Paolo Ghia

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi request reprint Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly
    Paolo Ghia
    Istituto per la Ricerca e la Cura del Cancro, Candiolo, Italy
    Blood 103:2337-42. 2004
  2. ncbi request reprint Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene
    Paolo Ghia
    Department of Oncological Sciences, University of Torino, Italy
    Blood 105:1678-85. 2005
  3. ncbi request reprint The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression
    Paolo Ghia
    Department of Oncological Sciences, University of Torino, Italy
    Blood 101:1262-9. 2003
  4. ncbi request reprint CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes
    Luisa Granziero
    Department of Oncological Sciences, University of Torino, Institute for Cancer Research and Treatment IRCC, Candiolo TO and Division of Clinical Immunology and Hematology, Ospedale Mauriziano Umberto I, Torino, Italy
    Blood 101:1962-9. 2003
  5. ncbi request reprint Leukemia-derived immature dendritic cells differentiate into functionally competent mature dendritic cells that efficiently stimulate T cell responses
    Alessandro Cignetti
    Laboratory of Cancer Immunology, Institute for Cancer Research and Treatment, Candiolo, Italy
    J Immunol 173:2855-65. 2004
  6. ncbi request reprint Chronic B cell malignancies and bone marrow microenvironment
    Paolo Ghia
    Department of Biomedical Sciences and Human Oncology, University of Torino, Italy
    Semin Cancer Biol 12:149-55. 2002
  7. ncbi request reprint IL-12 regulates an endothelial cell-lymphocyte network: effect on metalloproteinase-9 production
    Stefania Mitola
    Institute for Cancer Research and Treatment and Department of Oncological Sciences, University of Torino, Candiolo, Italy
    J Immunol 171:3725-33. 2003
  8. ncbi request reprint Chronic lymphocytic leukaemia: a model for investigating potential new targets for the therapy of indolent lymphomas
    Federico Caligaris-Cappio
    Department of Oncological Sciences, University of Torino, Division of Clinical Immunology and Haematology, Ospedale Mauriziano Umberto I, Torino, Italy
    Best Pract Res Clin Haematol 15:563-75. 2002
  9. ncbi request reprint Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22
    Paolo Ghia
    Department of Oncological Sciences, University of Torino, University Division of Clinical Immunology and Hematology, Ospedale Mauriziano Umberto I, Torino, Italy
    Eur J Immunol 32:1403-13. 2002
  10. ncbi request reprint Evaluation of ZAP-70 expression by flow cytometry in chronic lymphocytic leukemia: A multicentric international harmonization process
    Remi Letestu
    Service d Hematologie Biologique, Hopital Avicenne, Bobigny, France
    Cytometry B Clin Cytom 70:309-14. 2006

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly
    Paolo Ghia
    Istituto per la Ricerca e la Cura del Cancro, Candiolo, Italy
    Blood 103:2337-42. 2004
    ....
  2. ncbi request reprint Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene
    Paolo Ghia
    Department of Oncological Sciences, University of Torino, Italy
    Blood 105:1678-85. 2005
    ..The second subset may reflect the physiologic heterogeneity of expression of IGHV3-21 rearrangements in the normal repertoire and is characterized by a variable clinical outcome...
  3. ncbi request reprint The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression
    Paolo Ghia
    Department of Oncological Sciences, University of Torino, Italy
    Blood 101:1262-9. 2003
    ....
  4. ncbi request reprint CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes
    Luisa Granziero
    Department of Oncological Sciences, University of Torino, Institute for Cancer Research and Treatment IRCC, Candiolo TO and Division of Clinical Immunology and Hematology, Ospedale Mauriziano Umberto I, Torino, Italy
    Blood 101:1962-9. 2003
    ..The crosstalk operated by the CD100/Plexin-B1 interaction is not malignancy related but reproduces a mechanism used by normal CD5+ B cells...
  5. ncbi request reprint Leukemia-derived immature dendritic cells differentiate into functionally competent mature dendritic cells that efficiently stimulate T cell responses
    Alessandro Cignetti
    Laboratory of Cancer Immunology, Institute for Cancer Research and Treatment, Candiolo, Italy
    J Immunol 173:2855-65. 2004
    ..Our data indicate that acute myeloid leukemia cells can fully differentiate into functionally competent m-DC and lay the ground for testing their efficacy as a tumor vaccine...
