E G Giannini

Summary

Affiliation: University of Genoa
Country: Italy

Publications

  1. ncbi Influence of 1-week Helicobacter pylori eradication therapy with rabeprazole, clarithromycin, and metronidazole on 13C-aminopyrine breath test
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Dig Dis Sci 50:1207-13. 2005
  2. pmc Use of the platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices in patients with schistosomiasis
    Adnan Agha
    Department of Medicine, King Fahad Hospital, Armed Forces Hospitals Southern Region, Khamis Mushyt, Saudi Arabia
    Saudi J Gastroenterol 17:307-11. 2011
  3. doi Peg-interfon alpha-2a and low-dose ribavirin for treatment of hepatitis C virus infection in patients with sickle-cell anemia in Saudi Arabia
    Adnan Agha
    Prof Edoardo Giovanni Giannini, Department of Internal Medicine, Gastroenterology Unit, Viale Benedetto XV, No 6, Genova 16146, Italy, T 390103537950, F 390103538638
    Ann Saudi Med 33:610-3. 2013
  4. doi Relationship between 13C-aminopyrine breath test and the MELD score and its long-term prognostic use in patients with cirrhosis
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy
    Dig Dis Sci 58:3024-8. 2013
  5. doi Feasibility of the cut-and-push method for removing large-caliber soft percutaneous endoscopic gastrostomy devices
    Adnan Agha
    Department of Internal Medicine, King Fahad Hospital, Armed Forces Hospitals Southern Region, Khamis Mushyt, Kingdom of Saudi Arabia
    Nutr Clin Pract 28:490-2. 2013
  6. doi Eltrombopag in patients with chronic liver disease
    Edoardo G Giannini
    University of Genoa, Department of Internal Medicine, Gastroenterology Unit, Viale Benedetto XV, No 6, 16132, Genoa, Italy
    Expert Opin Pharmacother 14:669-78. 2013
  7. doi Hepatocellular carcinoma in patients without cirrhosis in Italy
    Edoardo G Giannini
    Department of Internal Medicine, Gastroenterology Unit, University of Genoa, Genoa, Italy
    Dig Liver Dis 45:164-9. 2013
  8. doi Alpha-fetoprotein has no prognostic role in small hepatocellular carcinoma identified during surveillance in compensated cirrhosis
    Edoardo G Giannini
    Dipartimento di Medicina Interna, Unita di Gastroenterologia, Universita di Genova, Italy
    Hepatology 56:1371-9. 2012
  9. doi Peripheral blood cytopaenia limiting initiation of treatment in chronic hepatitis C patients otherwise eligible for antiviral therapy
    Edoardo G Giannini
    Department of Internal Medicine, Gastroenterology Unit, University of Genoa, Genoa, Italy
    Liver Int 32:1113-9. 2012
  10. pmc Early and very early hepatocellular carcinoma: when and how much do staging and choice of treatment really matter? A multi-center study
    Fabio Farinati
    Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Universita degli Studi di Padova, Padova, Italia
    BMC Cancer 9:33. 2009

Collaborators

Detail Information

Publications43

  1. ncbi Influence of 1-week Helicobacter pylori eradication therapy with rabeprazole, clarithromycin, and metronidazole on 13C-aminopyrine breath test
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Dig Dis Sci 50:1207-13. 2005
    ..In everyday clinical practice rabeprazole-based H. pylori eradication therapy does not seem to display any significant interactions with CYP-dependent liver function, even in patients on multiple drugs...
  2. pmc Use of the platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices in patients with schistosomiasis
    Adnan Agha
    Department of Medicine, King Fahad Hospital, Armed Forces Hospitals Southern Region, Khamis Mushyt, Saudi Arabia
    Saudi J Gastroenterol 17:307-11. 2011
    ..In this study we aimed to evaluate the platelet count/spleen diameter ratio as a noninvasive tool for the prediction of the presence of esophageal varices in patients with schistosoma-related chronic liver disease...
