 35128, Padua, Italy
    J Thromb Thrombolysis 37:293-7. 2014
    ..12. This indicates that arterial thrombosis is more frequent in hemophilia A as compared to hemophilia B and the opposite is true for venous thrombosis. The potential significance of this discrepancy is discussed. ..
  3. doi request reprint Discrepant ratios of arterial vs. venous thrombosis in hemophilias A and B as compared to FVII deficiency
    Antonio Girolami
    Department of Medicine, University of Padua, Medical School, Padua, Italy
    Eur J Haematol 91:152-6. 2013
    ..Little is known on the comparative prevalence of arterial vs. venous thrombosis in these patients...
  4. doi request reprint Occurrence of thrombosis in congenital thrombocytopenic disorders: a critical annotation of the literature
    Antonio Girolami
    Department of Medicine, University of Padua Medical School, Padua, Italy
    Blood Coagul Fibrinolysis 24:18-22. 2013
    ..The significance of these findings is discussed with particular emphasis on the discrepancy between venous and arterial thrombosis seen in patients with Glanzmann thrombasthenia and Bernard-Soulier syndrome...
  5. doi request reprint Congenital FVII deficiency and pulmonary embolism: a critical appraisal of all reported cases
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua, Medical School, Padua, Italy
    Clin Appl Thromb Hemost 19:55-9. 2013
    ..Heparin and Coumadin together with adequate substitution therapy were carried out in 5 patients with satisfactory results. The FVII deficiency does not grant a sure protection from venous thromboembolism...
  6. doi request reprint Homozygous FVII deficiencies with different reactivity towards tissue thromboplastins of different origin
    A Girolami
    Department of Medical and Surgical Sciences and Northeastern Italy Association for the Study of Coagulation Disorders, University of Padua Medical School, Padua, Italy
    Hematology 17:350-4. 2012
    ....
  7. doi request reprint Recombinant FVIIa concentrate-associated thrombotic events in congenital bleeding disorders other than hemophilias
    Antonio Girolami
    Department of Medicine, University of Padua, Medical School, Padua, Italy
    Hematology 17:346-9. 2012
    ..Two patients with FXI deficiency had inhibitors. Dosage was variable. There was at least one fatality but in five cases evolution was not reported. The remaining patients recovered with variable sequels...
  8. doi request reprint Myocardial infarction in two cousins heterozygous for ASN41HIS autosomal dominant variant of Bernard-Soulier syndrome
    Antonio Girolami
    Department of Medical and Surgical Sciences, Padua University, Via Ospedale 105, 35128, Padua, Italy
    J Thromb Thrombolysis 34:513-7. 2012
    ..These clinical observations are in contrast with experimental studies which demonstrate that Bernard-Soulier-like strains of mice show a decreased thrombus generation in several experimental settings...
  9. doi request reprint Rare and unusual bleeding manifestations in congenital bleeding disorders: an annotated review
    Antonio Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
    Clin Appl Thromb Hemost 18:121-7. 2012
    ..Physicians should always keep in mind that a congenital hemorrhagic disorder may cause bleeding in any tissue of the body and therefore alter the normal clinical features of a given disease...
  10. doi request reprint A cluster of factor XI-deficient patients due to a new mutation (Ile 436 Lys) in northeastern Italy
    Antonio Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Eur J Haematol 88:229-36. 2012
    ..The compound heterozygosis with the Glu 117 stop mutation, common among Jews, was not surprising because of the past strict ties of the Republic of Venice with the Middle East...
  11. ncbi request reprint Previous thrombosis-free pregnancies are no guarantee that subsequent oral contraception may also remain asymptomatic
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua 35128, Italy
    J Thromb Thrombolysis 26:62-3. 2008
  12. ncbi request reprint Arterial thrombosis in young women after ovarian stimulation: case report and review of the literature
    Antonio Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Via Ospedale 105, 35128 Padua, Italy
    J Thromb Thrombolysis 24:169-74. 2007
    ..Only seven of these 19 pregnancies were brought to term with fetal survival. Abortion was spontaneous in 5 cases and therapeutic in the additional 7. There were two maternal fatalities...
  13. ncbi request reprint Congenital combined defects of factor VII: a critical review
    A Girolami
    University of Padua Medical School, Department of Medical and Surgical Sciences, Padua, Italy
    Acta Haematol 117:51-6. 2007
    ..Finally, the elevated incidence of mental and skeletal malformations present in these combined defects indicates the need for a careful evaluation of all these patients lest some aspects of the defect are missed...
  14. ncbi request reprint Myocardial infarction and other arterial occlusions in hemophilia a patients. A cardiological evaluation of all 42 cases reported in the literature
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Acta Haematol 116:120-5. 2006
    ....