  6. ncbi request reprint Chronic B cell malignancies and bone marrow microenvironment
    Paolo Ghia
    Department of Biomedical Sciences and Human Oncology, University of Torino, Italy
    Semin Cancer Biol 12:149-55. 2002
    ..In contrast, MM takes advantage of the actual BM microenvironment by 'instructing' it through an abnormal activation state...
  7. ncbi request reprint IL-12 regulates an endothelial cell-lymphocyte network: effect on metalloproteinase-9 production
    Stefania Mitola
    Institute for Cancer Research and Treatment and Department of Oncological Sciences, University of Torino, Candiolo, Italy
    J Immunol 171:3725-33. 2003
    ..Altogether these results suggest the existence of an IL-12-regulated circuit between endothelium and lymphocytes resulting in a shift of proteolytic homeostasis at site of tissue injury...
  8. ncbi request reprint Chronic lymphocytic leukaemia: a model for investigating potential new targets for the therapy of indolent lymphomas
    Federico Caligaris-Cappio
    Department of Oncological Sciences, University of Torino, Division of Clinical Immunology and Haematology, Ospedale Mauriziano Umberto I, Torino, Italy
    Best Pract Res Clin Haematol 15:563-75. 2002
    ..molecular pathways through which the microenvironment exerts its influence on the malignant clone? (2) What are the relationships between proliferation and defective apoptosis? (3)Is there any evidence of a role for antigenic stimulation?..
  9. ncbi request reprint Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22
    Paolo Ghia
    Department of Oncological Sciences, University of Torino, University Division of Clinical Immunology and Hematology, Ospedale Mauriziano Umberto I, Torino, Italy
    Eur J Immunol 32:1403-13. 2002
    ....
  10. ncbi request reprint Evaluation of ZAP-70 expression by flow cytometry in chronic lymphocytic leukemia: A multicentric international harmonization process
    Remi Letestu
    Service d Hematologie Biologique, Hopital Avicenne, Bobigny, France
    Cytometry B Clin Cytom 70:309-14. 2006
    ..These studies have demonstrated progress toward a consensus reporting procedure, and further work is underway to harmonize the preparation and analysis procedures...
  11. ncbi request reprint Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations
    Kostas Stamatopoulos
    Hematology Department and HCT Unit, G Papanicolaou Hospital, Thessaloniki, Greece
    Blood 109:259-70. 2007
    ..These findings suggest that a particular antigen-binding site can be critical in determining the clinical features and outcome for at least some CLL patients...
  12. ncbi request reprint The normal counterpart to the chronic lymphocytic leukemia B cell
    Federico Caligaris-Cappio
    Department of Oncology, Lymphoma Unit, Università Vita Salute San Raffaele and Istituto Scientifico San Raffaele, Via Olgettina 58, 20132 Milano, Italy
    Best Pract Res Clin Haematol 20:385-97. 2007
    ..It is the purpose of this review to discuss the features a cell must possess to be considered with reasonable approximation the normal counterpart of a CLL B cell...
  13. ncbi request reprint Age-dependent accumulation of monoclonal CD4+CD8+ double positive T lymphocytes in the peripheral blood of the elderly
    Paolo Ghia
    Laboratory and Unit of Lymphoid Malignancies, Department of Oncology, Universita Vita Salute San Raffaele, Milano and Istituto Scientifico San Raffaele, Milano, Italy
    Br J Haematol 139:780-90. 2007
    ..The similarities between DP clones and MBL in the elderly may help to better understand the mechanisms of immunosenescence and their relationships with the development of lymphoproliferative disorders...
  14. ncbi request reprint IGHV gene insertions and deletions in chronic lymphocytic leukemia: "CLL-biased" deletions in a subset of cases with stereotyped receptors
    Chrysoula J Belessi
    Hematology Department, Nikea General Hospital, Athens, Greece
    Eur J Immunol 36:1963-74. 2006
    ..This finding further supports the idea of selective antigenic pressures playing a pathogenetic role in some CLL cases...
  15. ncbi request reprint Diagnostic criteria for monoclonal B-cell lymphocytosis
    Gerald E Marti
    Center for Biologics Evaluation and Research CBER, US Food and Drug Administration FDA, NIH, Bethesda, MD, USA
    Br J Haematol 130:325-32. 2005
    ..Future studies of MBL should be directed towards determining its relationship to clinical disease, particularly in individuals from families with a genetic predisposition to developing CLL...
