Luigi Gennari

Summary

Affiliation: University of Siena
Country: Italy

Publications

  1. ncbi request reprint Lasofoxifene, from the preclinical drug discovery to the treatment of postmenopausal osteoporosis
    Luigi Gennari
    University of Siena, Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, Policlinico Le Scotte, Viale Bracci 1, 53100 Siena, Italy 39 577 585364 39 577 233446
    Expert Opin Drug Discov 6:205-17. 2011
  2. doi request reprint Circulating sclerostin levels and bone turnover in type 1 and type 2 diabetes
    Luigi Gennari
    Department of Internal Medicine Endocrine Metabolic Sciences, and Biochemistry, University of Siena, Viale Bracci 1, 53100 Siena, Italy
    J Clin Endocrinol Metab 97:1737-44. 2012
  3. doi request reprint Pharmacokinetic evaluation of toremifene and its clinical implications for the treatment of osteoporosis
    Luigi Gennari
    University of Siena, Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, Policlinico Le Scotte 53100 Siena, Italy
    Expert Opin Drug Metab Toxicol 8:505-13. 2012
  4. ncbi request reprint Calcium and vitamin D nutrition and bone disease of the elderly
    C Gennari
    Institute of Internal Medicine, University of Siena, Italy
    Public Health Nutr 4:547-59. 2001
  5. ncbi request reprint Selective estrogen receptor modulators for postmenopausal osteoporosis: current state of development
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Policlinico Le Scotte, Siena, Italy
    Drugs Aging 24:361-79. 2007
  6. ncbi request reprint Genetics of osteoporosis: role of steroid hormone receptor gene polymorphisms
    L Gennari
    Department of Internal Medicine, University of Florence, Viale Pieraccini 6, 50135 Florence, Italy
    J Steroid Biochem Mol Biol 81:1-24. 2002
  7. ncbi request reprint Steroid hormone receptor gene polymorphisms and osteoporosis: a pharmacogenomic review
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Viale Bracci 1, 53100 Siena, Italy
    Expert Opin Pharmacother 8:537-53. 2007
  8. ncbi request reprint Lasofoxifene: a third-generation selective estrogen receptor modulator for the prevention and treatment of osteoporosis
    Luigi Gennari
    University of Siena, Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, Viale Bracci 1, 53100 Siena, Italy
    Expert Opin Investig Drugs 15:1091-103. 2006
  9. ncbi request reprint Lasofoxifene: a new type of selective estrogen receptor modulator for the treatment of osteoporosis
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Policlinico Le Scotte, Siena, Italy
    Drugs Today (Barc) 42:355-67. 2006
  10. ncbi request reprint Lasofoxifene (Pfizer)
    Luigi Gennari
    University of Siena, Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, Policlinico Le Scotte, Siena, Italy
    Curr Opin Investig Drugs 6:1067-78. 2005

Detail Information

Publications73

  1. ncbi request reprint Lasofoxifene, from the preclinical drug discovery to the treatment of postmenopausal osteoporosis
    Luigi Gennari
    University of Siena, Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, Policlinico Le Scotte, Viale Bracci 1, 53100 Siena, Italy 39 577 585364 39 577 233446
    Expert Opin Drug Discov 6:205-17. 2011
    ..e., hot flushes and risk of venous thromboembolic events), may offer an improved skeletal efficacy over raloxifene, addressing other postmenopausal conditions, including reduction in breast cancer risk and treatment of vaginal atrophy...
  2. doi request reprint Circulating sclerostin levels and bone turnover in type 1 and type 2 diabetes
    Luigi Gennari
    Department of Internal Medicine Endocrine Metabolic Sciences, and Biochemistry, University of Siena, Viale Bracci 1, 53100 Siena, Italy
    J Clin Endocrinol Metab 97:1737-44. 2012
    ..Sclerostin is a secreted Wnt antagonist produced by osteocytes that regulates osteoblast activity and thus bone turnover. Its levels increase with age and are regulated by PTH...
  3. doi request reprint Pharmacokinetic evaluation of toremifene and its clinical implications for the treatment of osteoporosis
    Luigi Gennari
    University of Siena, Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, Policlinico Le Scotte 53100 Siena, Italy
    Expert Opin Drug Metab Toxicol 8:505-13. 2012
    ..Toremifene is a triphenylethylene selective estrogen receptor modulator (SERM) that differs from tamoxifen in a single chloride ion addition on a side chain, resulting in a potentially more favorable toxicity profile...
