L Ghiadoni

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi Effect of acute blood pressure reduction on endothelial function in the brachial artery of patients with essential hypertension
    L Ghiadoni
    Department of Internal Medicine, University of Pisa, Italy
    J Hypertens 19:547-51. 2001
  2. ncbi Clinical and methodological aspects of endothelial function in patients with systemic autoimmune diseases
    L Ghiadoni
    Hypertension Unit, Department of Internal Medicine, University of Pisa, Italy
    Clin Exp Rheumatol 26:680-7. 2008
  3. ncbi Different effect of antihypertensive drugs on conduit artery endothelial function
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 41:1281-6. 2003
  4. ncbi Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Circulation 101:2896-901. 2000
  5. ncbi Mechanisms responsible for endothelial dysfunction induced by fasting hyperhomocystinemia in normotensive subjects and patients with essential hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Coll Cardiol 38:1106-15. 2001
  6. ncbi Vasodilation to bradykinin is mediated by an ouabain-sensitive pathway as a compensatory mechanism for impaired nitric oxide availability in essential hypertensive patients
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    Circulation 100:1400-5. 1999
  7. ncbi Age-related reduction of NO availability and oxidative stress in humans
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 38:274-9. 2001
  8. ncbi Effect of verapamil, trandolapril and their combination on vascular function and structure in essential hypertensive patients
    D Versari
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Atherosclerosis 205:214-20. 2009
  9. ncbi Effects of angiotensin converting enzyme inhibition on endothelium-dependent vasodilatation in essential hypertensive patients
    S Taddei
    I Clinica Medica, University of Pisa, Italy
    J Hypertens 16:447-56. 1998
  10. ncbi Obesity in the childhood: a link to adult hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Italy
    Curr Pharm Des 15:1063-71. 2009

Collaborators

Detail Information

Publications77

  1. ncbi Effect of acute blood pressure reduction on endothelial function in the brachial artery of patients with essential hypertension
    L Ghiadoni
    Department of Internal Medicine, University of Pisa, Italy
    J Hypertens 19:547-51. 2001
    ..To evaluate the effect of acute blood pressure reduction on endothelium-dependent vasodilation in the peripheral circulation of essential hypertensive patients...
  2. ncbi Clinical and methodological aspects of endothelial function in patients with systemic autoimmune diseases
    L Ghiadoni
    Hypertension Unit, Department of Internal Medicine, University of Pisa, Italy
    Clin Exp Rheumatol 26:680-7. 2008
    ..No single test currently available is specific for the vascular district tested or the risk factor/diseases considered, and a panel of several tests is therefore needed to characterize the multiple aspects of endothelial biology...
  3. ncbi Different effect of antihypertensive drugs on conduit artery endothelial function
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 41:1281-6. 2003
    ..In patients with essential hypertension, ACE inhibitors appear to be the only compounds able to improve conduit artery endothelium-dependent vasodilation...
  4. ncbi Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Circulation 101:2896-901. 2000
    ..Since exercise can improve endothelium-dependent vasodilation, in the present study we tested whether long-term physical activity could prevent aging-related endothelial dysfunction...
  5. ncbi Mechanisms responsible for endothelial dysfunction induced by fasting hyperhomocystinemia in normotensive subjects and patients with essential hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Coll Cardiol 38:1106-15. 2001
    ..We sought to evaluate whether fasting hyperhomocystinemia reduces endothelial function by oxidative stress in normotensive subjects and hypertensive patients...
  6. ncbi Vasodilation to bradykinin is mediated by an ouabain-sensitive pathway as a compensatory mechanism for impaired nitric oxide availability in essential hypertensive patients
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    Circulation 100:1400-5. 1999
    ..The present study was designed to identify the mechanism(s) responsible for NO-independent vasodilation to bradykinin in patients with essential hypertension...
  7. ncbi Age-related reduction of NO availability and oxidative stress in humans
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 38:274-9. 2001
    ..These alterations are similar but anticipated in hypertensive patients compared with normotensive subjects...