  16. pmc HS1 protein is differentially expressed in chronic lymphocytic leukemia patient subsets with good or poor prognoses
    Cristina Scielzo
    Department of Oncology, Universita Vita e Salute San Raffaele, Milan, Italy
    J Clin Invest 115:1644-50. 2005
    ..These data indicate a central role for antigen stimulation in CLL and suggest a new therapeutic target for patients with aggressive disease...
  17. ncbi request reprint Vdelta1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acid
    Alessandro Poggi
    Laboratory of Immunology, National Cancer Research Institute, Genoa, Italy
    Cancer Res 64:9172-9. 2004
    ..These data suggest that Vdelta1 T lymphocytes may play a role in limiting the progression of B-CLL...
  18. ncbi request reprint The characterization of chemokine production and chemokine receptor expression reveals possible functional cross-talks in AML blasts with monocytic differentiation
    Alessandro Cignetti
    University Division of Clinical Immunology and Hematology, Ospedale Mauriziano Umberto I, Turin, Italy
    Exp Hematol 31:495-503. 2003
    ..We aimed at defining the pattern of chemokine and chemokine receptor expression of acute myeloid leukemia (AML) blasts in comparison with their putative normal cell counterparts...
  19. ncbi request reprint CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells
    Herve Husson
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Br J Haematol 119:492-5. 2002
    ..The production of CXCL13 by FL cells and CXCL12 by stromal cells probably directs and participates in the accumulation of FL cells within specific anatomic sites...
  20. ncbi request reprint Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia
    Sara Maia
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 65:10050-8. 2005
    ..This study suggests that (a) BAX-delta may serve as a widely expressed TAA in B-ALL and (b) gene expression profiling can be a generalizable tool to identify immunologic targets for cancer immunotherapy...
  21. doi request reprint Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy
    Marta Muzio
    Department of Oncology, Unit and Laboratory of Lymphoid Malignancies, Università Vita Salute San Raffaele and Istituto Scientifico San Raffaele, Milan, Italy
    Blood 112:188-95. 2008
    ..CLL cases with this signature may be taken as a human model of anergic B cells aberrantly expanded...
  22. ncbi request reprint From normal to clonal B cells: Chronic lymphocytic leukemia (CLL) at the crossroad between neoplasia and autoimmunity
    Paolo Ghia
    Unit of Lymphoid Malignancies, Department of Oncology, Università Vita Salute San Raffaele and Istituto Scientifico San Raffaele, Milano, Italy
    Autoimmun Rev 7:127-31. 2007
    ..The crucial issues have become to what extent this deleterious binding capacity is central to the natural history of the disease and how it relates to the malignant transformation of the cell...
  23. ncbi request reprint Overview of monoclonal B-cell lymphocytosis
    Gerald Marti
    Center for Biologics Evaluation and Research CBER, US Food and Drug Administration FDA, NIH, Bethesda, MD, USA
    Br J Haematol 139:701-8. 2007
    ..Environmental health studies suggest that exposure to certain toxins may lead to MBL but further work is needed. MBL is a precursor to CLL but may also regress, remain stable or progress to clinical CLL...
  24. ncbi request reprint Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis
    Fiona Murray
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Blood 111:1524-33. 2008
    ..The precise targeting and distinctive features of somatic hypermutation (SHM) in selected subgroups of CLL patients provide further evidence for selection by specific antigenic element(s)...
  25. ncbi request reprint Expansion of tumor-specific CD8+ T cell clones in patients with relapsed myeloma after donor lymphocyte infusion
    Enrica Orsini
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Res 63:2561-8. 2003
    ..In contrast, T-cell clones associated with GVHD are expanded de novo after DLI...
  26. ncbi request reprint The origin of B-cell chronic lymphocytic leukemia
    Paolo Ghia
    Department of Oncology, Università Vita Salute San Raffaele and Istituto Scientifico San Raffaele, Milano, Italy
    Semin Oncol 33:150-6. 2006
    ....
  27. doi request reprint Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease?
    Federico Caligaris-Cappio
    Department of Oncology, Unit and Laboratory of Lymphoid Malignancies, Universita Vita Salute San Raffaele, Istituto Scientifico San Raffaele, Milano, Italy
    J Clin Oncol 26:4497-503. 2008
    ....