  4. ncbi request reprint Calcium and vitamin D nutrition and bone disease of the elderly
    C Gennari
    Institute of Internal Medicine, University of Siena, Italy
    Public Health Nutr 4:547-59. 2001
    ..This is an effective, safe and cheap means of preventing osteoporotic fractures...
  5. ncbi request reprint Selective estrogen receptor modulators for postmenopausal osteoporosis: current state of development
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Policlinico Le Scotte, Siena, Italy
    Drugs Aging 24:361-79. 2007
    ..Clinical efficacy data from ongoing phase III trials are awaited so that a true understanding of the therapeutic potential of these compounds can be obtained...
  6. ncbi request reprint Genetics of osteoporosis: role of steroid hormone receptor gene polymorphisms
    L Gennari
    Department of Internal Medicine, University of Florence, Viale Pieraccini 6, 50135 Florence, Italy
    J Steroid Biochem Mol Biol 81:1-24. 2002
    ....
  7. ncbi request reprint Steroid hormone receptor gene polymorphisms and osteoporosis: a pharmacogenomic review
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Viale Bracci 1, 53100 Siena, Italy
    Expert Opin Pharmacother 8:537-53. 2007
    ..This review analyses major pharmacogenetic studies of polymorphisms in steroid hormone receptor genes...
  8. ncbi request reprint Lasofoxifene: a third-generation selective estrogen receptor modulator for the prevention and treatment of osteoporosis
    Luigi Gennari
    University of Siena, Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, Viale Bracci 1, 53100 Siena, Italy
    Expert Opin Investig Drugs 15:1091-103. 2006
    ..Dose modelling from Phase II studies allowed the selection of lasofoxifene 0.25 mg/day as the lowest fully effective dose...
  9. ncbi request reprint Lasofoxifene: a new type of selective estrogen receptor modulator for the treatment of osteoporosis
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Policlinico Le Scotte, Siena, Italy
    Drugs Today (Barc) 42:355-67. 2006
    ..25 mg/day as the lowest fully effective dose. The compound shows a favorable safety profile and is currently in phase III development for the prevention and treatment of osteoporosis in postmenopausal women...
  10. ncbi request reprint Lasofoxifene (Pfizer)
    Luigi Gennari
    University of Siena, Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, Policlinico Le Scotte, Siena, Italy
    Curr Opin Investig Drugs 6:1067-78. 2005
    ..In August 2004, Pfizer submitted a New Drug Application to the Food and Drug Administration (FDA) seeking approval of lasofoxifene for the treatment of osteoporosis; however, in September 2005, the FDA issued a non-approvable letter...
  11. ncbi request reprint Prevalence of Paget's disease of bone in Italy
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Siena, and Department of Radiology, U O A I S Giovanni Battista Hospital of Torino, Italy
    J Bone Miner Res 20:1845-50. 2005
    ..7% to 2.4%, were higher in males than in females, and slightly differed between the two towns. Unlike previous studies in populations of British descent, no secular trend for a decreasing prevalence emerged...
  12. ncbi request reprint Longitudinal association between sex hormone levels, bone loss, and bone turnover in elderly men
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, 53100 Siena, Italy
    J Clin Endocrinol Metab 88:5327-33. 2003
    ..In conclusion, results from the present study indicate an important role of estrogens, and particularly of the ability to aromatize T to E(2), in the regulation of bone loss and bone metabolism in elderly men...
  13. ncbi request reprint Ospemifene Hormos
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Policlinico Le Scott, 53100 Siena, Italy
    Curr Opin Investig Drugs 5:448-55. 2004
    ..By November 2003, Hormos had advanced the drug into phase II/III testing for both indications...
  14. ncbi request reprint Aromatase activity and bone homeostasis in men
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences, and Biochemistry, University of Siena, Siena 53100, Italy
    J Clin Endocrinol Metab 89:5898-907. 2004
    ....
  15. ncbi request reprint Estrogen receptor gene polymorphisms and the genetics of osteoporosis: a HuGE review
    L Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, Faculty of Medicine, University of Siena, 53100 Siena, Italy
    Am J Epidemiol 161:307-20. 2005
    ..At the moment, no recommendations for population-based screening can be made...
