Lisa Giovannelli

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. doi request reprint Effects of de-alcoholised wines with different polyphenol content on DNA oxidative damage, gene expression of peripheral lymphocytes, and haemorheology: an intervention study in post-menopausal women
    Lisa Giovannelli
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Eur J Nutr 50:19-29. 2011
  2. doi request reprint Dietary extra-virgin olive oil rich in phenolic antioxidants and the aging process: long-term effects in the rat
    Michela Jacomelli
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    J Nutr Biochem 21:290-6. 2010
  3. ncbi request reprint Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats
    Piero Dolara
    Department of Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Mutat Res 591:237-46. 2005
  4. doi request reprint Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols
    Cinzia Castagnini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    Br J Nutr 102:1620-8. 2009
  5. ncbi request reprint Liver and colon DNA oxidative damage and gene expression profiles of rats fed Arabidopsis thaliana mutant seeds containing contrasted flavonoids
    Cristina Luceri
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Food Chem Toxicol 46:1213-20. 2008
  6. doi request reprint Environmental ozone exposure and oxidative DNA damage in adult residents of Florence, Italy
    Domenico Palli
    Molecular and Nutritional Epidemiology Unit, Cancer Prevention and Research Institute ISPO, Via Cosimo il Vecchio 2, 50139 Florence, Italy
    Environ Pollut 157:1521-5. 2009
  7. ncbi request reprint Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women
    Simonetta Salvini
    Molecular and Nutritional Epidemiology Unit, Centro per lo Studio e la Prevenzione Oncologica CSPO, Scientific Institute of Tuscany, Florence, Italy
    Br J Nutr 95:742-51. 2006
  8. doi request reprint Effects of dietary extra-virgin olive oil on behaviour and brain biochemical parameters in ageing rats
    Vanessa Pitozzi
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Br J Nutr 103:1674-83. 2010
  9. doi request reprint Long-term dietary extra-virgin olive oil rich in polyphenols reverses age-related dysfunctions in motor coordination and contextual memory in mice: role of oxidative stress
    Vanessa Pitozzi
    Department of Preclinical and Clinical Pharmacology, University of Florence, 50139 Florence, Italy
    Rejuvenation Res 15:601-12. 2012
  10. doi request reprint Chronic resveratrol treatment ameliorates cell adhesion and mitigates the inflammatory phenotype in senescent human fibroblasts
    Vanessa Pitozzi
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    J Gerontol A Biol Sci Med Sci 68:371-81. 2013

