L Gattinoni

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi Reduced tidal volumes and lung protective ventilatory strategies: where do we go from here?
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico IRCCS, Milano, Italy
    Curr Opin Crit Care 8:45-50. 2002
  2. ncbi How to ventilate patients with acute lung injury and acute respiratory distress syndrome
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano IRCCS, Universita degli Studi di Milano, Milano, Italy
    Curr Opin Crit Care 11:69-76. 2005
  3. ncbi Pulmonary computed tomography and adult respiratory distress syndrome
    Luciano Gattinoni
    Istituto de Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico IRCCS, Italy
    Swiss Med Wkly 135:169-74. 2005
  4. ncbi Monitoring of pulmonary mechanics in acute respiratory distress syndrome to titrate therapy
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano IRCCS, Universita degli Studi di Milano, Milano, Italy
    Curr Opin Crit Care 11:252-8. 2005
  5. pmc Chest wall mechanics during pressure support ventilation
    Andrea Aliverti
    Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy
    Crit Care 10:R54. 2006
  6. ncbi Effect of prone positioning on the survival of patients with acute respiratory failure
    L Gattinoni
    Istituto di Anestesia e Rianimazione, Universita di Milano, Ospedale Maggiore di Milano, Milan, Italy
    N Engl J Med 345:568-73. 2001
  7. ncbi Sepsis: state of the art
    L Gattinoni
    Department of Anesthesiology, Ospedale Maggiore Policlinico IRCCS, Milano University of Milan, Milan, Italy
    Minerva Anestesiol 69:539-54, 554-61. 2003
  8. ncbi Recruitment and derecruitment during acute respiratory failure: a clinical study
    S Crotti
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:131-40. 2001
  9. ncbi Estimation of end-expiratory lung volume variations by optoelectronic plethysmography
    R L Dellaca
    Dipartimento di Bioingegneria Politecnico Di Milano and the Centro di Bioingegneria, Fond Don Gnocchi IRCCS, Politecnico di Milano, Milano, Italy
    Crit Care Med 29:1807-11. 2001
  10. doi Extracorporeal lung perfusion and ventilation to improve donor lung function and increase the number of organs available for transplantation
    F Valenza
    Dipartimento di Anestesia, Terapia Intensiva e Subintensiva e Terapia del Dolore, Universita degli Studi di Milano, Milano, Italy
    Transplant Proc 44:1826-9. 2012

Collaborators

Detail Information

Publications71

  1. ncbi Reduced tidal volumes and lung protective ventilatory strategies: where do we go from here?
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico IRCCS, Milano, Italy
    Curr Opin Crit Care 8:45-50. 2002
    ..Full" protective lung strategy was tested in only one study and in a limited number of patients. Several physiologic studies strongly suggest the advantages of the lung protective strategy...
  2. ncbi How to ventilate patients with acute lung injury and acute respiratory distress syndrome
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano IRCCS, Universita degli Studi di Milano, Milano, Italy
    Curr Opin Crit Care 11:69-76. 2005
    ..The purpose of this paper is to review the mechanisms of ventilator-induced lung injury as a basis for providing the less damaging mechanical ventilation in patients with acute respiratory failure...
  3. ncbi Pulmonary computed tomography and adult respiratory distress syndrome
    Luciano Gattinoni
    Istituto de Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico IRCCS, Italy
    Swiss Med Wkly 135:169-74. 2005
    ..In this brief review we will emphasize the most relevant new knowledge achieved using CT scanning and we will briefly discuss its clinical use in ARDS patients...
  4. ncbi Monitoring of pulmonary mechanics in acute respiratory distress syndrome to titrate therapy
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano IRCCS, Universita degli Studi di Milano, Milano, Italy
    Curr Opin Crit Care 11:252-8. 2005
    ..This paper reviews recent findings regarding the respiratory mechanics during acute respiratory distress syndrome as a tool for tailoring its ventilatory management...