  16. ncbi request reprint Oral ibandronic acid
    Luigi Gennari
    University of Siena, Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, Policlinico Le Scotte, 53100 Siena, Italy
    IDrugs 8:155-69. 2005
    ..Roche and its Japanese subsidiary Chugai Pharmaceutical Co Ltd, in collaboration with GlaxoSmithKline plc, have also developed the formulation for the treatment of osteoporosis...
  17. ncbi request reprint The use of intravenous aminobisphosphonates for the treatment of Paget's disease of bone
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, 53100 Siena, Italy
    Mini Rev Med Chem 9:1052-63. 2009
    ..Recently, the availability of newer, more potent nitrogen-containing bisphosphonates has improved treatment outcomes, allowing a more effective and convenient management of this disorder...
  18. pmc Selective estrogen receptor modulator (SERM) for the treatment of osteoporosis in postmenopausal women: focus on lasofoxifene
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Siena, Italy
    Clin Interv Aging 5:19-29. 2010
    ....
  19. ncbi request reprint Paget's disease of bone in Italy
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Siena, Italy
    J Bone Miner Res 21:P14-21. 2006
    ..These results confirm PDB to be the most common bone remodeling disorder in elderly people in Italy, excluding osteoporosis...
  20. doi request reprint Lasofoxifene, a new selective estrogen receptor modulator for the treatment of osteoporosis and vaginal atrophy
    Luigi Gennari
    University of Siena, Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, Viale Bracci 1, 53100 Siena, Italy
    Expert Opin Pharmacother 10:2209-20. 2009
    ..With its increased potency and efficacy on the prevention of nonvertebral fractures and its positive effects on the vagina, this new SERM may represent an alternative therapy for osteoporosis in postmenopausal women...
  21. doi request reprint Ospemifene use in postmenopausal women
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Viale Bracci 1, Policlinico Le Scotte, Siena, Italy
    Expert Opin Investig Drugs 18:839-49. 2009
    ..However, currently available SERMS are also responsible for side effects such as thromboembolic disorders, or gynecological symptoms (especially vaginal dryness and hot flushes)...
  22. doi request reprint Update on the pharmacogenetics of the vitamin D receptor and osteoporosis
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Viale Bracci 1, 53100 Siena, Italy
    Pharmacogenomics 10:417-33. 2009
    ..This review analyzes major pharmacogenetic studies of polymorphisms in the vitamin D receptor gene and osteoporosis...
  23. ncbi request reprint Raloxifene in breast cancer prevention
    Luigi Gennari
    University of Siena, Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, Viale Bracci 1, 53100 Siena, Italy
    Expert Opin Drug Saf 7:259-70. 2008
    ..This compound was first approved in different countries for the prevention and treatment of osteoporosis...
  24. ncbi request reprint PTH in the pathogenesis and treatment of glucocorticoid-induced osteoporosis
    C Gennari
    Institute of Internal Medicine, University of Siena, Italy
    Front Horm Res 30:184-97. 2002
  25. doi request reprint SQSTM1 gene analysis and gene-environment interaction in Paget's disease of bone
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Siena, Italy
    J Bone Miner Res 25:1375-84. 2010
    ..84 +/- 2.5 versus 2.76 +/- 2.2, p < .05). Overall, these data suggest that animal-related factors may be important in the etiology of PDB and may interact with SQSTM1 mutations in influencing disease severity...
  26. ncbi request reprint Aromatase activity and bone loss
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Siena, Italy
    Adv Clin Chem 54:129-64. 2011
    ..Moreover, with aging, individual differences in aromatase activity and thus in estrogen levels may significantly affect bone loss and fracture risk in both genders...
  27. doi request reprint Perspectives in the treatment and prevention of osteoporosis
    L Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Siena, Italy
    Drugs Today (Barc) 45:629-47. 2009
    ..This review summarizes the effects of existing treatment options and of promising new therapies for osteoporosis prevention and treatment...
  28. doi request reprint Comparison of intravenous and intramuscular neridronate regimens for the treatment of Paget disease of bone
    Daniela Merlotti
    Department of Internal Medicine, Endocrine Metabolic Sciences, and Biochemistry, University of Siena, Siena, Italy
    J Bone Miner Res 26:512-8. 2011
    ....
