Research Topics
Species | Paolo GhiaSummaryAffiliation: University of Turin Country: Italy Publications
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Detail Information
Publications
Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderlyPaolo Ghia
Istituto per la Ricerca e la Cura del Cancro, Candiolo, Italy
Blood 103:2337-42. 2004....- Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 genePaolo Ghia
Department of Oncological Sciences, University of Torino, Italy
Blood 105:1678-85. 2005..The second subset may reflect the physiologic heterogeneity of expression of IGHV3-21 rearrangements in the normal repertoire and is characterized by a variable clinical outcome... - The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progressionPaolo Ghia
Department of Oncological Sciences, University of Torino, Italy
Blood 101:1262-9. 2003.... - CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytesLuisa Granziero
Department of Oncological Sciences, University of Torino, Institute for Cancer Research and Treatment IRCC, Candiolo TO and Division of Clinical Immunology and Hematology, Ospedale Mauriziano Umberto I, Torino, Italy
Blood 101:1962-9. 2003..The crosstalk operated by the CD100/Plexin-B1 interaction is not malignancy related but reproduces a mechanism used by normal CD5+ B cells... - Leukemia-derived immature dendritic cells differentiate into functionally competent mature dendritic cells that efficiently stimulate T cell responsesAlessandro Cignetti
Laboratory of Cancer Immunology, Institute for Cancer Research and Treatment, Candiolo, Italy
J Immunol 173:2855-65. 2004..Our data indicate that acute myeloid leukemia cells can fully differentiate into functionally competent m-DC and lay the ground for testing their efficacy as a tumor vaccine... - Chronic B cell malignancies and bone marrow microenvironmentPaolo Ghia
Department of Biomedical Sciences and Human Oncology, University of Torino, Italy
Semin Cancer Biol 12:149-55. 2002..In contrast, MM takes advantage of the actual BM microenvironment by 'instructing' it through an abnormal activation state... - IL-12 regulates an endothelial cell-lymphocyte network: effect on metalloproteinase-9 productionStefania Mitola
Institute for Cancer Research and Treatment and Department of Oncological Sciences, University of Torino, Candiolo, Italy
J Immunol 171:3725-33. 2003..Altogether these results suggest the existence of an IL-12-regulated circuit between endothelium and lymphocytes resulting in a shift of proteolytic homeostasis at site of tissue injury... - Chronic lymphocytic leukaemia: a model for investigating potential new targets for the therapy of indolent lymphomasFederico Caligaris-Cappio
Department of Oncological Sciences, University of Torino, Division of Clinical Immunology and Haematology, Ospedale Mauriziano Umberto I, Torino, Italy
Best Pract Res Clin Haematol 15:563-75. 2002..molecular pathways through which the microenvironment exerts its influence on the malignant clone? (2) What are the relationships between proliferation and defective apoptosis? (3)Is there any evidence of a role for antigenic stimulation?.. - Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22Paolo Ghia
Department of Oncological Sciences, University of Torino, University Division of Clinical Immunology and Hematology, Ospedale Mauriziano Umberto I, Torino, Italy
Eur J Immunol 32:1403-13. 2002.... - Evaluation of ZAP-70 expression by flow cytometry in chronic lymphocytic leukemia: A multicentric international harmonization processRemi Letestu
, , Bobigny, France
Cytometry B Clin Cytom 70:309-14. 2006..These studies have demonstrated progress toward a consensus reporting procedure, and further work is underway to harmonize the preparation and analysis procedures... - Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlationsKostas Stamatopoulos
Hematology Department and HCT Unit, G Papanicolaou Hospital, Thessaloniki, Greece
Blood 109:259-70. 2007..These findings suggest that a particular antigen-binding site can be critical in determining the clinical features and outcome for at least some CLL patients... - The normal counterpart to the chronic lymphocytic leukemia B cellFederico Caligaris-Cappio
Department of Oncology, Lymphoma Unit, Università Vita Salute San Raffaele and Istituto Scientifico San Raffaele, Via Olgettina 58, 20132 Milano, Italy
Best Pract Res Clin Haematol 20:385-97. 2007..It is the purpose of this review to discuss the features a cell must possess to be considered with reasonable approximation the normal counterpart of a CLL B cell... - Age-dependent accumulation of monoclonal CD4+CD8+ double positive T lymphocytes in the peripheral blood of the elderlyPaolo Ghia
Laboratory and Unit of Lymphoid Malignancies, Department of Oncology, Universita Vita Salute San Raffaele, Milano and Istituto Scientifico San Raffaele, Milano, Italy
Br J Haematol 139:780-90. 2007..The similarities between DP clones and MBL in the elderly may help to better understand the mechanisms of immunosenescence and their relationships with the development of lymphoproliferative disorders... - IGHV gene insertions and deletions in chronic lymphocytic leukemia: "CLL-biased" deletions in a subset of cases with stereotyped receptorsChrysoula J Belessi
Hematology Department, Nikea General Hospital, Athens, Greece
Eur J Immunol 36:1963-74. 2006..This finding further supports the idea of selective antigenic pressures playing a pathogenetic role in some CLL cases... - Diagnostic criteria for monoclonal B-cell lymphocytosisGerald E Marti
Center for Biologics Evaluation and Research CBER, US Food and Drug Administration FDA, NIH, Bethesda, MD, USA
Br J Haematol 130:325-32. 2005..Future studies of MBL should be directed towards determining its relationship to clinical disease, particularly in individuals from families with a genetic predisposition to developing CLL... 
