Giuseppe Giannini

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. pmc Human MRE11 is inactivated in mismatch repair-deficient cancers
    Giuseppe Giannini
    Department of Experimental Medicine and Pathology, University La Sapienza, 00161 Rome, Italy
    EMBO Rep 3:248-54. 2002
  2. ncbi request reprint Molecular mechanism of HMGA1 deregulation in human neuroblastoma
    Giuseppe Giannini
    Department of Experimental Medicine and Pathology, Department of Pediatrics, University La Sapienza, Policlinico Umberto 1, Viale Regina Elena, 324, 00161 Rome, Italy
    Cancer Lett 228:97-104. 2005
  3. pmc MUC gene abnormalities in sporadic and hereditary mucinous colon cancers with microsatellite instability
    Chiara Pastrello
    Department of Preclinical Research and Epidemiology, Centro Riferimento Oncologico, IRCCS, Aviano PN, Italy
    Dis Markers 21:121-6. 2005
  4. pmc Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
    Valentina Silvestri
    Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy
    Breast Cancer Res 18:15. 2016
  5. pmc Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers.
    Karoline B Kuchenbaecker
    Breast Cancer Res 16:3416. 2014
  6. doi request reprint Characterization of medulloblastoma in Fanconi Anemia: a novel mutation in the BRCA2 gene and SHH molecular subgroup.
    Evelina Miele
    Department of Molecular Medicine Sapienza University, Viale Regina Elena 291, 00161 Rome, Italy
    Biomark Res 3:13. 2015
  7. pmc Galectin-3 is a marker of favorable prognosis and a biologically relevant molecule in neuroblastic tumors
    V Veschi
    Department of Molecular Medicine, University La Sapienza, Rome, Italy
    Cell Death Dis 5:e1100. 2014
  8. pmc Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille's heel to be exploited for the therapy of MYCN-amplified neuroblastoma
    Marialaura Petroni
    Department of Molecular Medicine, University La Sapienza Rome, Italy
    Front Oncol 2:141. 2012
  9. ncbi request reprint Novel BRCA1 and BRCA2 germline mutations and assessment of mutation spectrum and prevalence in Italian breast and/or ovarian cancer families
    Giuseppe Giannini
    Department of Experimental Medicine and Pathology, University La Sapienza, Policlinico Umberto I Viale Regina Elena, 324, 00161 Rome, Italy
    Breast Cancer Res Treat 100:83-91. 2006
  10. ncbi request reprint High mobility group A1 is a molecular target for MYCN in human neuroblastoma
    Giuseppe Giannini
    Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
    Cancer Res 65:8308-16. 2005

Detail Information

Publications57

  1. pmc Human MRE11 is inactivated in mismatch repair-deficient cancers
    Giuseppe Giannini
    Department of Experimental Medicine and Pathology, University La Sapienza, 00161 Rome, Italy
    EMBO Rep 3:248-54. 2002
    ..Our findings identify MRE11 as a novel and major target for inactivation in mismatch repair-defective cells and suggest its impairment may contribute to the development of colorectal cancer...
  2. ncbi request reprint Molecular mechanism of HMGA1 deregulation in human neuroblastoma
    Giuseppe Giannini
    Department of Experimental Medicine and Pathology, Department of Pediatrics, University La Sapienza, Policlinico Umberto 1, Viale Regina Elena, 324, 00161 Rome, Italy
    Cancer Lett 228:97-104. 2005
    ..In this report, we overview part of the current information on HMGA1 and focus our attention on the analysis of its human promoter...
  3. pmc MUC gene abnormalities in sporadic and hereditary mucinous colon cancers with microsatellite instability
    Chiara Pastrello
    Department of Preclinical Research and Epidemiology, Centro Riferimento Oncologico, IRCCS, Aviano PN, Italy
    Dis Markers 21:121-6. 2005
    ....
  4. pmc Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
    Valentina Silvestri
    Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy
    Breast Cancer Res 18:15. 2016
    ..Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs)...
