Lorenzo Ghiadoni

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi request reprint Hypertension and endothelial dysfunction: therapeutic approach
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Vasc Pharmacol 10:42-60. 2012
  2. ncbi request reprint Ramipril dose-dependently increases nitric oxide availability in the radial artery of essential hypertension patients
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 25:361-6. 2007
  3. ncbi request reprint Management of high blood pressure in type 2 diabetes: perindopril/indapamide fixed-dose combination and the ADVANCE trial [corrected]
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Expert Opin Pharmacother 11:1647-57. 2010
  4. doi request reprint Fixed dose combination of perindopril and indapamide improves peripheral vascular function in essential hypertensive patients
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 22:506-12. 2009
  5. ncbi request reprint Non-invasive diagnostic tools for investigating endothelial dysfunction
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma 67, Pisa, Italy
    Curr Pharm Des 14:3715-22. 2008
  6. doi request reprint Perindopril for the treatment of hypertension
    Lorenzo Ghiadoni
    University of Pisa, Internal Medicine, Via Roma 67, Pisa 56126, Italy
    Expert Opin Pharmacother 12:1633-42. 2011
  7. ncbi request reprint Endothelial dysfunction and oxidative stress in chronic renal failure
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Nephrol 17:512-9. 2004
  8. ncbi request reprint Change in forearm reactive hyperemia after telmisartan: an endothelial effect?
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 20:1312-3. 2007
  9. ncbi request reprint Metabolic syndrome and vascular alterations in normotensive subjects at risk of diabetes mellitus
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 51:440-5. 2008
  10. ncbi request reprint Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Coll Cardiol 48:508-15. 2006

Detail Information

Publications84

  1. ncbi request reprint Hypertension and endothelial dysfunction: therapeutic approach
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Vasc Pharmacol 10:42-60. 2012
    ..Some beneficial effects were also exerted by nebivolol and statins. Future studies are needed to confirm whether the improvement in endothelial dysfunction is associated to better cardiovascular prognosis in hypertension...
  2. ncbi request reprint Ramipril dose-dependently increases nitric oxide availability in the radial artery of essential hypertension patients
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 25:361-6. 2007
    ..Plasma angiotensin II and oxidative stress markers were also assessed...
  3. ncbi request reprint Management of high blood pressure in type 2 diabetes: perindopril/indapamide fixed-dose combination and the ADVANCE trial [corrected]
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Expert Opin Pharmacother 11:1647-57. 2010
    ....
  4. doi request reprint Fixed dose combination of perindopril and indapamide improves peripheral vascular function in essential hypertensive patients
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 22:506-12. 2009
    ..625 mg, daily) and atenolol (50 mg, daily), was evaluated in 62 untreated essential hypertensive patients according a double-blind, parallel group, randomized study...
  5. ncbi request reprint Non-invasive diagnostic tools for investigating endothelial dysfunction
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma 67, Pisa, Italy
    Curr Pharm Des 14:3715-22. 2008
    ....
  6. doi request reprint Perindopril for the treatment of hypertension
    Lorenzo Ghiadoni
    University of Pisa, Internal Medicine, Via Roma 67, Pisa 56126, Italy
    Expert Opin Pharmacother 12:1633-42. 2011
    ..Treatment of hypertension is fundamental for the prevention of cardiovascular events and mortality. This review focuses on the specific benefits of the ACE inhibitor perindopril...
  7. ncbi request reprint Endothelial dysfunction and oxidative stress in chronic renal failure
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Nephrol 17:512-9. 2004
    ..HD patients showed a more marked alteration, which seems to be related, at least in part, to increased oxidative stress...
  8. ncbi request reprint Change in forearm reactive hyperemia after telmisartan: an endothelial effect?
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 20:1312-3. 2007
  9. ncbi request reprint Metabolic syndrome and vascular alterations in normotensive subjects at risk of diabetes mellitus
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 51:440-5. 2008
    ..60, confidence limits: 1.01 to 12.78). In conclusion, in normotensive subjects at risk of developing diabetes mellitus, the presence of MS is associated with a selective alteration of central PWV...