  8. ncbi Effect of verapamil, trandolapril and their combination on vascular function and structure in essential hypertensive patients
    D Versari
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Atherosclerosis 205:214-20. 2009
    ..The aim of the present study is to evaluate the effect of treatment with verapamil, trandolapril and their combination on peripheral microcirculation vasoreactivity...
  9. ncbi Effects of angiotensin converting enzyme inhibition on endothelium-dependent vasodilatation in essential hypertensive patients
    S Taddei
    I Clinica Medica, University of Pisa, Italy
    J Hypertens 16:447-56. 1998
    ..Essential hypertension is characterized by an impairment of endothelium-dependent vasodilatation...
  10. ncbi Obesity in the childhood: a link to adult hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Italy
    Curr Pharm Des 15:1063-71. 2009
    ....
  11. ncbi Endothelial function in young subjects with vaso-vagal syncope
    F Galetta
    Department of Internal Medicine, University of Pisa, Via Roma 67, Pisa, Italy
    Biomed Pharmacother 60:448-52. 2006
    ..The aim of this study was to determine whether endothelial function and inappropriate peripheral vasomotion have a significant role in the pathogenesis of neurally mediated syncope...
  12. ncbi Endothelial dysfunction in hypertension
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    J Cardiovasc Pharmacol 38:S11-4. 2001
    ..This alteration in the NO pathway could be the main mechanism through which a dysfunctional endothelium could be a promoter of atherosclerosis and thrombosis and therefore lead to cardiovascular events in essential hypertensive patients...
  13. ncbi Effect of calcium antagonist or beta blockade treatment on nitric oxide-dependent vasodilation and oxidative stress in essential hypertensive patients
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    J Hypertens 19:1379-86. 2001
    ..Since calcium antagonists can improve endothelial function in hypertensive patients, we tested whether this beneficial effect could be related to restoration of NO availability by antioxidant activity...
  14. ncbi Dynamic evaluation of renal resistive index in normoalbuminuric patients with newly diagnosed hypertension or type 2 diabetes
    R M Bruno
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Diabetologia 54:2430-9. 2011
    ....
  15. ncbi Role of endothelin in the control of peripheral vascular tone in human hypertension
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Heart Fail Rev 6:277-85. 2001
    ..Therefore endothelin-1 could potentially be involved in the pathogenesis of essential hypertension or of its complications, and blockade of this system is a fascinating new target for therapeutic intervention in this disease...
  16. ncbi Endothelial dysfunction and vascular disease in later life
    A Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Maturitas 67:20-4. 2010
    ..Regular physical training is an important non-pharmacological intervention which protects the vascular endothelium from ageing-related alterations and ameliorates the cardiovascular risk profile among the elderly population...
  17. ncbi Endothelial function assessment in complicated hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Pharm Des 14:1761-70. 2008
    ....
  18. ncbi Presence of cardiovascular structural changes in essential hypertensive patients with coronary microvascular disease and effects of long-term treatment
    A Virdis
    I Clinica Medica, University of Pisa, Italy
    Am J Hypertens 9:361-9. 1996
    ..Our results also indicate that both cardiac and forearm vascular abnormalities can be reversed by antihypertensive treatment with an ACE inhibitor...
  19. ncbi Hypertension in the elderly: an evidence-based review
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Pharm Des 17:3020-31. 2011
    ..However the HYVET study suggests that a goal of 150/90 mmHg can be reasonable in patients aged 80 years or more. Drug treatment should be titrated with particular caution to adverse responses and excessive blood pressure lowering...
  20. ncbi Soluble E-selectin in essential hypertension: a correlate of vascular structural changes
    R De Caterina
    CNR Institute of Clinical Physiology, University of Pisa, Italy
    Am J Hypertens 14:259-66. 2001
    ..We evaluated plasma soluble (s) E-selectin to assess its relationship with endothelium-dependent and endothelium-independent vasodilation in patients with hypertension...
  21. ncbi Ambulatory blood pressure monitoring and endothelium-dependent vasodilation in the elderly athletes
    F Galetta
    Department of Internal Medicine, University of Pisa, Via Roma 67, Pisa, Italy
    Biomed Pharmacother 60:443-7. 2006
    ..Aim of the present study was to evaluate in elderly athletes the effect of regular aerobic exercise on arterial blood pressure (BP) and on endothelium-dependent flow-mediated dilation (FMD) of the brachial artery...