  15. ncbi request reprint Tentative guidelines and practical suggestions to avoid venous thromboembolism during oral contraceptive therapy
    A Girolami
    University of Padua Medical School, Department of Medical and Surgical Sciences, Second Chair of Medicine, Italy
    Clin Appl Thromb Hemost 8:97-102. 2002
    ..Other noncoagulation-related conditions such as hypertension, liver damage, and obesity may represent absolute or relative contraindications to the use of OCT...
  16. ncbi request reprint Arterial and venous thrombosis in rare congenital bleeding disorders: a critical review
    A Girolami
    University of Padua Medical School, Department of Medical and Surgical Sciences, Padua, Italy
    Haemophilia 12:345-51. 2006
    ..The fact that thrombosis has never been described in patients with factor II or factor X seems to underscore the central antithrombotic role that these two factors have in the coagulation system...
  17. ncbi request reprint Non-catheter associated venous thrombosis in hemophilia A and B. A critical review of all reported cases
    Antonio Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Via Ospedale 105, 35128, Padua, Italy
    J Thromb Thrombolysis 21:279-84. 2006
    ..In a few instances low molecular weight heparin was given for a few days. The frequent association of venous thrombosis with infusion of concentrates indicates the need for a careful evaluation of patients about to receive such therapy...
  18. ncbi request reprint Arterial and venous thrombosis in patients with von Willebrand's disease: a critical review of the literature
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    J Thromb Thrombolysis 21:175-8. 2006
    ..As a conclusion of this review it seems safe to assume that both arterial and venous thrombosis appear rare in vWD. This is confirmed by the fact that arterial or venous thrombosis appears slightly more frequent in hemophilia A and B...
  19. ncbi request reprint Pregnancy and oral contraceptives in congenital bleeding disorders of the vitamin K-dependent coagulation factors
    Antonio Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Acta Haematol 115:58-63. 2006
    ..This led to a decrease in transfusional needs and to improved general conditions...
  20. ncbi request reprint A new mutation (Arg251Trp) in the Ca2+ binding site of factor X protease domain appears to be responsible for the defect in the extrinsic pathway activation of factor X Padua
    Antonio Girolami
    Department of Medical and Surgical Sciences, Second Chair of Medicine, Via Ospedale 105, University of Padua Medical School, 35121 Padua, Italy
    Clin Appl Thromb Hemost 10:5-8. 2004
    ..A niece of the proposita was shown to be heterozygous for the abnormality. Molecular modeling suggested that the mutation does not alter significantly folding and stability of the protein but may be involved in the Ca2+ binding site...
  21. ncbi request reprint Clinical aspects of venous thrombophilia
    Antonio Girolami
    University of Padua Medical School, Department of Medical and Surgical Sciences, Padua, Italy
    Pathophysiol Haemost Thromb 32:258-62. 2002
    ..An early diagnosis, as often in medicine, is of paramount importance for a prompt treatment and a satisfactory outcome...
  22. ncbi request reprint Effect of age on oral contraceptive-induced venous thrombosis
    A Girolami
    University of Padua Medical School, Department of Medical and Surgical Science, Second Chair of Medicine, Padua, Italy
    Clin Appl Thromb Hemost 10:259-63. 2004
    ..Because the majority of women took preparations that contained third-generation progestins during the second course of therapy, concomitant contributing effects of these compounds cannot be excluded...
  23. ncbi request reprint Long term use of oral contraceptives without thrombosis in patients with FV Leiden polymorphism: a study of 37 patients (2 homozygous and 35 heterozygous)
    A Girolami
    University of Padua Medical School, Department of Medical and Surgical Sciences, Second Chair of Medicine, Padua, Italy
    J Thromb Thrombolysis 17:145-9. 2004
    ..Unfortunately so far there is no sure way to distinguish the women with this polymorphism who will develop venous thrombosis from those who will remain asymptomatic during oral contraceptive therapy...
  24. ncbi request reprint Pregnancy and oral contraceptives in factor V deficiency: a study of 22 patients (five homozygotes and 17 heterozygotes) and review of the literature
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Haemophilia 11:26-30. 2005
    ..In the remaining two pregnancies no bleeding was noted and no substitution therapy was given. No data are apparently available in the literature about the use of OCs in FV deficiency...
  25. ncbi request reprint Unusual longevity in a patient with factor X Friuli coagulation disorder
    Antonio Girolami
    University of Padua, Medical School, Department of Medical and Surgical Sciences, Padua, 35100 Italy
    Thromb Haemost 93:385-7. 2005
  26. ncbi request reprint Main clinical manifestations of a bleeding diathesis: an often disregarded aspect of medical and surgical history taking
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Haemophilia 11:193-202. 2005
    ..g. a platelet count for petechiae, a PTT for a patient with haemarthrosis, etc.)...