  29. ncbi request reprint Comparison of different intravenous bisphosphonate regimens for Paget's disease of bone
    Daniela Merlotti
    Department of Internal Medicine, Endocrine, Metabolic Sciences, and Biochemistry, University of Siena, Siena, Italy
    J Bone Miner Res 22:1510-7. 2007
    ..Single neridronate and zoledronate infusion showed a similar efficacy in up to 90% of patients nonresponders to pamidronate...
  30. ncbi request reprint Characteristics and familial aggregation of Paget's disease of bone in Italy
    Daniela Merlotti
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Siena, Italy
    J Bone Miner Res 20:1356-64. 2005
    ..Familial aggregation was observed in 15% of cases...
  31. ncbi request reprint A polymorphic CYP19 TTTA repeat influences aromatase activity and estrogen levels in elderly men: effects on bone metabolism
    Luigi Gennari
    Department of Internal Medicine, University of Florence, 50139 Florence, Italy
    J Clin Endocrinol Metab 89:2803-10. 2004
    ..In conclusion, differences in estrogen levels due to polymorphism at the aromatase CYP19 gene may predispose men to increased age-related bone loss and fracture risk...
  32. doi request reprint The effects of recombinant TSH on bone turnover markers and serum osteoprotegerin and RANKL levels
    Giuseppe Martini
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, Section of Internal Medicine, University of Siena, Siena, Italy
    Thyroid 18:455-60. 2008
    ....
  33. doi request reprint The effects of zoledronic acid on serum lipids in multiple myeloma patients
    Alessandro Gozzetti
    Division of Hematology and Transplants, Policlinico Santa Maria Le Scotte, University of Siena, Siena 53100, Italy
    Calcif Tissue Int 82:258-62. 2008
    ..In conclusion, ZA given intravenously at high doses in patients with smoldering myeloma seems to be able to modify the lipid profile with an improvement of atherosclerotic risk index...
  34. ncbi request reprint Quantitative ultrasound and dual-energy X-ray absorptiometry in the prediction of fragility fracture in men
    Stefano Gonnelli
    Department of Internal Medicine, Endocrine Metabolic Science and Biochemistry, University of Siena, Policlinico Le Scotte, Viale Bracci 2, 53100 Siena, Italy
    Osteoporos Int 16:963-8. 2005
    ..QUS seems to play an independent and complementary role, with respect to DXA, in order to enhance the power for predicting osteoporotic fractures in men...
  35. ncbi request reprint Relation of plasma brain natriuretic peptide levels in non-ST-elevation coronary disease and preserved systolic function to number of narrowed coronary arteries
    Alberto Palazzuoli
    Division of Cardiology, Institute of Internal Medicine and Metabolic Diseases, University of Siena, Siena, Italy
    Am J Cardiol 96:1705-10. 2005
    ..BNP was also associated with multivessel disease and left anterior descending involvement...
  36. pmc Beyond glycemic control in diabetes mellitus: effects of incretin-based therapies on bone metabolism
    Elena Ceccarelli
    Diabetes Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy
    Front Endocrinol (Lausanne) 4:73. 2013
    ....
  37. ncbi request reprint Dual X-ray and laser absorptiometry of the calcaneus: comparison with quantitative ultrasound and dual-energy X-ray absorptiometry
    Giuseppe Martini
    Department of Internal Medicine and Metabolic Diseases, University of Siena, Siena, Italy
    J Clin Densitom 7:349-54. 2004
    ....
  38. ncbi request reprint Infection by CagA-positive Helicobacter pylori strains in patients with ischemic heart disease: prevalence and association with exercise-induced electrocardiographic abnormalities
    N Figura
    Institute of Internal Medicine, University of Siena, Policlinico Le Scotte, Italy
    Dig Dis Sci 47:831-6. 2002
    ..pylori infection with IHD. Coronary vessels of IHD patients infected by CagA-positive H. pylori strains may be damaged more severely than those of uninfected patients...
  39. pmc Bazedoxifene for the prevention of postmenopausal osteoporosis
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Policlinico Le Scotte 53100 Siena, Italy
    Ther Clin Risk Manag 4:1229-42. 2008
    ..These properties and the safety profile of this combination, if confirmed long-term in ongoing phase 3 trials, might significantly affect the way women and physicians approach menopause and its related disorders...