  22. ncbi High serum levels of CXC (CXCL10) and CC (CCL2) chemokines in untreated essential hypertension
    A Antonelli
    Department of Internal Medicine, Metabolism Unit, University of Pisa School of Medicine, Pisa, Italy
    Int J Immunopathol Pharmacol 25:387-95. 2012
    ..In conclusion, this study demonstrates increased circulating levels of the prototype chemokines CXCL10 and CCL2 in patients with hypertension...
  23. ncbi Endothelial dysfunction in hypertension
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    J Nephrol 13:205-10. 2000
    ..This alteration in the NO pathway could be the main mechanism through which a dysfunctional endothelium could be a promoter of atherosclerosis and thrombosis in essential hypertension...
  24. ncbi Cigarette smoking and hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 6756100 Pisa, Italy
    Curr Pharm Des 16:2518-25. 2010
    ..Hypertensive smokers are more likely to develop severe forms of hypertension, including malignant and renovascular hypertension, an effect likely due to an accelerated atherosclerosis...
  25. ncbi C-reactive protein and hypertension: is there a causal relationship?
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Pharm Des 13:1693-8. 2007
    ..Without such crucial information, at the present time the causal connection between inflammation and blood pressure, although regarded as an intriguing possibility, remains undiscovered...
  26. ncbi Exclusion of the ACE D/I gene polymorphism as a determinant of endothelial dysfunction
    G P Rossi
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    Hypertension 37:293-300. 2001
    ....
  27. ncbi The role of endothelium in human hypertension
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    Curr Opin Nephrol Hypertens 7:203-9. 1998
    ..Available evidence indicates that different classes of antihypertensive compounds have different effects on endothelial dysfunction...
  28. ncbi Mechanisms of endothelial dysfunction: clinical significance and preventive non-pharmacological therapeutic strategies
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    Curr Pharm Des 9:2385-402. 2003
    ..It is worth noting that most of non-pharmacological measures act by preventing or reducing oxidative stress...
  29. ncbi Automatic evaluation of arterial diameter variation from vascular echographic images
    F Beux
    Scuola Normale Superiore di Pisa, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Ultrasound Med Biol 27:1621-9. 2001
    ..It thus represents a valuable tool for assessment of endothelium-dependent vasodilation, especially in large, multicentric clinical trials...
  30. ncbi Type 2 diabetes mellitus worsens arterial stiffness in hypertensive patients through endothelial dysfunction
    R M Bruno
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56126, Pisa, Italy
    Diabetologia 55:1847-55. 2012
    ..The aim of the study was to investigate whether endothelial function could be a determinant of arterial stiffness in essential hypertensive patients, in relation with the concomitant presence of type 2 diabetes mellitus...
  31. ncbi Is Hyperhomocyst(e)inemia a humoral predictor of coronary heart disease?
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Pharm Des 11:2187-97. 2005
    ....
  32. ncbi Restoration of nitric oxide availability after calcium antagonist treatment in essential hypertension
    S Taddei
    Department of Internal Medicine, University of Pisa Italy
    Hypertension 37:943-8. 2001
    ..These results indicate that nifedipine increases endothelium-dependent vasodilation by restoring NO availability, an effect probably determined by antioxidant activity...
  33. ncbi Ultrasound measurement of the brachial artery flow-mediated dilation without ECG gating
    Vincenzo Gemignani
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Ultrasound Med Biol 34:385-91. 2008
    ..Further advantages were also found both in terms of reliability of the measure and simplification of the instrumentation. (E-mail: gemi@ifc.cnr.it)...
  34. ncbi Endothelial function in hypertension: role of gender
    Agostino Virdis
    Department of Internal Medicine, Hypertension Unit, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    J Hypertens Suppl 20:S11-6. 2002
    ..Finally, whether endogenous androgen can impair endothelial function is still an unsolved issue since data concerning the effect of testosterone on endothelial function are scanty and contradictory...
  35. ncbi Nitric oxide modulates tissue plasminogen activator release in normotensive subjects and hypertensive patients
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 49:878-84. 2007
    ....