  27. ncbi request reprint Retinal central artery occlusion in a young woman after ten days of a drospirenone-containing oral contraceptive (Yasmin)
    Antonio Girolami
    Department of Medical and Surgical Sciences, Padua University, Via Ospedale 105, Padua PD 35128, Italy
    Thromb Haemost 98:473-4. 2007
  28. doi request reprint Worldwide diffusion of FVII Arg304Gln coagulation defect (FVII Padua)
    Antonio Girolami
    Department of Medical and Surgical Sciences, University of Padua, Via Ospedale 105, Padua, Italy
    Eur J Haematol 86:135-9. 2011
    ..The defect is characterized by low FVII activity when rabbit brain thromboplastins are used in the assay system. On the contrary, FVII levels are normal when ox-brain thromboplastins are used. FVII antigen is always normal...
  29. doi request reprint Congenital prekallikrein deficiency
    Antonio Girolami
    Department of Medical and Surgical Sciences, Padua University, Via Ospedale, Padua, Italy
    Expert Rev Hematol 3:685-95. 2010
    ..Bradykinin causes inflammation, vasodilatation and an increase in vessel permeability. The activation of pro-urokinase results in enhanced fibrinolysis. However, fibrinolysis has been reported to be normal or defective in these patients...
  30. doi request reprint Persistent validity of a classification of congenital factor X defects based on clotting, chromogenic and immunological assays even in the molecular biology era
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Haemophilia 17:17-20. 2011
    ..By using this nosographic approach, all reported cases of FX deficiency can be adequately allocated to one of these groups...
  31. doi request reprint Ox brain versus rabbit brain thromboplastin assays are the best tool for a preliminary diagnosis of the Arg304Gln factor VII defect (FVII Padua)
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
    Acta Haematol 124:229-34. 2010
    ..The antigen/ox brain activity ratio of 1.1 fully confirms this assertion...
  32. doi request reprint Activated FVII levels in factor VII Padua (Arg304Gln) coagulation disorder and in true factor VII deficiency: a study in homozygotes and heterozygotes
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Via Ospedale 105, Padua, Italy
    Hematology 16:308-12. 2011
    ..The low levels of activated FVIIa found in homozygotes with FVII Padua indicate that the normal FVII activity found with ox-brain thromboplastin cannot be attributed to higher than normal circulating levels of FVIIa...
  33. doi request reprint Congenital FVII deficiency and thrombotic events after replacement therapy
    Antonio Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Via Ospedale 105, Padua, Italy
    J Thromb Thrombolysis 32:362-7. 2011
    ..The actual needs of substitution therapy in patients with some variants of FVII deficiency is discussed, together with comments on the therapeutic management of the thrombotic events in these patients...
  34. doi request reprint Comparative incidence of thrombosis in reported cases of deficiencies of factors of the contact phase of blood coagulation
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Via Ospedale 105, 35128 Padua, Italy
    J Thromb Thrombolysis 31:57-63. 2011
    ..This study clearly indicates that the severe in vitro coagulation defect seen in these conditions does not protect from thrombosis...
  35. doi request reprint Thrombotic events in patients with congenital prekallikrein deficiency: a critical evaluation of all reported cases
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
    Acta Haematol 123:210-4. 2010
    ..One patient who presented both a stroke and a pulmonary embolism had a fatal outcome. The article clearly indicates that prekallikrein deficiency does not protect from thrombosis in spite of the severe in vitro coagulation defect...
  36. doi request reprint Associated prothrombotic conditions are probably responsible for the occurrence of thrombosis in almost all patients with congenital FVII deficiency. Critical review of the literature
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical, Padua, Italy
    J Thromb Thrombolysis 30:172-8. 2010
    ..As a consequence it may be only stated that FVII deficiency does not protect from thrombosis...
  37. doi request reprint Similarities and discrepancies in homozygous factor VII defects due to mutations in the region of residues Met298 to Cys310 (exon 8) in the catalytic domain of factor VII
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Lab Hematol 17:17-21. 2011
    ....
  38. doi request reprint Unexplained discrepancies in the activity--antigen ratio in congenital FX deficiencies with defects in the catalytic domain
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Clin Appl Thromb Hemost 15:621-7. 2009
    ..The study analyzes the need to have a multipronged approach to the study of congenital FX deficiency. The indication of a mutation in a given domain does not provide clear information about the phenotype...
  39. ncbi request reprint Congenital FX deficiency combined with other clotting defects or with other abnormalities: a critical evaluation of the literature
    A Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Haemophilia 14:323-8. 2008
    ..Only specific assays could allow one to reach the correct diagnosis. In cases of casual association with other defects, it is also important to study family members, as the two defects should segregate independently...
  40. doi request reprint Congenital factor X deficiencies with a defect only or predominantly in the extrinsic or in the intrinsic system: a critical evaluation
    Antonio Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Northeastern Italy Association for the Study of Coagulation Disorders, Padua, Italy
    Am J Hematol 83:668-71. 2008
    ..The study underlines the importance of a multipronged evaluation of all cases with Factor X deficiency. In fact only by this approach can an acceptable classification of the defect be reached...