  5. pmc Chest wall mechanics during pressure support ventilation
    Andrea Aliverti
    Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy
    Crit Care 10:R54. 2006
    ....
  6. ncbi Effect of prone positioning on the survival of patients with acute respiratory failure
    L Gattinoni
    Istituto di Anestesia e Rianimazione, Universita di Milano, Ospedale Maggiore di Milano, Milan, Italy
    N Engl J Med 345:568-73. 2001
    ..Although placing patients with acute respiratory failure in a prone (face down) position improves their oxygenation 60 to 70 percent of the time, the effect on survival is not known...
  7. ncbi Sepsis: state of the art
    L Gattinoni
    Department of Anesthesiology, Ospedale Maggiore Policlinico IRCCS, Milano University of Milan, Milan, Italy
    Minerva Anestesiol 69:539-54, 554-61. 2003
    ..Multinodal modulation of several interdependent processes may be the probable reason for the proven effectiveness of this treatment...
  8. ncbi Recruitment and derecruitment during acute respiratory failure: a clinical study
    S Crotti
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:131-40. 2001
    ..When superimposed gravitational pressure exceeded PEEP, end-expiratory collapse increased. We concluded that the rules governing recruitment and derecruitment equally apply in an oleic acid model and in human ALI/ARDS...
  9. ncbi Estimation of end-expiratory lung volume variations by optoelectronic plethysmography
    R L Dellaca
    Dipartimento di Bioingegneria Politecnico Di Milano and the Centro di Bioingegneria, Fond Don Gnocchi IRCCS, Politecnico di Milano, Milano, Italy
    Crit Care Med 29:1807-11. 2001
    ..To test the capability of optoelectronic plethysmography (OEP) to monitor positive end-expiratory pressure (PEEP)-induced changes of end-expiratory lung volume (EELV) changes in mechanically ventilated paralyzed patients...
  10. doi Extracorporeal lung perfusion and ventilation to improve donor lung function and increase the number of organs available for transplantation
    F Valenza
    Dipartimento di Anestesia, Terapia Intensiva e Subintensiva e Terapia del Dolore, Universita degli Studi di Milano, Milano, Italy
    Transplant Proc 44:1826-9. 2012
    ..Ex vivo lung perfusion (EVLP) has been validated as a valuable technique to increase the pool of organs available for lung transplantation...
  11. ncbi Physical and biological triggers of ventilator-induced lung injury and its prevention
    L Gattinoni
    Institute of Anaesthesia and Intensive Care, University of Milan, Policlinico Hospital, IRCCS, Milan, Italy
    Eur Respir J Suppl 47:15s-25s. 2003
    ....
  12. ncbi Kidney instant monitoring (K.IN.G): a new analyzer to monitor kidney function
    P Caironi
    Department of Anesthesiology, Intensive Care Unit and Dermatological Sciences, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, University of Milan, Milan, Italy
    Minerva Anestesiol 76:316-24. 2010
    ..Accordingly, we developed and tested a urine analyzer, allowing quasi-continuous urinary analysis...
  13. ncbi An improved in vivo rat model for the study of mechanical ventilatory support effects on organs distal to the lung
    F Valenza
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano IRCCS, Italy
    Crit Care Med 28:3697-704. 2000
    ....
  14. ncbi Time to reach a new steady state after changes of positive end expiratory pressure
    D Chiumello
    Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy
    Intensive Care Med 39:1377-85. 2013
    ..To assess the time interval required to reach a new steady state of oxygenation-, ventilation-, respiratory mechanics- and hemodynamics-related variables after decreasing/increasing positive end expiratory pressure (PEEP)...
  15. ncbi Preoperative changes of forced vital capacity due to body position do not correlate with postoperative respiratory function in obese subjects
    F Valenza
    Dipartimento di Anestesia Rianimazione Intensiva e Subintensiva e Terapia del dolore, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milano, Italy
    Minerva Anestesiol 79:342-8. 2013
    ..We hypothesized that preoperative changes in dynamic spirometry due to body posture would correlate with the drop of forced vital capacity (FVC) measured early after surgery...
