Paolo Gionchetti

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi request reprint Review article: treatment of mild to moderate ulcerative colitis and pouchitis
    P Gionchetti
    Department of Internal Medicine, University of Bologna, Italy
    Aliment Pharmacol Ther 16:13-9. 2002
  2. ncbi request reprint Management of inflammatory bowel disease: does rifaximin offer any promise?
    Paolo Gionchetti
    IBD Unit, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Chemotherapy 51:96-102. 2005
  3. pmc Probiotics and barrier function in colitis
    P Gionchetti
    Policlinic Sant Orsola, Department of Internal Medicine and Gastroenterology, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Gut 54:898-900. 2005
  4. pmc Antibiotics and probiotics in chronic pouchitis: a comparative proteomic approach
    Silvia Turroni
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    World J Gastroenterol 16:30-41. 2010
  5. ncbi request reprint Antibiotic combination therapy in patients with chronic, treatment-resistant pouchitis
    P Gionchetti
    Dipartimento di Medicina Interna e Gastroenterologia, Italy
    Aliment Pharmacol Ther 13:713-8. 1999
  6. ncbi request reprint Review article: problematic proctitis and distal colitis
    P Gionchetti
    Department of Internal Medicine, University of Bologna, Italy
    Aliment Pharmacol Ther 20:93-6. 2004
  7. ncbi request reprint Management of pouch dysfunction or pouchitis with an ileoanal pouch
    Paolo Gionchetti
    Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S Orsola, Via Massarenti 9, 40138 Bologna, Italy
    Best Pract Res Clin Gastroenterol 18:993-1006. 2004
  8. ncbi request reprint Antibiotics and probiotics in treatment of inflammatory bowel disease
    Paolo Gionchetti
    Department of Internal Medicine and Gastroenterology, Bologna, Italy
    World J Gastroenterol 12:3306-13. 2006
  9. ncbi request reprint VSL#3: an analysis of basic and clinical contributions in probiotic therapeutics
    Paolo Gionchetti
    Department of Internal Medicine and Gastroenterology, Policlinic Sant Orsola, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Gastroenterol Clin North Am 34:499-513, ix-x. 2005
  10. ncbi request reprint Antimicrobials in the management of inflammatory bowel disease
    Paolo Gionchetti
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Digestion 73:77-85. 2006

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Review article: treatment of mild to moderate ulcerative colitis and pouchitis
    P Gionchetti
    Department of Internal Medicine, University of Bologna, Italy
    Aliment Pharmacol Ther 16:13-9. 2002
    ..Chronic refractory pouchitis may benefit from a prolonged course of a combination of antibiotics. Highly concentrated probiotics (VSL#3) are effective both for the prevention of pouchitis onset and the prevention of relapses...
  2. ncbi request reprint Management of inflammatory bowel disease: does rifaximin offer any promise?
    Paolo Gionchetti
    IBD Unit, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Chemotherapy 51:96-102. 2005
    ..Some preliminary data show its efficacy in severe active ulcerative colitis, pouchitis and prevention of postoperative recurrence in Crohn's disease...
  3. pmc Probiotics and barrier function in colitis
    P Gionchetti
    Policlinic Sant Orsola, Department of Internal Medicine and Gastroenterology, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Gut 54:898-900. 2005
    ..Probiotic administration may exert a protective effect in colitis by preventing mucosal barrier disruption and influencing the extent of mucosal injury...
  4. pmc Antibiotics and probiotics in chronic pouchitis: a comparative proteomic approach
    Silvia Turroni
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    World J Gastroenterol 16:30-41. 2010
    ..To profile protein expression in mucosal biopsies from patients with chronic refractory pouchitis following antibiotic or probiotic treatment, using a comparative proteomic approach...
  5. ncbi request reprint Antibiotic combination therapy in patients with chronic, treatment-resistant pouchitis
    P Gionchetti
    Dipartimento di Medicina Interna e Gastroenterologia, Italy
    Aliment Pharmacol Ther 13:713-8. 1999
    ..Pouchitis is the major long-term complication after ileal pouch-anal anastomosis for ulcerative colitis. About 15% of patients have a chronic, treatment-resistant disease...