Collaborators

Detail Information

Publications27

  1. doi request reprint Effects of de-alcoholised wines with different polyphenol content on DNA oxidative damage, gene expression of peripheral lymphocytes, and haemorheology: an intervention study in post-menopausal women
    Lisa Giovannelli
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Eur J Nutr 50:19-29. 2011
    ..The present intervention study was undertaken to evaluate the in vivo effects of wine polyphenols on gene expression in humans, along with their supposed antioxidant activity...
  2. doi request reprint Dietary extra-virgin olive oil rich in phenolic antioxidants and the aging process: long-term effects in the rat
    Michela Jacomelli
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    J Nutr Biochem 21:290-6. 2010
    ..Thus, although olive oil phenols cannot reverse the detrimental effects of a prolonged intake of high amounts of fat, improving the quality of olive oil in terms of antioxidant content can be beneficial...
  3. ncbi request reprint Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats
    Piero Dolara
    Department of Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Mutat Res 591:237-46. 2005
    ..In conclusion, reduction of oxidative damage, modulation of colonic flora and variation in gene expression may all concur in the modulation of intestinal function and carcinogenesis by wine polyphenols...
  4. doi request reprint Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols
    Cinzia Castagnini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    Br J Nutr 102:1620-8. 2009
    ....
  5. ncbi request reprint Liver and colon DNA oxidative damage and gene expression profiles of rats fed Arabidopsis thaliana mutant seeds containing contrasted flavonoids
    Cristina Luceri
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Food Chem Toxicol 46:1213-20. 2008
    ..In conclusion, flavonols exhibited antioxidant effects at systemic level, whereas high molecular weight flavonoids affected only the colon, probably due to their limited absorption...
  6. doi request reprint Environmental ozone exposure and oxidative DNA damage in adult residents of Florence, Italy
    Domenico Palli
    Molecular and Nutritional Epidemiology Unit, Cancer Prevention and Research Institute ISPO, Via Cosimo il Vecchio 2, 50139 Florence, Italy
    Environ Pollut 157:1521-5. 2009
    ..Our results suggest that ozone concentrations at ground levels modulate oxidative DNA damage in circulating lymphocytes of residents of polluted areas...
  7. ncbi request reprint Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women
    Simonetta Salvini
    Molecular and Nutritional Epidemiology Unit, Centro per lo Studio e la Prevenzione Oncologica CSPO, Scientific Institute of Tuscany, Florence, Italy
    Br J Nutr 95:742-51. 2006
    ..Despite the small sample size, the present study showed a reduction of DNA damage by consumption of an EVOO rich in phenols, particularly hydroxytyrosol...
  8. doi request reprint Effects of dietary extra-virgin olive oil on behaviour and brain biochemical parameters in ageing rats
    Vanessa Pitozzi
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Br J Nutr 103:1674-83. 2010
    ..These results indicate a previously undetected effect of a diet containing an olive oil rich in phenols. Further studies are warranted to verify whether specific food antioxidants might also have an effect on emotional behaviour...
  9. doi request reprint Long-term dietary extra-virgin olive oil rich in polyphenols reverses age-related dysfunctions in motor coordination and contextual memory in mice: role of oxidative stress
    Vanessa Pitozzi
    Department of Preclinical and Clinical Pharmacology, University of Florence, 50139 Florence, Italy
    Rejuvenation Res 15:601-12. 2012
    ..Such a modulation can be obtained with an olive oil intake that is normal in the Mediterranean area, provided that the oil has a sufficiently high content of polyphenols...
  10. doi request reprint Chronic resveratrol treatment ameliorates cell adhesion and mitigates the inflammatory phenotype in senescent human fibroblasts
    Vanessa Pitozzi
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    J Gerontol A Biol Sci Med Sci 68:371-81. 2013
    ..Considering these low concentrations proved effective in vitro, translation of these data to human research on inflammation-related pathologies can be envisaged...
  11. ncbi request reprint Oxidative DNA damage and plasma antioxidant capacity in type 2 diabetic patients with good and poor glycaemic control
    Maura Lodovici
    Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Mutat Res 638:98-102. 2008
    ..Therefore, the addition of antioxidant supplements to the current pharmacological treatment could have potentially beneficial effects in diabetic patients with poor glycaemic control...
  12. ncbi request reprint Nutritional and lifestyle determinants of DNA oxidative damage: a study in a Mediterranean population
    Lisa Giovannelli
    Department of Pharmacology, University of Florence, Italy
    Carcinogenesis 23:1483-9. 2002
    ....
  13. ncbi request reprint Seasonal variations of DNA damage in human lymphocytes: correlation with different environmental variables
    Lisa Giovannelli
    Dipartimento di Farmacologia Preclinica e Clinica, Universita di Firenze, Viale Pieraccini 6, 50139 Firenze, Italy
    Mutat Res 593:143-52. 2006
    ..The results of multivariate regression analysis showed a positive correlation between lymphocyte DNA damage and air temperature, and a less strong correlation with global solar radiation and air ozone levels...
