Emanuele Giordano

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. pmc Priming adult stem cells by hypoxic pretreatments for applications in regenerative medicine
    Claudio Muscari
    Department of Biomedical and NeuroMotor Sciences DiBiNeM, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy
    J Biomed Sci 20:63. 2013
  2. pmc Mechanostimulation protocols for cardiac tissue engineering
    Marco Govoni
    BioEngLab, Health Science and Technology Interdepartmental Center for Industrial Research HST CIRI, University of Bologna, I 40064 Ozzano Emilia, Italy
    Biomed Res Int 2013:918640. 2013
  3. pmc Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy
    Emanuele Giordano
    Department of Cellular and Molecular Physiology, The Penn State College of Medicine, Hershey, PA 17033 2390, USA
    Amino Acids 42:507-18. 2012
  4. ncbi request reprint Involvement of polyamines in apoptosis of cardiac myoblasts in a model of simulated ischemia
    Benedetta Tantini
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    J Mol Cell Cardiol 40:775-82. 2006
  5. doi request reprint Leupeptin preserves cardiac nitric oxide synthase 3 during reperfusion following long-term cardioplegia
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    J Surg Res 164:e27-35. 2010
  6. ncbi request reprint Different expression of NOS isoforms in early endothelial progenitor cells derived from peripheral and cord blood
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Italy
    J Cell Biochem 102:992-1001. 2007
  7. ncbi request reprint Early preconditioning prevents the loss of endothelial nitric oxide synthase and enhances its activity in the ischemic/reperfused rat heart
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Italy
    Life Sci 74:1127-37. 2004
  8. ncbi request reprint Ischemic preconditioning preserves proton leakage from mitochondrial membranes but not oxidative phosphorylation during heart reperfusion
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Cell Biochem Funct 24:511-8. 2006
  9. doi request reprint Molecular mechanisms of ischemic preconditioning and postconditioning as putative therapeutic targets to reduce tumor survival and malignancy
    Claudio Muscari
    Department of Biomedical and NeuroMotor Sciences DiBiNeM, University of Bologna, Bologna, Italy National Institute for Cardiovascular Research, Bologna, Italy BioEngLab, Health Science and Technology Interdepartmental Center for Industrial Research HST CIRI, University of Bologna, Ozzano Emilia BO, Italy Electronic address
    Med Hypotheses 81:1141-5. 2013
  10. ncbi request reprint Activation of glucose transport during simulated ischemia in H9c2 cardiac myoblasts is mediated by protein kinase C isoforms
    Giulio Agnetti
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Life Sci 78:264-70. 2005

Detail Information

Publications23

  1. pmc Priming adult stem cells by hypoxic pretreatments for applications in regenerative medicine
    Claudio Muscari
    Department of Biomedical and NeuroMotor Sciences DiBiNeM, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy
    J Biomed Sci 20:63. 2013
    ..Stem cell adaptation to their natural hypoxic microenvironments (niche) in healthy and neoplastic tissues will be also considered. ..
  2. pmc Mechanostimulation protocols for cardiac tissue engineering
    Marco Govoni
    BioEngLab, Health Science and Technology Interdepartmental Center for Industrial Research HST CIRI, University of Bologna, I 40064 Ozzano Emilia, Italy
    Biomed Res Int 2013:918640. 2013
    ..In the last fifteen years a large number of dynamic culture devices have been developed and many results have been collected. The aim of this brief review is to resume in a single streamlined paper the state of the art in this field. ..
  3. pmc Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy
    Emanuele Giordano
    Department of Cellular and Molecular Physiology, The Penn State College of Medicine, Hershey, PA 17033 2390, USA
    Amino Acids 42:507-18. 2012
    ..Since considerable variations in human cardiac polyamine and L-Arg content are likely, it is possible that alterations in these factors may influence myocyte contractility...
  4. ncbi request reprint Involvement of polyamines in apoptosis of cardiac myoblasts in a model of simulated ischemia
    Benedetta Tantini
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    J Mol Cell Cardiol 40:775-82. 2006
    ..In conclusion, this finding may suggest novel pharmacological approaches for the protection of cardiomyocytes injury caused by ischemia...
