Research Topics
Species | L GesualdoSummaryAffiliation: University of Foggia Country: Italy Publications
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Detail Information
Publications
Predictors of bleeding complications in percutaneous ultrasound-guided renal biopsyCarlo Manno
Department of Emergency and Organ Transplantation, Division of Nephrology, University of Bari, Bari, Italy
Kidney Int 66:1570-7. 2004..However, bleeding complications still occur, resulting in increased hospital stay and treatment costs...
The Italian experience of the national registry of renal biopsiesLoreto Gesualdo
Dipartimento di Scienze Biomediche, Sezione di Nefrologia, Universita di Foggia, Italy
Kidney Int 66:890-4. 2004..The aim of this study was to report on the relative frequency of nephropathies according to gender, age at time of biopsy, clinical presentation and renal function, based on the histologic diagnosis during the years 1996 to 2000...
TRPC6 mutations in children with steroid-resistant nephrotic syndrome and atypical phenotypeMaddalena Gigante
Department of Biomedical Sciences, University of Foggia, Viale Pinto, 1, 71100 Foggia, Italy
Clin J Am Soc Nephrol 6:1626-34. 2011..To extend the screening, we analyzed TRPC6 in 33 Italian children with sporadic early-onset SRNS and three Italian families with adult-onset FSGS...
Percutaneous ultrasound-guided renal biopsy in supine antero-lateral position: a new approach for obese and non-obese patientsLoreto Gesualdo
Department of Biomedical Sciences, Nephrology, Dialysis and Transplantation Unit, University of Foggia, Viale Luigi Pinto, 1, 71100 Foggia, Italy
Nephrol Dial Transplant 23:971-6. 2008....
[Census 2004 of the Italian renal and dialysis units. Basilicata - Calabria - Puglia]L Gesualdo
S C di Nefrologia e Dialisi, Azienda Ospedaliero Universitaria OO RR di Foggia Italy
G Ital Nefrol 23:323-36. 2006..These data highlight many differences among these three South-East regions, as well as among Piemonte, Emilia Romagna and Puglia. A relevant inequality in health care structures and resources has been found and discussed...
Kidney biopsy in the elderlyAnna Maria Di Palma
University Hospital Ospedali Riuniti, Foggia, Italy
J Nephrol 23:S55-60. 2010..Our experience supported by larger studies from the United States showed that native kidney biopsy is safe and essential for diagnosis of renal disease and to direct the best therapeutic strategies in elderly patients...
[Sepsis: from pathophysiology to treatment]L Gesualdo
Dipartimento di Scienze Biomediche e BIOAGROMED, Universita di Foggia
G Ital Nefrol 23:S74-8. 2006....
[The advent of biosimilars: new rules to guarantee patient safety]L Gesualdo
Struttura Complessa di Nefrologia, Dialisi e Trapianto, Az Ospedaliero Universitaria, Foggia
G Ital Nefrol 26:161-70. 2009..Patient safety should be the fundamental principle guiding therapeutic choices, and making these choices should be the prerogative of physicians...
ID2-VEGF-related pathways in the pathogenesis of Kaposi's sarcoma: a link disrupted by rapamycinG Stallone
Department of Biomedical Sciences, Section of Nephrology, University of Foggia, Italy
Am J Transplant 9:558-66. 2009..In conclusion, our data would suggest a novel molecular mechanism for the antineoplastic effects of RAPA in posttransplant KS...
Rapamycin for treatment of chronic allograft nephropathy in renal transplant patientsGiovanni Stallone
Department of Biomedical Sciences, Division of Nephrology, University of Foggia, Foggia, Italy
J Am Soc Nephrol 16:3755-62. 2005..005). This study demonstrates that rapamycin introduction/CNI withdrawal improves graft survival and reduces interstitial and vascular alpha-SMA expression, slowing down the progression of allograft injury in patients with CAN...
