Affiliation: University of Messina
Location: Messina, Italy
Piperno A, Chiacchio U, Iannazzo D, Giofrè S, Romeo G, Romeo R. First example of direct RuO4-catalyzed oxidation of isoxazolidines to 3-isoxazolidones. J Org Chem. 2007;72:3958-60 pubmed
..RuO2/NaIO4 oxidation of 3-unsubstituted isoxazolidines, under ethyl acetate/water biphasic conditions, affords 3-isoxazolidones in good yields. The methodology can be used on both racemic and optically active isoxazolidines. ..
Piperno A, Giofrè S, Iannazzo D, Romeo R, Romeo G, Chiacchio U, et al
. Synthesis of C-4'truncated phosphonated carbocyclic 2'-oxa-3'-azanucleosides as antiviral agents. J Org Chem. 2010;75:2798-805 pubmed publisher
..Preliminary biological assays show that beta-anomers of TPCOANs are able to inhibit the reverse transcriptase of different retroviruses at concentrations in the nanomolar range, with a potency comparable with that of tenofovir. ..
Balestrieri E, Pizzimenti F, Ferlazzo A, Giofrè S, Iannazzo D, Piperno A, et al
. Antiviral activity of seed extract from Citrus bergamia towards human retroviruses. Bioorg Med Chem. 2011;19:2084-9 pubmed publisher
..The cytotoxicity of the assayed compounds of natural origin was substantially less pronounced than that of the reference compounds, thus showing a favourable selectivity index for the novel BSext product. ..
Ettari R, Zappala M, Micale N, Grazioso G, Giofrè S, Schirmeister T, et al
. Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors. Eur J Med Chem. 2011;46:2058-65 pubmed publisher
..Our goal is to modify the P(3) site of this motif in order to identify the structural requirements for the interaction with the target. ..
Romeo R, Giofrè S, Macchi B, Balestrieri E, Mastino A, Merino P, et al
. Truncated reverse isoxazolidinyl nucleosides: a new class of allosteric HIV-1 reverse transcriptase inhibitors. ChemMedChem. 2012;7:565-9 pubmed publisher
Romeo R, Carnovale C, Giofrè S, Romeo G, Macchi B, Frezza C, et al
. Truncated phosphonated C-1'-branched N,O-nucleosides: a new class of antiviral agents. Bioorg Med Chem. 2012;20:3652-7 pubmed publisher
..Higher SI values with respect to AZT indicated that the compounds were endowed with low cytotoxicity. ..
Vadalà R, Mottese A, Bua G, Salvo A, Mallamace D, Corsaro C, et al
. Statistical Analysis of Mineral Concentration for the Geographic Identification of Garlic Samples from Sicily (Italy), Tunisia and Spain. Foods. 2016;5: pubmed publisher
..In particular, we found a relatively high content of Selenium in the garlic variety known as Nubia red garlic, and, indeed, it could be used as an anticarcinogenic agent. ..
Trombetta D, Smeriglio A, Marcoccia D, Giofrè S, Toscano G, Mazzotti F, et al
. Analytical Evaluation and Antioxidant Properties of Some Secondary Metabolites in Northern Italian Mono- and Multi-Varietal Extra Virgin Olive Oils (EVOOs) from Early and Late Harvested Olives. Int J Mol Sci. 2017;18: pubmed publisher