  41. doi request reprint Control of ovulation-induced hemoperitoneum by oral contraceptives in a patient with congenital hypoprothrombinemia and in another with congenital factor V deficiency
    A Girolami
    Department of Medical and Surgical Sciences, Northeastern Italy Association for the Study of Coagulation Disorders, Padua, Italy
    Acta Haematol 119:236-40. 2008
    ..OC are the treatment of choice in congenital bleeding disorders to control both the menorrhagia and, more importantly, ovulation-related hemoperitoneum...
  42. doi request reprint Thrombotic events in MYH9 gene-related autosomal macrothrombocytopenias (old May-Hegglin, Sebastian, Fechtner and Epstein syndromes)
    Antonio Girolami
    Department of Medical and Surgical Sciences, University of Padua Medical School, Via Ospedale 105, Padua 35128, Italy
    J Thromb Thrombolysis 32:474-7. 2011
    ..However, the occurrence of thrombotic events in only one of these conditions may be used as a new tentative differentiability feature...
  43. doi request reprint Hemospermia in patients with congenital coagulation disorders: a study of three cases
    A Girolami
    University of Padua Medical School, Department of Medical and Surgical Sciences, Padua, Italy
    Acta Haematol 121:42-6. 2009
    ..The rarity of hemospermia in congenital bleeding disorders remains unexplained, although the strong perineal and sphincter muscles may exercise a compressive hemostatic effect which could prevent or reduce bleeding...
  44. doi request reprint The clinical significance of the lack of arterial or venous thrombosis in patients with congenital prothrombin or FX deficiency
    Antonio Girolami
    University of Padua, Padua, Italy
    J Thromb Thrombolysis 29:299-302. 2010
    ..These observations may indirectly support the rationale for the use of direct thrombin or Factor X inhibitors in the prophylaxis and/or therapy of thrombotic manifestations...
  45. doi request reprint The clinical and laboratory significance of cases of congenital FX deficiency due to defects in the Gla-domain
    Antonio Girolami
    University of Padua Medical School, Department of Medical and Surgical Sciences, North Eastern Italy Association for the Study of Coagulation Disorders, Padua, Italy
    Hematology 14:177-81. 2009
    ..On the contrary, no firm conclusion could be drawn for kindred who showed mutations in the Gla-domain associated with defects in other domains...
  46. ncbi request reprint Contraceptive pills induce an improvement in congenital hypoplasminogenemia in two unrelated patients with ligneous conjunctivitis
    Maria Teresa Sartori
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, Padova, Italy
    Thromb Haemost 90:86-91. 2003
    ..In conclusion, oral contraceptive therapy may improve plasminogen deficiency and deserves attention as an alternative therapeutic approach in selected cases of ligneous conjunctivitis with low, but not absent, plasminogen synthesis...
  47. ncbi request reprint A novel type I factor X variant (factor X Cys350Phe) due to loss of a disulfide bond in the catalytic domain
    Fabrizio Vianello
    Department of Medical and Surgical Sciences, Second Chair of Medicine, Via Ospedale 105, University of Padua Medical School, Padua, Italy
    Blood Coagul Fibrinolysis 14:401-5. 2003
    ..Comparison with other topologically equivalent mutations in other vitamin K-dependent proteins suggests that this disruption could adversely affect protein folding/stability, accounting for the cross-reactive material negative phenotype...
  48. pmc The long term clinical course of acute deep vein thrombosis of the arm: prospective cohort study
    Paolo Prandoni
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University Hospital of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
    BMJ 329:484-5. 2004
  49. ncbi request reprint The PAI-1 gene 4G/5G polymorphism and deep vein thrombosis in patients with inherited thrombophilia
    Maria Teresa Sartori
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Clin Appl Thromb Hemost 9:299-307. 2003
    ..In conclusion, PAI-1 4G/5G polymorphism may influence PAI-1 expression and thrombotic risk in patients with inherited thrombophilia...
  50. ncbi request reprint Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis
    Paolo Prandoni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University Hospital of Padua, Italy
    Blood 100:3484-8. 2002
    ..These risks correlate with the extent of cancer. Possibilities for improvement using the current paradigms of anticoagulation seem limited and new treatment strategies should be developed...
  51. ncbi request reprint Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism
    Paolo Prandoni
    Department of Medical and Surgical Sciences, University of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
    Ann Intern Med 137:955-60. 2002
    ..Contributing to the controversy is uncertainty about whether residual venous thrombosis, as assessed by repeated ultrasonography over time, increases the risk for recurrent thromboembolism...
  52. ncbi request reprint Difficulties in the mutation analysis of plasminogen gene: a study in two patients with ligneous conjunctivitis
    Maria Teresa Sartori
    Second Chair of Internal Medicine, Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
    Clin Appl Thromb Hemost 12:77-84. 2006
    ..In conclusion, these data confirm the difficulty of plasminogen genetic analysis and may help researchers to better identify the true plasminogen gene mutations causing molecular defects...