  5. pmc Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers.
    Karoline B Kuchenbaecker
    Breast Cancer Res 16:3416. 2014
    ..Estimates of the risks associated with these variants based on population-based studies are likely to be applicable to mutation carriers after taking ER status into account, which has implications for risk prediction...
  6. doi request reprint Characterization of medulloblastoma in Fanconi Anemia: a novel mutation in the BRCA2 gene and SHH molecular subgroup.
    Evelina Miele
    Department of Molecular Medicine Sapienza University, Viale Regina Elena 291, 00161 Rome, Italy
    Biomark Res 3:13. 2015
    ..Our report provides new findings that shed new light on the genetic and molecular pathogenesis of MB in FA patients with implications in the disease management...
  7. pmc Galectin-3 is a marker of favorable prognosis and a biologically relevant molecule in neuroblastic tumors
    V Veschi
    Department of Molecular Medicine, University La Sapienza, Rome, Italy
    Cell Death Dis 5:e1100. 2014
    ....
  8. pmc Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille's heel to be exploited for the therapy of MYCN-amplified neuroblastoma
    Marialaura Petroni
    Department of Molecular Medicine, University La Sapienza Rome, Italy
    Front Oncol 2:141. 2012
    ..Here we discuss implications and caveats of exploiting this pathway and its connections to MYCN-induced DDR for a tailored therapy of MYCN-amplified neuroblastoma...
  9. ncbi request reprint Novel BRCA1 and BRCA2 germline mutations and assessment of mutation spectrum and prevalence in Italian breast and/or ovarian cancer families
    Giuseppe Giannini
    Department of Experimental Medicine and Pathology, University La Sapienza, Policlinico Umberto I Viale Regina Elena, 324, 00161 Rome, Italy
    Breast Cancer Res Treat 100:83-91. 2006
    ..Finally in hereditary breast cancer families with three or more female breast cancer cases we observed a low mutation prevalence and a significant association with BRCA2 mutations...
  10. ncbi request reprint High mobility group A1 is a molecular target for MYCN in human neuroblastoma
    Giuseppe Giannini
    Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
    Cancer Res 65:8308-16. 2005
    ..Finally, HMGA1 repression by RNA interference reduced neuroblastoma cell proliferation, indicating that HMGA1 is a novel MYCN target gene relevant for neuroblastoma tumorigenesis...
  11. ncbi request reprint Prevalence of BRCA1 and BRCA2 genomic rearrangements in a cohort of consecutive Italian breast and/or ovarian cancer families
    Amelia Buffone
    Department of Experimental Medicine, University La Sapienza, Policlinico Umberto I, Viale Regina Elena, 324, Rome 00161, Italy
    Breast Cancer Res Treat 106:289-96. 2007
    ..In contrast, they suggest BRCA2 rearrangements might be very rare out of the high risk families including a male breast cancer...
  12. ncbi request reprint Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability
    Giuseppe Giannini
    Department of Experimental Medicine and Pathology, University La Sapienza, Policlinico Umberto I, Viale Regina Elena, 324, 00161 Rome, Italy
    Oncogene 23:2640-7. 2004
    ....
  13. doi request reprint BRCA1/BRCA2 mutation status and clinical-pathologic features of 108 male breast cancer cases from Tuscany: a population-based study in central Italy
    Laura Ottini
    Department of Experimental Medicine, University of Rome La Sapienza, 00161 Rome, Italy
    Breast Cancer Res Treat 116:577-86. 2009
    ..MBC appears to be biologically similar to breast cancer in females, however the phenotypic characteristics of BRCA1/2-related MBCs are not yet well elucidated...
  14. pmc Galectin-3 impairment of MYCN-dependent apoptosis-sensitive phenotype is antagonized by nutlin-3 in neuroblastoma cells
    Veronica Veschi
    Department of Experimental Medicine, Sapienza University, Rome, Italy
    PLoS ONE 7:e49139. 2012
    ....