  5. doi request reprint Leupeptin preserves cardiac nitric oxide synthase 3 during reperfusion following long-term cardioplegia
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    J Surg Res 164:e27-35. 2010
    ..The observed decrease in GSH/GSSG ratio and activation of JNK in the reperfused heart suggested that proteolysis could be triggered by reactive oxygen species...
  6. ncbi request reprint Different expression of NOS isoforms in early endothelial progenitor cells derived from peripheral and cord blood
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Italy
    J Cell Biochem 102:992-1001. 2007
    ....
  7. ncbi request reprint Early preconditioning prevents the loss of endothelial nitric oxide synthase and enhances its activity in the ischemic/reperfused rat heart
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Italy
    Life Sci 74:1127-37. 2004
    ..This suggest that early ischemic preconditioning may be useful to accelerate the complete recovery of endothelial function by preserving the level of cardiac eNOS and stimulating the basal production of nitric oxide...
  8. ncbi request reprint Ischemic preconditioning preserves proton leakage from mitochondrial membranes but not oxidative phosphorylation during heart reperfusion
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Cell Biochem Funct 24:511-8. 2006
    ..Mitochondria can contribute to cell survival by the attenuation of proton leak from inner membrane...
  9. doi request reprint Molecular mechanisms of ischemic preconditioning and postconditioning as putative therapeutic targets to reduce tumor survival and malignancy
    Claudio Muscari
    Department of Biomedical and NeuroMotor Sciences DiBiNeM, University of Bologna, Bologna, Italy National Institute for Cardiovascular Research, Bologna, Italy BioEngLab, Health Science and Technology Interdepartmental Center for Industrial Research HST CIRI, University of Bologna, Ozzano Emilia BO, Italy Electronic address
    Med Hypotheses 81:1141-5. 2013
    ..As a consequence, this strategy should be effective in blunting tumor capacity to progress toward malignancy and survive in ischemic conditions. ..
  10. ncbi request reprint Activation of glucose transport during simulated ischemia in H9c2 cardiac myoblasts is mediated by protein kinase C isoforms
    Giulio Agnetti
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Life Sci 78:264-70. 2005
    ....
  11. ncbi request reprint Long-term treatment with N-acetylcysteine, but not caloric restriction, protects mesenchymal stem cells of aged rats against tumor necrosis factor-induced death
    Claudio Muscari
    Department of Biochemistry, University of Bologna, Bologna, Italy
    Exp Gerontol 41:800-4. 2006
    ..In conclusion, a prolonged supplementation with N-acetylcysteine in rats can increase resistance to necrotic death of MSCs and may also counteract an excessive rate of MSC proliferation...
  12. doi request reprint Epigenetic signature of early cardiac regulatory genes in native human adipose-derived stem cells
    Alice Pasini
    Laboratory of Cellular and Molecular Engineering S Cavalcanti, University of Bologna, Campus of Cesena, Via Venezia, 52, 47521, Cesena, FC, Italy
    Cell Biochem Biophys 67:255-62. 2013
    ..These results suggest that the chromatin arrangement of these early cardiac regulatory genes could be explored as a level of intervention to address the differentiation of human ADSCs toward the cardiac lineage. ..
  13. ncbi request reprint Evaluation of cellular energetics by the pasteur effect in intact cardiomyoblasts and isolated perfused hearts
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    Mol Cell Biochem 258:91-7. 2004
    ..9%), it was 25% lower than control (p < 0.05). Therefore, we proposed this test as a tool for quantifying both physiological and pathological energetic modifications in living intact cardiomyocytes and in isolated and perfused hearts...
  14. pmc Proteomic profiling of endothelin-1-stimulated hypertrophic cardiomyocytes reveals the increase of four different desmin species and alpha-B-crystallin
    Giulio Agnetti
    Department of Biochemistry G Moruzzi, INRC, University of Bologna, Italy
    Biochim Biophys Acta 1784:1068-76. 2008
    ..In conclusion, proteomic profiling of ET1-stimulated rat neonatal cardiomyocytes reveals specific changes in cardiac molecular phenotype mainly involving intermediate filament and molecular chaperone proteins...