  53. ncbi request reprint Severe prekallikrein (Fletcher factor) deficiency due to a compound heterozygosis (383Trp stop codon and Cys529Tyr)
    Anna Maria Lombardi
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Via Ospedale Civile 105, 35128 Padua, Italy
    Thromb Haemost 90:1040-5. 2003
    ..No associated abnormality was apparent in the propositus or his parents. As expected, no tendency for bleeding was noted even after tonsillectomy...
  54. ncbi request reprint Below-knee elastic compression stockings to prevent the post-thrombotic syndrome: a randomized, controlled trial
    Paolo Prandoni
    Department of Medical and Surgical Sciences, University Hospital of Padua, Padua, Italy
    Ann Intern Med 141:249-56. 2004
    ..Because only limited evidence suggests that elastic stockings prevent the post-thrombotic syndrome in patients with symptomatic deep venous thrombosis (DVT), these stockings are not widely used...
  55. ncbi request reprint The incidence of heparin-induced thrombocytopenia in hospitalized medical patients treated with subcutaneous unfractionated heparin: a prospective cohort study
    Bruno Girolami
    Division of Internal Medicine, Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University Hospital of Padua, Italy
    Blood 101:2955-9. 2003
    ..Although the frequency of HIT in hospitalized medical patients treated with subcutaneous heparin is lower than that observed in other clinical settings, this complication is associated with a similarly high rate of thromboembolic events...
  56. ncbi request reprint Conformation sensitive gel electrophoresis for detection of factor X gene mutations
    Fabrizio Vianello
    Department of Medical and Surgical Sciences, Second Chair of Medicine, University of Padua Medical School, Via Ospedale, 105, 35100, Padua, Italy
    Thromb Res 107:51-4. 2002
    ..CSGE may be an effective and simple procedure for screening factor X gene mutations...
  57. ncbi request reprint Does hemophilia protect against atherosclerosis? A case-control study
    Franca Bilora
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Clin Appl Thromb Hemost 12:193-8. 2006
    ..In all the examined districts, the mean IMT was significantly lower in patients with hemophilia than in controls. Hemophilia protects against asymptomatic atherosclerosis...
  58. ncbi request reprint Changes in prescription patterns of oral contraceptives in a northern Italian province: relation with venous thromboembolism
    Antonio Girolami
    University of Padua Medical School, Department of Medical and Surgical Sciences, Padua, Italy
    Clin Appl Thromb Hemost 9:125-30. 2003
    ..The increase in the prevalence of VTE episodes appeared to be proportional to the increased use of OC, regardless of the type of progestin contained in the oral contraceptive preparations...
  59. ncbi request reprint An Arg760Cys mutation in the consensus sequence of the von Willebrand factor propeptide cleavage site is responsible for a new von Willebrand disease variant
    Alessandra Casonato
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua, Medical School, Italy
    Blood 101:151-6. 2003
    ..These findings confirm that a normal consensus sequence for VWF propeptide cleavage and efficient cleavage are required in vivo for normal FVIII binding capacity of VWF...
  60. ncbi request reprint Anti-prothrombin antibodies as a potential risk factor of recurrent venous thromboembolism
    Ezio Zanon
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Thromb Haemost 91:255-8. 2004
    ..3; 95% CI, 1.3 to 8.6). Since aPT antibodies are more commonly identifiable in patients with multiple thrombotic episodes, they are a likely risk factor for recurrent thromboembolism...
  61. ncbi request reprint Role of fibrinolytic and clotting parameters in the diagnosis of liver veno-occlusive disease after hematopoietic stem cell transplantation in a pediatric population
    Maria Teresa Sartori
    Internal Medicine, Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
    Thromb Haemost 93:682-9. 2005
    ..In conclusion, variations in fibrinolytic test findings after HSCT, and PAI-1 in particular, may facilitate the early diagnosis of VOD in pediatric patients after HSCT...
  62. ncbi request reprint An association between atherosclerosis and venous thrombosis
    Paolo Prandoni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    N Engl J Med 348:1435-41. 2003
    ..Whether atherosclerosis is associated with an increased risk of venous thrombosis is unknown...
  63. ncbi request reprint Incidence of venous thromboembolism in asymptomatic family members who are carriers of factor V Leiden: a prospective cohort study
    Paolo Simioni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Via Ospedale, 105 35128 Padua, Italy
    Blood 99:1938-42. 2002
    ..Screening families of symptomatic probands with the factor V Leiden mutation has the potential to identify those asymptomatic carriers who might benefit from thromboprophylaxis during risk periods...
  64. ncbi request reprint A new factor X defect (factor X Padua 3): a compound heterozygous between true deficiency (Gly(380)-->Arg) and an abnormality (Ser(334)-->Pro)
    F Vianello
    Department of Medical and Surgical Sciences, Second Chair of Medicine, University of Padua, Via Ospedale 105, 35100 Padua, Italy
    Thromb Res 104:257-64. 2001
    ..The substitution of Gly for Arg causes the introduction of a large charged amino acid which could affect the catalytic function of FX leading to secretion problem, accounting for the cross-reactive material (CRM) negative phenotype...