  16. doi Use of the Oto lung donor score to analyze the 2010 donor pool of the Nord Italia Transplant program
    G A Porro
    Department of Anesthesia and Intensive Care, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Transplant Proc 44:1830-4. 2012
    ..The feasibility and utility of a lung donor score that has been recently proposed was tested among a pool of lung donors referred to the Nord Italia Transplant program (NITp) organ procurement organization...
  17. doi Long-term outcomes in survivors of acute respiratory distress syndrome ventilated in supine or prone position
    D Chiumello
    Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, Milan, Italy
    Intensive Care Med 38:221-9. 2012
    ....
  18. ncbi Prone positioning improves survival in severe ARDS: a pathophysiologic review and individual patient meta-analysis
    L Gattinoni
    Department of Anesthesia, Intensive e Subintensive Resuscitation and Pain Therapy, CĂ  Granda Foundation, Ospedale Maggiore Policlinico, Milan, Italy
    Minerva Anestesiol 76:448-54. 2010
    ..On the other hand, all data suggest that long-term prone positioning may expose patients with less severe ARDS to unnecessary complications...
  19. ncbi Positive end-expiratory pressure applied to the dependent lung during one-lung ventilation improves oxygenation and respiratory mechanics in patients with high FEV1
    F Valenza
    Istituto di Anestesia e Rianimazione, Milan, Italy
    Eur J Anaesthesiol 21:938-43. 2004
    ..The aim of this study was to test the efficacy of positive end-expiratory pressure (PEEP) to the dependent lung during one-lung ventilation, taking into consideration underlying lung function in order to select responders to PEEP...
  20. ncbi Effects of recombinant human activated protein C on the fibrinolytic system of patients undergoing conventional or tight glycemic control
    F Polli
    Institute of Anesthesia and Intensive Care, University of Milan, Milan, Italy
    Minerva Anestesiol 75:417-26. 2009
    ..Our aim was to evaluate the effects on the fibrinolytic system after the administration of rh-APC in septic patients undergoing conventional or TGC...
  21. ncbi Recruitment and derecruitment during acute respiratory failure: an experimental study
    P Pelosi
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:122-30. 2001
    ..86, p < 0.0001), suggesting that as more tissue is recruited at end-inspiration, more remains recruited at end-expiration. When superimposed pressure exceeded applied airway pressure (Paw), collapse significantly increased...
  22. doi The rule regulating pH changes during crystalloid infusion
    E Carlesso
    Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Universita degli Studi, Milan, Italy
    Intensive Care Med 37:461-8. 2011
    ..To define the rule according to which crystalloid solutions characterized by different strong ion difference (SID) modify the acid-base variables of human plasma...
  23. ncbi Effects of volume shift on the pressure-volume curve of the respiratory system in ALI/ARDS patients
    D Chiumello
    Department of Anesthesia and Intensive Care, IRCCS Foundation, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Milan, Italy
    Minerva Anestesiol 73:109-18. 2007
    ..Another possible confounding factor is the volume shift, primarily blood, out of the chest wall when the intrathoracic pressures rise. We set out to quantify the volume shift and investigate its mechanisms...
  24. ncbi The ratio between arterio-venous PCO2 difference and arterio-jugular oxygen difference as estimator of critical cerebral hypoperfusion
    E R Zanier
    Department of Anesthesiology and Intensive Care, Ospedale Maggiore IRCCS, University of Milan, Milan, Italy
    Minerva Anestesiol 72:543-9. 2006
    ....
  25. ncbi Different modes of assisted ventilation in patients with acute respiratory failure
    D Chiumello
    Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico IRCCS, Italy
    Eur Respir J 20:925-33. 2002
    ..During assist control, tidal volume and peak inspiratory flow (set by the physician) are the main determinants of the patient/ventilator interaction...
  26. doi A validation study of a new nasogastric polyfunctional catheter
    D Chiumello
    Dipartimento di Anestesia, Rianimazione, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Intensive Care Med 37:791-5. 2011
    ..We compared the Pes and IGP measured using this new device with those obtained with a standard balloon catheter taken as gold standard...