  10. ncbi request reprint Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Coll Cardiol 48:508-15. 2006
    ....
  11. doi request reprint Arterial stiffness, intima-media thickness and carotid artery fibrosis in patients with primary aldosteronism
    Giampaolo Bernini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 26:2399-405. 2008
    ..To evaluate vascular wall structure and conduit artery stiffness in patients with primary aldosteronism...
  12. ncbi request reprint Nitric oxide modulates tissue plasminogen activator release in normotensive subjects and hypertensive patients
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 49:878-84. 2007
    ....
  13. ncbi request reprint Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma, 67 56100 Pisa, Italy
    J Clin Endocrinol Metab 91:5076-82. 2006
    ..The objective of this study was to assess whether low-grade systemic inflammation might contribute to the pathogenesis of endothelial dysfunction in patients with subclinical hypothyroidism (sHT) and autoimmune thyroiditis...
  14. ncbi request reprint Endothelium-dependent vasodilation and carotid artery wall remodeling in athletes and sedentary subjects
    Fabio Galetta
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56126, Pisa, Italy
    Atherosclerosis 186:184-92. 2006
    ..56, p<0.0001). In conclusion, regular physical training can attenuate the age-related impairment of endothelium-dependent vasodilation, which is related to an attenuation of the age-induced remodeling of the carotid wall...
  15. ncbi request reprint Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients
    Yvonne Plantinga
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 20:392-7. 2007
    ..We evaluated the effect of short-term combined treatment with the antioxidants vitamins C and E on endothelial function, arterial stiffness, and oxidative stress in untreated essential hypertensive patients...
  16. ncbi request reprint Vascular reactivity in congenital hypogonadal men before and after testosterone replacement therapy
    Giampaolo Bernini
    Department of Internal Medicine, Pisa University, Italy
    J Clin Endocrinol Metab 91:1691-7. 2006
    ..The contribution of endogenous testosterone (TS) in the functional integrity of peripheral circulation in men was studied...
  17. pmc Adipocytokine levels mark endothelial function in normotensive individuals
    Anna Solini
    Department of Internal Medicine University of Pisa, Via Roma 67, Pisa I 56100, Italy
    Cardiovasc Diabetol 11:103. 2012
    ..Inflammatory mediators released by the adipose tissue can lead to local insulin resistance and endothelial dysfunction. This study addressed the relationship of adipocytokines with endothelial function and blood pressure...
  18. ncbi request reprint Different effect of antihypertensive drugs on conduit artery endothelial function
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 41:1281-6. 2003
    ..In patients with essential hypertension, ACE inhibitors appear to be the only compounds able to improve conduit artery endothelium-dependent vasodilation...
  19. ncbi request reprint Vascular reactivity in patients with undifferentiated connective tissue diseases
    Marta Mosca
    Rheumatology Unit, Department of Internal Medicine, University of Pisa, Italy
    Atherosclerosis 203:185-91. 2009
    ..We investigated endothelial function in the peripheral circulation of patients with undifferentiated connective tissue diseases (UCTDs), in comparison to healthy controls...
  20. doi request reprint Effect of acute administration of vitamin C on muscle sympathetic activity, cardiac sympathovagal balance, and baroreflex sensitivity in hypertensive patients
    Rosa M Bruno
    Department of Internal Medicine, University Hospital of Pisa, Italy
    Am J Clin Nutr 96:302-8. 2012
    ..Essential hypertension is characterized by both increased oxidative stress and sympathetic traffic. Experimental studies have shown that reactive oxygen species can modulate autonomic activity...
  21. doi request reprint Peripheral wave reflection and endothelial function in untreated essential hypertensive patients with and without the metabolic syndrome
    Yvonne Plantinga
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 26:1216-22. 2008
    ..We evaluated whether metabolic syndrome is associated with early vascular alterations, such as increased peripheral wave reflections and endothelial dysfunction, in untreated essential hypertensive patients...