Angiotensin IV stimulates plasminogen activator inhibitor-1 expression in proximal tubular epithelial cellsL Gesualdo
Dipartimento dell Emergenza e dei Trapianti di Organi, Sezione di Nefrologia, Policlinico, Bari, Italy
Kidney Int 56:461-70. 1999..PAI-1 induction by Ang II in endothelial cells seems to be mediated by Ang IV via a receptor that is different from Ang II type 1 and 2 receptors (AT1 and AT2)...
Xanthogranulomatous pyelonephritis is associated with higher tissue expression of monocyte chemotactic protein-1F Bartoli
Department of Surgical Science, Section of Pediatric Surgery, University of Foggia, Foggia, Italy
Eur J Pediatr Surg 17:365-9. 2007..It is associated with both chronic urinary obstruction and urinary tract infection (UTI)...
Rapamycin inhibits PAI-1 expression and reduces interstitial fibrosis and glomerulosclerosis in chronic allograft nephropathyPaola Pontrelli
Division of Nephrology, Department of Biomedical Sciences, University of Foggia, Foggia, Italy
Transplantation 85:125-34. 2008..The aim of the study was to evaluate the molecular mechanisms underlying the beneficial effects of rapamycin on CAN progression at glomerular and tubulointerstitial level...
Rapamycin-induced hypophosphatemia and insulin resistance are associated with mTORC2 activation and Klotho expressionT Tataranni
Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari A Moro, Italy
Am J Transplant 11:1656-64. 2011..In conclusion, our data would suggest that rapamycin may influence phosphate homeostasis and insulin resistance modulating Klotho expression through mTORC2 activation...
The ratio of epidermal growth factor to monocyte chemotactic peptide-1 in the urine predicts renal prognosis in IgA nephropathyD D Torres
Renal, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
Kidney Int 73:327-33. 2008..Our study suggests that the urinary EGF/MCP-1 ratio may be used as a prognostic marker of ESRD for patients with IgAN...
[Renal neoplasms and renal transplantation: current problems and future perspectives]G Carrieri
Struttura Complessa Universitaria di Urologia e Centro Trapianti, Policlinico Ospedali Riuniti, Foggia
G Ital Nefrol 21:547-53. 2004..However, a conservative approach with nephron sparing surgery has been reported for selected cases as a useful strategy to treat renal carcinoma in the allograft...
Translational mini-review series on vaccines: Dendritic cell-based vaccines in renal cancerE Ranieri
Clinical Pathology, Department of Biomedical Sciences, University of Foggia, Italy
Clin Exp Immunol 147:395-400. 2007..Instead, we turned our attention to how the perception and practical application of DC-based vaccinations are evolving...
Older donors and older recipients in kidney transplantationGiovanni Stallone
Department of Biomedical Sciences, University of Foggia, Italy
J Nephrol 23:S98-103. 2010....
Ischemia-reperfusion induces glomerular and tubular activation of proinflammatory and antiapoptotic pathways: differential modulation by rapamycinAntonia Loverre
Department of Nephrology, University of Foggia, Italy
J Am Soc Nephrol 15:2675-86. 2004....
Para- and perirenal fat thickness is an independent predictor of chronic kidney disease, increased renal resistance index and hyperuricaemia in type-2 diabetic patientsOlga Lamacchia
Unit of Endocrinology and Metabolic Diseases, Department of Medical Sciences and 2Unit of Nephrology, University of Foggia, Italy
Nephrol Dial Transplant 26:892-8. 2011..Therefore, we determined the independent associations of para- and perirenal ultrasonographic fat thickness with the main markers of kidney function...
Kaposi's sarcoma and mTOR: a crossroad between viral infection neoangiogenesis and immunosuppressionGiovanni Stallone
Section of Nephrology, Dialysis and Transplant, Department of Biomedical Sciences, University of Foggia, Foggia, Italy
Transpl Int 21:825-32. 2008....
Cigarette smoking and kidney dysfunction in diabetes mellitusMauro Cignarelli
Unit of Endocrinology and Metabolic Diseases, Department of Medical Sciences, University of Foggia, Foggia, Italy
J Nephrol 21:180-9. 2008..Consequently, smoking prevention and cessation programs must be strongly encouraged not only to reduce the cardiovascular risk, but also to avoid the deterioration of renal function among diabetic patients...