  36. ncbi [Obesity and endothelial dysfunction]
    Stefano Taddei
    Prof Stefano Taddei Dipartimento di Medicina Interna, Universita degli Studi, Via Roma, 67 56100 Pisa
    G Ital Cardiol (Rome) 7:715-23. 2006
    ..At present, whether an improvement of endothelial dysfunction secondary to weight loss is significantly associated with a better cardiovascular prognosis is still unknown. (G Ital Cardiol 2006; 7 (11): 715-723)..
  37. ncbi Ramipril dose-dependently increases nitric oxide availability in the radial artery of essential hypertension patients
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 25:361-6. 2007
    ..Plasma angiotensin II and oxidative stress markers were also assessed...
  38. ncbi Soy protein diet improves endothelial dysfunction in renal transplant patients
    Adamasco Cupisti
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Nephrol Dial Transplant 22:229-34. 2007
    ....
  39. ncbi Therapeutic implications of recent megatrials: in favor of old drugs
    Antonio Salvetti
    Department of Internal Medicine, University of Pisa, Pisa Italy
    J Nephrol 20:S4-S11. 2007
    ....
  40. ncbi Metabolic syndrome and vascular alterations in normotensive subjects at risk of diabetes mellitus
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 51:440-5. 2008
    ..60, confidence limits: 1.01 to 12.78). In conclusion, in normotensive subjects at risk of developing diabetes mellitus, the presence of MS is associated with a selective alteration of central PWV...
  41. ncbi Long life to olive oil and wine! Long life with olive oil and wine?
    Daniele Versari
    J Hypertens 26:186-7. 2008
  42. ncbi Phosphodiesterase 5 inhibition in essential hypertension
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Curr Hypertens Rep 10:52-7. 2008
    ..Studies on safety during long-term administration, interactions with antihypertensive and nonantihypertensive drugs, and effect on target organ damage are needed...
  43. ncbi Peripheral wave reflection and endothelial function in untreated essential hypertensive patients with and without the metabolic syndrome
    Yvonne Plantinga
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 26:1216-22. 2008
    ..We evaluated whether metabolic syndrome is associated with early vascular alterations, such as increased peripheral wave reflections and endothelial dysfunction, in untreated essential hypertensive patients...
  44. ncbi Change in forearm reactive hyperemia after telmisartan: an endothelial effect?
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 20:1312-3. 2007
  45. ncbi Vascular reactivity in congenital hypogonadal men before and after testosterone replacement therapy
    Giampaolo Bernini
    Department of Internal Medicine, Pisa University, Italy
    J Clin Endocrinol Metab 91:1691-7. 2006
    ..The contribution of endogenous testosterone (TS) in the functional integrity of peripheral circulation in men was studied...
  46. ncbi Anthropometric and dietary determinants of blood pressure in over 7000 Mediterranean women: the European Prospective Investigation into Cancer and Nutrition-Florence cohort
    Giovanna Masala
    Molecular and Nutritional Epidemiology Unit, ISPO, Florence, Italy
    J Hypertens 26:2112-20. 2008
    ..Anthropometric characteristics and dietary habits are widely recognized to influence blood pressure. We evaluated their role in a large series of Mediterranean adult women...
  47. ncbi Effects of antihypertensive drugs on endothelial dysfunction: clinical implications
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Drugs 62:265-84. 2002
    ..In the near future, large scale clinical trials are required to demonstrate that treatment of endothelial dysfunction can lead to better prognosis in patients with essential hypertension...
  48. ncbi Tissue-type plasminogen activator release in healthy subjects and hypertensive patients: relationship with beta-adrenergic receptors and the nitric oxide pathway
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 52:314-21. 2008
    ..This impaired fibrinolytic activity might contribute to the increased cardiovascular risk associated with hypertension...
  49. ncbi Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma, 67 56100 Pisa, Italy
    J Clin Endocrinol Metab 91:5076-82. 2006
    ..The objective of this study was to assess whether low-grade systemic inflammation might contribute to the pathogenesis of endothelial dysfunction in patients with subclinical hypothyroidism (sHT) and autoimmune thyroiditis...