  22. ncbi request reprint Calcium antagonist treatment by lercanidipine prevents hyperpolarization in essential hypertension
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 41:950-5. 2003
    ..These results indicate that in essential hypertension, lercanidipine increases endothelium-dependent vasodilation by restoring NO availability and preventing hyperpolarization, an effect probably determined by antioxidant activity...
  23. doi request reprint Effect of aliskiren treatment on endothelium-dependent vasodilation and aortic stiffness in essential hypertensive patients
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Eur Heart J 33:1530-8. 2012
    ..We assessed whether aliskiren may improve peripheral endothelial function and arterial stiffness in essential hypertensive patients (EH), when compared with the angiotensin-converting enzyme-inhibitor ramipril...
  24. doi request reprint Local carotid stiffness and intima-media thickness assessment by a novel ultrasound-based system in essential hypertension
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Atherosclerosis 223:372-7. 2012
    ..RF-based echotracking device...
  25. ncbi request reprint Soy protein diet improves endothelial dysfunction in renal transplant patients
    Adamasco Cupisti
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Nephrol Dial Transplant 22:229-34. 2007
    ....
  26. doi request reprint Tissue-type plasminogen activator release in healthy subjects and hypertensive patients: relationship with beta-adrenergic receptors and the nitric oxide pathway
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 52:314-21. 2008
    ..This impaired fibrinolytic activity might contribute to the increased cardiovascular risk associated with hypertension...
  27. doi request reprint The sulfaphenazole-sensitive pathway acts as a compensatory mechanism for impaired nitric oxide availability in patients with primary hyperparathyroidism. Effect of surgical treatment
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    J Clin Endocrinol Metab 95:920-7. 2010
    ..A compensatory CYP 2C9-derived EDHF pathway is activated to sustain endothelium-dependent vasodilation. This PHPT-related endothelial dysfunction is reversed after PTx...
  28. ncbi request reprint Phosphodiesterase 5 inhibition in essential hypertension
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Curr Hypertens Rep 10:52-7. 2008
    ..Studies on safety during long-term administration, interactions with antihypertensive and nonantihypertensive drugs, and effect on target organ damage are needed...
  29. doi request reprint Human endothelial dysfunction: EDCFs
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100, Pisa, Italy
    Pflugers Arch 459:1015-23. 2010
    ..The mechanisms that regulate the balance between NO and EDCFs and the processes transforming the endothelium from a protective organ to a source of vasoconstrictor, proaggregatory and promitogenic mediators, remain to be determined...
  30. ncbi request reprint Endothelium, aging, and hypertension
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Curr Hypertens Rep 8:84-9. 2006
    ..Currently, dynamic physical activity represents the only effective intervention in preventing age-related impaired endothelium-dependent vasodilation in aged healthy individuals...
  31. ncbi request reprint Physical activity, plasma antioxidant capacity, and endothelium-dependent vasodilation in young and older men
    Ferdinando Franzoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 18:510-6. 2005
    ..The aim of this study was to evaluate the relationship between long-term physical activity, plasma antioxidant status, and conduit artery endothelial function in young and older healthy men...
  32. ncbi request reprint Recombinant human thyrotropin reduces endothelium-dependent vasodilation in patients monitored for differentiated thyroid carcinoma
    Angela Dardano
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    J Clin Endocrinol Metab 91:4175-8. 2006
    ..We evaluated endothelial-dependent vasodilation after administration of recombinant human TSH (rhTSH) in patients monitored for differentiated thyroid carcinoma. The role of inflammation and oxidative stress was also assessed...
  33. ncbi request reprint Poor sleep quality and resistant hypertension
    Rosa Maria Bruno
    Institute of Clinical Physiology CNR, Pisa, Italy Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Sleep Med 14:1157-63. 2013
    ..We aimed to determine the relationship between sleep quality and treatment-resistant hypertension (RH)...
  34. ncbi request reprint Functional and structural alterations of large arteries: methodological issues
    Elisabetta Bianchini
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Curr Pharm Des 19:2390-400. 2013
    ....