  65. ncbi request reprint A large deletion due to a new mutation (intron 13/exon 23) in a sporadic case of severe hemophilia A
    Anna Maria Lombardi
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Clin Appl Thromb Hemost 10:61-4. 2004
    ..In the index patient, an approximate 13-kb product was obtained, whereas no product was obtained from his mother. The mother investigated by means of polymorphism was shown not to be a carrier...
  66. ncbi request reprint Confirmation of the value of a modified long-distance polymerase chain reaction in the detection of inversion intron 22 in severe hemophilia a: a technical note
    Anna Maria Lombardi
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Clin Appl Thromb Hemost 11:493-6. 2005
    ..The need for a rapid response is determined in the case of hemophilia A patients, not only by the desire to reach a proper classification, but also by the urgency to inform the carrier status of the mother or of a female relative...
  67. ncbi request reprint Platelet-associated autoantibodies as detected by a solid-phase modified antigen capture ELISA test (MACE) are a useful prognostic factor in idiopathic thrombocytopenic purpura
    Fabrizio Fabris
    Department of Medical and Surgical Sciences, University of Padua Medical School, Via Ospedale 105, 35128 Padua, Italy
    Blood 103:4562-4. 2004
    ..The median time to clinical worsening was 2.1 months for MACE-positive patients and 27.7 months for MACE-negatives. The assay of specific platelet autoantibodies may be a useful prognostic tool for the clinical course of ITP...
  68. ncbi request reprint The incidence of venous thromboembolism in thrombophilic children: a prospective cohort study
    Daniela Tormene
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Blood 100:2403-5. 2002
    ..Accordingly, screening for thrombophilia in otherwise healthy children younger than 15 years who belong to families with inherited defects predisposing to thrombosis seems unjustified...
  69. ncbi request reprint Fainting induces an acute increase in the concentration of plasma factor VIII and von Willebrand factor
    Alessandra Casonato
    Department of Medical and Surgical Sciences, Padova, Italy
    Haematologica 88:688-93. 2003
    ..von Willebrand factor (VWF) is stored in the Weibel-Palade bodies of endothelial cells and may be released in response to different secretion stimuli such as stress, physical exercise, adrenaline, DDAVP and thrombin...
  70. ncbi request reprint Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis
    P Simioni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University Hospital of Padua, Italy
    Blood 96:3329-33. 2000
    ..2 to 30.1) in patients without the mutations. Prothrombin and factor V gene mutations occur frequently in patients with venous thrombosis and are associated with an increased risk for recurrent venous thromboembolic complications...
  71. ncbi request reprint Influence of the Alu-repeat I/D polymorphism in t-PA gene intron 8 on the stimulated t-PA release after venous occlusion
    Maria Teresa Sartori
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padova, Italy
    Clin Appl Thromb Hemost 9:63-9. 2003
    ..05). A slight and nonsignificant trend of association between genotype and t-PA:Ag 20/0 ratio was seen in the t-PA group patients. In conclusion, these data suggest a possible genetic modulation of t-PA-regulated secretion...
  72. ncbi request reprint Factor V Leiden mutation and the risk of venous thromboembolism in pregnant women
    D Tormene
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Via Ospedale Civile 105, 35128 Padua, Italy
    Haematologica 86:1305-9. 2001
    ....
  73. ncbi request reprint Long-term use of oral contraceptive therapy in women with the prothrombin 20210 G-A polymorphism without thrombotic complications: a study of 13 women (12 heterozygotes and 1 homozygote)
    A Girolami
    Department of Medical and Surgical Sciences, Second Chair of Medicine, University of Padua Medical School, Padua, Italy
    Thromb Res 102:205-10. 2001
    ..Occasional reports suggesting a link between this polymorphism and oral contraception-related venous thrombosis should be carefully evaluated in order to avoid premature and incorrect conclusions...
  74. ncbi request reprint Type 2M von Willebrand disease variant characterized by abnormal von willebrand factor multimerization
    A Casonato
    Department of Medical and Surgical Sciences and the Second Chair of Internal Medicine, University of Padua Medical School, Italy
    J Lab Clin Med 137:70-6. 2001
    ..We include this variant in type 2M VWD, focusing on the abnormality in GPIb-dependent VWF function. We advance that this defect depends on the mutation in the GPIb binding domain of VWF rather than the abnormal VWF multimer pattern...
  75. doi request reprint Genetic study in patients with factor XII deficiency: a report of three new mutations exon 13 (Q501STOP), exon 14 (P547L) and -13C>T promoter region in three compound heterozygotes
    Anna Maria Lombardi
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Blood Coagul Fibrinolysis 19:639-43. 2008
    ..The significance and importance of genetic analysis in addition to clotting and immunological studies in FXII deficiency is emphasized...