  15. ncbi request reprint Improving the accuracy of BRCA1/2 mutation prediction: validation of the novel country-customized IC software
    Carlo Capalbo
    Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
    Eur J Hum Genet 14:49-54. 2006
    ..Whether the IC or other country-customized models might improve BRCA1/2 mutation prediction also in non-Italian families needs to be further explored...
  16. doi request reprint MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response
    Marialaura Petroni
    Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena, 324, 00161, Rome, Italy
    Mol Cancer Res 9:67-77. 2011
    ..Altogether, our data uncover a novel mechanism linking MYCN to apoptosis that can be triggered by the p53-reactivating compound Nutlin-3, supporting its use in the most difficult-to-treat subset of neuroblastoma...
  17. ncbi request reprint EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer
    Giuseppe Giannini
    Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
    Mol Carcinog 38:188-200. 2003
    ..Thus its overexpression might be regarded not only as a tumor marker but also as a potentially pathogenetic event...
  18. pmc Human papilloma virus-dependent HMGA1 expression is a relevant step in cervical carcinogenesis
    Massimiliano Mellone
    Department of Experimental Medicine, Sapienza University, Rome 00161, Italy
    Neoplasia 10:773-81. 2008
    ..Finally, we show that HMGA1 is necessary for the full expression of HPV18 E6 and E7 oncoproteins thus establishing a positive autoregulatory loop between HPV E6/E7 and HMGA1 expression...
  19. pmc An integrated approach identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastoma
    Enrico De Smaele
    Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
    Neoplasia 10:89-98. 2008
    ..Remarkably, the expression of these genes is also upregulated in mouse and human HH-dependent MBs, suggesting that they may be either a part of the HH-induced tumorigenic process or a specific trait of HH-dependent tumor cells...
  20. ncbi request reprint MRE11 expression is impaired in gastric cancer with microsatellite instability
    Laura Ottini
    Department of Experimental Medicine and Pathology, University La Sapienza, 00161 Rome, Italy
    Carcinogenesis 25:2337-43. 2004
    ..Overall, our results indicate that MSI-associated mutations occurring in non-coding repeats may affect protein expression in MSI-H GC...
  21. doi request reprint The HMGA1 protoncogene frequently deregulated in cancer is a transcriptional target of E2F1
    Isabella Massimi
    Department of Experimental Medicine, Sapienza University, Rome, Italy
    Mol Carcinog 52:526-34. 2013
    ....
  22. pmc The coactivator CRTC1 promotes cell proliferation and transformation via AP-1
    Gianluca Canettieri
    Department of Experimental Medicine and Pasteur Institute, Cenci Bolognetti Foundation, Sapienza University, Rome, Italy
    Proc Natl Acad Sci U S A 106:1445-50. 2009
    ..Together, these data illustrate a novel mechanism required to couple mitogenic signals to the AP-1 gene regulatory program...
  23. ncbi request reprint BRCA1/BRCA2 rearrangements and CHEK2 common mutations are infrequent in Italian male breast cancer cases
    Mario Falchetti
    Department of Experimental Medicine, University of Rome La Sapienza, Viale Regina Elena, 324, Rome, 00161, Italy
    Breast Cancer Res Treat 110:161-7. 2008
    ..Overall, our data suggest that screening of BRCA1/2 rearrangements is not advantageous in MBC cases not belonging to high-risk breast cancer families and that common CHEK2 mutations play an irrelevant role in MBC predisposition in Italy...
  24. doi request reprint Validation of the Ion Torrent PGM sequencing for the prospective routine molecular diagnostic of colorectal cancer
    Francesca Belardinilli
    Department of Molecular Medicine, University La Sapienza, V le R Elena, 291, 00161 Rome, Italy
    Clin Biochem 48:908-10. 2015
    ..To this aim, we evaluated the Ion Semiconductor sequencing using the Ion Torrent Personal Genome Machine (IT-PGM) in our routine molecular diagnostics for CRC in comparison with the gold standard direct Sanger sequencing...