HS1 protein is differentially expressed in chronic lymphocytic leukemia patient subsets with good or poor prognosesCristina Scielzo
Department of Oncology, , Milan, Italy
J Clin Invest 115:1644-50. 2005..These data indicate a central role for antigen stimulation in CLL and suggest a new therapeutic target for patients with aggressive disease...- Vdelta1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acidAlessandro Poggi
Laboratory of Immunology, National Cancer Research Institute, Genoa, Italy
Cancer Res 64:9172-9. 2004..These data suggest that Vdelta1 T lymphocytes may play a role in limiting the progression of B-CLL... - The characterization of chemokine production and chemokine receptor expression reveals possible functional cross-talks in AML blasts with monocytic differentiationAlessandro Cignetti
University Division of Clinical Immunology and Hematology, Ospedale Mauriziano Umberto I, Turin, Italy
Exp Hematol 31:495-503. 2003..We aimed at defining the pattern of chemokine and chemokine receptor expression of acute myeloid leukemia (AML) blasts in comparison with their putative normal cell counterparts... - CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cellsHerve Husson
Department of Medicine, Harvard Medical School, Boston, MA, USA
Br J Haematol 119:492-5. 2002..The production of CXCL13 by FL cells and CXCL12 by stromal cells probably directs and participates in the accumulation of FL cells within specific anatomic sites... - Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemiaSara Maia
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Cancer Res 65:10050-8. 2005..This study suggests that (a) BAX-delta may serve as a widely expressed TAA in B-ALL and (b) gene expression profiling can be a generalizable tool to identify immunologic targets for cancer immunotherapy... 
Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergyMarta Muzio
Department of Oncology, Unit and Laboratory of Lymphoid Malignancies, Università Vita Salute San Raffaele and Istituto Scientifico San Raffaele, Milan, Italy
Blood 112:188-95. 2008..CLL cases with this signature may be taken as a human model of anergic B cells aberrantly expanded...- From normal to clonal B cells: Chronic lymphocytic leukemia (CLL) at the crossroad between neoplasia and autoimmunityPaolo Ghia
Unit of Lymphoid Malignancies, Department of Oncology, Università Vita Salute San Raffaele and Istituto Scientifico San Raffaele, Milano, Italy
Autoimmun Rev 7:127-31. 2007..The crucial issues have become to what extent this deleterious binding capacity is central to the natural history of the disease and how it relates to the malignant transformation of the cell... - Overview of monoclonal B-cell lymphocytosisGerald Marti
Center for Biologics Evaluation and Research CBER, US Food and Drug Administration FDA, NIH, Bethesda, MD, USA
Br J Haematol 139:701-8. 2007..Environmental health studies suggest that exposure to certain toxins may lead to MBL but further work is needed. MBL is a precursor to CLL but may also regress, remain stable or progress to clinical CLL... - Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesisFiona Murray
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
Blood 111:1524-33. 2008..The precise targeting and distinctive features of somatic hypermutation (SHM) in selected subgroups of CLL patients provide further evidence for selection by specific antigenic element(s)... - Expansion of tumor-specific CD8+ T cell clones in patients with relapsed myeloma after donor lymphocyte infusionEnrica Orsini
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Cancer Res 63:2561-8. 2003..In contrast, T-cell clones associated with GVHD are expanded de novo after DLI... - The origin of B-cell chronic lymphocytic leukemiaPaolo Ghia
Department of Oncology, Universita Vita-Salute San Raffaele and Istituto Scientifico San Raffaele, Milano, Italy
Semin Oncol 33:150-6. 2006.... - Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease?Federico Caligaris-Cappio
Department of Oncology, Unit and Laboratory of Lymphoid Malignancies, Universita Vita Salute San Raffaele, Istituto Scientifico San Raffaele, Milano, Italy
J Clin Oncol 26:4497-503. 2008....