Management of side effects of sirolimus therapyGiovanni Stallone
Department of Biomedical Sciences, Section of Nephrology, University of Foggia, Foggia, Italy
Transplantation 87:S23-6. 2009..Thus, to limit SRL-related side effects the two golden rules are (1) accurate selection of patients to be treated and (2) avoidance of high SRL doses...
There is a choice for immunosuppressive drug nephrotoxicity: Is it time to change?Giovanni Stallone
Department of Biomedical Sciences, Section of Nephrology, Dialysis and Transplant, University of Foggia, Foggia Italy
J Nephrol 22:326-32. 2009..To obtain significant long-term improvement in renal allograft outcomes, it may be necessary to adopt new immunosuppressive regimens that rely less on CNIs...
Dysfunctional DC subsets in RCC patients: ex vivo correction to yield an effective anti-cancer vaccineM Gigante
Bioagromed, University of Foggia, Via Napoli, 71100 Foggia, Italy
Mol Immunol 46:893-901. 2009..These DC stimulated robust anti-tumor CTL in vitro and would be envisioned for use in DC-based vaccines applied in patients with RCC whose existing immune system is judged dysfunctional, anergic or prone to undergo apoptosis...
[Nocturnal hemodialysis: an alternative treatment for a better quality of life]L Tartaglia
S C Nefrologia e Dialisi a direzione Universitaria, Azienda Ospedaliero Universitaria OO R R, Viale Luigi Pinto 1, Foggia, Italy
G Ital Nefrol 25:702-7. 2008....
Proteinuria in the prognosis of IgA nephropathyF Aucella
Department of Nephrology and Dialysis, Scientific Institute Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
Minerva Urol Nefrol 61:235-48. 2009..Consequently, targeting proteinuria may be a valid surrogate for individualized kidney protective therapy...
Cigarette smoking is associated with low glomerular filtration rate in male patients with type 2 diabetesSalvatore De Cosmo
Unit of Endocrinology and Metabolic Diseases, Department of Medical Sciences, University of Foggia, Via Luigi Pinto, 71100 Foggia, Italy
Diabetes Care 29:2467-70. 2006..0 +/- 91.5 vs. 442.7 +/- 87.2, P < 0.0001). CONCLUSIONS: In a large population of male patients with type 2 diabetes, the risk of low GFR is markedly enhanced by smoking and is at least partially mediated by metabolic syndrome...
IgA nephropathy in systemic lupus erythematosusA Corrado
Rheumatology Unit and Division of Nephrology, University of Foggia, Ospedale Co D Avanzo, Foggia, Italy
Clin Exp Rheumatol 25:467-9. 2007..Our case highlights the importance of renal biopsy in lupus patients with urinary alterations since a correct diagnosis would permit the most appropriate treatment to be started, thus avoiding unnecessary immunosuppressive treatments...
Waist-to-height ratio is the best anthropometric index in association with adverse cardiorenal outcomes in type 2 diabetes mellitus patientsO Lamacchia
Unit of Endocrinology and Metabolic Diseases, Department of Medical Sciences, University of Foggia, Foggia, Italy
Am J Nephrol 29:615-9. 2009..Thus, the aim of our study was to investigate the association of the frequency of cardiorenal complications with waist-to-height index (W/Ht) in T2DM...
Ischemia-reperfusion injury-induced abnormal dendritic cell traffic in the transplanted kidney with delayed graft functionA Loverre
Nephrology, Dialysis and Transplant Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
Kidney Int 72:994-1003. 2007..Our data suggest that ischemia-reperfusion injury may cause an imbalance between intragraft myeloid and plasmacytoid DCs, which might be related to DGF and acute rejection...
Complete renal allograft calcificationLuigi Cormio
Department of Urology and Kidney Transplant, University of Foggia, Foggia, Italy
Urology 74:1019. 2009..Preoperative imaging and familiarity with both extra- and intracapsular technique of graft nephrectomy are essential for urologists called upon to perform such procedure...