  3. doi Peg-interfon alpha-2a and low-dose ribavirin for treatment of hepatitis C virus infection in patients with sickle-cell anemia in Saudi Arabia
    Adnan Agha
    Prof Edoardo Giovanni Giannini, Department of Internal Medicine, Gastroenterology Unit, Viale Benedetto XV, No 6, Genova 16146, Italy, T 390103537950, F 390103538638
    Ann Saudi Med 33:610-3. 2013
    ..In this study, our aim was to evaluate the safety and efficacy of antiviral therapy with PEG-IFN and low-dose RBV in patients with SCD and chronic HCV infection receiving hydroxyurea in Saudi Arabia...
  4. doi Relationship between 13C-aminopyrine breath test and the MELD score and its long-term prognostic use in patients with cirrhosis
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy
    Dig Dis Sci 58:3024-8. 2013
    ..13)C-Aminopyrine breath test ((13)C-ABT) is a non-invasive, dynamic, quantitative liver function test, and the model for end-stage liver disease (MELD) is a recognised biochemical score used to predict survival in patients with cirrhosis...
  5. doi Feasibility of the cut-and-push method for removing large-caliber soft percutaneous endoscopic gastrostomy devices
    Adnan Agha
    Department of Internal Medicine, King Fahad Hospital, Armed Forces Hospitals Southern Region, Khamis Mushyt, Kingdom of Saudi Arabia
    Nutr Clin Pract 28:490-2. 2013
    ..The feeding catheters are designed to be removed by external traction or by endoscopy...
  6. doi Eltrombopag in patients with chronic liver disease
    Edoardo G Giannini
    University of Genoa, Department of Internal Medicine, Gastroenterology Unit, Viale Benedetto XV, No 6, 16132, Genoa, Italy
    Expert Opin Pharmacother 14:669-78. 2013
    ..Eltrombopag is a thrombopoietic drug that acts upon binding thrombopoietin receptor and stimulates megakaryocytopoiesis and platelet production...
  7. doi Hepatocellular carcinoma in patients without cirrhosis in Italy
    Edoardo G Giannini
    Department of Internal Medicine, Gastroenterology Unit, University of Genoa, Genoa, Italy
    Dig Liver Dis 45:164-9. 2013
    ..In the Western world, hepatocellular carcinoma seldom develops in patients without cirrhosis, and reports describing the characteristics of non-cirrhotic patients with hepatocellular carcinoma are rather infrequent...
  8. doi Alpha-fetoprotein has no prognostic role in small hepatocellular carcinoma identified during surveillance in compensated cirrhosis
    Edoardo G Giannini
    Dipartimento di Medicina Interna, Unita di Gastroenterologia, Universita di Genova, Italy
    Hepatology 56:1371-9. 2012
    ..465-0.606) to discriminate between survivors and deceased patients. Conclusion: Alpha-fetoprotein serum levels have no prognostic meaning in well-compensated cirrhosis patients with single, small HCC treated with curative intent...
  9. doi Peripheral blood cytopaenia limiting initiation of treatment in chronic hepatitis C patients otherwise eligible for antiviral therapy
    Edoardo G Giannini
    Department of Internal Medicine, Gastroenterology Unit, University of Genoa, Genoa, Italy
    Liver Int 32:1113-9. 2012
    ..In patients with chronic hepatitis C virus (HCV) infection, the presence of peripheral blood cytopaenia may represent an obstacle to pegylated interferon and ribavirin treatment...
  10. pmc Early and very early hepatocellular carcinoma: when and how much do staging and choice of treatment really matter? A multi-center study
    Fabio Farinati
    Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Universita degli Studi di Padova, Padova, Italia
    BMC Cancer 9:33. 2009
    ..We investigated how many patients are diagnosed in "very early" and "early" stage, follow the AASLD guidelines for treatment and whether their survival depends on treatment...