  76. ncbi request reprint Thrombocytosis and recurrent hepatic outflow obstruction (Budd-Chiari syndrome) after successful thrombolysis: case report and literature review
    Maria Luigia Randi
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Clin Appl Thromb Hemost 8:369-74. 2002
    ..The patient was given low-molecular-weight heparin with a dramatic reduction in previously elevated fibrinogen level and a good control of the hepatic function...
  77. ncbi request reprint The diagnostic value of compression ultrasonography in patients with suspected recurrent deep vein thrombosis
    Paolo Prandoni
    Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
    Thromb Haemost 88:402-6. 2002
    ..In conclusion, it is safe to withhold anticoagulant treatment from patients with suspected recurrent ipsilateral DVT in whom compression ultrasonography showed improved or stable vein diameters...
  78. ncbi request reprint Safety of dental extraction among consecutive patients on oral anticoagulant treatment managed using a specific dental management protocol
    Ezio Zanon
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Blood Coagul Fibrinolysis 14:27-30. 2003
    ..The protocol proposed in the present study makes dental extractions in anticoagulated patients possible on an outpatient basis with a cost reduction for the community and minor discomfort for the patients...
  79. ncbi request reprint Seasonal variation in the incidence of deep vein thrombosis in patients with deficiency of protein C or protein S
    F Bilora
    University of Padua Medical School, Department of Medical and Surgery Sciences, Italy
    Clin Appl Thromb Hemost 8:231-7. 2002
    ..There was also a significant falling circaseptanal rhythm on Fridays. These observations may optimize an adequate and precise anticoagulant therapy in patients with protein C or protein S deficits...
  80. ncbi request reprint Attempt to improve the diagnosis of immune thrombocytopenia by combined use of two different platelet autoantibodies assays (PAIgG and MACE)
    Fabrizio Fabris
    Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
    Haematologica 87:1046-52. 2002
    ..The aim of the present study was to compare the diagnostic value of PAIgG with a modified antigen capture ELISA (MACE) in patients with primary and secondary immune thrombocytopenia and in patients with non-immune thrombocytopenia...
  81. ncbi request reprint Efficacy of AT in pre-eclampsia: a case-control prospective trial
    Delia M Paternoster
    Department of Gynecology and Human Reproduction, University of Padua, Padua, Italy
    Thromb Haemost 91:283-9. 2004
    ..In conclusion, the bio-chemical findings support a role for AT in controlling the haemostasis at conventional doses, and the inflammatory state at higher doses...
  82. ncbi request reprint Autosomal dominant macrothrombocytopenia with ineffective thrombopoiesis
    Fabrizio Fabris
    Istituto di Semeiotica Medica, Via Ospedale 105, 35128 Padova Italy
    Haematologica 87:ELT27. 2002
  83. ncbi request reprint Prolonged thromboprophylaxis with oral anticoagulants after total hip arthroplasty: a prospective controlled randomized study
    Paolo Prandoni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University Hospital of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
    Arch Intern Med 162:1966-71. 2002
    ..Although oral anticoagulants are still widely used for the prevention of venous thromboembolism after hip replacement, to our knowledge no study has assessed the benefit of prolonging anticoagulation beyond the hospital stay...
  84. ncbi request reprint C-reactive protein in hypertensive disorders in pregnancy
    Delia M Paternoster
    Department of Gynecology and Human Reproduction Padova, Italy
    Clin Appl Thromb Hemost 12:330-7. 2006
    ..Finally CRP levels in preeclampsia are believed to correlate with preeclamptic process severity...
  85. ncbi request reprint Splenectomy after portal thrombosis in patients with polycythemia vera and essential thrombocythemia
    Maria Luigia Randi
    Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
    Haematologica 87:1180-4. 2002
    ..We describe a single-institution experience in patients with ET and PV, diagnosed in agreement with the Polycthemia Vera Study Group criteria, with portal vein thrombosis who did or did not undergo splenectomy...
  86. ncbi request reprint Reduced von Willebrand factor survival in type Vicenza von Willebrand disease
    Alessandra Casonato
    Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
    Blood 99:180-4. 2002
    ..In addition, because normal VWF-platelet GPIb interaction was observed before or after DDAVP administration, it is proposed that type Vicenza VWD not be considered a 2M subtype...
  87. ncbi request reprint Plasma fibrinolytic capacity in renal transplant recipients: effect of steroid-free immunosuppression therapy
    Maria T Sartori
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Via Ospedale Civile n 105, 35128 Padua, Italy
    Transplantation 75:994-8. 2003
    ..We evaluated plasma fibrinolytic behavior in two groups of RTRs treated with different immunosuppressive regimens...
  88. ncbi request reprint Recent progress in the therapeutic management of pre-eclampsia
    Delia Maria Paternoster
    University of Padova, Department of Gynaecology and Human Reproduction, Via Giustiniani 3, 35128 Padova, Italy
    Expert Opin Pharmacother 5:2233-9. 2004
    ....
