Francesco Giorgino

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. ncbi request reprint Pathophysiology of type 2 diabetes: rationale for different oral antidiabetic treatment strategies
    Francesco Giorgino
    Dipartimento dell Emergenza e dei Trapianti di Organi Sezione di Medicina Interna, Endocrinologia e Malattie Metaboliche, Universita degli Studi di Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    Diabetes Res Clin Pract 68:S22-9. 2005
  2. pmc Cross-Talk between PPARgamma and Insulin Signaling and Modulation of Insulin Sensitivity
    Anna Leonardini
    Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, 70124 Bari, Italy
    PPAR Res 2009:818945. 2009
  3. ncbi request reprint Factors associated with progression to macroalbuminuria in microalbuminuric Type 1 diabetic patients: the EURODIAB Prospective Complications Study
    F Giorgino
    Department of Emergency and Organ Transplantation Section on Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari School of Medicine, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Diabetologia 47:1020-8. 2004
  4. doi request reprint Multifactorial intervention in Type 2 diabetes: the promise of incretin-based therapies
    F Giorgino
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    J Endocrinol Invest 34:69-77. 2011
  5. ncbi request reprint Abnormalities of insulin-like growth factor-I signaling and impaired cell proliferation in osteoblasts from subjects with osteoporosis
    Sebastio Perrini
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, and Metabolic Diseases, University of Bari, Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    Endocrinology 149:1302-13. 2008
  6. doi request reprint Involvement of the p66Shc protein in glucose transport regulation in skeletal muscle myoblasts
    Annalisa Natalicchio
    Dept of Emergency and Organ Transplantation, Section on Internal Medicine, Endocrinology and Metabolic Diseases, Univ of Bari, Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    Am J Physiol Endocrinol Metab 296:E228-37. 2009
  7. ncbi request reprint Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling
    Luigi Laviola
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    Endocrinology 146:1498-505. 2005
  8. doi request reprint Exendin-4 prevents c-Jun N-terminal protein kinase activation by tumor necrosis factor-alpha (TNFalpha) and inhibits TNFalpha-induced apoptosis in insulin-secreting cells
    Annalisa Natalicchio
    Department of Emergency and Organ Transplantation, Section on Internal Medicine, Endocrinology, Andrology, and Metabolic Diseases, University of Bari, Piazza Giulio Cesare, Bari, Italy
    Endocrinology 151:2019-29. 2010
  9. ncbi request reprint Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway
    Annalisa Natalicchio
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Piazza Giulio Cesare, 11, 70124, Bari, Italy
    Diabetologia 56:2456-66. 2013
  10. ncbi request reprint Effect of family history of type 2 diabetes on white blood cell count in adult women
    Nicola Pannacciulli
    Internal Medicine, Endocrinology, and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
    Obes Res 11:1232-7. 2003

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Pathophysiology of type 2 diabetes: rationale for different oral antidiabetic treatment strategies
    Francesco Giorgino
    Dipartimento dell Emergenza e dei Trapianti di Organi Sezione di Medicina Interna, Endocrinologia e Malattie Metaboliche, Universita degli Studi di Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    Diabetes Res Clin Pract 68:S22-9. 2005
    ..Individual phenotypic and genetic characterisation of the patients may help to solve this conundrum, eventually providing tailored treatment algorithms...
  2. pmc Cross-Talk between PPARgamma and Insulin Signaling and Modulation of Insulin Sensitivity
    Anna Leonardini
    Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, 70124 Bari, Italy
    PPAR Res 2009:818945. 2009
    ..Disturbances in the production of these factors may contribute to metabolic abnormalities, and PPARgamma activation is also associated with beneficial effects on expression and secretion of a whole range of cytokines...
  3. ncbi request reprint Factors associated with progression to macroalbuminuria in microalbuminuric Type 1 diabetic patients: the EURODIAB Prospective Complications Study
    F Giorgino
    Department of Emergency and Organ Transplantation Section on Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari School of Medicine, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Diabetologia 47:1020-8. 2004
    ..It is therefore important to identify potential factors that can predict progression to macroalbuminuria...
  4. doi request reprint Multifactorial intervention in Type 2 diabetes: the promise of incretin-based therapies
    F Giorgino
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    J Endocrinol Invest 34:69-77. 2011
    ..Although GLP-1 agonists and DPP-4 inhibitors are at present not appropriate for primary treatment of cardiovascular risks factors, the reduction of these parameters is evidently beneficial...