  11. doi Successful antiviral therapy determines a significant decrease in squamous cell carcinoma antigen-associated (SCCA) variants' serum levels in anti-HCV positive cirrhotic patients
    E G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genova, Genova, Italy
    J Viral Hepat 17:563-8. 2010
    ..Because of the pathophysiological correlation between SCCA and liver carcinogenesis, it is hypothesized that in patients with liver cirrhosis, SVR may be accompanied by a decreased proliferative stimulation...
  12. doi Predictive factors for response to peginterferon-alpha and ribavirin treatment of chronic HCV infection in patients aged 65 years and more
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Viale Benedetto XV no 6, Genoa, Italy
    Dig Dis Sci 55:3193-9. 2010
    ..Elderly patients with chronic hepatitis C virus (HCV) infection represent an understudied population, and little is known regarding the predictive factors for sustained virological response (SVR) to antiviral therapy in these patients...
  13. doi Hepatocellular carcinoma in patients with cryptogenic cirrhosis
    Edoardo Giovanni Giannini
    Cattedra di Gastroenterologia, Dipartimento di Medicina Interna, Universita di Genova, Genova, Italy
    Clin Gastroenterol Hepatol 7:580-5. 2009
    ..We aimed to characterize the clinical features of patients diagnosed with HCC after CC during a 15-year period (1992-2006)...
  14. doi Thrombocytopenia in liver disease
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genova, Italy
    Curr Opin Hematol 15:473-80. 2008
    ..To evaluate recent findings in the multifaceted pathophysiological mechanisms underlying thrombocytopenia in patients with chronic liver disease and to assess its therapeutic management...
  15. doi Sustained virological response to pegylated interferon and ribavirin is maintained during long-term follow-up of chronic hepatitis C patients
    E G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Aliment Pharmacol Ther 31:502-8. 2010
    ..There are few data in the literature regarding the long-term virological follow-up of chronic hepatitis C patients who obtain sustained virological response (SVR) to pegylated interferon (PEG-IFN) and ribavirin therapy...
  16. doi Incidence of bleeding following invasive procedures in patients with thrombocytopenia and advanced liver disease
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Clin Gastroenterol Hepatol 8:899-902; quiz e109. 2010
    ....
  17. ncbi Can Helicobacter pylori eradication regimens be shortened in clinical practice? An open-label, randomized, pilot study of 4 and 7-day triple therapy with rabeprazole, high-dose levofloxacin, and tinidazole
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Clin Gastroenterol 40:515-20. 2006
    ..pylori eradication regimens have shown good efficacy and very few side effects. Shorter treatment and absence of significant side effects should improve compliance to therapy and increase the Hp H. pylori eradication rate...
  18. doi Impact of evidence-based medicine on the treatment of patients with unresectable hepatocellular carcinoma
    E G Giannini
    Cattedra di Gastroenterologia, Dipartimento di Medicina Interna, Universita di Genova, Genova, Italy
    Aliment Pharmacol Ther 31:493-501. 2010
    ....
  19. ncbi Prevalence and prognostic significance of the presence of esophageal varices in patients with hepatocellular carcinoma
    Edoardo Giovanni Giannini
    Cattedra di Gastroenterologia, Dipartimento di Medicina Interna, Universita di Genova, Genova, Italia
    Clin Gastroenterol Hepatol 4:1378-84. 2006
    ..In this study our aim was to evaluate the prevalence and prognostic relevance of the presence of esophageal varices in a large series of patients with HCC...
  20. pmc Liver enzyme alteration: a guide for clinicians
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    CMAJ 172:367-79. 2005
    ....
  21. doi Relative decrease in the role played by hepatitis B virus infection in the aetiology of hepatocellular carcinoma during a 20-year period: a multicentre Italian study
    Edoardo G Giannini
    Dipartimento di Medicina Interna, University of Genoa, Genoa, Italy
    Liver Int 31:192-6. 2011
    ..Chronic hepatitis B virus (HBV) infection is one of the most frequent aetiological factors associated with the development of hepatocellular carcinoma (HCC)...