  89. ncbi request reprint Activated protein C resistance in normal and pre-eclamptic pregnancies
    D M Paternoster
    Department of Obstetrics and Gynecology, Padova University, Padova, Italy
    Gynecol Obstet Invest 54:145-9. 2002
    ..Finally, this prospective study was performed to investigate the prevalence of APC-R among pregnant women and to elucidate its obstetric consequences...
  90. ncbi request reprint Psychological aspects and coping of parents with a haemophilic child: a quantitative approach
    N Saviolo-Negrin
    General Psychology Department, Padua University, Italy
    Haemophilia 5:63-8. 1999
    ..The results show that the parents paid great attention to the problems of their sons, but mothers were more depressed and anxious about the disease of their child...
  91. ncbi request reprint Psychological aspects and coping styles of parents with Haemophilic child undergoing a programme of counselling and psychological support
    A M Bottos
    Department of Medical and Surgical Sciences, Haemophilia Centre, Second Chair of Medicine, University of Padua Medical School, Padua, Italy
    Haemophilia 13:305-10. 2007
    ..Also the other psychological aspects investigated, namely depression and anxiety, did receive a positive influence. The results show how significant such programme has been for parents...
  92. ncbi request reprint Age as the major predictive factor of long-term response to splenectomy in immune thrombocytopenic purpura
    F Fabris
    Department of Medical and Surgical Sciences, University of Padua Medical School, City Hospital, Via Ospedale 105, 35128 Padua, Italy
    Br J Haematol 112:637-40. 2001
    ..005). Neither duration of thrombocytopenia nor previous response to medical treatment (steroids and/or intravenous immunoglobulins) were related to splenectomy response...
  93. ncbi request reprint Lack of multimer organization of von Willebrand factor in an acquired von Willebrand syndrome
    A Casonato
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Br J Haematol 116:899-904. 2002
    ....
  94. ncbi request reprint Homozygous patients with the 20210 G to A prothrombin polymorphism remain often asymptomatic in spite of the presence of associated risk factors
    A Girolami
    University of Padua Medical School, Department of Medical and Surgical Sciences, Second Chair of Medicine, Italy
    Clin Appl Thromb Hemost 7:122-5. 2001
    ..Until this problem is clarified, the clinician must abstain from attributing a prothrombotic effect to this polymorphism...
  95. ncbi request reprint Treatment of intermittent claudication with physical training, smoking cessation, pentoxifylline, or nafronyl: a meta-analysis
    B Girolami
    Institute of Medical Semeiotics, University Hospital of Padua, Italy
    Arch Intern Med 159:337-45. 1999
    ..There is no consensus on the efficacy of physical training, smoking cessation, and pharmacological therapy (pentoxifylline or nafronyl oxalate) in the treatment of patients with intermittent claudication at Fontaine stage II of disease...
  96. ncbi request reprint Role of the 4G/5G polymorphism of PaI-1 gene promoter on PaI-1 levels in obese patients: influence of fat distribution and insulin-resistance
    M T Sartori
    Department of Medical and Surgical Sciences, University of Padua, Italy
    Thromb Haemost 86:1161-9. 2001
    ..Since subjects with central obesity are at high risk for cardiovascular disease, the effects of the 4G/5G polymorphism on PAI-1 concentration may further enhance this risk...
  97. ncbi request reprint Mild bleeding diathesis in a boy with combined severe haemophilia B (C(10400)-->T) and heterozygous factor V Leiden
    F Vianello
    Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
    Haemophilia 7:511-4. 2001
    ..The implications of this unusual association are discussed...
  98. ncbi request reprint Psychological aspects and coping in haemophilic patients: a case-control study
    M Canclini
    Department of General Psychology, University of Padua, Italy
    Haemophilia 9:619-24. 2003
    ..This information could indicate the enormous importance that the psychological variable 'self-esteem' plays in haemophiliacs with respect to whether or not they develop depressive disorders and/or anxiety states...
  99. ncbi request reprint Plasma and platelet von Willebrand factor abnormalities in patients with uremia: lack of correlation with uremic bleeding
    A Casonato
    University of Padua Medical School, Department of Medical and Surgery Sciences, Second Chair of Internal Medicine, Padua, Italy
    Clin Appl Thromb Hemost 7:81-6. 2001
    ..The results suggest that vWF abnormalities are present in uremia. Moreover, thrombopathy caused by impaired collagen-induced platelet aggregation is constantly present and apparently not improved by dialytic treatment...
  100. ncbi request reprint Hemophilia A, von Willebrand disease, and atherosclerosis of abdominal aorta and leg arteries: factor VIII and von Willebrand factor defects appear to protect abdominal aorta and leg arteries from atherosclerosis
    F Bilora
    Department of Medical and Surgery Sciences, University of Padua Medical School, Italy
    Clin Appl Thromb Hemost 7:311-3. 2001
    ..The most serious hemophilic patients had fewer plaques than controls or than patients with mild hemophilia. Both hemophilia and von Willebrand disease seem to protect against atherosclerosis...