  5. ncbi request reprint Abnormalities of insulin-like growth factor-I signaling and impaired cell proliferation in osteoblasts from subjects with osteoporosis
    Sebastio Perrini
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, and Metabolic Diseases, University of Bari, Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    Endocrinology 149:1302-13. 2008
    ....
  6. doi request reprint Involvement of the p66Shc protein in glucose transport regulation in skeletal muscle myoblasts
    Annalisa Natalicchio
    Dept of Emergency and Organ Transplantation, Section on Internal Medicine, Endocrinology and Metabolic Diseases, Univ of Bari, Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    Am J Physiol Endocrinol Metab 296:E228-37. 2009
    ....
  7. ncbi request reprint Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling
    Luigi Laviola
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    Endocrinology 146:1498-505. 2005
    ..The observed abnormalities in IGF-I signaling may contribute to altered fetal growth and development in human IUGR...
  8. doi request reprint Exendin-4 prevents c-Jun N-terminal protein kinase activation by tumor necrosis factor-alpha (TNFalpha) and inhibits TNFalpha-induced apoptosis in insulin-secreting cells
    Annalisa Natalicchio
    Department of Emergency and Organ Transplantation, Section on Internal Medicine, Endocrinology, Andrology, and Metabolic Diseases, University of Bari, Piazza Giulio Cesare, Bari, Italy
    Endocrinology 151:2019-29. 2010
    ..By inhibiting JNK phosphorylation in a PKA-dependent manner, exendin-4 counteracts TNFalpha-mediated apoptosis and reverses the inhibitory events in the IRS/Akt pathway, resulting in promotion of cell survival...
  9. ncbi request reprint Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway
    Annalisa Natalicchio
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Piazza Giulio Cesare, 11, 70124, Bari, Italy
    Diabetologia 56:2456-66. 2013
    ..The mechanisms of the protective effects of exendin-4 on NEFA-induced beta cell apoptosis were investigated...
  10. ncbi request reprint Effect of family history of type 2 diabetes on white blood cell count in adult women
    Nicola Pannacciulli
    Internal Medicine, Endocrinology, and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
    Obes Res 11:1232-7. 2003
    ..To evaluate the effect of a first-degree family history of type 2 diabetes on white blood cell (WBC) count, a risk factor for atherosclerotic vascular disease, in glucose-tolerant adult women...
  11. ncbi request reprint Insulin signaling in human visceral and subcutaneous adipose tissue in vivo
    Luigi Laviola
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari, Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    Diabetes 55:952-61. 2006
    ..In conclusion, the adipocyte insulin signaling system of omental fat shows greater and earlier responses to insulin than that of subcutaneous fat. These findings may contribute to explain the biological diversity of the two fat depots...
  12. doi request reprint Role of UBC9 in the regulation of the adipogenic program in 3T3-L1 adipocytes
    Angelo Cignarelli
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology, and Metabolic Diseases, Università degli Studi di Bari Aldo Moro, I 70124 Bari, Italy
    Endocrinology 151:5255-66. 2010
    ..In conclusion, UBC9 appears to play an important role in adipogenesis. The temporal profile of UBC9 induction and its ability to affect C/EBPδ mRNA induction support a role for this protein during early adipogenesis...
  13. pmc TNFα signals via p66(Shc) to induce E-Selectin, promote leukocyte transmigration and enhance permeability in human endothelial cells
    Luigi Laviola
    Department of Emergency and Organ Transplantation Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy
    PLoS ONE 8:e81930. 2013
    ..In conclusion, p66(Shc) acts as a novel intermediate in the TNFα pathway mediating endothelial dysfunction, and its action requires JNK-dependent phosphorylation of p66(Shc) on Ser(36). ..
  14. doi request reprint Human adipose tissue stem cells: relevance in the pathophysiology of obesity and metabolic diseases and therapeutic applications
    Angelo Cignarelli
    Department of Emergency and Organ Transplantation Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy
    Expert Rev Mol Med 14:e19. 2012
    ....
  15. doi request reprint Independent influence of insulin, catecholamines, and thyroid hormones on metabolic syndrome
    Giovanni De Pergola
    Internal Medicine, Endocrinology, and Metabolic Disease, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Bari, Italy
    Obesity (Silver Spring) 16:2405-11. 2008
    ..001), male sex (P < 0.001), insulin (P < 0.001), and 24-h urinary noradrenaline (P < 0.001). In conclusion, this study suggests that insulin and noradrenaline cooperate independently to the development of the metabolic syndrome...