  40. ncbi request reprint Left ventricular hypertrophy differences in male professional runners and in young patients suffering from mild hypertension
    Alberto Palazzuoli
    Department of Internal Medicine and Metabolic Disease, Section of Cardiology, University of Siena
    Blood Press 13:14-9. 2004
    ..Twenty-one male sprinter runners were checked during a period of training and compared with 19 young patients suffering from mild hypertension and 15 healthy controls matched for gender and body size...
  41. ncbi request reprint Food allergy and Helicobacter pylori infection
    N Figura
    Institute of Internal Medicine, University of Siena, Italy
    Ital J Gastroenterol Hepatol 31:186-91. 1999
    ..Inflammatory processes, such as Helicobacter pylori-associated gastritis, could alter the integrity of the gastric barrier, increase the mucosal permeability, and enhance crossing of food antigens which may stimulate allergic reactions...
  42. ncbi request reprint Graphic trace analysis of ultrasound at the phalanges may differentiate between subjects with primary hyperparathyroidism and with osteoporosis: a pilot study
    A Montagnani
    Institute of Internal Medicine, University of Siena, Policlinico Le Scotte, Italy
    Osteoporos Int 13:222-7. 2002
    ..This suggests that the QUS signal could be a useful instrument in discriminating and studying some of the bone alterations typical of metabolic bone diseases...
  43. ncbi request reprint Hyperuricemia and gout in thyroid endocrine disorders
    N Giordano
    Institute of Internal Medicine, University of Siena, Italy
    Clin Exp Rheumatol 19:661-5. 2001
    ..The present study evaluates the prevalence of hyperuricemia and gout in patients affected by primary hypothyroidism and hyperthyroidism...
  44. ncbi request reprint Usefulness of bone quantitative ultrasound in management of osteoporosis in men
    A Montagnani
    Institute of Internal Medicine, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
    J Clin Densitom 4:231-7. 2001
    ..In conclusion, our data show that QUS parameters are reduced in osteoporotic males; however, only BTT was comparable to DXA parameters in the prediction of fracture risk in men...
  45. ncbi request reprint Acute hepatitis induced by cyproterone acetate
    N Giordano
    Institute of Internal Medicine, University of Siena, Italy
    Ann Pharmacother 35:1053-5. 2001
    ..To report a case of acute hepatitis resulting from the use of cyproterone acetate, an adjuvant treatment for prostate cancer...
  46. ncbi request reprint Aerobic exercise training fails to reduce blood pressure in nondipper-type hypertension
    R Nami
    Department of Cardiology, Institute of Internal Medicine, University of Siena, Italy
    Am J Hypertens 13:593-600. 2000
    ....
  47. ncbi request reprint Quantitative ultrasound and bone mineral density in patients with primary hyperparathyroidism before and after surgical treatment
    S Gonnelli
    Institute of Internal Medicine, University of Siena, Italy
    Osteoporos Int 11:255-60. 2000
    ..The combined use of BMD and QUS could improve the assessment of skeletal status in patients with PHPT before and after surgery...
  48. ncbi request reprint CagA-positive Helicobacter pylori infection may increase the risk of food allergy development
    N Figura
    Institute of Internal Medicine, University of Siena, Italy
    J Physiol Pharmacol 50:827-31. 1999
    ..28 kU/L (SD 3.93), vs. 1.99 kU/L (SD 1.53), P = 0.002, 95% confidence interval = 0.61 to 2.53). Infection by CagA-positive H. pylori increases the risk of developing food allergy...
  49. ncbi request reprint The infection by Helicobacter pylori strains expressing CagA is highly prevalent in women with autoimmune thyroid disorders
    N Figura
    Institute of Internal Medicine, University of Siena, Policlinico Le Scotte, Italy
    J Physiol Pharmacol 50:817-26. 1999
    ..0%) than that in controls (8/33, or 24.2%) (P = 0.006, OR = 3.99, RR = 2.31). The other tests gave negative or inexplicable results. In conclusion: CagA-positive H. pylori infection increases the risk of ATD development...