  25. doi request reprint NF-kappaB, and not MYCN, regulates MHC class I and endoplasmic reticulum aminopeptidases in human neuroblastoma cells
    Matteo Forloni
    Research Center, Ospedale Bambino Gesu, Rome, Italy
    Cancer Res 70:916-24. 2010
    ..Thus, the coordinated downregulation of MHC class I, ERAP1, and ERAP2 in aggressive NB cells is attributable to a low transcriptional availability of NF-kappaB, possibly due to an unknown suppressor other than MYCN...
  26. ncbi request reprint retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines
    Fabio Cerignoli
    Department of Experimental Medicine, University of L Aquila, Italy
    Cancer Res 62:1196-204. 2002
    ....
  27. ncbi request reprint New mutations and protein variants of NBS1 are identified in cancer cell lines
    Alessandra Tessitore
    Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    Genes Chromosomes Cancer 36:198-204. 2003
    ..In addition, two shorter NBS1 protein variants were detected in two cell lines. These data suggest a possible involvement of NBS1 in tumor development...
  28. doi request reprint Clinical and pathologic characteristics of BRCA-positive and BRCA-negative male breast cancer patients: results from a collaborative multicenter study in Italy
    Laura Ottini
    Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy
    Breast Cancer Res Treat 134:411-8. 2012
    ..The identification of a BRCA2-associated phenotype might define a subset of MBC patients eligible for personalized clinical management...
  29. ncbi request reprint BRCA1 and BRCA2: the genetic testing and the current management options for mutation carriers
    Marzia Palma
    Department of Experimental Medicine and Pathology, University La Sapienza, Policlinico Umberto I, Viale Regina Elena 324, 00161 Rome, Italy
    Crit Rev Oncol Hematol 57:1-23. 2006
    ..The most currently employed methods for genetic testing are critically overviewed, together with some indications for the interpretation of the test outcome and the clinical management of mutation carriers...
  30. doi request reprint Whole-exome sequencing and targeted gene sequencing provide insights into the role of PALB2 as a male breast cancer susceptibility gene
    Valentina Silvestri
    Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
    Cancer 123:210-218. 2017
    ..To further explain the genetic susceptibility for MBC, whole-exome sequencing (WES) and targeted gene sequencing were applied to high-risk, BRCA1/2 mutation-negative MBC cases...
  31. doi request reprint Novel and recurrent BRCA2 mutations in Italian breast/ovarian cancer families widen the ovarian cancer cluster region boundaries to exons 13 and 14
    Anna Coppa
    Department of Experimental Medicine, University La Sapienza, V le R Elena 324, 00161, Rome, Italy
    Breast Cancer Res Treat 148:629-35. 2014
    ..91; p = 0.004), but also with the exon 13-14 region (OR = 7.37; p = 0.001) in our BRCA2-mutated families. Our data provide initial evidence for a novel putative OCCR in BRCA2 exons 13-14. ..
  32. doi request reprint Novel and known genetic variants for male breast cancer risk at 8q24.21, 9p21.3, 11q13.3 and 14q24.1: results from a multicenter study in Italy
    Valentina Silvestri
    Department of Molecular Medicine, Sapienza University of Rome, Italy
    Eur J Cancer 51:2289-95. 2015
    ..Furthermore, we showed that the SNPs rs1562430/8q24.21 and rs1314913/14q24.1 strongly influence BC risk in men and suggested that the SNP rs1314913/14q24.1 may act as a risk modifier locus in male BRCA1/2 mutation carriers...
  33. ncbi request reprint Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome
    Ida Casorelli
    Istituto Superiore di Sanita, Laboratorio di Tossicologia Comparata, Rome, Italy
    DNA Repair (Amst) 2:547-59. 2003
    ..In view of the established relationship between drug resistance and mismatch repair defects, we suggest that selection for therapeutic drug resistance may contribute to the incidence of MSI(+) tAL/MDS...