  35. ncbi request reprint Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy
    J Clin Endocrinol Metab 88:3731-7. 2003
    ..Patients with sHT are characterized by endothelial dysfunction resulting from a reduction in NO availability, an alteration partially independent of dyslipidemia and reversed by levothyroxine supplementation...
  36. ncbi request reprint Relationship between wave reflection and renal damage in hypertensive patients: a retrospective analysis
    Francesco Stea
    aInstitute of Clinical Physiology, National Research Council bDepartment of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 31:2418-24. 2013
    ..The aim of this study was, therefore, to explore the relationship between wave reflection and small vessel damage in the kidney...
  37. doi request reprint Increased finger skin vasoreactivity and stimulated vasomotion associated with simvastatin therapy in systemic sclerosis hypercholesterolemic patients
    Marco Rossi
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Rheumatol Int 32:3715-21. 2012
    ....
  38. doi request reprint Effect of mild hyperisulinemia on conduit vessel endothelial function: role of noradrenergic activation
    Cecilia Morgantini
    Metabolism and Hypertension Units, Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 30:720-4. 2012
    ..The aim of this study was to verify whether this effect is caused by the enhancement of insulin-induced adrenergic tone...
  39. ncbi request reprint Blood pressure and vascular alterations with growth in childhood
    Stefano Masi
    Department of Internal Medicine, University of Pisa, Italy
    Curr Pharm Des 17:3045-61. 2011
    ..We also summarise current non-invasive approaches to investigate the precursors and early development of CV disease, emphasising their potential applications in childhood...
  40. doi request reprint Interactions between sympathetic nervous system and endogenous endothelin in patients with essential hypertension
    Rosa Maria Bruno
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 57:79-84. 2011
    ..Moreover, essential hypertension shows an increased susceptibility to the sympathoexcitatory effect of endogenous endothelin 1...
  41. pmc Endothelium-dependent contractions and endothelial dysfunction in human hypertension
    Daniele Versari
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Br J Pharmacol 157:527-36. 2009
    ..The mechanisms that regulate the balance between NO and EDCF, and the processes transforming the endothelium from a protective organ to a source of vasoconstrictor, proaggregatory and promitogenic mediators remain to be determined...
  42. pmc Osteopontin is associated with increased arterial stiffness in rheumatoid arthritis
    Laura Bazzichi
    Department of Internal Medicine, Division of Rheumatology, University of Pisa, Pisa, Italy
    Mol Med 15:402-6. 2009
    ....
  43. ncbi request reprint Carotid vascular remodeling in patients with pheochromocytoma
    Giampaolo Bernini
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    J Clin Endocrinol Metab 91:1754-60. 2006
    ..The influence of catecholamines on vascular remodeling in humans was investigated...
  44. ncbi request reprint Assessment of carotid stiffness and intima-media thickness from ultrasound data: comparison between two methods
    Elisabetta Bianchini
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    J Ultrasound Med 29:1169-75. 2010
    ..The aim of this study was to compare a system recently developed in our laboratory for automatic assessment of these parameters from ultrasound image sequences to a reference radio frequency (RF) echo-tracking system...
  45. ncbi request reprint The ageing endothelium, cardiovascular risk and disease in man
    Daniele Versari
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Exp Physiol 94:317-21. 2009
    ..Therefore, it is conceivable that endothelial dysfunction plays a major role in predisposing to age-related increased cardiovascular risk in the elderly...
  46. ncbi request reprint Real-time measurement system for evaluation of the carotid intima-media thickness with a robust edge operator
    Francesco Faita
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    J Ultrasound Med 27:1353-61. 2008
    ....
  47. ncbi request reprint Current treatment of patients with hypertension: therapeutic implications of INSIGHT
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Drugs 63:1435-44. 2003
    ..The clinical significance of this effect in the prevention of cardiovascular events still remains to be established...
  48. doi request reprint Cholecalciferol administration blunts the systemic renin-angiotensin system in essential hypertensives with hypovitaminosis D
    Davide Carrara
    Department of Internal Medicine, University of Pisa, Italy
    J Renin Angiotensin Aldosterone Syst 15:82-7. 2014
    ..Renin-angiotensin system (RAS) suppression may be one of the mechanisms involved. However, there are no interventional prospective studies demonstrating a reduction in circulating RAS components after vitamin D treatment...
