Roberto Gerli

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. ncbi request reprint Precocious atherosclerosis in rheumatoid arthritis: role of traditional and disease-related cardiovascular risk factors
    Roberto Gerli
    Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Ann N Y Acad Sci 1108:372-81. 2007
  2. doi request reprint Expansion of CD4+CD25-GITR+ regulatory T-cell subset in the peripheral blood of patients with primary Sjögren's syndrome: correlation with disease activity
    A Alunno
    SSD di Reumatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Italy
    Reumatismo 64:293-8. 2012
  3. doi request reprint IL-17-producing CD4-CD8- T cells are expanded in the peripheral blood, infiltrate salivary glands and are resistant to corticosteroids in patients with primary Sjogren's syndrome
    Alessia Alunno
    Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Via Enrico Dal Pozzo, Perugia I 06122, Italy
    Ann Rheum Dis 72:286-92. 2013
  4. ncbi request reprint Anti-ribosomal P protein antibodies
    Roberto Gerli
    Department of Clinical and Experimental Medicine, Center for the Study of Rheumatic Diseases, University of Perugia 06122, Italy
    Autoimmunity 38:85-92. 2005
  5. ncbi request reprint Cardiovascular involvement in rheumatoid arthritis
    R Gerli
    Rheumatology Unit, Center for the Study of Rheumatic Diseases, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Lupus 14:679-82. 2005
  6. ncbi request reprint Anti-tumor necrosis factor-alpha response in rheumatoid arthritis is associated with an increase in serum soluble CD30
    Roberto Gerli
    Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    J Rheumatol 35:14-9. 2008
  7. doi request reprint Functional impairment of the arterial wall in primary Sjögren's syndrome: combined action of immunologic and inflammatory factors
    Roberto Gerli
    University of Perugia, Perugia, Italy
    Arthritis Care Res (Hoboken) 62:712-8. 2010
  8. ncbi request reprint CD4+CD28- T lymphocytes contribute to early atherosclerotic damage in rheumatoid arthritis patients
    Roberto Gerli
    Center for the Study of Rheumatic Diseases, Section of Internal Medicine and Oncological Sciences, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico di Monteluce, I 06122 Perugia, Italy
    Circulation 109:2744-8. 2004
  9. ncbi request reprint The role of T cell cytokines in modulating joint inflammation in rheumatoid arthritis
    Roberto Gerli
    Department of Clinical and Experimental Medicine, Section of Internal Medicine and Oncological Sciences, Center for the Study of Rheumatic Diseases, University of Perugia, Perugia, Italy
    Isr Med Assoc J 4:949-52. 2002
  10. pmc In vivo activated T cells in rheumatoid synovitis. Analysis of Th1- and Th2-type cytokine production at clonal level in different stages of disease
    R Gerli
    Department of Clinical and Experimental Medicine, Section of Internal Medicine and Oncologic Sciences, Rheumatology Unit, University of Perugia, Italy
    Clin Exp Immunol 129:549-55. 2002

Detail Information

Publications42

  1. ncbi request reprint Precocious atherosclerosis in rheumatoid arthritis: role of traditional and disease-related cardiovascular risk factors
    Roberto Gerli
    Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Ann N Y Acad Sci 1108:372-81. 2007
    ....
  2. doi request reprint Expansion of CD4+CD25-GITR+ regulatory T-cell subset in the peripheral blood of patients with primary Sjögren's syndrome: correlation with disease activity
    A Alunno
    SSD di Reumatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Italy
    Reumatismo 64:293-8. 2012
    ..Aim of the present study was to investigate the characteristics of different subsets of TREG cells in Sjögren's syndrome and the potential role of GITR as marker of human TREG cells...
  3. doi request reprint IL-17-producing CD4-CD8- T cells are expanded in the peripheral blood, infiltrate salivary glands and are resistant to corticosteroids in patients with primary Sjogren's syndrome
    Alessia Alunno
    Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Via Enrico Dal Pozzo, Perugia I 06122, Italy
    Ann Rheum Dis 72:286-92. 2013
    ..Since IL-17 production is enhanced in salivary gland infiltrates of primary Sjögren's syndrome (SS) patients, we investigated whether DN T cells may be involved in the pathogenesis of salivary gland damage...