Waist circumference is strongly associated with renal resistive index in normoalbuminuric patients with type 2 diabetesOlga Lamacchia
Unit of Endocrinology and Metabolic Diseases, Department of Medical Sciences, University of Foggia, Foggia, Italy
Am J Nephrol 28:54-8. 2008..The aim of this study was to evaluate whether anthropometric indices and the metabolic syndrome are associated with alterations of the renal resistive index (RI) in normoalbuminuric type 2 diabetic (T2DM) patients...
LCAT deficiency: molecular and phenotypic characterization of an Italian familyMaddalena Gigante
Department of Biomedical Sciences, University of Foggia, Foggia, Italy
J Nephrol 19:375-81. 2006..This study describes for the first time the occurrence of two homozygous missense mutations as the common variant p.S208T and the mutation p.L372R in familial LCAT deficiency...
Urine protein profile of IgA nephropathy patients may predict the response to ACE-inhibitor therapyMaria Teresa Rocchetti
Molecular Medicine Center, Section of Nephrology, Department of Biomedical Sciences and Bioagromed, Faculty of Medicine, University of Foggia, Viale Pinto 1, Foggia, Italy
Proteomics 8:206-16. 2008..Concluding, the analysis of urine proteome of IgAN patients generated a set of proteins which distinguished subjects responsive to ACEi from those unresponsive to the inhibition of renin-angiotensin system (RAS)...
Posttransplant recurrence of proteinuria in a case of focal segmental glomerulosclerosis associated with WT1 mutationG M Ghiggeri
Laboratory on Pathophysiology of Uremia, Department of Nephrology, G Gaslini Children s Hospital, Genoa, and Department of Biomedical Sciences Nephrology Section, University of Foggia, Italy
Am J Transplant 6:2208-11. 2006..This observation confirms the concept that recurrence of proteinuria may occur in inherited forms of FSGS so far reported only for patients carrying NPHS2 mutations and reinforces the idea on multifactorial origin of the disease...
[Immunosuppressive drugs and renal transplantation]G Stallone
Struttura Complessa Universitaria di Nefrologia, Dialisi e Trapianto, Azienda Ospedaliero-Universitaria OO.RR, Foggia
G Ital Nefrol 22:S76-9. 2005..Another drug used in the last years, is sirolimus (SRL) or rapamycine, an immunosuppressive agent that act, through the inhibition of T lymphocyte activation...
In vitro and in vivo human herpesvirus 8 infection of placentaMariantonietta Di Stefano
Laboratory of Molecular Medicine, University of Foggia, Foggia, Italy
PLoS ONE 3:e4073. 2008....
Congenital nephrotic syndrome of Finnish type: detection of new nephrin mutations and prenatal diagnosis in an Italian familyMaddalena Gigante
Department of Scienze Biomediche, Division of Nephrology, University of Foggia, Italy
Prenat Diagn 25:407-10. 2005..The aim of this work was to investigate the disease mutations in a CNF Italian family and to perform genetic prenatal diagnosis in the second pregnancy...
Postconditioning is an effective strategy to reduce renal ischaemia/reperfusion injuryGaetano Serviddio
Division of Nephrology, Department of Biomedical Sciences, University of Foggia Viale Pinto, 71100 Foggia, Italy
Nephrol Dial Transplant 23:1504-12. 2008..e. kidney, is not available and is investigated in the present study. We also tested the hypothesis that mitochondria play a central role in renal protection during reperfusion...
Clinical and therapeutic aspects of diabetic nephropathyGiovanni F Strippoli
Department of Emergency and Organ Transplantation (DETO, Section of Nephrology, University of Bari, Italy
J Nephrol 16:487-99. 2003....
Protease-activated receptor-2 expression in IgA nephropathy: a potential role in the pathogenesis of interstitial fibrosisGiuseppe Grandaliano
Division of Nephrology, Department of Emergency and Transplantation, University of Bari, Policlinico, Bari
J Am Soc Nephrol 14:2072-83. 2003..These molecular mechanisms may underlie interstitial fibrosis in IgAN...
