Giovanna Giordano

..An unusual histologic finding in tissue obtained from voluntary pregnancy termination (VPT) is reported to demonstrate the utility of pathologic examination of this specimen...

..The objective was to evaluate the usefulness of post-mortem examination in cases of renal malformations by a comparison of the post-mortem findings with clinical diagnosis...

..In addition, a review was made of the literature to identify the clinical and pathological features of this rare malignancy...

..In both cases, UC components were characterized by a high degree of instability, in accordance of its aggressive behaviour and its architectural heterogeneity. Further studies with more numerous cases are mandatory to confirm these data...

..The follow ups of the patients with or without HPV DNA were also considered to evaluate whether HPV DNA in these tumors could be an indicator of prognosis...

..Other cases of CM associated with beta thalassaemia should be reported to confirm these hypotheses...

..PCR of NEC DNA did not show any signal for HPV DNA. Thus, this neoplasm is not due to an HPV infection, but a mutation of p53 gene which could cause immunohistochemical overexpression of p53 protein...

..Thus, Cox-2 inhibitors could be used for treating all cases of WT. Further studies, including molecular investigations, would be useful to confirm our hypotheses...

..We examined CD117 expression in Wilms' tumour in order to correlate this marker with clinico-pathological data and to clarify its prognostic impact...

..Moreover, in many instances, for an accurate diagnosis, immunohistochemical analysis with a panel of markers is more useful than a study with a single antibody...

..However, this study did demonstrate that cytology does not alter patient management or outcome. In effect, in accordance with other studies, our cases of metastatic extragenital neoplasms to the uterus have poor prognosis...

..These findings suggest that this lesion can be considered a conventional splenic angiosarcoma with focal histocytic differentiation...

..Moreover, because no foci of endometriosis were identified in several sections of the neoplasm, uterine and cervical wall, and tissues nearby the neoplasm could represent a rare subtype of PARVS arising in the absence of endometriosis...

..The differential diagnosis of UTROSCT and the role of immunohistochemistry in confirming a diagnosis are discussed...

..In summary, in this case we showed that the PSCCS was not due to human papilloma virus infection, but in all probability due to other pathogenetic mechanisms that cause a mutation of the p53 tumor-suppressor gene...

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..In our view, other cases of TCCE associated with ovarian Brenner tumor should be reported to confirm the last 2 hypotheses...

..Thus, the metastases to the uterus and to other organs of the genital tract can be considered a preterminal event...

..However, in our view, other cases of these rare malignancies should be investigated in order to confirm this hypothesis...

..In this paper, we report a case of primary squamous cell carcinoma of the endometrium (PSCCE) with immunohistochemical and molecular study to evaluate the phenotype and to define the etiopathogenesis of this tumor...

..We, moreover believe that the paucity of spinal motoneurons could be due to the anomalies of programmed death during fetal development and the consequence of genetic defects...

..Behavioral cofactors, such as HSV infection (types 1 and 2), oral contraceptive use and smoking, involved in the pathogenesis of other cervical malignancies, can be excluded for the present cases...

..Moreover, to clarify the mechanisms of carcinogenesis in malignant endometrial polyps we examined the expression of cyclooxygenase-2 (COX-2), P53 and Ki 67 and their relationships with clinicopathologic characteristics...

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..We reported a new bilateral case of serous psammocarcinoma. We also reviewed the literature in order to delineate clinical, pathological, and prognostic features of this rare neoplasm...

..Moreover, in the presence of metastatic endometrial carcinoma to the vulva, it is necessary to verify if other visceral metastases are present...

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..We also evaluated the concordance for the degree of tumor differentiation between diagnostic biopsy and final histologic results...

..However, in our opinion, further molecular studies should be conducted on other cases of MPTs to confirm this hypothesis...

..After a follow-up of an average of 5 years there was, neither in the abdominal operated patients nor in the vaginal operated patients, a recurrence of disease...

..In conclusion, our case, which is the first case of VSAC with polymerase chain reaction analysis and immunohistochemical expression of p16 protein, suggested that this neoplasm could be related to human papillomavirus infection...

..Although the neurotrophin-inducible gene vgf is expressed in mammalian neurons and endocrine cells, limited data is available in man...

..In reporting this case, we emphasize the importance of accurate postmortem examination and clinical data for the diagnosis of metabolic lactic acidosis...

..We suggest that lack of epidermal T cells, although the LC network was fully represented, might reflect the scarce opportunity of fetal LC to contact foreign antigens in utero...

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..The primary objective of the present paper was to delineate possible causes of SIDS as derived from a review of autoptic studies reported in the literature...

..At present, no final consensus has been reached on the choice of the best strategy for surgery and adjuvant therapy...

..RESULTS AND CONCLUSIONS: The prenatal karyotype revealed an unbalanced male fetus. The postmortem examination showed a malformed fetus with female external genitalia. Lack of DMRT1-2 genes established by FISH...