  14. ncbi request reprint Calibration of the comet assay for the measurement of DNA damage in mammalian cells
    Vanessa Pitozzi
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    Free Radic Res 40:1149-54. 2006
    ..76 and 0.80 breaks/10(9) Da, respectively, (0.50 and 0.52 breaks/10(6) bp). The values of oxidative DNA damage were in the same order of magnitude as those found by others with HPLC methods...
  15. ncbi request reprint Extremely low-frequency electromagnetic fields do not affect DNA damage and gene expression profiles of yeast and human lymphocytes
    Cristina Luceri
    Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy
    Radiat Res 164:277-85. 2005
    ..The results suggest that extremely low-frequency EMFs do not induce DNA damage or affect gene expression in these two different eukaryotic cell systems...
  16. ncbi request reprint Effect of 4-coumaric and 3,4-dihydroxybenzoic acid on oxidative DNA damage in rat colonic mucosa
    Francesco Guglielmi
    Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Br J Nutr 89:581-7. 2003
    ..Only the expression of GST-M2 was significantly induced by 4-coumaric acid, while protocatechuic acid was inactive. The data suggest that 4-coumaric acid acts as an antioxidant in the colonic mucosa in vivo...
  17. ncbi request reprint Oxidative DNA damage in peripheral blood cells in type 2 diabetes mellitus: higher vulnerability of polymorphonuclear leukocytes
    Vanessa Pitozzi
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Mutat Res 529:129-33. 2003
    ..Thus, the measurement of oxidative DNA damage in leukocytes by means of the comet assay is a suitable marker for the evaluation of systemic oxidative stress in diabetic patients...
  18. ncbi request reprint Increased oxidative DNA damage in mononuclear leukocytes in vitiligo
    Lisa Giovannelli
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Firenze, Florence, Italy
    Mutat Res 556:101-6. 2004
    ..However, these findings support an adjuvant role of antioxidant treatment in vitiligo...
  19. doi request reprint Protective effects of resveratrol against senescence-associated changes in cultured human fibroblasts
    Lisa Giovannelli
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    J Gerontol A Biol Sci Med Sci 66:9-18. 2011
    ..A reduction in the levels of acetylated forms of H3 and H4 histones and p53 protein was also found...
  20. ncbi request reprint Vulnerability to DNA damage in the aging rat substantia nigra: a study with the comet assay
    Lisa Giovannelli
    Department of Pharmacology, University of Florence, Florence, Italy
    Brain Res 969:244-7. 2003
    ....
  21. doi request reprint Pharmacological effects of exogenous NAD on mitochondrial bioenergetics, DNA repair, and apoptosis
    Maria Pittelli
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    Mol Pharmacol 80:1136-46. 2011
    ....
  22. ncbi request reprint Effect of N-acetyl-L-cysteine on peroxynitrite and superoxide anion production of lung alveolar macrophages in systemic sclerosis
    Paola Failli
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139, Firenze, Italy
    Nitric Oxide 7:277-82. 2002
    ..We conclude that since SSc lung macrophages express high levels of iNOS and produce a significant quantity of ONOO(-), NAC administration reduces ONOO(-) production and can be an useful treatment to alleviate SSc symptoms...
  23. ncbi request reprint Measurement of DNA breaks and oxidative damage in polymorphonuclear and mononuclear white blood cells: a novel approach using the comet assay
    Lisa Giovannelli
    Dipartimento di Farmacologia Preclinica e Clinica, Universita di Firenze, Italy
    Mutat Res 538:71-80. 2003
    ..This method can be useful for measuring DNA damage in different subtypes of human peripheral leukocytes, avoiding the artifacts and the time involved in the cell separation procedures...
  24. ncbi request reprint The comet assay approach to senescent human diploid fibroblasts identifies different phenotypes and clarifies relationships among nuclear size, DNA content, and DNA damage
    Alessandra Mocali
    Department of Experimental Pathology and Oncology, Viale G B Morgagni 50, 50134 Firenze, Italy
    J Gerontol A Biol Sci Med Sci 60:695-701. 2005
    ..The comet assay allowed us to identify different senescent phenotypes and to investigate changes in nuclear features and/or DNA damage irrespective of time elapsed in culture...
  25. ncbi request reprint Association between atmospheric ozone levels and damage to human nasal mucosa in Florence, Italy
    Stefania Pacini
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Italy
    Environ Mol Mutagen 42:127-35. 2003
    ..These data suggest an association between ozone air levels and damage in the upper respiratory tract. It remains unclear whether ozone itself or other associated pollutants are responsible for the observed alterations...
  26. ncbi request reprint FGF2-mediated upregulation of urokinase-type plasminogen activator expression requires a MAP-kinase dependent activation of poly(ADP-ribose) polymerase
    Riccardo Caldini
    Department of Experimental Pathology and Oncology, University of Florence, Italy
    J Cell Physiol 202:125-34. 2005
    ..Poly(ADP-ribose) polymerase involved in this mechanism is mainly the 60 kDa molecular mass isoform, that presents an increase in serine phosphorylation in the presence of FGF2...
  27. ncbi request reprint Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors
    Lisa Giovannelli
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    J Cereb Blood Flow Metab 22:697-704. 2002
    ....