  22. ncbi Application of the platelet count/spleen diameter ratio to rule out the presence of oesophageal varices in patients with cirrhosis: a validation study based on follow-up
    E G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Viale Benedetto XV, No 6, 16132 Genoa, Italy
    Dig Liver Dis 37:779-85. 2005
    ..We have previously shown that the platelet count/spleen diameter ratio is a parameter that can rule out the presence of oesophageal varices safely and in a cost-effective fashion...
  23. ncbi 5-ASA and colorectal cancer chemoprevention in inflammatory bowel disease: can we afford to wait for 'best evidence'?
    E G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Viale Benedetto XV, No 6, Genoa 16132, Italy
    Dig Liver Dis 37:723-31. 2005
    ....
  24. ncbi Longitudinal modifications of the MELD score have prognostic meaning in patients with liver cirrhosis
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Viale Benedetto XV no 6, 16132 Genoa, Italy
    J Clin Gastroenterol 39:912-4. 2005
    ..It has been suggested that the longitudinal evaluation of the MELD score may reflect the progression of liver failure more reliably and therefore be more useful in prognostic assessment...
  25. ncbi A study of 4- and 7-day triple therapy with rabeprazole, high-dose levofloxacin and tinidazole rescue treatment for Helicobacter pylori eradication
    E G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Aliment Pharmacol Ther 23:281-7. 2006
    ..Helicobacter pylori treatment failure is becoming an emergent problem in clinical practice. Shorter treatment duration should improve compliance to therapy and keep an acceptable H. pylori eradication rate...
  26. ncbi Role of partially hydrolyzed guar gum in the treatment of irritable bowel syndrome
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Nutrition 22:334-42. 2006
    ..Moreover, PHGG seems to have prebiotic properties because it increases the colonic contents of short-chain fatty acids, Lactobacilli, and Bifidobacteria...
  27. ncbi Review article: thrombocytopenia in chronic liver disease and pharmacologic treatment options
    E G Giannini
    Department of Internal Medicine, Gastroenterology Unit, University of Genoa, Genoa, Italy
    Aliment Pharmacol Ther 23:1055-65. 2006
    ..Human studies with thrombopoietin-mimetic agents are eagerly awaited in order to assess both effectiveness and safety of these drugs...
  28. ncbi A simple approach to noninvasively identifying significant fibrosis in chronic hepatitis C patients in clinical practice
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Clin Gastroenterol 40:521-7. 2006
    ..Identification of the presence of significant fibrosis is an important part of the diagnostic work-up of patients with chronic hepatitis C (CHC)...
  29. ncbi Monitoring cytochrome P-450 activity during rabeprazole treatment in patients with gastresophageal reflux disease
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Viale Benedetto XV, No 6, 16132 Genoa, Italy
    Dig Dis Sci 51:1602-6. 2006
    ..In patients with GORD, 1-week, full-dose rabeprazole does not display any significant interactions with CYP-450 activity...
  30. doi Epidemiology of thrombocytopenia in patients with chronic hepatitis C: more than meets the eye
    E G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Viral Hepat 18:8-10. 2011
    ..Lastly, this study shows that up to 25% of patients treated with interferon may develop some degree of thrombocytopenia, and this may be associated with decreased sustained virological response rates...
  31. doi Predictive value of on-treatment response during full-dose antiviral therapy of patients with hepatitis C virus cirrhosis and portal hypertension
    E G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Intern Med 266:537-46. 2009
    ..In this study, we evaluated the efficacy and tolerability of full-dose antiviral therapy in patients with compensated, fully developed cirrhosis, and assessed the predictive value of on-treatment virological response...
  32. doi Elevations in alanine aminotransferase levels late in the course of antiviral therapy in hepatitis C virus RNA-negative patients are associated with virological relapse
    Monica Basso
    Centro per le Diagnosi e Terapia delle Epatiti, Dipartimento di Medicina Interna, Universita di Genova, Genoa, Italy
    Hepatology 49:1442-8. 2009
    ..Although ALT elevation per se is not associated with a greater risk of relapse, its occurrence in the later phases of therapy is more common in relapsing patients...