  16. doi request reprint The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis
    Sebastio Perrini
    Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    J Endocrinol 205:201-10. 2010
    ..This article will focus on the molecular mechanisms of impaired GH and IGF1 signaling and action in aging, and their role in the pathogenesis of sarcopenia and osteoporosis...
  17. ncbi request reprint Biological specificity of visceral adipose tissue and therapeutic intervention
    Sebastio Perrini
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari School of Medicine, Bari, Italy
    Arch Physiol Biochem 114:277-86. 2008
    ....
  18. pmc Differences in gene expression and cytokine release profiles highlight the heterogeneity of distinct subsets of adipose tissue-derived stem cells in the subcutaneous and visceral adipose tissue in humans
    Sebastio Perrini
    Department of Emergency and Organ Transplantation, Section on Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy
    PLoS ONE 8:e57892. 2013
    ..On the other hand, inter-depot seem to prevail over intra-depot differences in the ASC gene expression assets and network functions, contributing to the high degree of specificity of Sc and V adipose tissue in humans...
  19. doi request reprint Human adipose tissue precursor cells: a new factor linking regulation of fat mass to obesity and type 2 diabetes?
    Sebastio Perrini
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari School of Medicine, Bari, Italy
    Arch Physiol Biochem 115:218-26. 2009
    ..In this review, we discuss some aspects of ASCs basic biology, the methodology involved in ASCs isolation and culture, and some implications of ASCs availability for the understanding of metabolic diseases in humans...
  20. pmc Increased carotid IMT in overweight and obese women affected by Hashimoto's thyroiditis: an adiposity and autoimmune linkage?
    Marco M Ciccone
    Department of Emergency and Organ Transplantation, University of Bari, Italy
    BMC Cardiovasc Disord 10:22. 2010
    ..Hashimoto's thyroiditis is a systemic disease. The aim is to examine whether autoimmune thyroiditis and adiposity can effect carotid IMT independently of thyroid hormones and cardiovascular risk factors...
  21. ncbi request reprint Adipose tissue, metabolic syndrome and polycystic ovary syndrome: from pathophysiology to treatment
    Gabriella Garruti
    Department of Emergency and Organ Transplantation DETO, Section of Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari Medical School, Bari, Italy
    Reprod Biomed Online 19:552-63. 2009
    ..Promising treatments for PCOS seem to be insulin sensitizers such as metformin and glitazones...
  22. doi request reprint Abnormalities of IGF-I signaling in the pathogenesis of diseases of the bone, brain, and fetoplacental unit in humans
    Luigi Laviola
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, and Metabolic Diseases, University of Bari, Bari, Italy
    Am J Physiol Endocrinol Metab 295:E991-9. 2008
    ....
  23. ncbi request reprint Insulin signalling in human adipose tissue
    Luigi Laviola
    Section of Internal Medicine, Endocrinology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
    Arch Physiol Biochem 112:82-8. 2006
    ....
  24. ncbi request reprint Dehydroepiandrosterone stimulates glucose uptake in human and murine adipocytes by inducing GLUT1 and GLUT4 translocation to the plasma membrane
    Sebastio Perrini
    Department of Emergency and Organ Transplantation, Section on Internal Medicine, Endocrinology and Metabolic Diseases, Bari, Italy
    Diabetes 53:41-52. 2004
    ..PI 3-kinase, phospholipase C gamma, and the conventional PKC-beta(2) seem to be involved in DHEA effects...
  25. pmc Cardiovascular disease and glycemic control in type 2 diabetes: now that the dust is settling from large clinical trials
    Francesco Giorgino
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy
    Ann N Y Acad Sci 1281:36-50. 2013
    ....
  26. doi request reprint p66Shc, a multifaceted protein linking Erk signalling, glucose metabolism, and oxidative stress
    Annalisa Natalicchio
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari School of Medicine, Bari, Italy
    Arch Physiol Biochem 117:116-24. 2011
    ..Thus changes in p66Shc expression and/or function may play an important role in the pathogenesis of type 2 diabetes and potentially serve as an effective target for its treatment...
  27. ncbi request reprint The IGF-I signaling pathway
    Luigi Laviola
    Department of Emergency and Organ Transplantation, Section on Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari, Bari, Italy
    Curr Pharm Des 13:663-9. 2007
    ..This review will focus on the IGF-I receptor structure and function, its intracellular signaling pathways, and some important implications of the activation of the IGF-I signal transduction system in specific tissues...
  28. ncbi request reprint Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts
    Annalisa Natalicchio
    Department of Emergency and Organ Transplantation, Section on Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari, Italy
    J Biol Chem 279:43900-9. 2004
    ....
