Gianluigi Giannelli

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. pmc Complete response for advanced liver cancer during sorafenib therapy: case report
    Rodolfo Sacco
    Gastroenterology Department, Pisa University Hospital, Via Paradisa 2, 56124 Pisa, Italy
    BMC Gastroenterol 11:4. 2011
  2. pmc AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease
    Gary Beale
    Paul O Gorman Building, Northern Institute for Cancer Research, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, UK
    BMC Cancer 8:200. 2008
  3. ncbi request reprint Matrix metalloproteinase imbalance in muscle disuse atrophy
    G Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, 70124 Bari, Italy
    Histol Histopathol 20:99-106. 2005
  4. pmc Laminin-5 offsets the efficacy of gefitinib ('Iressa') in hepatocellular carcinoma cells
    G Giannelli
    Section of Internal Medicine, Department of Internal Medicine, Immunology, and Infectious Diseases, University of Bari Medical School, Bari, Italy
    Br J Cancer 91:1964-9. 2004
  5. ncbi request reprint Overexpression of retinoic acid receptor alpha in hepatocellular carcinoma
    Keiji Sano
    Hepato Biliary Pancreatic Surgery Division, Artificial Organ and Transplantation Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Clin Cancer Res 9:3679-83. 2003
  6. ncbi request reprint MMP-2, MMP-9, TIMP-1 and TIMP-2 levels in patients with rheumatoid arthritis and psoriatic arthritis
    G Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Clin Exp Rheumatol 22:335-8. 2004
  7. ncbi request reprint Proteolytic imbalance is reversed after therapeutic surgery in breast cancer patients
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Int J Cancer 109:782-5. 2004
  8. ncbi request reprint Laminin-5 chains are expressed differentially in metastatic and nonmetastatic hepatocellular carcinoma
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, 70124 Bari, Italy
    Clin Cancer Res 9:3684-91. 2003
  9. ncbi request reprint MxA and PKR expression in chronic hepatitis C
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    J Interferon Cytokine Res 24:659-63. 2004
  10. ncbi request reprint Predictive value of early virological response to treatment with different interferon-based regimens plus ribavirin in patients with chronic hepatitis C
    Nicola Napoli
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    New Microbiol 28:13-21. 2005

Detail Information

Publications76

  1. pmc Complete response for advanced liver cancer during sorafenib therapy: case report
    Rodolfo Sacco
    Gastroenterology Department, Pisa University Hospital, Via Paradisa 2, 56124 Pisa, Italy
    BMC Gastroenterol 11:4. 2011
    ....
  2. pmc AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease
    Gary Beale
    Paul O Gorman Building, Northern Institute for Cancer Research, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, UK
    BMC Cancer 8:200. 2008
    ..We conducted a cross sectional study assessing the value of these serum proteins, as well a novel candidate biomarker -follistatin - in patients with HCC arising on a background of ALD or NAFLD...
  3. ncbi request reprint Matrix metalloproteinase imbalance in muscle disuse atrophy
    G Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, 70124 Bari, Italy
    Histol Histopathol 20:99-106. 2005
    ....
  4. pmc Laminin-5 offsets the efficacy of gefitinib ('Iressa') in hepatocellular carcinoma cells
    G Giannelli
    Section of Internal Medicine, Department of Internal Medicine, Immunology, and Infectious Diseases, University of Bari Medical School, Bari, Italy
    Br J Cancer 91:1964-9. 2004
    ..As patients with HCC have different Ln-5 expression levels, these results may help to better understand which patients might benefit from gefitinib treatment...
  5. ncbi request reprint Overexpression of retinoic acid receptor alpha in hepatocellular carcinoma
    Keiji Sano
    Hepato Biliary Pancreatic Surgery Division, Artificial Organ and Transplantation Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Clin Cancer Res 9:3679-83. 2003
    ..However, the expression profile of retinoic acid receptors (RARs) in HCC has not been fully clarified. In this study, we investigated the expression of RAR mRNAs and proteins in resected HCC and nontumor liver tissue...
  6. ncbi request reprint MMP-2, MMP-9, TIMP-1 and TIMP-2 levels in patients with rheumatoid arthritis and psoriatic arthritis
    G Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Clin Exp Rheumatol 22:335-8. 2004
    ..The goal of this study was to quantify the expression of MMPs such as MMP-2 and MMP-9, and their physiological tissue inhibitors TIMP-2 and TIMP-1, respectively, in serum and synovial fluid...