  50. ncbi request reprint Quantitative ultrasound in the assessment of skeletal status in uremic patients
    A Montagnani
    Institute of Internal Medicine, University of Siena, Italy
    J Clin Densitom 2:389-95. 1999
    ..Our results seem to demonstrate that US parameters are a useful tool in the assessment of skeletal status in patients on maintenance dialysis...
  51. ncbi request reprint Helicobacter pylori infection and infertility
    N Figura
    Institute of Internal Medicine, University of Sienna, Sienna, Italy
    Eur J Gastroenterol Hepatol 14:663-9. 2002
    ..pylori antibodies in samples of follicular fluid, vaginal secretions and sperm; and (3) the existence of a structural homology between a major spermatozoa protein, tubulin, and H. pylori proteins...
  52. ncbi request reprint IgG and IgM antiganglioside M1 antibodies in primary Sjogren's syndrome with and without peripheral neuropathy
    N Giordano
    Department of Internal Medicine, University of Siena, Viale Bracci 1, 53100 Siena, Italy
    Clin Rheumatol 22:256-8. 2003
  53. ncbi request reprint Changes in serum HDL and LDL cholesterol in patients with Paget's bone disease treated with pamidronate
    A Montagnani
    Institute of Internal Medicine, Policlinico Le Scotte, University of Siena, Viale Bracci, 53100 Siena, Italy
    Bone 32:15-9. 2003
    ....
  54. ncbi request reprint Effect of simvastatin treatment on bone mineral density and bone turnover in hypercholesterolemic postmenopausal women: a 1-year longitudinal study
    A Montagnani
    Department of Internal Medicine, University of Siena, Italy
    Bone 32:427-33. 2003
    ..05) for both BMD-LS and BMD-Fn only at Month 12. In conclusion our results, although obtained from a small sample of postmenopausal hypercholesterolemic women, suggest a probable positive effect of simvastatin on bone formation and BMD...
  55. ncbi request reprint Heel ultrasonography in monitoring alendronate therapy: a four-year longitudinal study
    S Gonnelli
    Institute of Internal Medicine, University of Siena, Italy
    Osteoporos Int 13:415-21. 2002
    ..2 years for BMD, SOS, BUA and Stiffness respectively. Therefore, although the spinal BMD remains the optimal method, QUS at the heel, and in particular Stiffness, seems to be a sensitive tool for monitoring the response to alendronate...
  56. ncbi request reprint Alendronate treatment in men with primary osteoporosis: a three-year longitudinal study
    S Gonnelli
    Department of Internal Medicine, Endocrine Metabolic Science and Biochemistry, University of Siena, Italy
    Calcif Tissue Int 73:133-9. 2003
    ..BMD at the lumbar spine appears to be the best method for monitoring the effect of alendronate on bone mass in osteoporotic men...
  57. ncbi request reprint HLA antigens and primary osteoarthritis of the hand
    Daniela Merlotti
    Department of Internal Medicine, University of Siena, Italy
    J Rheumatol 30:1298-304. 2003
    ..We investigated the interrelationship between HLA antigens and primary OA...
  58. pmc Aromatase activity and bone loss in men
    Daniela Merlotti
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, Viale Bracci 1, 53100 Siena, Italy
    J Osteoporos 2011:230671. 2011
    ..Moreover, with aging, individual differences in aromatase activity may significantly affect bone loss and fracture risk in men...
  59. pmc Lasofoxifene: Evidence of its therapeutic value in osteoporosis
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Policlinico Le Scotte 53100 Siena, Italy
    Core Evid 4:113-29. 2010
    ..PLACE IN THERAPY: With its increased potency and efficacy on the prevention of nonvertebral fractures lasofoxifene may be an alternative and cost-effective therapy for osteoporosis in postmenopausal women...
  60. ncbi request reprint Dual X-ray absorptiometry and bone ultrasonography in patients with Rett syndrome
    C Cepollaro
    Institute of Internal Medicine, University of Siena, Policlinico Le Scotte, Italy
    Calcif Tissue Int 69:259-62. 2001
    ..Whatever the cause, girls with RS present abnormal bone status with an increase in the risk of fracture...
  61. pmc Endocrine actions of osteocalcin
    Aurora Patti
    Department of Clinical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy
    Int J Endocrinol 2013:846480. 2013
    ....