  50. ncbi Combination of lisinopril and nifedipine GITS increases blood pressure control compared with single drugs in essential hypertensive patients
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Cardiovasc Pharmacol 41:579-85. 2003
    ....
  51. ncbi The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4 University Hospital, University of Padua, Via Giustiniani 2, 35126 Padua, Italy
    J Am Coll Cardiol 41:938-45. 2003
    ..We sought to investigate whether two polymorphisms located in the promoter (T(-786)C) and exon 7 (Glu298Asp) of the endothelial nitric oxide (NO) synthase (eNOS) gene affected agonists-mediated NO release...
  52. ncbi Carotid vascular remodeling in patients with pheochromocytoma
    Giampaolo Bernini
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    J Clin Endocrinol Metab 91:1754-60. 2006
    ..The influence of catecholamines on vascular remodeling in humans was investigated...
  53. ncbi Effect of a soy protein diet on serum lipids of renal transplant patients
    Adamasco Cupisti
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Ren Nutr 14:31-5. 2004
    ..The aim of the present study was to evaluate the effect of a soy-protein diet on plasma lipid levels of renal transplant recipients with moderate hypercholesterolemia...
  54. ncbi Interleukin-8 is a powerful prognostic predictor of all-cause and cardiovascular mortality in dialytic patients
    Vincenzo Panichi
    Internal Medicine, University of Pisa, Pisa, Italy
    Nephron Clin Pract 102:c51-8. 2006
    ..Interleukin-8 (IL-8) appears to be not only the plasma expression of the acute-phase response but also a direct pathogenetic mediator of the atherosclerotic process...
  55. ncbi Endothelium-dependent vasodilation and carotid artery wall remodeling in athletes and sedentary subjects
    Fabio Galetta
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56126, Pisa, Italy
    Atherosclerosis 186:184-92. 2006
    ..56, p<0.0001). In conclusion, regular physical training can attenuate the age-related impairment of endothelium-dependent vasodilation, which is related to an attenuation of the age-induced remodeling of the carotid wall...
  56. ncbi [Clinical significance of the assessment of endothelial function]
    Stefano Taddei
    Dipartimento di Medicina Interna, Universita degli Studi, Pisa
    Ital Heart J Suppl 5:357-65. 2004
    ....
  57. ncbi Physical activity, plasma antioxidant capacity, and endothelium-dependent vasodilation in young and older men
    Ferdinando Franzoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 18:510-6. 2005
    ..The aim of this study was to evaluate the relationship between long-term physical activity, plasma antioxidant status, and conduit artery endothelial function in young and older healthy men...
  58. ncbi High-frequency ultrasonographic imaging of the endothelium-dependent flow-mediated dilatation (FMD) in a brachial artery: normative ranges in a group of low CV risk subjects of different ages
    Ligita Ryliskyte
    Clinic of Heart Diseases, Vilnius University, Klinikos, Lithuania
    Proc West Pharmacol Soc 47:67-8. 2004
    ..Data about the impact of age on FMD are also available in the literature. However, this is the first attempt to classify normal values into groups according to age and diameter...
  59. ncbi Endothelial dysfunction and oxidative stress in chronic renal failure
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Nephrol 17:512-9. 2004
    ..HD patients showed a more marked alteration, which seems to be related, at least in part, to increased oxidative stress...
  60. ncbi Which endothelium-derived factors are really important in humans?
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, I 56100 Pisa, Italy
    Biol Chem 387:151-7. 2006
    ..Further studies are needed in the future to assess the specific impact of different endothelial responses on the clinical outcome in patients with cardiovascular risk factors and disease...
  61. ncbi Thiazide diuretics in the treatment of hypertension: an update
    Antonio Salvetti
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56127 Pisa, Italy
    J Am Soc Nephrol 17:S25-9. 2006
    ....
  62. ncbi Current treatment of patients with hypertension: therapeutic implications of INSIGHT
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Drugs 63:1435-44. 2003
    ..The clinical significance of this effect in the prevention of cardiovascular events still remains to be established...
  63. ncbi Hyperhomocyst(e)inemia: is this a novel risk factor in hypertension?
    Agostino Virdis
    Department of Internal Medicine University of Pisa, Italy
    J Nephrol 15:414-21. 2002
    ....