Sirolimus for Kaposi's sarcoma in renal-transplant recipientsGiovanni Stallone
Division of Nephrology, Department of Emergency and Transplantation, University of Bari, Bari, Italy
N Engl J Med 352:1317-23. 2005..CONCLUSIONS: Sirolimus inhibits the progression of dermal Kaposi's sarcoma in kidney-transplant recipients while providing effective immunosuppression...
Early withdrawal of cyclosporine A improves 1-year kidney graft structure and function in sirolimus-treated patientsGiovanni Stallone
Department of Emergency and Organ Transplant, Division of Nephrology, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
Transplantation 75:998-1003. 2003..002). CONCLUSIONS: These results suggest that early withdrawal of CsA is a safe option, which allows a significant reduction of chronic histologic damage, particularly vascular injury, of cadaveric kidney allografts...
Monitoring antitumor efficacy of rapamycin in Kaposi sarcomaSalvatore Di Paolo
Department of Emergency and Organ Transplants, Division of Nephrology, Dialysis and Transplantation, University of Bari, Policlinico Piazza Giulio Cesare, 11 70124 Bari, Italy
Am J Kidney Dis 49:462-70. 2007....
A search for antibodies to HHV-8 in hemodialysis patients from South-Eastern Italy argues against HHV-8 spread in hemodialysis unitsMariantonietta Di Stefano
J Clin Virol 37:75-6. 2006
Captopril enhances transforming growth factor (TGF)-beta1 expression in peripheral blood mononuclear cells: a mechanism independent from angiotensin converting enzyme inhibition? A study in cyclosporine-treated kidney-transplanted patientsSalvatore Di Paolo
Department of Emergency and Organ Transplant, Division of Nephrology, University of Bari, Bari, Italy
Transplantation 74:1710-5. 2002....
Addition of sirolimus to cyclosporine delays the recovery from delayed graft function but does not affect 1-year graft functionGiovanni Stallone
Department of Emergency and Organ Transplantation, Division of Nephrology, University of Bari, Policlinico, Bari, Italy
J Am Soc Nephrol 15:228-33. 2004..2 versus 53.3 +/- 9.4 ml/min). In conclusion, in de novo renal transplanted patients, the administration of SRL, in combination with low-dose CsA, is associated with a delayed recovery from DGF but does not worsen 1-yr graft function...
Vitamin E-modified filters modulate Jun N-terminal kinase activation in peripheral blood mononuclear cellsGiovanni Pertosa
Division of Nephrology, Department of Emergency and Organ Transplantation, University of Bari, Polyclinic, Bari, Italy
Kidney Int 62:602-10. 2002..Jun N-terminal kinase (JNK) is a novel mitogen-activated protein (MAP) kinase phosphorylated and activated in response to oxidative stress and directly involved in cell activation...
Epidemiology of end-stage renal disease in an interregional perspective: Registries of Puglia and Basilicata, southern ItalyFelice Vitullo
Laboratory of Epidemiology and Health Policy, Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, S. Maria Imbaro, Italy
J Nephrol 16:813-21. 2003..By looking at variations of rates and outcomes among areas, potential improvements of local DTR for planning and research uses are discussed...
Preeclampsia and fetal triploidy: a rarely reported association in nephrologic literatureMichele Giannattasio
Nephrology and Dialysis Unit, Santa Maria degli Angeli Hospital, Putignano, Bari, Italy
J Nephrol 15:74-8. 2002..This information is important in counseling patients who are hesitant to terminate the pregnancy purely for a fetal abnormality, even if lethal...
The role of hyperparathyroidism, erythropoietin therapy, and CMV infection in the failure of arteriovenous fistula in hemodialysisGiuseppe Grandaliano
Division of Nephrology, Department of Emergency and Transplantation, University of Bari, Policlinico, Bari, Italy
Kidney Int 64:715-9. 2003..In addition to the classic atherogenic risk factors, recently, cytomegalovirus (CMV) infection and parathyroid hormone (PTH) have been suggested as a potential cause of vascular disease...