  7. ncbi request reprint Proteolytic imbalance is reversed after therapeutic surgery in breast cancer patients
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Int J Cancer 109:782-5. 2004
    ..In conclusion, our study suggests that pro-MMP-9 and TIMP-1 could be used as markers of disease during the follow-up of breast cancer patients and possibly as prognostic markers, although more studies are needed to address this issue...
  8. ncbi request reprint Laminin-5 chains are expressed differentially in metastatic and nonmetastatic hepatocellular carcinoma
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, 70124 Bari, Italy
    Clin Cancer Res 9:3684-91. 2003
    ..Although Ln-5 has been shown to promote motility and scatter of rat liver cells, it has never been found in the liver...
  9. ncbi request reprint MxA and PKR expression in chronic hepatitis C
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    J Interferon Cytokine Res 24:659-63. 2004
    ..No differences were observed regarding the hepatitis C virus (HCV) genotype and the viral load. These results suggest that expression of the MxA protein could play a role among the mechanisms underlying responsiveness to therapy...
  10. ncbi request reprint Predictive value of early virological response to treatment with different interferon-based regimens plus ribavirin in patients with chronic hepatitis C
    Nicola Napoli
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    New Microbiol 28:13-21. 2005
    ..Finally, patients who do not clear the virus within the first 12 weeks of treatment have no chance of achieving SVR, justifying discontinuation of therapy in these patients...
  11. ncbi request reprint Infliximab therapy does not modify MMP-2 and MMP-9 serum concentrations in chronic arthritis
    G Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Clin Exp Rheumatol 23:867-72. 2005
    ..In this study MMP-2 and MMP-9 serum were evaluated in patients with chronic arthritis during therapy with the anti-TNFalpha mAb, infliximab...
  12. ncbi request reprint The effect of bosentan on matrix metalloproteinase-9 levels in patients with systemic sclerosis-induced pulmonary hypertension
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Curr Med Res Opin 21:327-32. 2005
    ..Recently, a dual inhibitor of endothelin-1, bosentan, has been successfully evaluated in clinical trials in PAH patients...
  13. ncbi request reprint Clinical role of tissue and serum levels of SCCA antigen in hepatocellular carcinoma
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Int J Cancer 116:579-83. 2005
    ..In conclusion, in HCC patients, the SCCA antigen could represent a useful marker for the detection of micro-metastasis in the tissues and for large-scale screening of serum in patients at risk...
  14. ncbi request reprint SCCA antigen combined with alpha-fetoprotein as serologic markers of HCC
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari, Bari, Italy
    Int J Cancer 117:506-9. 2005
    ..A small percentage of patients remain undetected, likely because of the low specificity of SCCA. In conclusion, the combined use of alpha-FP and SCCA antigen represents a more powerful tool for the serologic detection of HCC...
  15. ncbi request reprint Immunological and molecular aspects of liver fibrosis in chronic hepatitis C virus infection
    G Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Cesare Frugoni Medical Clinic, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Histol Histopathol 20:939-44. 2005
    ..Finally, we analyze one of the aspects involved in the activation of the HSCs, namely the proteolytic remodeling of the surrounding environment...
  16. ncbi request reprint ZD6474 inhibits proliferation and invasion of human hepatocellular carcinoma cells
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Biochem Pharmacol 71:479-85. 2006
    ..Nonetheless, co-incubation with Ln-5 completely recovered this effect. Our results support the hypothesis that ZD6474 could represent an interesting therapeutic opportunity for patients with HCC scarcely expressing the ECM protein, Ln-5...
  17. ncbi request reprint New frontiers in biomarkers for hepatocellular carcinoma
    G Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Dig Liver Dis 38:854-9. 2006
    ..In this review, we will focus on new biomarkers currently under investigation, but also on still newer, very promising biomarkers that seem to significantly improve diagnosis...
  18. ncbi request reprint Tissue remodelling in liver diseases
    G Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Histol Histopathol 18:1267-74. 2003
    ..Finally, we analyze the role of alterations of the surrounding microenvironment including ECM, growth factors, cytokines and membrane receptors for ECM ligands in the development of HCC and in its invasive behaviour...