  6. ncbi request reprint Review article: problematic proctitis and distal colitis
    P Gionchetti
    Department of Internal Medicine, University of Bologna, Italy
    Aliment Pharmacol Ther 20:93-6. 2004
    ..Surgical colectomy may be required in those rare patients refractory or intolerant to pharmacotherapy...
  7. ncbi request reprint Management of pouch dysfunction or pouchitis with an ileoanal pouch
    Paolo Gionchetti
    Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S Orsola, Via Massarenti 9, 40138 Bologna, Italy
    Best Pract Res Clin Gastroenterol 18:993-1006. 2004
    ..Highly concentrated probiotics (VSL#3) have been shown to be effective in preventing the onset and relapse of pouchitis...
  8. ncbi request reprint Antibiotics and probiotics in treatment of inflammatory bowel disease
    Paolo Gionchetti
    Department of Internal Medicine and Gastroenterology, Bologna, Italy
    World J Gastroenterol 12:3306-13. 2006
    ..Both antibiotics and probiotics appear to play a beneficial role in the treatment and prevention of pouchitis and further trials are warranted to fully quantify their clinical efficacy...
  9. ncbi request reprint VSL#3: an analysis of basic and clinical contributions in probiotic therapeutics
    Paolo Gionchetti
    Department of Internal Medicine and Gastroenterology, Policlinic Sant Orsola, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Gastroenterol Clin North Am 34:499-513, ix-x. 2005
  10. ncbi request reprint Antimicrobials in the management of inflammatory bowel disease
    Paolo Gionchetti
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Digestion 73:77-85. 2006
    ..Preliminary data suggest that rifaximin may be beneficial in the treatment of active ulcerative colitis (and pouchitis), mild to moderate CD as well as prevention of post-operative recurrence of CD...
  11. ncbi request reprint Review article: aminosalicylates for distal colitis
    P Gionchetti
    Department of Internal Medicine, University of Bologna, Bologna, Italy
    Aliment Pharmacol Ther 24:41-4. 2006
    ..Patients who prefer not to continue on long-term rectal therapy can be treated with oral aminosalicylates...
  12. ncbi request reprint Oral budesonide in the treatment of chronic refractory pouchitis
    P Gionchetti
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Aliment Pharmacol Ther 25:1231-6. 2007
    ..Pouchitis is the major long-term complication after ileal-pouch nal anastomosis for ulcerative colitis. Ten to 15% of patients develop a chronic pouchitis, either treatment responsive or treatment refractory...
  13. ncbi request reprint Standard treatment of ulcerative colitis
    Paolo Gionchetti
    Department of Internal Medicine, University of Bologna, Bologna, Italy
    Dig Dis 21:157-67. 2003
    ..Close monitoring of these hematologic and biochemical parameters will improve safety. The use of biologic therapy with infliximab in more severe disease has not been established...
  14. ncbi request reprint Probiotics for the treatment of postoperative complications following intestinal surgery
    Paolo Gionchetti
    Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S Orsola, Via Massarenti no 9, 40138 Bologna, Italy
    Best Pract Res Clin Gastroenterol 17:821-31. 2003
    ..Further controlled studies are needed to establish the efficacy of probiotics in the prophylaxis of postoperative recurrences of Crohn's disease and in the treatment of mild pouchitis...
  15. ncbi request reprint Probiotics in infective diarrhoea and inflammatory bowel diseases
    P Gionchetti
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    J Gastroenterol Hepatol 15:489-93. 2000
    ..This review focuses on the available data concerning the mechanisms of action of probiotics, and on the results from clinical studies using probiotics to treat infective diarrhoea and inflammatory bowel disease...
  16. ncbi request reprint Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial
    P Gionchetti
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Gastroenterology 119:305-9. 2000
    ..thermophilus compared with placebo in maintenance of remission of chronic pouchitis...
  17. ncbi request reprint Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial
    Paolo Gionchetti
    Department of Internal Medicine, University of Bologna, Italy
    Gastroenterology 124:1202-9. 2003
    ..The aim of this study was to compare probiotic therapy with VSL#3 versus placebo in the ability to prevent the onset of acute pouchitis during the first year after ileal pouch-anal anastomosis...