  64. ncbi Calcium antagonist treatment by lercanidipine prevents hyperpolarization in essential hypertension
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 41:950-5. 2003
    ..These results indicate that in essential hypertension, lercanidipine increases endothelium-dependent vasodilation by restoring NO availability and preventing hyperpolarization, an effect probably determined by antioxidant activity...
  65. ncbi Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Coll Cardiol 48:508-15. 2006
    ....
  66. ncbi Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy
    J Clin Endocrinol Metab 88:3731-7. 2003
    ..Patients with sHT are characterized by endothelial dysfunction resulting from a reduction in NO availability, an alteration partially independent of dyslipidemia and reversed by levothyroxine supplementation...
  67. ncbi Guidelines for antihypertensive treatment: an update after the ALLHAT study
    Antonio Salvetti
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Soc Nephrol 15:S51-4. 2004
    ....
  68. ncbi Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients
    Yvonne Plantinga
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 20:392-7. 2007
    ..We evaluated the effect of short-term combined treatment with the antioxidants vitamins C and E on endothelial function, arterial stiffness, and oxidative stress in untreated essential hypertensive patients...
  69. ncbi Aging and hypertension: what about the endothelium?
    Lorenzo Ghiadoni
    J Hypertens 24:1243-4. 2006
  70. ncbi Endothelium, aging, and hypertension
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Curr Hypertens Rep 8:84-9. 2006
    ..Currently, dynamic physical activity represents the only effective intervention in preventing age-related impaired endothelium-dependent vasodilation in aged healthy individuals...
  71. ncbi Tissue kallikrein gene polymorphisms induce no change in endothelium-dependent or independent vasodilation in hypertensive and normotensive subjects
    Gian Paolo Rossi
    DMCS Internal Medicine 4, University of Padova, Padova, Italy
    J Hypertens 24:1955-63. 2006
    ....
  72. ncbi Real-time measurement system for evaluation of the carotid intima-media thickness with a robust edge operator
    Francesco Faita
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    J Ultrasound Med 27:1353-61. 2008
    ....
  73. ncbi Characterization and quantification of soy isoflavone metabolites in serum of renal transplanted patients by high-performance liquid chromatography/electrospray ionization mass spectrometry
    Daniela Locati
    Department of Agri Food Molecular Sciences, Laboratory of Food Chemistry and Mass Spectrometry, University of Milan, Via Celoria 2, 20133 Milan, Italy
    Rapid Commun Mass Spectrom 19:3473-81. 2005
    ..6% and 4.8% at the maximum concentration. On the basis of the results obtained in the dietary intervention study, it was possible to split the patients into five groups characterized by different metabolic pathways...
  74. ncbi Recombinant human thyrotropin reduces endothelium-dependent vasodilation in patients monitored for differentiated thyroid carcinoma
    Angela Dardano
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    J Clin Endocrinol Metab 91:4175-8. 2006
    ..01). CONCLUSIONS: rhTSH administration acutely impaired endothelium-dependent vasodilation, possibly through the induction of low-grade inflammation and reduced nitric oxide availability by oxidative stress...
  75. ncbi A system for real-time measurement of the brachial artery diameter in B-mode ultrasound images
    Vincenzo Gemignani
    Institute of Clinical Physiology, National Research Council, Pisa, 56124 Italy
    IEEE Trans Med Imaging 26:393-404. 2007
    ..The system was tested both on synthetic ultrasound images and in clinical studies of flow-mediated dilation. Accuracy, robustness, and intra/inter observer variability of the method were evaluated...
  76. ncbi Cardiovascular parameter changes in patients with erectile dysfunction using pde-5 inhibitors: a study with sildenafil and vardenafil
    Giorgio Pomara
    Department of Urology, Pisa University, Pisa, Italy
    J Androl 25:625-9. 2004
    ..quot; Moreover, it is necessary to pay particular attention to those patients in treatment with other drugs that could have a synergistic hypotensive effect as a result of vasodilation potentiation...
  77. ncbi Phosphodiesterase 5 inhibition to treat essential hypertension: is this the beginning of the story?
    Stefano Taddei
    Hypertension 48:546-8. 2006