  19. ncbi request reprint Human hepatocellular carcinoma (HCC) cells require both alpha3beta1 integrin and matrix metalloproteinases activity for migration and invasion
    G Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Lab Invest 81:613-27. 2001
    ..In conclusion, our data suggest that both alpha3beta1 integrin and gelatinase activity are required for HCC migration and invasion...
  20. ncbi request reprint Biological and clinical relevance of Laminin-5 in cancer
    G Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, University of Bari, Medical School, Italy
    Clin Exp Metastasis 18:439-43. 2000
    ..This will then be followed by a discussion of the presented data and its limitations. Finally, suggestions will be provided to improve the current state of knowledge in the field and future implications will be briefly discussed...
  21. ncbi request reprint Gelatinases and their inhibitors in tumor metastasis: from biological research to medical applications
    G Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, University of Bari Medical School, Italy
    Histol Histopathol 17:339-45. 2002
    ....
  22. ncbi request reprint Gelatinase levels in male and female breast cancer
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Medical School, University of Bari, Piazza G Cesare 11, 70124 Bari, Italy
    Biochem Biophys Res Commun 292:161-6. 2002
    ..In conclusion, the increased expression of gelatinases in male breast cancer patients together with anatomical features might explain the high tendency toward metastasis and the worse prognosis...
  23. doi request reprint Inhibiting TGF-β signaling in hepatocellular carcinoma
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine University of Bari Medical School, Bari, Italy
    Biochim Biophys Acta 1815:214-23. 2011
    ..Hence, it is anticipated that there will soon be new agents available for clinical investigations to evaluate the role of the TGF-β-associated signaling in this deadly cancer...
  24. ncbi request reprint Antifibrogenic effect of IFN-alpha2b on hepatic stellate cell activation by human hepatocytes
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    J Interferon Cytokine Res 26:301-8. 2006
    ..In conclusion, our results show that hepatocytes stimulated by inflammatory cytokines participate in the activation of HSCs via MMP-9 production and that antiviral therapy modulates such activation...
  25. ncbi request reprint Targeting transforming growth factor (TGF)-betaRI inhibits activation of beta1 integrin and blocks vascular invasion in hepatocellular carcinoma
    Emilia Fransvea
    Department of Internal Medicine, Section of Internal Medicine University of Bari Medical School, Bari, Italy
    Hepatology 49:839-50. 2009
    ..In human HCC tissues with microvascular invasion, phospho-beta1 integrin was detected as well as TGF-beta1, p-Smad-2, and E-cadherin...
  26. pmc Transforming growth factor-beta1 triggers hepatocellular carcinoma invasiveness via alpha3beta1 integrin
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, University of Bari Medical School, Bari, Italy
    Am J Pathol 161:183-93. 2002
    ..In conclusion, TGF-beta1 may play an important role in HCC invasiveness by stimulating alpha3-integrin expression, and could therefore be an important target for new therapies...
  27. ncbi request reprint Proteolytic balance in patients with multiple sclerosis during interferon treatment
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    J Interferon Cytokine Res 22:689-92. 2002
    ..These results suggest that IFN-beta modulates T cell activities, including MMP and TIMP production, thus contributing either to maintaining the integrity of the BBB or to slowing the progression of the disease...
  28. doi request reprint EGFR and VEGFR as potential target for biological therapies in HCC cells
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Cancer Lett 262:257-64. 2008
    ..All these biological effects seem to depend on the activity of gefitinib and vandetanib blocking activity towards p-EGFR mediated pathways...
  29. ncbi request reprint Tyrosine kinase inhibitors: a potential approach to the treatment of hepatocellular carcinoma
    G Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Curr Pharm Des 13:3301-4. 2007
    ....
  30. ncbi request reprint Clinical validation of combined serological biomarkers for improved hepatocellular carcinoma diagnosis in 961 patients
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Clin Chim Acta 383:147-52. 2007
    ....
  31. ncbi request reprint Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma
    G Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Gastroenterology 129:1375-83. 2005
    ..We investigate how transforming growth factor (TGF)-beta1 and extracellular matrix protein Laminin-5 (Ln-5) induce EMT and cancer invasion...