  4. ncbi request reprint Anti-ribosomal P protein antibodies
    Roberto Gerli
    Department of Clinical and Experimental Medicine, Center for the Study of Rheumatic Diseases, University of Perugia 06122, Italy
    Autoimmunity 38:85-92. 2005
    ..This review will summarize clinical and serological data on anti-P Abs provided by the main studies published in the last few years and the more recent findings about proteins constituting their targets...
  5. ncbi request reprint Cardiovascular involvement in rheumatoid arthritis
    R Gerli
    Rheumatology Unit, Center for the Study of Rheumatic Diseases, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Lupus 14:679-82. 2005
    ..However, as several CV disease risk factors and drug prescribing are also influenced by RA disease severity it is very difficult to separate out the effects of the inflammatory disease burden on the cardiovascular system in RA...
  6. ncbi request reprint Anti-tumor necrosis factor-alpha response in rheumatoid arthritis is associated with an increase in serum soluble CD30
    Roberto Gerli
    Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    J Rheumatol 35:14-9. 2008
    ..To verify the contribution of this T cell subset to disease remission, sCD30 levels were analyzed longitudinally in patients with active RA following infliximab therapy...
  7. doi request reprint Functional impairment of the arterial wall in primary Sjögren's syndrome: combined action of immunologic and inflammatory factors
    Roberto Gerli
    University of Perugia, Perugia, Italy
    Arthritis Care Res (Hoboken) 62:712-8. 2010
    ..The arterial wall was functionally evaluated in SS subjects with analysis of the role played by disease-related factors...
  8. ncbi request reprint CD4+CD28- T lymphocytes contribute to early atherosclerotic damage in rheumatoid arthritis patients
    Roberto Gerli
    Center for the Study of Rheumatic Diseases, Section of Internal Medicine and Oncological Sciences, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico di Monteluce, I 06122 Perugia, Italy
    Circulation 109:2744-8. 2004
    ..However, the potential association between CD4+CD28null T cells and early atherosclerotic changes in RA has never been investigated...
  9. ncbi request reprint The role of T cell cytokines in modulating joint inflammation in rheumatoid arthritis
    Roberto Gerli
    Department of Clinical and Experimental Medicine, Section of Internal Medicine and Oncological Sciences, Center for the Study of Rheumatic Diseases, University of Perugia, Perugia, Italy
    Isr Med Assoc J 4:949-52. 2002
  10. pmc In vivo activated T cells in rheumatoid synovitis. Analysis of Th1- and Th2-type cytokine production at clonal level in different stages of disease
    R Gerli
    Department of Clinical and Experimental Medicine, Section of Internal Medicine and Oncologic Sciences, Rheumatology Unit, University of Perugia, Italy
    Clin Exp Immunol 129:549-55. 2002
    ..The synthesis of both cytokines is a feature of the very early phase of RA, although the selective recruitment of IL-10-producing T cells is quickly lost...
  11. ncbi request reprint Salicylates inhibit T cell adhesion on endothelium under nonstatic conditions: induction of L-selectin shedding by a tyrosine kinase-dependent mechanism
    R Gerli
    Section of Internal Medicine, Center for the Study of Rheumatic Diseases, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    J Immunol 166:832-40. 2001
    ..These results suggest that salicylates interfere not only with integrin activation, but also with the L-selectin-mediated first steps of T cell binding to endothelium...
  12. doi request reprint Identification of regulatory T cells in systemic lupus erythematosus
    Roberto Gerli
    Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Autoimmun Rev 8:426-30. 2009
    ..Preliminary data seems to suggest that this marker may represent a good tool to identify cell populations included within Treg cell subsets...
  13. ncbi request reprint Early atherosclerosis in rheumatoid arthritis: effects of smoking on thickness of the carotid artery intima media
    Roberto Gerli
    Section of Internal Medicine and Oncological Sciences, Center for the Study of Rheumatic Diseases, University of Perugia, Perugia, Italy
    Ann N Y Acad Sci 1051:281-90. 2005
    ..RA is associated with higher carotid artery bifurcation IMT. The profile of factors associated with IMT values is different between RA patients and controls. Smoking is an important factor augmenting early atherosclerosis in RA patients...
