Research Topics
Species | Lisa GiovannelliSummaryAffiliation: University of Florence Country: Italy Publications
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Publications
Effects of de-alcoholised wines with different polyphenol content on DNA oxidative damage, gene expression of peripheral lymphocytes, and haemorheology: an intervention study in post-menopausal womenLisa Giovannelli
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Eur J Nutr 50:19-29. 2011..The present intervention study was undertaken to evaluate the in vivo effects of wine polyphenols on gene expression in humans, along with their supposed antioxidant activity...- Dietary extra-virgin olive oil rich in phenolic antioxidants and the aging process: long-term effects in the ratMichela Jacomelli
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
J Nutr Biochem 21:290-6. 2010..Thus, although olive oil phenols cannot reverse the detrimental effects of a prolonged intake of high amounts of fat, improving the quality of olive oil in terms of antioxidant content can be beneficial... 
Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 ratsPiero Dolara
Department of Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
Mutat Res 591:237-46. 2005..In conclusion, reduction of oxidative damage, modulation of colonic flora and variation in gene expression may all concur in the modulation of intestinal function and carcinogenesis by wine polyphenols...- Liver and colon DNA oxidative damage and gene expression profiles of rats fed Arabidopsis thaliana mutant seeds containing contrasted flavonoidsCristina Luceri
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Food Chem Toxicol 46:1213-20. 2008..In conclusion, flavonols exhibited antioxidant effects at systemic level, whereas high molecular weight flavonoids affected only the colon, probably due to their limited absorption... - Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenolsCinzia Castagnini
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
Br J Nutr 102:1620-8. 2009.... - Environmental ozone exposure and oxidative DNA damage in adult residents of Florence, ItalyDomenico Palli
Molecular and Nutritional Epidemiology Unit, Cancer Prevention and Research Institute ISPO, Via Cosimo il Vecchio 2, 50139 Florence, Italy
Environ Pollut 157:1521-5. 2009..Our results suggest that ozone concentrations at ground levels modulate oxidative DNA damage in circulating lymphocytes of residents of polluted areas... - Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal womenSimonetta Salvini
Molecular and Nutritional Epidemiology Unit, Centro per lo Studio e la Prevenzione Oncologica CSPO, Scientific Institute of Tuscany, Florence, Italy
Br J Nutr 95:742-51. 2006..Despite the small sample size, the present study showed a reduction of DNA damage by consumption of an EVOO rich in phenols, particularly hydroxytyrosol... - Effects of dietary extra-virgin olive oil on behaviour and brain biochemical parameters in ageing ratsVanessa Pitozzi
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
Br J Nutr 103:1674-83. 2010..These results indicate a previously undetected effect of a diet containing an olive oil rich in phenols. Further studies are warranted to verify whether specific food antioxidants might also have an effect on emotional behaviour... - Oxidative DNA damage and plasma antioxidant capacity in type 2 diabetic patients with good and poor glycaemic controlMaura Lodovici
Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Mutat Res 638:98-102. 2008..Therefore, the addition of antioxidant supplements to the current pharmacological treatment could have potentially beneficial effects in diabetic patients with poor glycaemic control... - Nutritional and lifestyle determinants of DNA oxidative damage: a study in a Mediterranean populationLisa Giovannelli
Department of Pharmacology, University of Florence, Italy
Carcinogenesis 23:1483-9. 2002.... - Seasonal variations of DNA damage in human lymphocytes: correlation with different environmental variablesLisa Giovannelli
Dipartimento di Farmacologia Preclinica e Clinica, , Viale Pieraccini 6, 50139 Firenze, Italy
Mutat Res 593:143-52. 2006..The results of multivariate regression analysis showed a positive correlation between lymphocyte DNA damage and air temperature, and a less strong correlation with global solar radiation and air ozone levels... - Effect of 4-coumaric and 3,4-dihydroxybenzoic acid on oxidative DNA damage in rat colonic mucosaFrancesco Guglielmi
Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Br J Nutr 89:581-7. 2003..Only the expression of GST-M2 was significantly induced by 4-coumaric acid, while protocatechuic acid was inactive. The data suggest that 4-coumaric acid acts as an antioxidant in the colonic mucosa in vivo... - Calibration of the comet assay for the measurement of DNA damage in mammalian cellsVanessa Pitozzi
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
Free Radic Res 40:1149-54. 2006..76 and 0.80 breaks/10(9) Da, respectively, (0.50 and 0.52 breaks/10(6) bp). The values of oxidative DNA damage were in the same order of magnitude as those found by others with HPLC methods... - Extremely low-frequency electromagnetic fields do not affect DNA damage and gene expression profiles of yeast and human lymphocytesCristina Luceri
Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy
Radiat Res 164:277-85. 2005..The results suggest that extremely low-frequency EMFs do not induce DNA damage or affect gene expression in these two different eukaryotic cell systems... - Long-term dietary extra-virgin olive oil rich in polyphenols reverses age-related dysfunctions in motor coordination and contextual memory in mice: role of oxidative stressVanessa Pitozzi
1 Department of Preclinical and Clinical Pharmacology, University of Florence, 50139 Florence, Italy
Rejuvenation Res 15:601-12. 2012..Such a modulation can be obtained with an olive oil intake that is normal in the Mediterranean area, provided that the oil has a sufficiently high content of polyphenols... - Increased oxidative DNA damage in mononuclear leukocytes in vitiligoLisa Giovannelli
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Firenze, Florence, Italy
Mutat Res 556:101-6. 2004..However, these findings support an adjuvant role of antioxidant treatment in vitiligo... - Protective effects of resveratrol against senescence-associated changes in cultured human fibroblastsLisa Giovannelli
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
J Gerontol A Biol Sci Med Sci 66:9-18. 2011..A reduction in the levels of acetylated forms of H3 and H4 histones and p53 protein was also found... - Oxidative DNA damage in peripheral blood cells in type 2 diabetes mellitus: higher vulnerability of polymorphonuclear leukocytesVanessa Pitozzi
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Mutat Res 529:129-33. 2003..Thus, the measurement of oxidative DNA damage in leukocytes by means of the comet assay is a suitable marker for the evaluation of systemic oxidative stress in diabetic patients... - Vulnerability to DNA damage in the aging rat substantia nigra: a study with the comet assayLisa Giovannelli
Department of Pharmacology, University of Florence, Florence, Italy
Brain Res 969:244-7. 2003.... - Chronic resveratrol treatment ameliorates cell adhesion and mitigates the inflammatory phenotype in senescent human fibroblastsVanessa Pitozzi
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
J Gerontol A Biol Sci Med Sci 68:371-81. 2013..Considering these low concentrations proved effective in vitro, translation of these data to human research on inflammation-related pathologies can be envisaged... - Pharmacological effects of exogenous NAD on mitochondrial bioenergetics, DNA repair, and apoptosisMaria Pittelli
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
Mol Pharmacol 80:1136-46. 2011.... - Effect of N-acetyl-L-cysteine on peroxynitrite and superoxide anion production of lung alveolar macrophages in systemic sclerosisPaola Failli
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139, Firenze, Italy
Nitric Oxide 7:277-82. 2002..We conclude that since SSc lung macrophages express high levels of iNOS and produce a significant quantity of ONOO(-), NAC administration reduces ONOO(-) production and can be an useful treatment to alleviate SSc symptoms... - Measurement of DNA breaks and oxidative damage in polymorphonuclear and mononuclear white blood cells: a novel approach using the comet assayLisa Giovannelli
Dipartimento di Farmacologia Preclinica e Clinica, Universita di Firenze, Italy
Mutat Res 538:71-80. 2003..This method can be useful for measuring DNA damage in different subtypes of human peripheral leukocytes, avoiding the artifacts and the time involved in the cell separation procedures... - The comet assay approach to senescent human diploid fibroblasts identifies different phenotypes and clarifies relationships among nuclear size, DNA content, and DNA damageAlessandra Mocali
Department of Experimental Pathology and Oncology, Viale G B Morgagni 50, 50134 Firenze, Italy
J Gerontol A Biol Sci Med Sci 60:695-701. 2005..The comet assay allowed us to identify different senescent phenotypes and to investigate changes in nuclear features and/or DNA damage irrespective of time elapsed in culture... - Association between atmospheric ozone levels and damage to human nasal mucosa in Florence, ItalyStefania Pacini
Department of Anatomy, Histology and Forensic Medicine, University of Florence, Italy
Environ Mol Mutagen 42:127-35. 2003..These data suggest an association between ozone air levels and damage in the upper respiratory tract. It remains unclear whether ozone itself or other associated pollutants are responsible for the observed alterations... - FGF2-mediated upregulation of urokinase-type plasminogen activator expression requires a MAP-kinase dependent activation of poly(ADP-ribose) polymeraseRiccardo Caldini
Department of Experimental Pathology and Oncology, University of Florence, Italy
J Cell Physiol 202:125-34. 2005..Poly(ADP-ribose) polymerase involved in this mechanism is mainly the 60 kDa molecular mass isoform, that presents an increase in serine phosphorylation in the presence of FGF2... - Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitorsLisa Giovannelli
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
J Cereb Blood Flow Metab 22:697-704. 2002....