  32. ncbi request reprint Clinical role of MMP-2/TIMP-2 imbalance in hepatocellular carcinoma
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Int J Cancer 97:425-31. 2002
    ..Furthermore, we found a strict correlation between tissue and serum levels of TIMP-2, this suggesting that a MMP-2/TIMP-2 imbalance and in particular TIMP-2 levels, could represent an important prognostic factor in patients with HCC...
  33. ncbi request reprint Clinical role of serum and tissue matrix metalloprotease-9 expression in chronic HCV patients treated with pegylated IFN-alpha2b and ribavirin
    Felice Marinosci
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    J Interferon Cytokine Res 25:453-8. 2005
    ..In conclusion, our results show that MMP-9 decreases in responder patients both in the serum and in the liver after therapy. Further studies are needed to investigate this new possible therapeutic activity of PEG-IFN-alpha2b...
  34. pmc Tissue expression of Squamous Cellular Carcinoma Antigen (SCCA) is inversely correlated to tumor size in HCC
    Paolo Trerotoli
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Mol Cancer 8:29. 2009
    ..We studied 27 patients with liver cirrhosis (LC) and 55 with HCC: 20 with a single nodule < 3 cm (s-HCC) and 35 with a single nodule > 3 cm or multifocal (l-HCC)...
  35. doi request reprint Inhibition of transforming growth factor beta receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation
    Antonio Mazzocca
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Hepatology 50:1140-51. 2009
    ..This effect was mediated by SMAD2/3 and affected the secretion of VEGF. Finally, LY2109761 does not show significant effects on physiological angiogenetic development...
  36. ncbi request reprint Laminin-5 stimulates hepatocellular carcinoma growth through a different function of alpha6beta4 and alpha3beta1 integrins
    Carlo Bergamini
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Italy
    Hepatology 46:1801-9. 2007
    ..Conclusions: Our study suggests a new mechanism of HCC growth whereby Ln-5 stimulates proliferation via a different function of alpha6beta4 and alpha3beta1...
  37. ncbi request reprint Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells
    Emilia Fransvea
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Hepatology 47:1557-66. 2008
    ..In 72 patients, E-cadherin tissue expression was more weakly expressed in metastatic than in nonmetastatic HCC (P < 0.0001)...
  38. doi request reprint Kinase activation profile associated with TGF-β-dependent migration of HCC cells: a preclinical study
    Emilia Fransvea
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Cancer Chemother Pharmacol 68:79-86. 2011
    ..To identify the molecular mechanisms responsible for tumor cell migration is essential for developing agents that can prevent the relapse or the metastatic spread of hepatocellular carcinoma (HCC)...
  39. doi request reprint Down-regulation of connective tissue growth factor by inhibition of transforming growth factor beta blocks the tumor-stroma cross-talk and tumor progression in hepatocellular carcinoma
    Antonio Mazzocca
    Department of Internal Medicine, Section of Internal Medicine, Policlinico, Bari, Italy
    Hepatology 51:523-34. 2010
    ..Interestingly, patients with high CTGF expression had poor prognosis, suggesting that treatment aimed at reducing TGF-beta-dependent CTGF expression may offer clinical benefits...
  40. ncbi request reprint Tumor-secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts
    Antonio Mazzocca
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Hepatology 54:920-30. 2011
    ..Analysis of microdissected tissues indicated that stroma is the main target of the LPA paracrine loop in HCC. As a consequence, α-SMA-positive cells were more widespread in tumoral compared with paired peritumoral stroma...
  41. doi request reprint Hepatic stellate cells stimulate HCC cell migration via laminin-5 production
    Angela Santamato
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Clin Sci (Lond) 121:159-68. 2011
    ..In human HCC tissues, Ln-5 is mainly distributed along α-SMA (smooth muscle actin)-positive cells, whereas in peritumoural tissues, Ln-5 is absent. HSCs stimulate HCC migration via the production and secretion of Ln-5...
  42. ncbi request reprint Role of the alpha3beta1 and alpha6beta4 integrins in tumor invasion
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, University of Bari Medical School, Italy
    Clin Exp Metastasis 19:217-23. 2002
    ..In this Review, we will focus on the role of these two receptors and the mechanisms by which they influence the invasion process...
