Research Topics
Species | Paolo GionchettiSummaryAffiliation: University of Bologna Country: Italy Publications
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Detail Information
Publications
Review article: treatment of mild to moderate ulcerative colitis and pouchitisP Gionchetti
Department of Internal Medicine, University of Bologna, Italy
Aliment Pharmacol Ther 16:13-9. 2002..Chronic refractory pouchitis may benefit from a prolonged course of a combination of antibiotics. Highly concentrated probiotics (VSL#3) are effective both for the prevention of pouchitis onset and the prevention of relapses...- Management of inflammatory bowel disease: does rifaximin offer any promise?Paolo Gionchetti
IBD Unit, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
Chemotherapy 51:96-102. 2005..Some preliminary data show its efficacy in severe active ulcerative colitis, pouchitis and prevention of postoperative recurrence in Crohn's disease... - Probiotics and barrier function in colitisP Gionchetti
Policlinic Sant Orsola, Department of Internal Medicine and Gastroenterology, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
Gut 54:898-900. 2005..Probiotic administration may exert a protective effect in colitis by preventing mucosal barrier disruption and influencing the extent of mucosal injury... - Antibiotics and probiotics in chronic pouchitis: a comparative proteomic approachSilvia Turroni
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
World J Gastroenterol 16:30-41. 2010..To profile protein expression in mucosal biopsies from patients with chronic refractory pouchitis following antibiotic or probiotic treatment, using a comparative proteomic approach... - Antibiotic combination therapy in patients with chronic, treatment-resistant pouchitisP Gionchetti
Dipartimento di Medicina Interna e Gastroenterologia, Italy
Aliment Pharmacol Ther 13:713-8. 1999..Pouchitis is the major long-term complication after ileal pouch-anal anastomosis for ulcerative colitis. About 15% of patients have a chronic, treatment-resistant disease... - Review article: problematic proctitis and distal colitisP Gionchetti
Department of Internal Medicine, University of Bologna, Italy
Aliment Pharmacol Ther 20:93-6. 2004..Surgical colectomy may be required in those rare patients refractory or intolerant to pharmacotherapy... - Management of pouch dysfunction or pouchitis with an ileoanal pouchPaolo Gionchetti
Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S Orsola, Via Massarenti 9, 40138 Bologna, Italy
Best Pract Res Clin Gastroenterol 18:993-1006. 2004..Highly concentrated probiotics (VSL#3) have been shown to be effective in preventing the onset and relapse of pouchitis... - Oral budesonide in the treatment of chronic refractory pouchitisP Gionchetti
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Aliment Pharmacol Ther 25:1231-6. 2007..Pouchitis is the major long-term complication after ileal-pouch nal anastomosis for ulcerative colitis. Ten to 15% of patients develop a chronic pouchitis, either treatment responsive or treatment refractory... - Review article: aminosalicylates for distal colitisP Gionchetti
Department of Internal Medicine, University of Bologna, Bologna, Italy
Aliment Pharmacol Ther 24:41-4. 2006..Patients who prefer not to continue on long-term rectal therapy can be treated with oral aminosalicylates... - VSL#3: an analysis of basic and clinical contributions in probiotic therapeuticsPaolo Gionchetti
Department of Internal Medicine and Gastroenterology, Policlinic Sant'Orsola, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
Gastroenterol Clin North Am 34:499-513, ix-x. 2005 - Antibiotics and probiotics in treatment of inflammatory bowel diseasePaolo Gionchetti
Department of Internal Medicine and Gastroenterology, Bologna, Italy
World J Gastroenterol 12:3306-13. 2006..Both antibiotics and probiotics appear to play a beneficial role in the treatment and prevention of pouchitis and further trials are warranted to fully quantify their clinical efficacy... - Standard treatment of ulcerative colitisPaolo Gionchetti
Department of Internal Medicine, University of Bologna, Bologna, Italy
Dig Dis 21:157-67. 2003..Close monitoring of these hematologic and biochemical parameters will improve safety. The use of biologic therapy with infliximab in more severe disease has not been established... - Antimicrobials in the management of inflammatory bowel diseasePaolo Gionchetti
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Digestion 73:77-85. 2006..Preliminary data suggest that rifaximin may be beneficial in the treatment of active ulcerative colitis (and pouchitis), mild to moderate CD as well as prevention of post-operative recurrence of CD... - Probiotics--role in inflammatory bowel diseaseP Gionchetti
IBD Unit, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
Dig Liver Dis 34:S58-62. 2002..The encouraging results obtained in ulcerative colitis and Crohn's disease need to be further assessed in large double-blind trials... - Probiotics in infective diarrhoea and inflammatory bowel diseasesP Gionchetti
Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
J Gastroenterol Hepatol 15:489-93. 2000..This review focuses on the available data concerning the mechanisms of action of probiotics, and on the results from clinical studies using probiotics to treat infective diarrhoea and inflammatory bowel disease... - Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trialPaolo Gionchetti
Department of Internal Medicine, University of Bologna, Italy
Gastroenterology 124:1202-9. 2003..The aim of this study was to compare probiotic therapy with VSL#3 versus placebo in the ability to prevent the onset of acute pouchitis during the first year after ileal pouch-anal anastomosis... - Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trialP Gionchetti
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Gastroenterology 119:305-9. 2000..thermophilus compared with placebo in maintenance of remission of chronic pouchitis... - Probiotics for the treatment of postoperative complications following intestinal surgeryPaolo Gionchetti
Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S Orsola, Via Massarenti no 9, 40138 Bologna, Italy
Best Pract Res Clin Gastroenterol 17:821-31. 2003..Further controlled studies are needed to establish the efficacy of probiotics in the prophylaxis of postoperative recurrences of Crohn's disease and in the treatment of mild pouchitis... - High-dose probiotics for the treatment of active pouchitisPaolo Gionchetti
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Dis Colon Rectum 50:2075-82; discussion 2082-4. 2007..This study was designed to evaluate the efficacy of high-dose VSL#3 in the treatment of mildly active pouchitis... - Adult attachment and early parental experiences in patients with Crohn's diseaseAlessandro Agostini
Department of Psychology, University of Bologna, Bologna, Italy
Psychosomatics 51:208-15. 2010..Crohn's disease (CD) is a chronic, relapsing and remitting inflammatory bowel disease. The relationship of attachment to the illness is considered to be bidirectional... - Clinical course of microscopic colitis in a single-center cohort studyCarlo Calabrese
Department of Clinical Medicine, University of Bologna, Italy
J Crohns Colitis 5:218-21. 2011..The aims of this study were to evaluate the clinical course of microscopic colitis (MC) and to describe the morbidity evolution of the disease... - Effects of probiotic bacteria on gastrointestinal motility in guinea-pig isolated tissueMatteo Massi
Department of Pharmaceutical Sciences, University of Bologna, Italy
World J Gastroenterol 12:5987-94. 2006.... - Topical treatment of distal active ulcerative colitis with beclomethasone dipropionate or mesalamine: a single-blind randomized controlled trialPaolo Gionchetti
Institute of Clinical Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Italy
J Clin Gastroenterol 39:291-7. 2005..CONCLUSIONS: BDP administered as a rectal enema over a 6-week treatment period was efficacious and safe in patients with active UC, without interference with pituitary adrenal axis... - Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cellsKaren Manon Lammers
Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinic S Orsola, Via Massarenti 9, 40138 Bologna, Italy
FEMS Immunol Med Microbiol 38:165-72. 2003..Total bacterial DNA from feces collected after probiotic administration modulated the immune response by a decrease of interleukin-1 beta and an increase of interleukin-10... - Diagnosis and treatment of pouchitisPaolo Gionchetti
University of Bologna, Department of Internal Medicine and Gastroenterology, Policlinico S Orsola, Via Massarenti no 9, 40138 Bologna, Italy
Best Pract Res Clin Gastroenterol 17:75-87. 2003..Highly concentrated probiotics are effective for both prevention of relapses and prevention of pouchitis onset. There is no convincing evidence of the efficacy of other therapeutic agents... - Cutaneous manifestations in inflammatory bowel diseases: eight cases of psoriasis induced by anti-tumor-necrosis-factor antibody therapyBeatrice Passarini
Department of Specialistic and Experimental Clinical Medicine, Division of Dermatology, University Hospital of Bologna, Bologna, Italy
Dermatology 215:295-300. 2007.... - Probiotic therapy in the prevention of pouchitis onset: decreased interleukin-1beta, interleukin-8, and interferon-gamma gene expressionKaren M Lammers
Policlinico S Orsola, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
Inflamm Bowel Dis 11:447-54. 2005..Pouchitis has been associated with elevated levels of proinflammatory cytokines and chemokines... - Role of conventional therapies in the era of biological treatment in Crohn's diseasePaolo Gionchetti
Department of Clinical Medicine, University of Bologna, 40138 Bologna, Italy
World J Gastroenterol 17:1797-806. 2011..However, the large majority of patients with CD will be managed through conventional therapy, even if they are a prelude to biological therapy... - Cell proliferation of esophageal squamous epithelium in erosive and non-erosive reflux diseaseCarlo Calabrese