  34. ncbi request reprint Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination
    Lucia Di Marcotullio
    Department of Experimental Medicine and Pathology, University La Sapienza, Roma, 324 Viale Regina Elena, 00161 Roma, Italy
    Nat Cell Biol 8:1415-23. 2006
    ..This novel Numb-dependent regulatory loop may limit the extent and duration of Hedgehog signalling during neural-progenitor differentiation, and its subversion may be a relevant event in brain tumorigenesis...
  35. pmc Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer
    Andrea Prodosmo
    Unit of Cellular Networks and Molecular Therapeutic Targets, Department of Research, Advanced Diagnostic, and Technological Innovation, Regina Elena National Cancer Institute IRCCS, Via Elio Chianesi 53, 00144, Rome, Italy
    J Exp Clin Cancer Res 35:135. 2016
    ....
  36. pmc A MYCN-MRN complex axis controls replication stress for the safe expansion of neuroprogenitor cells
    Marialaura Petroni
    Dept Molecular Medicine, University La Sapienza, Rome
    Mol Cell Oncol 3:e1079673. 2016
    ..We have recently uncovered that MYCN-dependent expansion of neuroprogenitor cells is accompanied by replication stress, which is restrained by the MRN complex, a direct transcriptional target of the MYCN proto-oncogene. ..
  37. pmc Synthesis of ST7612AA1, a Novel Oral HDAC Inhibitor, via Radical 
Thioacetic Acid Addition
    Gianfranco Battistuzzi
    R and D Sigma Tau IFR S p A, Via Pontina Km 30, 400, I 00071 Pomezia, Rome, Italy
    Curr Bioact Compd 12:282-288. 2016
    ..Preliminary results of a synthetic optimization attempt towards a fast scale-up process are here proposed...
  38. pmc HE4 in the differential diagnosis of a pelvic mass: a case report
    Emanuela Anastasi
    Department of Molecular Medicine, Sapienza University, Rome 00161, Italy E Mails S C L F C M
    Int J Mol Sci 12:627-32. 2011
    ....
  39. doi request reprint PRDX1 and PRDX6 are repressed in papillary thyroid carcinomas via BRAF V600E-dependent and -independent mechanisms
    Arianna Nicolussi
    Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
    Int J Oncol 44:548-56. 2014
    ....
  40. doi request reprint E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation
    Giuseppe Giannini
    Sigma Tau Research and Development, Via Pontina Km 30 400, I 00040 Pomezia, Rome, Italy
    Bioorg Med Chem Lett 18:2910-5. 2008
    ..A selected compound of this series exhibited an excellent antitumor activity against human gastrointestinal tumor xenografts...
  41. doi request reprint Clinical classification of BRCA1 DNA missense variants: H1686Q is a novel pathogenic mutation occurring in the ontogenetically invariant THV motif of the N-terminal BRCT domain
    Giuseppe Giannini
    J Clin Oncol 26:4212-4; author reply 4214-5. 2008
  42. ncbi request reprint A novel atypical retinoid endowed with proapoptotic and antitumor activity
    Raffaella Cincinelli
    Dipartimento di Scienze Molecolari Agroalimentari, Universita di Milano, Milano, Italy
    J Med Chem 46:909-12. 2003
    ....
  43. ncbi request reprint Does the search for large genomic rearrangements impact BRCAPRO carrier prediction?
    Carlo Capalbo
    J Clin Oncol 25:2632-4; author reply 2634-5. 2007
  44. ncbi request reprint Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence
    Stephen Hanessian
    Department of Chemistry, Universite de Montreal, Station Centre Ville, Montreal, Quebec, Canada
    Bioorg Med Chem Lett 17:6261-5. 2007
    ..However, no significant difference in antiproliferative activity was observed between two enantiomers bearing the benzyl ether moiety...
  45. ncbi request reprint Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids
    Raffaella Cincinelli
    Dipartimento di Scienze Molecolari Agroalimentari, Universita di Milano, Via Celoria 2, 20133 Milano, Italy
    Bioorg Med Chem 15:4863-75. 2007
    ....