  33. ncbi 13C-breath tests and liver fibrosis
    E G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Eur Rev Med Pharmacol Sci 8:51-4. 2004
    ..Further studies are needed to evaluate the diagnostic yield of the 13C-BT in particular clinical situations, such as in patients with normal static parameters of liver function, or after therapy...
  34. doi Clinical trial: the combination of rifaximin with partially hydrolysed guar gum is more effective than rifaximin alone in eradicating small intestinal bacterial overgrowth
    M Furnari
    Department of Internal Medicine, University of Genoa, Italy
    Aliment Pharmacol Ther 32:1000-6. 2010
    ..It is known that partially hydrolysed guar gum affects intestinal motility. Eradication therapy of SIBO is based on antibiotic treatment: no data are available on the role of fibre supplementation in eradicating SIBO...
  35. ncbi 13C-galactose breath test and 13C-aminopyrine breath test for the study of liver function in chronic liver disease
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Clin Gastroenterol Hepatol 3:279-85. 2005
    ....
  36. doi Management strategy for patients with gastroesophageal reflux disease: a comparison between empirical treatment with esomeprazole and endoscopy-oriented treatment
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Am J Gastroenterol 103:267-75. 2008
    ....
  37. ncbi Platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices: results of a multicenter, prospective, validation study
    Edoardo G Giannini
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Am J Gastroenterol 101:2511-9. 2006
    ..In this multicenter, international study, our aim was to prospectively validate the use of the platelet count/spleen diameter ratio for the noninvasive diagnosis of EV...
  38. doi A significant proportion of patients with chronic hepatitis B who are candidates for antiviral treatment are untreated: A region-wide survey in Italy
    Edoardo G Giannini
    Cattedra di Gastroenterologia, Dipartimento di Medicina Interna, Universita di Genova, Italy
    J Clin Gastroenterol 43:1001-7. 2009
    ..In clinical practice, however, it is not known how many patients chronically infected by HBV and eligible for antiviral therapy are not treated...
  39. ncbi Efficacy of 48-hour post-operative antibiotics prophylaxis for patients undergoing percutaneous endoscopic gastrostomy tube in preventing site infection
    Adnan Agha
    Department of Medicine, King Fahad Hospital, Armed Forces Hospitals Southern Region, Khamis Mushit, Kingdom of Saudi Arabia
    J Gastrointestin Liver Dis 20:131-4. 2011
    ..Malnutrition can increase the risk of wound infection, whose incidence can be decreased by using antibiotic prophylaxis...
  40. ncbi Initial high dose of lamivudine delays the appearance of viral resistance in chronic hepatitis B patients
    Francesco Torre
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Gastrointestin Liver Dis 20:47-50. 2011
    ..Moreover, lamivudine therapy is hampered by the early and high rate of drug-resistance...
  41. ncbi A comparison between sodium alginate and magaldrate anhydrous in the treatment of patients with gastroesophageal reflux symptoms
    Edoardo G Giannini
    Cattedra di Gastroenterologia, Dipartimento di Medicina Interna, Universita degli Studi di Genova, Viale Benedetto XV, No 6, 16132, Genoa, Italy
    Dig Dis Sci 51:1904-9. 2006
    ..We conclude that sodium alginate was faster than magaldrate in relieving GRO symptoms and showed a tendency toward a more prolonged duration of action and a higher level of efficacy...
  42. doi Clinical and virological survey of patients with hepatitis B surface antigen in an Italian region: clinical considerations and disease burden
    Francesco Torre
    Dipartimento di Medicina Interna, Universita di Genova, Genova 16132, Italy
    J Med Virol 81:1882-6. 2009
    ..HBV infection is still an underestimated health problem, and few potential infectious or treatable patients are referred to tertiary centers...
  43. ncbi Predictors of pathological severity in non-alcoholic fatty liver disease: is East meeting West in the middle?
    Edoardo G Giannini
    J Gastroenterol Hepatol 22:461-3. 2007