Carlo Calabrese, Giuseppina Liguori, Paolo Gionchetti, Fernando Rizzello, Massimo Campieri, Department of Clinical Medicine, University of Bologna, 40138 Bologna, Italy
World J Gastroenterol 17:4496-502. 2011..To elucidate cell proliferation in erosive reflux disease (ERD) and non-erosive reflux disease (NERD), we evaluated markers in squamous epithelial cells... - Parental bonding and inflammatory bowel diseaseAlessandro Agostini
Dept of Psychology, Univ of Bologna, Bologna, Italy
Psychosomatics 51:14-21. 2010..Previous studies have shown a relationship between inflammatory bowel disease (IBD) and psychological stress. Adverse parenting is recognized as an important risk factor for the development of psychiatric disorders in adulthood... - Parvovirus b19 infection localized in the intestinal mucosa and associated with severe inflammatory bowel diseaseLoris Pironi
Department of Internal Medicine and Gastroenterology, Center for Chronic Intestinal Failure, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
J Clin Microbiol 47:1591-5. 2009..Virus in the intestinal mucosa was detected in cells of the inflammatory infiltrate, identified as T lymphocytes and selectively localized in sites of active tissue degeneration... - Brain functional changes in patients with ulcerative colitis: a functional magnetic resonance imaging study on emotional processingAlessandro Agostini
Department of Psychology, University of Bologna, Bologna, Italy
Inflamm Bowel Dis 17:1769-77. 2011..The aim of this study was to investigate the brain emotional processing in UC patients compared to healthy people... - Ultrasound assessment of vascularization of the thickened terminal ileum wall in Crohn's disease patients using a low-mechanical index real-time scanning technique with a second generation ultrasound contrast agentCarla Serra
Department of Internal Medicine and Gastroenterology, S Orsola Malpighi Hospital, University of Bologna, Italy
Eur J Radiol 62:114-21. 2007.... - CXC and CC chemokine expression in inflamed and noninflamed pelvic ileal pouch tissueUlf Helwig
1st Department of Internal Medicine, University of Kiel, Schittenhelmstrasse 12, 24105 Kiel, Germany
Int J Colorectal Dis 19:165-70. 2004..This study examined the tissue expression of a panel of specific chemokines and the corresponding recruitment of inflammatory cells in IPAA tissue with and without inflammation and after antibiotic treatment... - Ileal pouchitis-related arthritisIgnazio Olivieri
Semin Arthritis Rheum 32:204-5. 2002 - VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitisRodrigo Bibiloni
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
Am J Gastroenterol 100:1539-46. 2005..At least some of the bacterial species incorporated in the probiotic product reached the target site in amounts that could be detected... - Probiotic therapy to prevent pouchitis onsetPaolo Gionchetti
Dis Colon Rectum 48:1493; author reply 1493-4. 2005 - Neuropeptide s receptor 1 gene polymorphism is associated with susceptibility to inflammatory bowel diseaseMauro D'Amato
Strategic Research Center IRIS, Karolinska Institutet, Stockholm, Sweden
Gastroenterology 133:808-17. 2007..We tested NPSR1 gene polymorphism for association with IBD and verified whether the expression of its 2 major isoforms (NPSR1-A and NPSR1-B) is altered in the intestine of IBD patients... - Sympathetic hyperactivity in patients with ulcerative colitisSimona Maule
Autonomic Unit, S Vito Hospital, University of Turin, Turin, Italy
Clin Auton Res 17:217-20. 2007..At rest, LF/HF ratios were significantly (P < 0.05) higher in chronic UC patients (2.4 +/- 1.6) compared to controls (1.2 +/- 1.0). Our results suggest a higher sympathetic tone at rest in patients with chronic UC... - Variants of CARD15 are associated with an aggressive clinical course of Crohn's disease--an IG-IBD studyVito Annese
Gastroenterology Unit, CSS IRCCS Hospital, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Italy
Am J Gastroenterol 100:84-92. 2005..Three major variants of the CARD15 gene confer susceptibility to Crohn's disease (CD). Whether or not these variants correlate with specific clinical features of the disease is under evaluation... - Potential role for the common cystic fibrosis DeltaF508 mutation in Crohn's diseaseFrancesca Bresso
Strategic Research Center IRIS, Karolinska Institutet, Stockholm, Sweden
Inflamm Bowel Dis 13:531-6. 2007..Given the important biological functions of CFTR in the intestine, we tested whether this mutation is of relevance to IBD... - Lactobacilli, bifidobacteria and E. coli nissle induce pro- and anti-inflammatory cytokines in peripheral blood mononuclear cellsUlf Helwig
University Hospital Schleswig Holstein, Campus Kiel, 1st Medical Department, 24105 Kiel, Germany
World J Gastroenterol 12:5978-86. 2006..To investigate whether the stimulation of peripheral blood mononuclear cells (PBMNC) with the cell debris and cell extraction of different probiotic strains is similar or species specific...