  46. doi request reprint Synthesis and DNA-cleaving activity of lactenediynes conjugated with DNA-complexing moieties
    Luca Banfi
    Dipartimento di Chimica e Chimica Industriale, Via Dodecaneso 31, I 16146 Genova, Italy
    Bioorg Med Chem 16:3501-18. 2008
    ..As potency and capacity to induce double cut, they rank among the best simple enediyne analogues ever prepared. A thorough investigation was carried out in order to develop the best suited linkers for assembling these conjugates...
  47. ncbi request reprint A lymphotactin-producing monoclonal T-cell lymphoproliferative disorder with extreme lymphocytopenia and progressive leukoencephalopathy
    Marcella Visentini
    Leuk Lymphoma 47:1421-3. 2006
  48. ncbi request reprint Synthesis and cytotoxic activity of polyamine analogues of camptothecin
    Sabrina Dallavalle
    Dipartimento di Scienze Molecolari Agroalimentari, Universita di Milano, Via Celoria 2, 20133 Milano, Italy
    J Med Chem 49:5177-86. 2006
    ....
  49. ncbi request reprint Novel combretastatin analogues endowed with antitumor activity
    Daniele Simoni
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    J Med Chem 49:3143-52. 2006
    ..Interestingly, both the pharmacokinetic profile of 29 and its in vivo antitumor effect and those of 30, active even after oral administration, suggest additional pharmacological differences between these compounds and CA-4P...
  50. doi request reprint Synthesis and biological activity of fluorinated combretastatin analogues
    Domenico Alloatti
    R and D, Sigma Tau Industrie Farmaceutiche Riunite S p A, Via Pontina Km 30 400, 00040 Pomezia, Italy
    J Med Chem 51:2708-21. 2008
    ..The position of a fluorine atom on the double bond may affect the inhibition of tubulin polymerization and cytotoxic activity of these compounds...
  51. ncbi request reprint Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist
    Laura Belvisi
    Organic and Industrial Chemistry Department, Centre for Biomolecular Interdisciplinary Studies and Industrial Applications, University of Milan, Italy
    Mol Cancer Ther 4:1670-80. 2005
    ..Taken together, these observations indicate that ST1646 represents a dual alpha(v)beta3/alpha(v)beta5 integrin antagonist with interesting biochemical and biological features to be tested in cancer therapy...
  52. ncbi request reprint Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity
    Raffaella Cincinelli
    Dipartimento di Scienze Molecolari Agroalimentari, Universita di Milano, Via Celoria 2, 20133 Milano, Italy
    J Med Chem 48:4931-46. 2005
    ..Among the compounds investigated, E-3-(3'-adamantan-1-yl-4'-hydroxybiphenyl-4-yl)acrylic acid (2) was chosen for further investigation...
  53. ncbi request reprint Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells
    Daniele Simoni
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    J Med Chem 48:4293-9. 2005
    ..Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases...
  54. ncbi request reprint Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines
    Daniele Simoni
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    J Med Chem 48:723-36. 2005
    ..The data suggest unambiguously that structural alteration of the stilbene motif of CA-4 can be extremely effective in producing potent apoptosis-inducing agents...
  55. ncbi request reprint Undersulfated and glycol-split heparins endowed with antiangiogenic activity
    Benito Casu
    G Ronzoni Institute for Chemical and Biochemical Research, 20133 Milan, Italy
    J Med Chem 47:838-48. 2004
    ....
  56. ncbi request reprint Cdc25A-inhibitory properties and antineoplastic activity of bisperoxovanadium analogues
    P James Scrivens
    Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, Montreal, Quebec, Canada
    Mol Cancer Ther 2:1053-9. 2003
    ....
  57. doi request reprint Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity
    Daniele Simoni
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Ferrara, Italy
    J Med Chem 51:6211-5. 2008
    ..Heterocombretastatins 9a,b inhibit tubulin polymerization similarly to CA-4 by having a binding to colchicine site five times stronger...