  27. ncbi Positive end-expiratory pressure delays the progression of lung injury during ventilator strategies involving high airway pressure and lung overdistention
    Franco Valenza
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano, Italy
    Crit Care Med 31:1993-8. 2003
    ..This study, however, set out to investigate the protective role of PEEP with respect to the time needed to reach similar levels of lung injury...
  28. ncbi Feasibility, limits and problems of clinical studies in Intensive Care Unit
    G Grasselli
    Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, University Milano Bicocca, Milan, Italy
    Minerva Anestesiol 73:595-601. 2007
    ..Few suggestions are formulated which could help looking forwards...
  29. ncbi Prolongation of antibiotic prophylaxis after clean and clean-contaminated surgery and surgical site infection
    S De Chiara
    Department of General Resuscitation, Institute of Anesthesia and Resuscitation University of Milan, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
    Minerva Anestesiol 76:413-9. 2010
    ..In this observational study, we evaluated the risk of surgical site infection (SSI) associated with the prolongation of AMP after clean and clean-contaminated surgery...
  30. ncbi Lung recruitment in patients with the acute respiratory distress syndrome
    Luciano Gattinoni
    Istituto di Anestesiologia e Rianimazione, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Universita degli Studi di Milano, Milan, Italy
    N Engl J Med 354:1775-86. 2006
    ....
  31. doi Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome
    Davide Chiumello
    Dipartimento di Anestesia, Rianimazione, Intensiva e Subintensivae, Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico Mangiagalli Regina Elena di Milano, Milan, Italy
    Am J Respir Crit Care Med 178:346-55. 2008
    ..Lung injury caused by a ventilator results from nonphysiologic lung stress (transpulmonary pressure) and strain (inflated volume to functional residual capacity ratio)...
  32. doi In vivo conditioning of acid-base equilibrium by crystalloid solutions: an experimental study on pigs
    T Langer
    Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico di Milano, Universita degli Studi, Via Francesco Sforza, 35 20122 Milano, Italy
    Intensive Care Med 38:686-93. 2012
    ..We wanted to prove in vivo, at constant PCO(2), that if the [SID] of the infused crystalloid is equal to baseline plasma bicarbonate, the arterial pH remains unchanged, if lower it decreases, and if higher it increases...
  33. ncbi Gastric tonometry
    E Carlesso
    Institute of Anesthesia and Intensive Care, University of Milan, Milan, Italy
    Minerva Anestesiol 72:529-32. 2006
    ..In this brief review we will discuss the value of the gastric tonometry, its physiological background and the clinical results observed so far...
  34. ncbi Respiratory acidosis: is the correction with bicarbonate worth?
    L Gattinoni
    Institute of Anesthesia and Intensive Care, University of Milan, Milan, Italy
    Minerva Anestesiol 72:551-7. 2006
    ..The effect is independent on (HCO3-) infusion and equivalent to adding (Na+ OH-) instead of (Na+ HCO3-)...
  35. doi The consumption of glucose during ex vivo lung perfusion correlates with lung edema
    F Valenza
    Dipartimento di Anestesia, Terapia Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Transplant Proc 43:993-6. 2011
    ..Ex vivo lung perfusion (EVLP) has been recently proposed to recondition organs before transplantation from donors with marginal or unacceptable features. The aim of our investigation was to explore glucose consumption during EVLP...
  36. ncbi Radiological imaging in acute lung injury and acute respiratory distress syndrome
    Pietro Caironi
    Dipartimento di Anestesia, Rianimazione, e Terapia del Dolore, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Universita degli Studi di Milano, Milano, Italy
    Semin Respir Crit Care Med 27:404-15. 2006
    ..CT scans may also help to diagnose ARDS because CT provides a good estimate of the high-permeability lung edema, the characteristic lesion of this syndrome...
