Giovanna Giordano


Affiliation: University of Parma
Country: Italy


  1. Giordano G, D Adda T, Dal Bello B, Brigati F, Bersiga A, Campanini N, et al. Clinicopathologic implications of the epidermal growth factor receptor, cyclooxygenase 2 expression, and human papillomavirus status in squamous cell carcinoma of the uterine cervix in the elderly. Int J Gynecol Cancer. 2011;21:337-48 pubmed publisher
    ..002), on univariate analysis.On multivariate analysis, Cox-2 and EGFR immunopositivity did not reveal any correlation between these markers and prognosis probably because the number of cases considered was not particularly high. ..
  2. Giordano G, D Adda T, Brigati F, Lombardi M, Raboni S. A Unique case of primary squamous carcinoma of the salpinx associated with serous carcinoma of the omentum: a pathological and molecular study. Int J Gynecol Pathol. 2010;29:533-8 pubmed publisher
    ..In summary, in this case we showed that the PSCCS was not due to human papilloma virus infection, but in all probability due to other pathogenetic mechanisms that cause a mutation of the p53 tumor-suppressor gene. ..
  3. Giordano G, D Adda T, Merisio C, Gnetti L. Primary squamous cell carcinoma of the endometrium: a case report with immunohistochemical and molecular study. Gynecol Oncol. 2005;96:876-9 pubmed
    ..Thus, it is reasonable to conclude that both HPV infection and unclear carcinogenic factors, responsible of p53 tumor-suppressor gene mutation, may cause PSCCE. ..
  4. Giordano G, D Adda T, Gnetti L, Merisio C, Gabrielli M, Melpignano M. Villoglandular adenocarcinoma of the cervix: two new cases with morphological and molecular study. Int J Gynecol Pathol. 2007;26:199-204 pubmed
    ..Behavioral cofactors, such as HSV infection (types 1 and 2), oral contraceptive use and smoking, involved in the pathogenesis of other cervical malignancies, can be excluded for the present cases. ..
  5. Giordano G, D Adda T, Gnetti L, Merisio C, Raboni S. Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature. Int J Gynecol Pathol. 2007;26:298-304 pubmed
    ..In our view, other cases of TCCE associated with ovarian Brenner tumor should be reported to confirm the last 2 hypotheses. ..
  6. Giordano G, Bersiga A, Marchetti G, Melpignano M. Primary adenocarcinoma of the rectovaginal septum arising in pregnancy in the absence of endometriosis. Eur J Gynaecol Oncol. 2010;31:211-3 pubmed
    ..Moreover, because no foci of endometriosis were identified in several sections of the neoplasm, uterine and cervical wall, and tissues nearby the neoplasm could represent a rare subtype of PARVS arising in the absence of endometriosis. ..
  7. Giordano G, Gnetti L, Melpignano M. Endometrial carcinoma metastatic to the vulva: a case report and review of the literature. Pathol Res Pract. 2005;201:751-6 pubmed
    ..Moreover, in the presence of metastatic endometrial carcinoma to the vulva, it is necessary to verify if other visceral metastases are present. ..
  8. Giordano G, Pizzi S, Berretta R, D Adda T. A new case of primary signet-ring cell carcinoma of the cervix with prominent endometrial and myometrial involvement: Immunohistochemical and molecular studies and review of the literature. World J Surg Oncol. 2012;10:7 pubmed publisher
  9. Giordano G, D Adda T, Gnetti L, Froio E, Merisio C, Melpignano M. Role of human papillomavirus in the development of epithelial ovarian neoplasms in Italian women. J Obstet Gynaecol Res. 2008;34:210-7 pubmed publisher
    ..The presence of HPV could be an expression of a latent infection. In both positive and negative HPV ovarian neoplasms, cervix showed only chronic cervicitis and no signal for HPV DNA on PCR analysis. ..

More Information


  1. Giordano G, Berretta R, Silini E. Primary pure spindle cell carcinoma (sarcomatoid carcinoma) of the ovary: A case report with immunohistochemical study. Diagn Pathol. 2016;11:70 pubmed publisher
    ..The distinction from true sarcomas and carcinosarcomas is important because of the more favorable prognosis of the spindle cell carcinomas. However their diagnosis necessitates a careful tissue sampling and immunohistochemical staining. ..
  2. Giordano G, D Adda T, Varotti E, Crovini G, Silini E. Primary alveolar soft part sarcoma of uterine corpus: a case report with immunohistochemical, ultrastructural study and review of literature. World J Surg Oncol. 2016;14:24 pubmed publisher
    ..Thus, in this unusual presentation an essential diagnostic marker is the nuclear over-expression of TFE3 as well as ultrastructural study, which reveals the presence of peculiar cytoplasmic crystalline inclusions. ..
  3. Giordano G, Lombardi M, Brigati F, Mancini C, Silini E. Clinicopathologic features of 2 new cases of uterine tumors resembling ovarian sex cord tumors. Int J Gynecol Pathol. 2010;29:459-67 pubmed publisher
    ..The differential diagnosis of UTROSCT and the role of immunohistochemistry in confirming a diagnosis are discussed. ..
  4. Giordano G, Campanini N, Rocco A, Donofrio V, Bertolini P, Falleti J, et al. C-kit protein expression in Wilms' tumour: an immunohistochemical study. Eur J Surg Oncol. 2009;35:629-35 pubmed publisher
    ..However, it seems likely that c-kit expression could be a secondary event related to tumour progression and could be influenced by chemotherapy and unfavourable histology. ..
  5. Giordano G, D Adda T, Gnetti L, Froio E, Merisio C, Melpignano M. Detection of human papillomavirus in organs of upper genital tract in women with cervical cancer. Int J Gynecol Cancer. 2006;16:1601-7 pubmed
  6. Giordano G, Corcione L, Giordano D, D Adda T, Gnetti L, Ferri T. Primary moderately differentiated neuroendocrine carcinoma (atypical carcinoid) of the larynx: A case report with immunohistochemical and molecular study. Auris Nasus Larynx. 2009;36:228-31 pubmed publisher
    ..PCR of NEC DNA did not show any signal for HPV DNA. Thus, this neoplasm is not due to an HPV infection, but a mutation of p53 gene which could cause immunohistochemical overexpression of p53 protein...
  7. Giordano G, Azzoni C, D Adda T, Rocco A, Gnetti L, Froio E, et al. Human papilloma virus (HPV) status, p16INK4a, and p53 overexpression in epithelial malignant and borderline ovarian neoplasms. Pathol Res Pract. 2008;204:163-74 pubmed publisher
  8. Giordano G, Brigati F, Varotti E. A case of ovarian psammocarcinoma with homolateral serous cystoadenofibroma and thecoma associated with Brenner tumour and cystoadenofibroma of the contralateral ovary. Eur J Gynaecol Oncol. 2013;34:569-71 pubmed
    ..Moreover, this example of psammocarcinoma is very interesting because it measures only 1.5 x 0.5 x 1.5 cm and, to the best of the author's knowledge, represents the smallest case ofpsammocarcinoma described so far in the literature...
  9. Giordano G, Gnetti L, Merisio C, Melpignano M. Postmenopausal status, hypertension and obesity as risk factors for malignant transformation in endometrial polyps. Maturitas. 2007;56:190-7 pubmed
    ..Moreover, to clarify the mechanisms of carcinogenesis in malignant endometrial polyps we examined the expression of cyclooxygenase-2 (COX-2), P53 and Ki 67 and their relationships with clinicopathologic characteristics...