  62. ncbi request reprint Left ventricular diastolic function improvement by carvedilol therapy in advanced heart failure
    Alberto Palazzuoli
    Department of Internal Medicine and Metabolic Diseases, Section of Cardiology, University of Siena, Siena, Italy
    J Cardiovasc Pharmacol 45:563-8. 2005
    ..These changes remained significant after 1 year of therapy together with improvement in systolic function...
  63. ncbi request reprint Osteoporosis in men
    Luigi Gennari
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Siena 53100, Italy
    Endocrinol Metab Clin North Am 36:399-419. 2007
    ..The purpose of this article is to review what is known about the factors in men that lead to acquisition, maintenance, and loss of bone, as well as new insights about the causes, pathogenesis, and treatment of osteoporosis in men...
  64. ncbi request reprint Validation of a food frequency questionnaire for nutritional calcium intake assessment in Italian women
    M Montomoli
    Institute of Internal Medicine, State University of Siena, Siena, Italy
    Eur J Clin Nutr 56:21-30. 2002
    ..To evaluate a food frequency questionnaire assessing calcium intake in women...
  65. ncbi request reprint Long-term treatment with calcitonin in osteoporosis
    C Gennari
    Institute of Internal Medicine and Medical Pathology, University of Siena, Italy
    Horm Metab Res 25:484-5. 1993
    ..Reported results of long-term calcitonin treatment demonstrated that it is possible to delay or to avoid the "resistance" to calcitonin by the cyclical or discontinued administration of the hormone...
  66. pmc Genetic markers of osteoarticular disorders: facts and hopes
    M L Brandi
    Department of Medicine, University of Florence, Viale Morgagni 85, 50135 Florence, Italy
    Arthritis Res 3:270-80. 2001
    ....
  67. ncbi request reprint Analgesic effect of calcitonin in osteoporosis
    C Gennari
    Institute of Internal Medicine, University of Siena, Siena, Italy
    Bone 30:67S-70S. 2002
    ..In support of this hypothesis are some observations of an analgesic effect obtained by direct epidural or subaracnoidal injection of calcitonin in humans...
  68. ncbi request reprint Evidence for increased clinical severity of familial and sporadic Paget's disease of bone in Campania, southern Italy
    Domenico Rendina
    Department of Clinical and Experimental Medicine, Federico II University Medical School, Naples, Italy
    J Bone Miner Res 21:1828-35. 2006
    ..A prevalent involvement of the spine and the skull, the sites preferentially involved in giant cell tumors complicating Paget's disease, was also shown in familial cases from this geographical region...
  69. ncbi request reprint The effect of zoledronic acid on serum osteoprotegerin in early stage multiple myeloma
    Giuseppe Martini
    Haematologica 91:1720-1. 2006
    ..In treated subjects we found an increase of OPG accounting for an effect of ZA on osteoblast and/or bone marrow stromal cells together with the direct effect on osteoclasts...
  70. ncbi request reprint Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density and fracture risk in women: a meta-analysis
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
    J Bone Miner Res 17:2048-60. 2002
    ..In summary, we have found that XX homozygotes may have higher BMD and also a decreased risk of fractures when compared with carriers of the x allele, whereas the PvuII polymorphism is not associated with either BMD or fracture risk...
  71. ncbi request reprint Osteoporosis in men: pathophysiology and treatment
    Luigi Gennari
    College of Physicians and Surgeons, 630 W 168th Street, New York, NY 10032, USA
    Curr Rheumatol Rep 9:71-7. 2007
    ..This article reviews what is known about the factors in men that lead to acquisition, maintenance, and loss of bone, as well as new insights into causes, pathogenesis, and treatment of osteoporosis in men...
  72. doi request reprint Bona fide genetic associations with bone mineral density
    Joel N Hirschhorn
    N Engl J Med 358:2403-5. 2008
  73. ncbi request reprint Osteoporosis in men: pathophysiology and treatment
    Luigi Gennari
    College of Physicians and Surgeons, 630 W 168th Street, New York, NY 10032, USA
    Curr Osteoporos Rep 5:22-8. 2007
    ..This article reviews what is known about the factors in men that lead to acquisition, maintenance, and loss of bone, as well as new insights into causes, pathogenesis, and treatment of osteoporosis in men...