Sirolimus and angiotensin-converting enzyme inhibitors together induce tongue oedema in renal transplant recipientsGiovanni Stallone
Division of Nephrology, Department of Emergency and Organ Transplant, University of Bari, Italy
Nephrol Dial Transplant 19:2906-8. 2004
The C677T methylenetetrahydrofolate reductase gene mutation does not influence cardiovascular risk in the dialysis population: results of a multicentre prospective studyFilippo Aucella
Department of Nephrology and Dialysis, Casa Sollievo della Sofferenza Hospital, IRCCS, 71013 San Giovanni Rotondo, Italy
Nephrol Dial Transplant 20:382-6. 2005....
Monitoring biological action of rapamycin in renal transplantationDomenica Leogrande
Department of Emergency and Organ Transplants, Division of Nephrology, Dialysis and Transplantation, University of Bari, Policlinico, Bari
Am J Kidney Dis 50:314-25. 2007..Inhibition of P70S6 kinase (P70(S6K)) phosphorylation in activated T cells is 1 of the major mechanisms by which rapamycin exerts its immunosuppressive action...
WT1 mutations in nephrotic syndrome revisited. High prevalence in young girls, associations and renal phenotypesFilippo Aucella
Nephrology Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Pediatr Nephrol 21:1393-8. 2006..WT1 hot spot mutation analysis should be routinely done in children with SRNS; if the molecular screening anticipates any further therapeutic approach it may modify the long term therapeutic strategy...
Saliva analysis by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF/MS): from sample collection to data analysisMassimo Papale
Molecular Medicine Center, Section of Nephrology, Department of Biomedical Sciences and Bioagromed, Faculty of Medicine, University of Foggia, Foggia, Italy
Clin Chem Lab Med 46:89-99. 2008..We standardized a protocol suitable for pre-analytical treatment and for the analysis of whole normal saliva by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF/MS)...
Dialysis-related systemic microinflammation is associated with specific genomic patternsGianluigi Zaza
Division of Nephrology, Department of Emergency and Transplantation, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy
Nephrol Dial Transplant 23:1673-81. 2008....
The molecular basis of lecithin:cholesterol acyltransferase deficiency syndromes: a comprehensive study of molecular and biochemical findings in 13 unrelated Italian familiesLaura Calabresi
Center E Grossi Paoletti, Department of Pharmacological Sciences, University of Milano, 20133 Milan, Italy
Arterioscler Thromb Vasc Biol 25:1972-8. 2005..To better understand the role of lecithin:cholesterol acyltransferase (LCAT) in lipoprotein metabolism through the genetic and biochemical characterization of families carrying mutations in the LCAT gene...
Coagulation cascade activation causes CC chemokine receptor-2 gene expression and mononuclear cell activation in hemodialysis patientsGiovanni Pertosa
Division of Nephrology, Department of Emergency and Transplantation, University of Bari, Policlinico, Piazza Giulio Cesare 11, Bari 70124, Italy
J Am Soc Nephrol 16:2477-86. 2005..The use of the less coagulation-activating membrane, EVAL, may reduce PBMC activation through the modulation of the stress-activated kinase JNK...
Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cellsBenedetta Mazzinghi
Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50121 Florence, Italy
J Exp Med 205:479-90. 2008....
Pathogenetic mechanisms of diabetic nephropathyFrancesco P Schena
Department of Emergency and Organ Transplantation, Renal Unit, University of Bari, Bari, Italy
J Am Soc Nephrol 16:S30-3. 2005....
Uraemic itching: do polymethylmethacrylate dialysis membranes play a role?Filippo Aucella
Dialysis Unit, F Lastaria Hospital, ASL Provincia di Foggia, Viale Lastaria, 71036 Lucera FG, Italy
Nephrol Dial Transplant 22:v8-12. 2007....
Hypertension is an independent predictor of delayed graft function and worse renal function only in kidneys with chronic pathological lesionsSalvatore Di Paolo
Department of Emergency and Organ Transplant, Division of Nephrology, University of Bari, Policlinico, Piazza Giulio Cesare, 11-70124 Bari, Italy
Transplantation 73:623-7. 2002..In addition, long-standing donor hypertension is a strong independent variable affecting both DGF and graft function of suboptimal cadaveric kidneys, at least up to 1 year...