  29. pmc Feasibility and effectiveness of a disease and care management model in the primary health care system for patients with heart failure and diabetes (Project Leonardo)
    Marco Matteo Ciccone
    Section of Cardiovascular Disease, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Policlinico, Bari, Italy
    Vasc Health Risk Manag 6:297-305. 2010
    ....
  30. ncbi request reprint HGF and M-CSF modulate adhesion of MDA-231 breast cancer cell by increasing osteopontin secretion
    M Grano
    Department of Human Anatomy and Histology, University of Bari, Italy
    J Biol Regul Homeost Agents 16:190-5. 2002
    ..Moreover HGF and M-CSF induce de novo synthesis of OPN. In conclusion, these data suggest that HGF and M-CSF stimulate OPN production by MDA-231 cells, and that OPN is subsequently used as a substrate for cell adhesion...
  31. ncbi request reprint Reversal of foetal hydrops and foetal tachyarrhythmia associated with maternal diabetic coma
    P Greco
    Istituto di Clinica Ostetrica e Ginecologica, Universita di Bari, 70124, Bari, Italy
    Eur J Obstet Gynecol Reprod Biol 93:33-5. 2000
    ....
  32. ncbi request reprint The IGF-I/IGF-I receptor pathway: Implications in the Pathophysiology of Thyroid Cancer
    A Ciampolillo
    Section of Internal Medicine, Endocrinology and Metabolic Disease, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Piazza Giulio Cesare, 11, 70124 Bari, Italy
    Curr Med Chem 12:2881-91. 2005
    ..In this review, various aspects of the IGF-I/IGF-I R pathway and its relationship to thyroid cancer are discussed...
  33. ncbi request reprint Neuroendocrine deregulation of food intake, adipose tissue and the gastrointestinal system in obesity and metabolic syndrome
    Gabriella Garruti
    Unit of Internal Medicine, Endocrinology and Metabolic Diseases, Department of Emergency and Organ Transplantations, University of Bari Medical School, Piazza G Cesare 11, Bari, Italy
    J Gastrointestin Liver Dis 17:193-8. 2008
    ..Nonetheless, it was recently discovered that a mutation in the prohormone convertase 1/3 simultaneously produces severe gastrointestinal dysfunctions and obesity...
  34. ncbi request reprint Interventional therapy in diabetic foot: risk factors, clinical events and prognosis at one year follow-up (a study of 103 cases)
    Marco Matteo Ciccone
    Department of Emergency and Organ Transplantation, Section of Cardiovascular Diseases, School of Medicine, University of Bari, Bari, Italy
    Pak J Biol Sci 15:789-94. 2012
    ..To improve diabetic foot mortality and morbidity rate, our study underlines the importance of a prompt diagnosis and appropriate revascularization treatment. Other studies are needed to ascertain these...
  35. pmc GnRH agonist versus GnRH antagonist in in vitro fertilization and embryo transfer (IVF/ET)
    Raffaella Depalo
    Unit of Physiopathology of Human Reproduction and Gametes Cryopreservation, Department of Gynecology, Obstetric and Neonatolgy, University of Bari Aldo Moro, Bari, Italy
    Reprod Biol Endocrinol 10:26. 2012
    ..Future developments have to be focused on timing of the administration of GnRH antagonists, by giving a great attention to new strategies of stimulation in patients in which radio-chemotherapy cycles are needed...
  36. ncbi request reprint Effect of family history of type 2 diabetes on the intima-media thickness of the common carotid artery in normal-weight, overweight, and obese glucose-tolerant young adults
    Nicola Pannacciulli
    Internal Medicine, Endocrinology, and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
    Diabetes Care 26:1230-4. 2003
    ..To evaluate the effect of a first-degree family history of type 2 diabetes on the intima-media thickness of the common carotid artery (IMT-CCA), a surrogate marker of coronary atherosclerosis, in glucose-tolerant young adults...
  37. pmc The sentrin-conjugating enzyme mUbc9 interacts with GLUT4 and GLUT1 glucose transporters and regulates transporter levels in skeletal muscle cells
    F Giorgino
    Istituto di Clinica Medica, Endocrinologia e Malattie Metaboliche, University of Bari School of Medicine, I 70124 Bari, Italy
    Proc Natl Acad Sci U S A 97:1125-30. 2000
    ..The mUbc9 sentrin-conjugating enzyme represents a novel regulator of GLUT1 and GLUT4 protein levels with potential importance as a determinant of basal and insulin-stimulated glucose uptake in normal and pathophysiological states...