  18. ncbi request reprint Probiotics--role in inflammatory bowel disease
    P Gionchetti
    IBD Unit, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Dig Liver Dis 34:S58-62. 2002
    ..The encouraging results obtained in ulcerative colitis and Crohn's disease need to be further assessed in large double-blind trials...
  19. ncbi request reprint High-dose probiotics for the treatment of active pouchitis
    Paolo Gionchetti
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Dis Colon Rectum 50:2075-82; discussion 2082-4. 2007
    ..This study was designed to evaluate the efficacy of high-dose VSL#3 in the treatment of mildly active pouchitis...
  20. doi request reprint Adult attachment and early parental experiences in patients with Crohn's disease
    Alessandro Agostini
    Department of Psychology, University of Bologna, Bologna, Italy
    Psychosomatics 51:208-15. 2010
    ..Crohn's disease (CD) is a chronic, relapsing and remitting inflammatory bowel disease. The relationship of attachment to the illness is considered to be bidirectional...
  21. ncbi request reprint Effects of probiotic bacteria on gastrointestinal motility in guinea-pig isolated tissue
    Matteo Massi
    Department of Pharmaceutical Sciences, University of Bologna, Italy
    World J Gastroenterol 12:5987-94. 2006
    ..To evaluate the intestinal motility changes evoked by 8 bacterial strains belonging to Bifidobacterium, Lactobacillus and Streptococcus genera within the probiotic preparation VSL#3...
  22. ncbi request reprint Diagnosis and treatment of pouchitis
    Paolo Gionchetti
    University of Bologna, Department of Internal Medicine and Gastroenterology, Policlinico S Orsola, Via Massarenti no 9, 40138 Bologna, Italy
    Best Pract Res Clin Gastroenterol 17:75-87. 2003
    ..Highly concentrated probiotics are effective for both prevention of relapses and prevention of pouchitis onset. There is no convincing evidence of the efficacy of other therapeutic agents...
  23. ncbi request reprint Topical treatment of distal active ulcerative colitis with beclomethasone dipropionate or mesalamine: a single-blind randomized controlled trial
    Paolo Gionchetti
    Institute of Clinical Medicine, S Orsola Malpighi Hospital, University of Bologna, Italy
    J Clin Gastroenterol 39:291-7. 2005
    ..Therapy for active ulcerative colitis (UC) usually involves rectal formulations of corticosteroids (CS), which are characterized by the risk of systemic steroid-related adverse effects...
  24. doi request reprint Clinical course of microscopic colitis in a single-center cohort study
    Carlo Calabrese
    Department of Clinical Medicine, University of Bologna, Italy
    J Crohns Colitis 5:218-21. 2011
    ..The aims of this study were to evaluate the clinical course of microscopic colitis (MC) and to describe the morbidity evolution of the disease...
  25. ncbi request reprint Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells
    Karen Manon Lammers
    Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinic S Orsola, Via Massarenti 9, 40138 Bologna, Italy
    FEMS Immunol Med Microbiol 38:165-72. 2003
    ..Total bacterial DNA from feces collected after probiotic administration modulated the immune response by a decrease of interleukin-1 beta and an increase of interleukin-10...
  26. ncbi request reprint Cutaneous manifestations in inflammatory bowel diseases: eight cases of psoriasis induced by anti-tumor-necrosis-factor antibody therapy
    Beatrice Passarini
    Department of Specialistic and Experimental Clinical Medicine, Division of Dermatology, University Hospital of Bologna, Bologna, Italy
    Dermatology 215:295-300. 2007
    ....
  27. pmc Role of conventional therapies in the era of biological treatment in Crohn's disease
    Paolo Gionchetti
    Department of Clinical Medicine, University of Bologna, 40138 Bologna, Italy
    World J Gastroenterol 17:1797-806. 2011
    ..However, the large majority of patients with CD will be managed through conventional therapy, even if they are a prelude to biological therapy...
  28. ncbi request reprint Probiotic therapy in the prevention of pouchitis onset: decreased interleukin-1beta, interleukin-8, and interferon-gamma gene expression
    Karen M Lammers
    Policlinico S Orsola, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Inflamm Bowel Dis 11:447-54. 2005
    ..Pouchitis has been associated with elevated levels of proinflammatory cytokines and chemokines...