  49. ncbi request reprint P2X7 receptor polymorphisms do not influence endothelial function and vascular tone in neo-diagnosed, treatment-naive essential hypertensive patients
    Lorenzo Ghiadoni
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    J Hypertens 31:2362-9. 2013
    ..This study evaluated the effects of P2X7R gene polymorphisms (single nucleotide polymorphisms, SNPs) on a detailed vascular hypertensive phenotype...
  50. ncbi request reprint Therapeutic implications of recent megatrials: in favor of old drugs
    Antonio Salvetti
    Department of Internal Medicine, University of Pisa, Pisa Italy
    J Nephrol 20:S4-S11. 2007
    ....
  51. ncbi request reprint Central blood pressure, arterial stiffness, and wave reflection: new targets of treatment in essential hypertension
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Curr Hypertens Rep 11:190-6. 2009
    ..Thus, whether these measurements should be routinely performed as a diagnostic or therapeutic indicator remains debatable...
  52. ncbi request reprint Renal vasodilating capacity and endothelial function are impaired in patients with obstructive sleep apnea syndrome and no traditional cardiovascular risk factors
    Rosa M Bruno
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    J Hypertens 31:1456-64; discussion 1464. 2013
    ..Aim of the study was to investigate whether vascular dysfunction is a feature of obstructive sleep apnea syndrome per se or instead related to the presence of traditional cardiovascular risk factors...
  53. ncbi request reprint Device-based therapies for resistant hypertension
    Rosa Maria Bruno
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Curr Pharm Des 19:2401-8. 2013
    ..Present limitations and future perspectives were also considered...
  54. doi request reprint Assessment of carotid elasticity during exercise: a reproducibility study
    Elisabetta Bianchini
    Institute of Clinical Physiology, CNR, Pisa, Italy
    Ultrasound Med Biol 38:223-30. 2012
    ..When designing future studies, acquisitions during first recovery minute might be preferred to peak measures...
  55. doi request reprint Comparison of two automatic methods for the assessment of brachial artery flow-mediated dilation
    Francesco Faita
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    J Hypertens 29:85-90. 2011
    ..The aim of this study is to compare our system with another automatic method (Brachial Analyzer, MIA LLC, IA, USA) which is currently considered as a reference method in FMD assessment...
  56. doi request reprint Effects of antihypertensive treatment on endothelial function
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Curr Hypertens Rep 13:276-81. 2011
    ..Large-scale clinical trials are required to definitively demonstrate that treatment of endothelial dysfunction can improve the prognosis of patients with essential hypertension...
  57. ncbi request reprint Which endothelium-derived factors are really important in humans?
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, I 56100 Pisa, Italy
    Biol Chem 387:151-7. 2006
    ..Further studies are needed in the future to assess the specific impact of different endothelial responses on the clinical outcome in patients with cardiovascular risk factors and disease...
  58. ncbi request reprint Ultrasound measurement of the brachial artery flow-mediated dilation without ECG gating
    Vincenzo Gemignani
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Ultrasound Med Biol 34:385-91. 2008
    ..Further advantages were also found both in terms of reliability of the measure and simplification of the instrumentation. (E-mail: gemi@ifc.cnr.it)...
  59. ncbi request reprint Effects of antihypertensive drugs on endothelial dysfunction: clinical implications
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Drugs 62:265-84. 2002
    ..In the near future, large scale clinical trials are required to demonstrate that treatment of endothelial dysfunction can lead to better prognosis in patients with essential hypertension...
  60. ncbi request reprint [Clinical significance of the assessment of endothelial function]
    Stefano Taddei
    Dipartimento di Medicina Interna, Universita degli Studi, Pisa
    Ital Heart J Suppl 5:357-65. 2004
    ....