  14. doi request reprint CD4(+) CD25(low) GITR(+) cells: a novel human CD4(+) T-cell population with regulatory activity
    Rodolfo Bianchini
    Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Eur J Immunol 41:2269-78. 2011
    ..Moreover, an anti-GITR Ab inhibited their suppressive activity, as observed in CD4(+) CD25(+) murine Tregs. Taken together, these data indicate that human CD4(+) CD25(low) GITR(+) cells represent a distinct Treg subpopulation...
  15. doi request reprint Atherosclerotic vascular damage and rheumatoid arthritis: a complex but intriguing link
    Elena Bartoloni
    Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Perugia 06100, Italy
    Expert Rev Cardiovasc Ther 8:1309-16. 2010
    ..The short- and long-term effects of immunosuppressive treatment on cardiovascular disease outcome is, however, uncertain and a multidisciplinary approach appears to represent the best management of cardiovascular risk in these patients...
  16. ncbi request reprint Precocious intima-media thickening in patients with primary Sjögren's syndrome
    Gaetano Vaudo
    University of Perugia, Perugia, Italy
    Arthritis Rheum 52:3890-7. 2005
    ..The present study therefore used this model to describe the presence of accelerated ATS in a group of young women...
  17. doi request reprint Characterization of a new regulatory CD4+ T cell subset in primary Sjögren's syndrome
    Alessia Alunno
    Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Via Enrico Dal Pozzo, I 06122 Perugia, Italy
    Rheumatology (Oxford) 52:1387-96. 2013
    ..The objective of the study was to investigate their presence and role in patients with primary SS (pSS)...
  18. pmc The microbial capsular polysaccharide galactoxylomannan inhibits IL-17A production in circulating T cells from rheumatoid arthritis patients
    Eva Pericolini
    Microbiology Section, Department of Experimental Medicine and Biochemical Science, University of Perugia, Perugia, Italy
    PLoS ONE 8:e53336. 2013
    ..In conclusion, GalXM triggered apoptosis of activated memory T cells and interfered with IL-17A production in RA. These data suggest therapeutic targeting of deleterious Th17 cells in RA and other autoimmune diseases...
  19. pmc Balance between regulatory T and Th17 cells in systemic lupus erythematosus: the old and the new
    Alessia Alunno
    Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Via Enrico Dal Pozzo, 06122 Perugia, Italy
    Clin Dev Immunol 2012:823085. 2012
    ..In this paper, the current knowledge about Treg and Th17 cells interplay in SLE will be discussed...
  20. doi request reprint How early is the atherosclerotic risk in rheumatoid arthritis?
    Elena Bartoloni
    Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Autoimmun Rev 9:701-7. 2010
    ..However, the effect of early immunosuppressive treatment on cardiovascular disease outcome remains uncertain. A multidisciplinary cardiovascular risk management is required to provide the better care of patients with RA at disease onset...
  21. doi request reprint Cardiovascular risk in rheumatoid arthritis and systemic autoimmune rheumatic disorders: a suggested model of preventive strategy
    Elena Bartoloni
    Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Via Enrico Dal Pozzo, 06122 Perugia, Italy
    Clin Rev Allergy Immunol 44:14-22. 2013
    ....
  22. doi request reprint Serum DNase I, soluble Fas/FasL levels and cell surface Fas expression in patients with SLE: a possible explanation for the lack of efficacy of hrDNase I treatment
    Elisa Tinazzi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, 37134 Verona, Italy
    Int Immunol 21:237-43. 2009
    ..This role may contribute to explain the inefficacy of hrDNase I in SLE, a treatment proposed for the ability of DNase I to remove DNA from auto-antigenic nucleoprotein complexes...