  43. ncbi request reprint The TGF-β signaling pathway as a pharmacological target in a hepatocellular carcinoma
    Antonio Mazzocca
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Allergology and Clinical Immunology, University of Bari School of Medicine, Italy
    Curr Pharm Des 18:4148-54. 2012
    ..Aim of this article is to make a brief review of the benefits and limitations of targeting the TGF-β signaling pathway in HCC...
  44. doi request reprint PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma
    Francesco Dituri
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Int J Cancer 130:2505-13. 2012
    ..Our results emphasize the role of p110γ as a promoter of HCC proliferation and unveil an important cell cycle regulation function of this molecule...
  45. ncbi request reprint Localization and possible role of two different alpha v beta 3 integrin conformations in resting and resorbing osteoclasts
    Roberta Faccio
    Department of Human Anatomy and Histology, University of Bari, Italy
    J Cell Sci 115:2919-29. 2002
    ..The capacity of growth factors to alter the affinity of alpha(v)beta(3) toward its ligands offers a potential explanation for the diverse responses of osteoclasts to the same ligand...
  46. ncbi request reprint Novel concepts in hepatocellular carcinoma: from molecular research to clinical practice
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    J Clin Gastroenterol 40:842-6. 2006
    ..In conclusion, this review will attempt to stimulate debate on translational research into HCC biology, in the field of clinical applications...
  47. doi request reprint Polyelectrolyte capsules as carriers for growth factor inhibitor delivery to hepatocellular carcinoma
    Francesca Baldassarre
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari, Medical School, Bari, Italy
    Macromol Biosci 12:656-65. 2012
    ....
  48. pmc PI3K functions in cancer progression, anticancer immunity and immune evasion by tumors
    Francesco Dituri
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Allergology and Clinical Immunology, University of Bari Medical School, 70124 Bari, Italy
    Clin Dev Immunol 2011:947858. 2011
    ..In addition, we discuss, from antitumor immunological point of view, the potential benefits and disadvantages arising from use of anticancer pharmacological agents targeting the PI3K pathway...
  49. ncbi request reprint Gelatinase expression at positive patch test reactions
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Contact Dermatitis 46:280-5. 2002
    ..These data suggest that MMP-2 and MMP-9 could play a role in the mechanisms inducing alterations of the epidermal architecture, and in the pathogenesis of the lesions...
  50. doi request reprint HCC heterogeneity: molecular pathogenesis and clinical implications
    Emilia Fransvea
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Cell Oncol 31:227-33. 2009
    ..A novel approach to mapping these differences is by investigating the epigenetics associated with certain clinical aspects...
  51. ncbi request reprint Involvement of ADAMs in tumorigenesis and progression of hepatocellular carcinoma: Is it merely fortuitous or a real pathogenic link?
    Antonio Mazzocca
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Piazza G Cesare 11, I 70124 Bari, Italy
    Biochim Biophys Acta 1806:74-81. 2010
    ..The potential role of ADAMs as key modulators of tumor-stroma interactions during tumor progression, by means of the activities of their constituent domains, is also discussed...
  52. ncbi request reprint Rationale for new drugs targeting the tissue microenvironment in patients with HCC
    S Antonaci
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Curr Pharm Des 13:3288-91. 2007
    ..In this review the role and the rationale of using biological drugs to target the microenvironment is discussed, taking into consideration new experimental advances in the field...
  53. pmc Body mass index and serum proteomic profile in breast cancer and healthy women: a prospective study
    Vito Michele Garrisi
    Clinical Experimental Oncology Department, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Bari, Italy
    PLoS ONE 7:e49631. 2012
    ..Further studies to identify specific proteins found in the serum and their role in breast cancerogenesis and progression are in progress...
  54. ncbi request reprint The Integrated Oncology Program of the Italian Ministry of Health. Analytical and clinical validation of new biomarkers for early diagnosis: network, resources, methodology, quality control, and data analysis
    Angelo Paradiso
    National Cancer Institute Giovanni Paolo II, Bari, Italy
    Int J Biol Markers 24:119-29. 2009
    ..During this meeting, methodological aspects, scientific programs and preliminary results were presented and discussed...
  55. ncbi request reprint [Clarkson syndrome: a rare clinical condition characterized by generalized edema associated to monoclonal gammopathy]
    Francesco Saverio Vella
    Sezione di Medicina Interna, Dipartimento di Medicina Interna, Immunologia e Malattie Infettive, Universita, Bari
    Recenti Prog Med 96:488-91. 2005
    ..During acute phase the patient underwent therapy with plasma-expanders and glucocorticoids, although in quiescent phase we administered aminophylline, salbutamol and prednisone. After three months, the patient is asymptomatic...
