Affiliation: University of Ferrara
Gemmati D, Vigliano M, Burini F, Mari R, El Mohsein H, Parmeggiani F, et al
. Coagulation Factor XIIIA (F13A1): Novel Perspectives in Treatment and Pharmacogenetics. Curr Pharm Des. 2016;22:1449-59 pubmed
..The present review accounts for the recognized role of FXIII in the healing process and gives some examples on how to use it as prognostic biological/ molecular marker or as potential tailored therapeutic molecule in complex diseases. ..
Ansani L, Marchesini J, Pestelli G, Luisi G, Scillitani G, Longo G, et al
. F13A1 Gene Variant (V34L) and Residual Circulating FXIIIA Levels Predict Short- and Long-Term Mortality in Acute Myocardial Infarction after Coronary Angioplasty. Int J Mol Sci. 2018;19: pubmed publisher
Gemmati D, Zeri G, Orioli E, Mari R, Moratelli S, Vigliano M, et al
. Factor XIII-A dynamics in acute myocardial infarction: a novel prognostic biomarker?. Thromb Haemost. 2015;114:123-32 pubmed publisher
..Different FXIII-A dynamics and levels could be utilised as early prognostic indicators during acute MI, revealing the individual potential to heal and suggesting tailored treatments to avoid heart failure or its extreme consequence. ..
Paraboschi E, Cardamone G, Rimoldi V, Gemmati D, Spreafico M, Duga S, et al
. Meta-Analysis of Multiple Sclerosis Microarray Data Reveals Dysregulation in RNA Splicing Regulatory Genes. Int J Mol Sci. 2015;16:23463-81 pubmed publisher
..In conclusion, for the first time we provide evidence of a consistent dysregulation of splicing-related genes in MS and we discuss its possible implications in modulating specific AS events in MS susceptibility genes. ..
Gemmati D, Zeri G, Orioli E, De Gaetano F, Salvi F, Bartolomei I, et al
. Polymorphisms in the genes coding for iron binding and transporting proteins are associated with disability, severity, and early progression in multiple sclerosis. BMC Med Genet. 2012;13:70 pubmed publisher
..This might account for the significant variability peculiar to MS phenotypes, particularly affecting MS risk and progression paving the way for personalized pharmacogenetic applications in the clinical practice. ..
Gemmati D, Ongaro A, Scapoli G, Della Porta M, Tognazzo S, Serino M, et al
. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Cancer Epidemiol Biomarkers Prev. 2004;13:787-94 pubmed
..These data are in accordance with the hypothesis that polymorphisms in the genes for folate and methionine metabolism might play a greater role in the occurrence of ALL than NHL by influencing DNA synthesis and/or DNA methylation. ..
Gemmati D, Tognazzo S, Catozzi L, Federici F, De Palma M, Gianesini S, et al
. Influence of gene polymorphisms in ulcer healing process after superficial venous surgery. J Vasc Surg. 2006;44:554-62 pubmed
Gemmati D, Federici F, Campo G, Tognazzo S, Serino M, De Mattei M, et al
. Factor XIIIA-V34L and factor XIIIB-H95R gene variants: effects on survival in myocardial infarction patients. Mol Med. 2007;13:112-20 pubmed
..Genetically determined higher FXIII activity might influence post-MI outcome. This paves the way for using FXIII molecules to improve myocardial healing, recovery of functions, and survival after infarction. ..
Gemmati D, Federici F, Catozzi L, Gianesini S, Tacconi G, Scapoli G, et al
. DNA-array of gene variants in venous leg ulcers: detection of prognostic indicators. J Vasc Surg. 2009;50:1444-51 pubmed publisher