  23. doi request reprint Diagnostic value of anti-mutated citrullinated vimentin in comparison to anti-cyclic citrullinated peptide and anti-viral citrullinated peptide 2 antibodies in rheumatoid arthritis: an Italian multicentric study and review of the literature
    Elena Bartoloni
    Rheumatology Unit, Department of Clinical and Experimentale Medicine, University of Perugia, Italy
    Autoimmun Rev 11:815-20. 2012
    ..Moreover, the high rate of detection in infectious diseases limits its diagnostic value in undifferentiated arthritis...
  24. pmc Endothelial dysfunction in young patients with rheumatoid arthritis and low disease activity
    G Vaudo
    Internal Medicine, Angiology and Arteriosclerosis, University of Perugia School of Medicine, Perugia, Italy
    Ann Rheum Dis 63:31-5. 2004
    ..Rheumatoid arthritis (RA) is associated with an increased risk of cardiovascular disease. Endothelial dysfunction represents the earliest stage of atherosclerosis...
  25. ncbi request reprint Accelerated atherosclerosis in systemic lupus erythematosus and other connective tissue diseases
    Elena Bartoloni Bocci
    Specialist in Internal Medicine, University of Perugia, Rheumatology Unit, Department of Clinical and Experimental Medicine, Policlinico Monteluce, I 06122 Perugia, Italy
    Expert Rev Clin Immunol 3:531-41. 2007
    ....
  26. ncbi request reprint Identification of tear lipocalin as a novel autoantigen target in Sjögren's syndrome
    Riccardo Navone
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico GB Rossi, Piazzale LA Scuro 10, Italy
    J Autoimmun 25:229-34. 2005
    ..Our findings suggest that EBV infection may be linked to the pathogenesis of SS and that tear lipocalin can be considered a novel and yet unidentified autoantigen in SS...
  27. doi request reprint Rituximab treatment for persistent scleritis associated with rheumatoid arthritis
    Barbara Iaccheri
    Department of Ophthalmology, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy
    Ocul Immunol Inflamm 18:223-5. 2010
    ..To report a clinical case of a patient with severe scleritis associated with rheumatoid arthritis (RA) refractive to conventional treatment that was treated effectively with rituximab...
  28. ncbi request reprint Ethanol-induced CD3 and CD2 hyporesponsiveness of peripheral blood T lymphocytes
    F Spinozzi
    Department of Internal Medicine, University of Perugia, Italy
    Immunopharmacol Immunotoxicol 14:939-53. 1992
    ..These data clearly indicate that a membrane-specific ethanol interaction both modifies surface glycoproteic and/or glycolipidic structures and alters transmembrane transduction of the activation signals...
  29. doi request reprint Long-term anti-TNF therapy and the risk of serious infections in a cohort of patients with rheumatoid arthritis: comparison of adalimumab, etanercept and infliximab in the GISEA registry
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Autoimmun Rev 12:225-9. 2012
    ..To evaluate the risk of serious infections (SIs) in RA patients receiving anti-TNF therapy on the basis of the data included in the GISEA register...
  30. doi request reprint Patient preferences in the choice of anti-TNF therapies in rheumatoid arthritis. Results from a questionnaire survey (RIVIERA study)
    Salvatore Scarpato
    Rheumatology Unit, M Scarlato Hospital, Scafati, 5, Via Passanti, 84018 Scafati SA, Italy
    Rheumatology (Oxford) 49:289-94. 2010
    ..To identify the determinants of anti-TNF-naive patients' preferences for the route of administration of anti-TNF agents...
  31. ncbi request reprint Role of CD30+ T cells in rheumatoid arthritis: a counter-regulatory paradigm for Th1-driven diseases
    R Gerli
    Section of Internal Medicine and Oncological Sciences, Department of Clinical and Experimental Medicine, Center for the Study of Rheumatic Diseases, University of Perugia, I-06122, Perugia, Italy
    Trends Immunol 22:72-7. 2001
    ..This article discusses the hypothesis that CD30(+) T cells might play a counter-regulatory role at sites of inflammation in Th1-mediated conditions, such as rheumatoid arthritis...