  29. doi request reprint Obscure gastrointestinal bleeding: single centre experience of capsule endoscopy
    Carlo Calabrese
    Department of Clinical Medicine, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy
    Intern Emerg Med 8:681-7. 2013
    ..9%) of cases. Capsule retention was noted in five patients (1.4%). In this study, CE was proven to be a safe, comfortable, and effective, with a high rate of accuracy for diagnosing OGIB. ..
  30. pmc Eviendep® reduces number and size of duodenal polyps in familial adenomatous polyposis patients with ileal pouch-anal anastomosis
    Carlo Calabrese
    Carlo Calabrese, Chiara Pratic├▓, Andrea Calafiore, Maurizio Coscia, Lorenzo Gentilini, Gilberto Poggioli, Paolo Gionchetti, Massimo Campieri, Fernando Rizzello, Dipartimento di Scienze Mediche e Chirurgiche DIMEC, University of Bologna, 40138 Bologna, Italy
    World J Gastroenterol 19:5671-7. 2013
    ..To evaluate if 3 mo oral supplementation with Eviendep® was able to reduce the number of duodenal polyps in familial adenomatous polyposis (FAP) patients with ileal pouch-anal anastomosis (IPAA)...
  31. doi request reprint Functional magnetic resonance imaging study reveals differences in the habituation to psychological stress in patients with Crohn's disease versus healthy controls
    Alessandro Agostini
    Department of Psychology, University of Bologna, Bologna, Italy
    J Behav Med 36:477-87. 2013
    ..The inadequate habituation to stress that we found in patients could play a role in the relationship between stress and inflammatory exacerbations in CD. ..
  32. pmc Cell proliferation of esophageal squamous epithelium in erosive and non-erosive reflux disease
    Carlo Calabrese
    Department of Clinical Medicine, University of Bologna, 40138 Bologna, Italy
    World J Gastroenterol 17:4496-502. 2011
    ..To elucidate cell proliferation in erosive reflux disease (ERD) and non-erosive reflux disease (NERD), we evaluated markers in squamous epithelial cells...
  33. doi request reprint Brain functional changes in patients with ulcerative colitis: a functional magnetic resonance imaging study on emotional processing
    Alessandro Agostini
    Department of Psychology, University of Bologna, Bologna, Italy
    Inflamm Bowel Dis 17:1769-77. 2011
    ..The aim of this study was to investigate the brain emotional processing in UC patients compared to healthy people...
  34. doi request reprint Parental bonding and inflammatory bowel disease
    Alessandro Agostini
    Dept of Psychology, Univ of Bologna, Bologna, Italy
    Psychosomatics 51:14-21. 2010
    ..Previous studies have shown a relationship between inflammatory bowel disease (IBD) and psychological stress. Adverse parenting is recognized as an important risk factor for the development of psychiatric disorders in adulthood...
  35. pmc Parvovirus b19 infection localized in the intestinal mucosa and associated with severe inflammatory bowel disease
    Loris Pironi
    Department of Internal Medicine and Gastroenterology, Center for Chronic Intestinal Failure, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
    J Clin Microbiol 47:1591-5. 2009
    ..Virus in the intestinal mucosa was detected in cells of the inflammatory infiltrate, identified as T lymphocytes and selectively localized in sites of active tissue degeneration...
  36. doi request reprint Rescue therapy: ciclosporin or infliximab?
    Fernando Rizzello
    Inflammatory Bowel Disease Unit, Dipartimento di Scienze Mediche e Chirurgiche DIMEC, Ospedale Sant Orsola Malpighi, University of Bologna, Via Massarenti 9, Bologna 40138, Italy
    Expert Rev Clin Immunol 9:503-5. 2013
    ..A head-to-head study proposed by Laharie et al. failed to demonstrate the superiority of ciclosporin but confirmed the efficacy and safety of infliximab to control active disease and to maintain remission...