  61. ncbi request reprint Combination of lisinopril and nifedipine GITS increases blood pressure control compared with single drugs in essential hypertensive patients
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Cardiovasc Pharmacol 41:579-85. 2003
    ....
  62. ncbi request reprint Endothelial function in hypertension: role of gender
    Agostino Virdis
    Department of Internal Medicine, Hypertension Unit, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    J Hypertens Suppl 20:S11-6. 2002
    ..Finally, whether endogenous androgen can impair endothelial function is still an unsolved issue since data concerning the effect of testosterone on endothelial function are scanty and contradictory...
  63. ncbi request reprint Thiazide diuretics in the treatment of hypertension: an update
    Antonio Salvetti
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56127 Pisa, Italy
    J Am Soc Nephrol 17:S25-9. 2006
    ....
  64. ncbi request reprint Guidelines for antihypertensive treatment: an update after the ALLHAT study
    Antonio Salvetti
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Soc Nephrol 15:S51-4. 2004
    ....
  65. ncbi request reprint Interleukin-8 is a powerful prognostic predictor of all-cause and cardiovascular mortality in dialytic patients
    Vincenzo Panichi
    Internal Medicine, University of Pisa, Pisa, Italy
    Nephron Clin Pract 102:c51-8. 2006
    ..Interleukin-8 (IL-8) appears to be not only the plasma expression of the acute-phase response but also a direct pathogenetic mediator of the atherosclerotic process...
  66. doi request reprint The correct administration of antihypertensive drugs according to the principles of clinical pharmacology
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Cardiovasc Drugs 11:13-20. 2011
    ....
  67. doi request reprint Patients with antiphospholipid syndrome display endothelial perturbation
    Massimo Cugno
    Department of Internal Medicine, University of Milan, IRCCS Foundation Maggiore Hospital Policlinico, Mangiagalli, Regina Elena, Italy
    J Autoimmun 34:105-10. 2010
    ..The aim of this observational case-control study was to evaluate several parameters of endothelial perturbation in patients with APS and without any other atherosclerosis risk factor...
  68. ncbi request reprint [Resistant hypertension: a case report]
    Rosa Maria Bruno
    Dipartimento di Medicina Interna, Ospedale Santa Chiara, Universita, Pisa
    Recenti Prog Med 101:35-8. 2010
    ..Blood pressure values remained elevated in spite of spironolactone therapy and surrenectomy, possibly because of renal insufficiency and vascular damage subsequent to long-term uncontrolled hypertension...
  69. ncbi request reprint Cardiovascular parameter changes in patients with erectile dysfunction using pde-5 inhibitors: a study with sildenafil and vardenafil
    Giorgio Pomara
    Department of Urology, Pisa University, Pisa, Italy
    J Androl 25:625-9. 2004
    ..Moreover, it is necessary to pay particular attention to those patients in treatment with other drugs that could have a synergistic hypotensive effect as a result of vasodilation potentiation...
  70. ncbi request reprint Effect of a soy protein diet on serum lipids of renal transplant patients
    Adamasco Cupisti
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Ren Nutr 14:31-5. 2004
    ..The aim of the present study was to evaluate the effect of a soy-protein diet on plasma lipid levels of renal transplant recipients with moderate hypercholesterolemia...
  71. ncbi request reprint [Obesity and endothelial dysfunction]
    Stefano Taddei
    Prof Stefano Taddei Dipartimento di Medicina Interna, Universita degli Studi, Via Roma, 67 56100 Pisa
    G Ital Cardiol (Rome) 7:715-23. 2006
    ..At present, whether an improvement of endothelial dysfunction secondary to weight loss is significantly associated with a better cardiovascular prognosis is still unknown. (G Ital Cardiol 2006; 7 (11): 715-723)..
  72. doi request reprint Assessment of flow-mediated dilation reproducibility: a nationwide multicenter study
    Lorenzo Ghiadoni
    Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 30:1399-405. 2012
    ..The aim of this study was to evaluate impact of methodological standardization among different investigation sites on brachial artery FMD reproducibility...