  32. ncbi request reprint Heat-shock protein 65 autoantibodies are differently associated with early atherosclerosis in rheumatoid arthritis and in healthy subjects
    Yaniv Sherer
    Department of Medicine B and Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Ann N Y Acad Sci 1108:408-13. 2007
    ..As opposed to the association with cardiovascular diseases and atherosclerosis of anti-HSPs in the general population, among RA patients anti-HSP-65 cannot be regarded as associated with early atherosclerosis...
  33. ncbi request reprint Good clinical response, remission, and predictors of remission in rheumatoid arthritis patients treated with tumor necrosis factor-alpha blockers: the GISEA study
    Luana Mancarella
    Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy
    J Rheumatol 34:1670-3. 2007
    ..To assess the prevalence of good clinical response and remission in rheumatoid arthritis (RA) patients with longstanding disease treated with anti-tumor necrosis factor-alpha (TNF-alpha) drugs at outpatient clinics...
  34. ncbi request reprint Effect of tumor necrosis factor alpha inhibition on CD28 surface expression on CD4+ T cells
    Roberto Gerli
    Arthritis Rheum 54:3060-1; author reply 3061. 2006
  35. ncbi request reprint Prednisone plus methotrexate for polymyalgia rheumatica: a randomized, double-blind, placebo-controlled trial
    Roberto Caporali
    University of Pavia, Pavia, Italy
    Ann Intern Med 141:493-500. 2004
    ..Steroids are the standard treatment for polymyalgia rheumatica. The efficacy of the candidate drug methotrexate has not yet been demonstrated in controlled studies...
  36. ncbi request reprint Low levels of heat shock proteins-60 and -65 autoantibodies in Sjögren's syndrome
    Ora Shovman
    Department of Medicine B and Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 7:778-80. 2005
    ..Heat shock proteins are highly conserved immunodominant antigens found in various species. Humoral immune responses to mycobacterial HSP65 and human HSP60 have been established in a number of human autoimmune diseases...
  37. ncbi request reprint Anti-cyclic citrullinated peptide antibodies as a diagnostic test for rheumatoid arthritis and predictor of an erosive disease
    Hedi Orbach
    Department of Medicine and Rheumatology Unit, Bikur Cholim Hospital, Jerusalem, Israel
    Isr Med Assoc J 4:892-3. 2002
  38. ncbi request reprint Infliximab plus prednisone or placebo plus prednisone for the initial treatment of polymyalgia rheumatica: a randomized trial
    Carlo Salvarani
    Arcispedale S Maria Nuova, Reggio Emilia, Italy
    Ann Intern Med 146:631-9. 2007
    ..A reliable alternative to steroids for treating polymyalgia rheumatica has not yet been identified. Although infliximab has been used occasionally in steroid-resistant cases, its efficacy has not been demonstrated in a controlled study...
  39. ncbi request reprint Evaluation of current methods for the measurement of serum anti double-stranded DNA antibodies
    Anna Ghirardello
    Division of Rheumatology, University of Padova, Italy
    Ann N Y Acad Sci 1109:401-6. 2007
    ..In the present article, an overview of current methods for anti-dsDNA antibody detection is presented, together with a look at the future trends in technologies newly employed in this field...
  40. pmc Autoantibodies profile in the sera of patients with Sjogren's syndrome: the ANA evaluation--a homogeneous, multiplexed system
    Boris Gilburd
    Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel
    Clin Dev Immunol 11:53-6. 2004
    ..It offers a rapid and sensitive method to assess multiple analyses in a single tube/well...
  41. ncbi request reprint [Recent views on the pathogenesis of cardiovascular damage associated with rheumatoid arthritis]
    Elena Bartoloni Bocci
    Sezione di Medicina Interna e Scienze Oncologiche, Centro per lo Studio delle Malattie Reumatiche, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi, Perugia
    Recenti Prog Med 96:65-9. 2005
    ....
  42. ncbi request reprint Prevalence of antiphospholipid and antioxidized low-density lipoprotein antibodies in rheumatoid arthritis
    Yaniv Sherer
    Department of Medicine B and Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel
    Ann N Y Acad Sci 1051:299-303. 2005
    ..Whether the presence of anticardiolipin signifies increased risk for thrombosis and atherosclerosis in these patients should be studied further...