  37. doi request reprint Drug delivery by polymeric micelles: an in vitro and in vivo study to deliver lipophilic substances to colonocytes and selectively target inflamed colon
    Maria Chiara Valerii
    Department of Clinical Medicine, University of Bologna, Bologna, Italy
    Nanomedicine 9:675-85. 2013
    ..These nanocarriers are also suitable for selective in vivo delivery of lipophilic drugs by enema administration to the inflamed colon tissue, specifically targeting the inflamed mucosa...
  38. ncbi request reprint Ultrasound assessment of vascularization of the thickened terminal ileum wall in Crohn's disease patients using a low-mechanical index real-time scanning technique with a second generation ultrasound contrast agent
    Carla Serra
    Department of Internal Medicine and Gastroenterology, S Orsola Malpighi Hospital, University of Bologna, Italy
    Eur J Radiol 62:114-21. 2007
    ....
  39. ncbi request reprint VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis
    Rodrigo Bibiloni
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
    Am J Gastroenterol 100:1539-46. 2005
    ..We evaluated the safety and efficacy of VSL#3 and the components, and the composition of the biopsy-associated microbiota in patients with active mild to moderate ulcerative colitis (UC)...
  40. ncbi request reprint Neuropeptide s receptor 1 gene polymorphism is associated with susceptibility to inflammatory bowel disease
    Mauro D'Amato
    Strategic Research Center IRIS, Karolinska Institutet, Stockholm, Sweden
    Gastroenterology 133:808-17. 2007
    ..We tested NPSR1 gene polymorphism for association with IBD and verified whether the expression of its 2 major isoforms (NPSR1-A and NPSR1-B) is altered in the intestine of IBD patients...
  41. ncbi request reprint Ileal pouchitis-related arthritis
    Ignazio Olivieri
    Semin Arthritis Rheum 32:204-5. 2002
  42. ncbi request reprint CXC and CC chemokine expression in inflamed and noninflamed pelvic ileal pouch tissue
    Ulf Helwig
    1st Department of Internal Medicine, University of Kiel, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Int J Colorectal Dis 19:165-70. 2004
    ..This study examined the tissue expression of a panel of specific chemokines and the corresponding recruitment of inflammatory cells in IPAA tissue with and without inflammation and after antibiotic treatment...
  43. ncbi request reprint Probiotic therapy to prevent pouchitis onset
    Paolo Gionchetti
    Dis Colon Rectum 48:1493; author reply 1493-4. 2005
  44. ncbi request reprint Variants of CARD15 are associated with an aggressive clinical course of Crohn's disease--an IG-IBD study
    Vito Annese
    Gastroenterology Unit, CSS IRCCS Hospital, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Italy
    Am J Gastroenterol 100:84-92. 2005
    ..Three major variants of the CARD15 gene confer susceptibility to Crohn's disease (CD). Whether or not these variants correlate with specific clinical features of the disease is under evaluation...
  45. ncbi request reprint Sympathetic hyperactivity in patients with ulcerative colitis
    Simona Maule
    Autonomic Unit, S Vito Hospital, University of Turin, Turin, Italy
    Clin Auton Res 17:217-20. 2007
    ..At rest, LF/HF ratios were significantly (P < 0.05) higher in chronic UC patients (2.4 +/- 1.6) compared to controls (1.2 +/- 1.0). Our results suggest a higher sympathetic tone at rest in patients with chronic UC...
  46. ncbi request reprint Lactobacilli, bifidobacteria and E. coli nissle induce pro- and anti-inflammatory cytokines in peripheral blood mononuclear cells
    Ulf Helwig
    University Hospital Schleswig Holstein, Campus Kiel, 1st Medical Department, 24105 Kiel, Germany
    World J Gastroenterol 12:5978-86. 2006
    ..To investigate whether the stimulation of peripheral blood mononuclear cells (PBMNC) with the cell debris and cell extraction of different probiotic strains is similar or species specific...
  47. ncbi request reprint Potential role for the common cystic fibrosis DeltaF508 mutation in Crohn's disease
    Francesca Bresso
    Strategic Research Center IRIS, Karolinska Institutet, Stockholm, Sweden
    Inflamm Bowel Dis 13:531-6. 2007
    ..Given the important biological functions of CFTR in the intestine, we tested whether this mutation is of relevance to IBD...