  38. ncbi request reprint A family history of Type 2 diabetes is associated with increased plasma levels of C-reactive protein in non-smoking healthy adult women
    N Pannacciulli
    Internal Medicine, Endocrinology, and Metabolic Diseases, Department of Emergency and Transplants, University of Bari, Via Putignani 236 70122, Bari, Italy
    Diabet Med 19:689-92. 2002
    ..The aim of our study was to test whether a family history of Type 2 diabetes (FH) in women is associated with plasma C-reactive protein (CRP)...
  39. ncbi request reprint Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies
    F Giorgino
    Medicina Interna, Endocrinologia e Malattie Metaboliche, Dipartimento dell Emergenza e dei Trapianti di Organi, Universita degli Studi di Bari, Piazza Giulio Cesare, 11, 1 70124 Bari, Italy
    Acta Physiol Scand 183:13-30. 2005
    ..The main scope is to describe the biological functions of adipose tissue, and to focus on metabolic, hormonal, and signalling differences between fat depots...
  40. ncbi request reprint Fat depot-related differences in gene expression, adiponectin secretion, and insulin action and signalling in human adipocytes differentiated in vitro from precursor stromal cells
    S Perrini
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari School of Medicine, Bari, Italy
    Diabetologia 51:155-64. 2008
    ..To test this hypothesis, human adipocytes were differentiated in vitro from precursor stromal cells obtained from visceral and subcutaneous fat depots and analysed for genetic, biochemical and metabolic endpoints...
  41. ncbi request reprint Effects of streptozocin diabetes and diabetes treatment by islet transplantation on in vivo insulin signaling in rat heart
    L Laviola
    Internal Medicine, Endocrinology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
    Diabetes 50:2709-20. 2001
    ....
  42. ncbi request reprint Metabolic implications of growth hormone therapy
    S Perrini
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari, I 70124 Bari, Italy
    J Endocrinol Invest 31:79-84. 2008
    ..In this review, we examine the consequences of acute and chronic effects of GH on visceral fat and on metabolic responses in adipocytes, and discuss experimental data illustrating the integrated crosstalk between GH and insulin...
  43. ncbi request reprint Islet transplantation restores normal levels of insulin receptor and substrate tyrosine phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle and myocardium of streptozocin-induced diabetic rats
    F Giorgino
    Istituto di Clinica Medica, Endocrinologia e Malattie Metaboliche, University of Bari School of Medicine, Italy
    Diabetes 48:801-12. 1999
    ..Thus, insulin delivered into the systemic circulation by pancreatic islets transplanted under the kidney capsule can adequately correct altered insulin signaling mechanisms in insulinopenic diabetes...
  44. ncbi request reprint Continuous subcutaneous glucose monitoring in diabetic patients: a multicenter analysis
    Alberto Maran
    Dipartimento di Medicina Clinica e Sperimentale, Cattedra di Malattie del Metabolismo, Universita di Padova, Via Giustiniani 2, 35123 Padua, Italy
    Diabetes Care 25:347-52. 2002
    ..To evaluate the accuracy of a new subcutaneous glucose sensor (Glucoday; A. Menarini Diagnostics) compared with venous blood glucose measurement in type 1 and type 2 diabetic patients...
  45. ncbi request reprint Expression and secretion of the atrial natriuretic peptide in human adipose tissue and preadipocytes
    Gabriella Garruti
    Department of Pharmacology and Toxicology, Faculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 27, CH 1005 Lausanne, Switzerland
    Obesity (Silver Spring) 15:2181-9. 2007
    ..Since the expression of ANP in adipose tissue has not been documented, we used real-time reverse transcriptase polymerase chain reaction (RT-PCR) to investigate the expression of ANP in human adipose tissue and preadipocytes...
  46. ncbi request reprint Timing of fetal growth acceleration in women with insulin-dependent diabetes
    Pantaleo Greco
    Obstetrics and Gynaecology, University of Foggia, Foggia, Italy
    Fetal Diagn Ther 18:437-41. 2003
    ....
  47. ncbi request reprint Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes: the EURODIAB Prospective Complications Study
    Miranda T Schram
    Institute for Cardiovascular Research, and Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 26:2165-73. 2003
    ..Inflammatory activity is increased in type 1 diabetes and may predispose to vascular disease. Its origin is not clear. We therefore investigated determinants of inflammation in type 1 diabetes...