  15. doi request reprint Induction of NO synthase 2 in ventricular cardiomyocytes incubated with a conventional bicarbonate dialysis bath
    Eleonora Grandi
    Laboratory of Cellular and Molecular Engineering, University of Bologna, Italy
    Nephrol Dial Transplant 23:2192-7. 2008
    ..NO overload might cause the impairment of cardiovascular reactivity observed during BD. In this study, a potential direct impact of the residual quote of acetate on the cardiac cells was investigated...
  16. ncbi request reprint Evaluation of nitric oxide release in the coronary effluent by a novel EPR technique: a study on isolated rat hearts subjected to cold cardioplegia and reperfusion
    Claudio Muscari
    Department of Biochemistry, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Life Sci 74:109-23. 2003
    ..Therefore, we suggest that the coronary spasm following a cold cardioplegic arrest is not due to an impaired production of basal NO and that NO-donors can be effective in relaxing vascular smooth muscle cells...
  17. doi request reprint Electrospun scaffolds of a polyhydroxyalkanoate consisting of omega-hydroxylpentadecanoate repeat units: fabrication and in vitro biocompatibility studies
    Maria Letizia Focarete
    University of Bologna, Department of Chemistry G Ciamician and National Consortium of Materials Science and Technology INSTM, RU Bologna, Via Selmi 2, 40126 Bologna, Italy
    J Biomater Sci Polym Ed 21:1283-96. 2010
    ..The results indicated that PPDL mats are not cytotoxic and they support proliferation of H9c2 cells. The cumulative results of this study suggest further exploration of PPDL fibrous mats as scaffolds for tissue-engineered constructs...
  18. ncbi request reprint H9c2 cardiac myoblasts undergo apoptosis in a model of ischemia consisting of serum deprivation and hypoxia: inhibition by PMA
    Francesca Bonavita
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio, 48 40126 Bologna, Italy
    FEBS Lett 536:85-91. 2003
    ..Phorbol-12-myristate-13-acetate significantly reduced the induction of apoptosis, inhibiting caspase 3 cleavage, Bax accumulation, Bcl-xL down-regulation as well as restoring cell viability...
  19. pmc Rational design of modular circuits for gene transcription: A test of the bottom-up approach
    Francesca Ceroni
    Laboratory of Cellular and Molecular Engineering, University of Bologna, I 47521 Cesena, Italy
    J Biol Eng 4:14. 2010
    ..We are at the point where an increasing number of modular, inter-changeable and well-characterized components is needed to expand the construction of synthetic devices and to allow a rational approach to the design...
  20. doi request reprint A synthetic post-transcriptional controller to explore the modular design of gene circuits
    Francesca Ceroni
    Laboratory of Cellular and Molecular Engineering, University of Bologna, I 47521 Cesena, Italy
    ACS Synth Biol 1:163-71. 2012
    ..Our findings shed doubts into the feasibility of a pure bottom-up approach in synthetic biology, highlighting the urgency for new strategies for the rational design of synthetic devices...
  21. doi request reprint Chromatin remodeling by polyamines and polyamine analogs
    Alice Pasini
    Laboratory of Cellular and Molecular Engineering S Cavalcanti, Department of Electrical, Electronic and Information Engineering G Marconi DEI, University of Bologna, Via Venezia 52, 47521, Cesena FC, Italy
    Amino Acids 46:595-603. 2014
    ..All these novel polyamine-based pharmacologically active molecules are thus promising tools, both as a stand-alone strategy and in combination with other anticancer compounds. ..
  22. ncbi request reprint NF-kappaB and ERK cooperate to stimulate DNA synthesis by inducing ornithine decarboxylase and nitric oxide synthase in cardiomyocytes treated with TNF and LPS
    Benedetta Tantini
    Department of Biochemistry G Moruzzi, School of Medicine, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy
    FEBS Lett 512:75-9. 2002
    ..In conclusion, these results indicate that NF-kappaB, in cooperation with ERK, plays a pivotal role in the growth stimulating effects of TNF and LPS, leading to the induction of both ODC and NOS and to the reduction of caspase activity...
  23. pmc Nitric oxide down-regulates brain-derived neurotrophic factor secretion in cultured hippocampal neurons
    Marco Canossa
    Department of Pharmacology, University of Bologna, Via Irnerio 48, 40216 Bologna, Italy
    Proc Natl Acad Sci U S A 99:3282-7. 2002
    ....