  56. ncbi request reprint [Extrapulmonary sarcoidosis with prevalent liver involvement: a new case and review of the literature]
    Francesco Saverio Vella
    Sezione di Medicina Interna, Dipartimento di Medicina Interna, Immunologia e Malattie Infettive, Università Bari
    Recenti Prog Med 97:469-71. 2006
    ....
  57. ncbi request reprint Altered expression of integrins and basement membrane proteins in malignant and pre-malignant lesions of oral mucosa
    G Giannelli
    Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari Medical School, Italy
    J Biol Regul Homeost Agents 15:375-80. 2001
    ..In conclusion, we suggest that abnormal re-distribution of alpha3beta1 and alpha6beta4 integrins and expression of ECM components such as Ln-5 could play an important role in SCC invasion and metastasis...
  58. ncbi request reprint HGF and M-CSF modulate adhesion of MDA-231 breast cancer cell by increasing osteopontin secretion
    M Grano
    Department of Human Anatomy and Histology, University of Bari, Italy
    J Biol Regul Homeost Agents 16:190-5. 2002
    ..Moreover HGF and M-CSF induce de novo synthesis of OPN. In conclusion, these data suggest that HGF and M-CSF stimulate OPN production by MDA-231 cells, and that OPN is subsequently used as a substrate for cell adhesion...
  59. ncbi request reprint Endometriosis is characterized by an impaired localization of laminin-5 and alpha3beta1 integrin receptor
    G Giannelli
    Departments of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Int J Gynecol Cancer 17:242-7. 2007
    ..The altered expression of Ln-5, by upregulating matrix metalloproteases activity, suggest an invading process similar to that of many cancer processes...
  60. ncbi request reprint Relation of C. pneumoniae antibodies to inflammation and atherosclerosclerosis in dialysis patients
    R Monno
    Department of Internal Medicine and Public Health, University of Bari, Bari, Italy
    Panminerva Med 52:283-8. 2010
    ..pneumoniae, some markers of inflammation and the presence of preclinical atherosclerotic lesions in hemodyalisis (HD) patients treated with different dialytic membranes...
  61. ncbi request reprint Clinical outcomes of bosentan in pulmonary arterial hypertension do not correlate with levels of TIMPs
    G Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Eur J Clin Invest 36:73-7. 2006
    ..We measured TIMP-1 and TIMP-2 in the serum of patients with SSc with and without PAH treated with long-term bosentan compared with healthy donors (HD)...
  62. ncbi request reprint The use of different Peg-interferon alpha-2b regimens plus ribavirin in HCV-1b-infected patients after rapid virological response does not affect the achievement of sustained virological response
    N Napoli
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    J Viral Hepat 15:300-4. 2008
    ..5%; P = 0.0058), because of a high prevalence of post-treatment relapse among patients with EVR...
  63. ncbi request reprint Malignant fibrous histiocytoma arising on chronic osteomyelitis
    C Foti
    Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari, Italy
    J Eur Acad Dermatol Venereol 16:390-2. 2002
    ..In the case we report the neoplasm was primitively localized at the dermal and subcutaneous level and presented as a rapidly growing mass...
  64. ncbi request reprint [Syndrome of overlap: Chronic hepatitis C/autoimmune hepatitis: fact or fancy?]
    Salvatore Antonaci
    Recenti Prog Med 96:27-31. 2005
    ..On the contrary, first-line therapy with corticosteroids should be restricted to the "true" hepatitis overlap syndrome with the new therapeutic option of interferon/corticosteroid association...
  65. doi request reprint Basiliximab versus steroids in double therapy immunosuppression in liver transplantation: a prospective randomized clinical trial
    Luigi Lupo
    Department of Emergency and Organ Transplantation, Institute of General Surgery and Liver Transplantation, University of Bari, Bari, Italy
    Transplantation 86:925-31. 2008
    ..The aim of this prospective randomized clinical trial was to compare B with S in a cyclosporin A (CsA)-based immunosuppression regimen in primary LTx...
  66. ncbi request reprint Cancer invasion: watch your neighbourhood!