  73. ncbi request reprint Markers of arrhythmogenic risk in hypertensive subjects
    Andrea Barison
    Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Curr Pharm Des 17:3062-73. 2011
    ....
  74. doi request reprint Coronary flow reserve in idiopathic dilated cardiomyopathy: relation with left ventricular wall stress, natriuretic peptides, and endothelial dysfunction
    Frank Lloyd Dini
    Unità Malattie Cardiovascolari 2, Santa Chiara Hospital, Pisa, Italy
    J Am Soc Echocardiogr 22:354-60. 2009
    ....
  75. ncbi request reprint Hyperhomocyst(e)inemia: is this a novel risk factor in hypertension?
    Agostino Virdis
    Department of Internal Medicine University of Pisa, Italy
    J Nephrol 15:414-21. 2002
    ....
  76. doi request reprint Anthropometric and dietary determinants of blood pressure in over 7000 Mediterranean women: the European Prospective Investigation into Cancer and Nutrition-Florence cohort
    Giovanna Masala
    Molecular and Nutritional Epidemiology Unit, ISPO, Florence, Italy
    J Hypertens 26:2112-20. 2008
    ..Anthropometric characteristics and dietary habits are widely recognized to influence blood pressure. We evaluated their role in a large series of Mediterranean adult women...
  77. ncbi request reprint The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4 University Hospital, University of Padua, Via Giustiniani 2, 35126 Padua, Italy
    J Am Coll Cardiol 41:938-45. 2003
    ..We sought to investigate whether two polymorphisms located in the promoter (T(-786)C) and exon 7 (Glu298Asp) of the endothelial nitric oxide (NO) synthase (eNOS) gene affected agonists-mediated NO release...
  78. ncbi request reprint High-frequency ultrasonographic imaging of the endothelium-dependent flow-mediated dilatation (FMD) in a brachial artery: normative ranges in a group of low CV risk subjects of different ages
    Ligita Ryliskyte
    Clinic of Heart Diseases, Vilnius University, Klinikos, Lithuania
    Proc West Pharmacol Soc 47:67-8. 2004
    ..Data about the impact of age on FMD are also available in the literature. However, this is the first attempt to classify normal values into groups according to age and diameter...
  79. ncbi request reprint Long life to olive oil and wine! Long life with olive oil and wine?
    Daniele Versari
    J Hypertens 26:186-7. 2008
  80. ncbi request reprint Aging and hypertension: what about the endothelium?
    Lorenzo Ghiadoni
    J Hypertens 24:1243-4. 2006
  81. ncbi request reprint Tissue kallikrein gene polymorphisms induce no change in endothelium-dependent or independent vasodilation in hypertensive and normotensive subjects
    Gian Paolo Rossi
    DMCS Internal Medicine 4, University of Padova, Padova, Italy
    J Hypertens 24:1955-63. 2006
    ....
  82. ncbi request reprint A system for real-time measurement of the brachial artery diameter in B-mode ultrasound images
    Vincenzo Gemignani
    Institute of Clinical Physiology, National Research Council, Pisa, 56124 Italy
    IEEE Trans Med Imaging 26:393-404. 2007
    ..The system was tested both on synthetic ultrasound images and in clinical studies of flow-mediated dilation. Accuracy, robustness, and intra/inter observer variability of the method were evaluated...
  83. ncbi request reprint Characterization and quantification of soy isoflavone metabolites in serum of renal transplanted patients by high-performance liquid chromatography/electrospray ionization mass spectrometry
    Daniela Locati
    Department of Agri Food Molecular Sciences, Laboratory of Food Chemistry and Mass Spectrometry, University of Milan, Via Celoria 2, 20133 Milan, Italy
    Rapid Commun Mass Spectrom 19:3473-81. 2005
    ..6% and 4.8% at the maximum concentration. On the basis of the results obtained in the dietary intervention study, it was possible to split the patients into five groups characterized by different metabolic pathways...
  84. ncbi request reprint Phosphodiesterase 5 inhibition to treat essential hypertension: is this the beginning of the story?
    Stefano Taddei
    Hypertension 48:546-8. 2006