    Vito Quaranta
    Department of Cell Biology, The Scripps Research Institute, USA
    Tumori 89:343-8. 2003
    ....
  67. ncbi request reprint Case of multiple myeloma mimicking an infectious disease with fever, intrahepatic cholestasis, renal failure, and pulmonary insufficiency
    Francesco S Vella
    Dipartimento di Clinica Medica, Immunologia e Malattie Infettive, University of Bari, Policlinico, Bari, Italy
    Am J Hematol 72:38-42. 2003
    ..The extremely aggressive course and pulmonary involvement in the form of pulmonary alveolar proteinosis (PAP) are discussed, stressing the unusual nature of the findings and the variable picture of MM...
  68. ncbi request reprint [Diarrhea as first clinical manifestation of hepatocellular carcinoma]
    Gianluigi Giannelli
    Sezione di Medicina Interna, Dipartimento di Clinica Medica, Immunologia e Malattie Infettive, Universita, Bari
    Recenti Prog Med 93:478-81. 2002
    ..This clinical report draws the attention to the possibility of paraneoplastic syndrome expression before the clinical onset of HCC and to the role that neuroendocrine hormones may have on the growth and spread of HCC...
  69. ncbi request reprint Treatment of community-acquired pneumonia: a descriptive study in an Apulian department of internal medicine
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Disease Section of Internal Medicine, Bari, Italy
    Med Sci Monit 11:CR434-9. 2005
    ..Infections of the lower airways pose a serious problem for the health service, both because of the burden of the disease and because of the large number of resources that need to be devoted to treating it...
  70. ncbi request reprint Rat hindlimb unloading by tail suspension reduces osteoblast differentiation, induces IL-6 secretion, and increases bone resorption in ex vivo cultures
    M Grano
    Department of Human Anatomy and Histology, University of Bari, Bari, Italy
    Calcif Tissue Int 70:176-85. 2002
    ..They also indicate for the first time that a possible mediator responsible for the increased osteoclastogenesis could be represented by the IL-6 whose secretion by bone marrow cells was significantly enhanced by unloading...
  71. ncbi request reprint Expression of metalloproteinases MMP-2 and MMP-9 in sentinel lymph node and serum of patients with metastatic and non-metastatic breast cancer
    A Daniele
    Department of Experimental Oncology, Laboratory of Analyses, Institute of Oncology, Via Hannhemann 10, Bari, Italy
    Anticancer Res 30:3521-7. 2010
    ..3 levels, and MMP-9 and grading. This study suggests a clinical utility of these proteolytic markers in malignant tumour, growth, invasion and metastasis in breast cancer...
  72. ncbi request reprint [Hepatocellular carcinoma: tumoral or peritumoral disease?]
    Gianluigi Giannelli
    Recenti Prog Med 98:23-8. 2007
    ..The aim of this review is to stimulate the debate on the translational research in the HCC field...
  73. ncbi request reprint Effects of interferon-alpha treatment on neutrophil oxidative metabolism, lymphocyte proliferation and monocyte HLA class I antigen expression in patients with chronic hepatitis C
    G Piazzolla
    Department of Internal Medicine, University of Bari Medical School, Italy
    Immunopharmacol Immunotoxicol 18:529-48. 1996
    ..Altogether, these findings suggest the occurrence of a strict relationship between immunoresponsiveness and IFN-alpha induced therapeutical effects in CH-C patients...
  74. ncbi request reprint MMP-2, MMP-9, VEGF and CA 15.3 in breast cancer
    M Quaranta
    Department of Experimental Oncology, Laboratory of Analyses, Institute of Oncology, Bari, Italy
    Anticancer Res 27:3593-600. 2007
    ..Owing to their matrix-degrading abilities and high expression in advanced tumours, MMPs were originally implicated in cancer progression, invasion and metastasis...
  75. ncbi request reprint 655Val and 1170Pro ERBB2 SNPs in familial breast cancer risk and BRCA1 alterations
    Stefania Tommasi
    National Cancer Institute Bari, Italy
    Cell Oncol 29:241-8. 2007
    ..In conclusion, these findings point to the existence of an association of ERBB2 allelic variants at both loci with specific breast tumor phenotypes and to the need of deeply investigate different gene SNPs association for risk defining...