  37. doi Lung opening and closing during ventilation of acute respiratory distress syndrome
    Pietro Caironi
    Dipartimento di Anestesiologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy
    Am J Respir Crit Care Med 181:578-86. 2010
    ....
  38. ncbi Acute respiratory distress syndrome, the critical care paradigm: what we learned and what we forgot
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico IRCCS, Milano, Italy
    Curr Opin Crit Care 10:272-8. 2004
    ..Measurements of variables as transpulmonary pressure and end expiratory lung volume, for a rational setting of mechanical ventilation, should be introduced in routine clinical practice...
  39. pmc In vitro and in vivo evaluation of a new active heat moisture exchanger
    Davide Chiumello
    Institute of Anesthesia and Critical Care, University of Milan, Policlinico Hospital, IRCCS, Milan, Italy
    Crit Care 8:R281-8. 2004
    ..In this study we evaluated the efficiency, both in vitro and in vivo, of a new active HME (the Performer; StarMed, Mirandola, Italy) as compared with that of existing HMEs (Hygroster and Hygrobac; Mallinckrodt, Mirandola, Italy)...
  40. ncbi [Albumin administration: volume replacement or pharmacological treatment?]
    L Gattinoni
    Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Fondazione IRCCS, Ospedale Maggiore Policlinico Mangiagalli, Regina Elena di Milano
    Minerva Anestesiol 71:27-40. 2005
  41. ncbi Heat stress: characteristics, pathophysiology and avoidable mistakes
    M L Caspani
    Intensive Care Unit, IRCCS Ospedale Maggiore Policlinico, Department of Anesthesia and Intensive Care, University of Milan, Milan, Italy
    Minerva Anestesiol 70:617-24. 2004
    ..The comparative analysis of these 2 studies suggests that the time of intervention may lead to significant differences in mortality. In these patients time is essential...
  42. ncbi [The fluid balance in the critically ill patient]
    P Bruzzone
    Istituto di Anestesia e Rianimazione, Ospedale Policlinico, IRCCS, Universita degli Studi di Milano, Milano, Italy
    Minerva Anestesiol 70:431-6. 2004
    ..Aim of this study was to prospectively evaluate the accuracy of the fluid balance compared to the body weight measured by a dedicated mattress (Hill-Rom)...
  43. ncbi Decrease in PaCO2 with prone position is predictive of improved outcome in acute respiratory distress syndrome
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico, Milan, Italy
    Crit Care Med 31:2727-33. 2003
    ..To determine whether gas exchange improvement in response to the prone position is associated with an improved outcome in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS)...
  44. ncbi Effect of different inspiratory rise time and cycling off criteria during pressure support ventilation in patients recovering from acute lung injury
    Davide Chiumello
    Istituto di Anestesia e Reanimazione, UniversitĂ  degli Studi Milano, Ospedale Policlinico IRCSS, Milan, Italy
    Crit Care Med 31:2604-10. 2003
    ..This study evaluated the effect of different inspiratory rise time and cycling off criteria on breathing pattern and work of breathing...
  45. ncbi Anatomical and functional intrapulmonary shunt in acute respiratory distress syndrome
    Massimo Cressoni
    Istituto di Anestesiologia e Rianimazione, Universita degli Studi di Milano, Milan, Italy
    Crit Care Med 36:669-75. 2008
    ..Therefore, we aimed to assess the value of venous admixture (functional shunt) in estimating the fraction of nonaerated lung tissue (anatomical shunt compartment) and to describe their relationship...
  46. ncbi Effects of the beach chair position, positive end-expiratory pressure, and pneumoperitoneum on respiratory function in morbidly obese patients during anesthesia and paralysis
    Franco Valenza
    Istituto di Anestesia e Rianimazione, Fondazione Ospedale Maggiore, Mangiagalli e Regina Elena IRCCS, Milan, Italy
    Anesthesiology 107:725-32. 2007
    ..The authors studied the effects of the beach chair (BC) position, 10 cm H2O positive end-expiratory pressure (PEEP), and pneumoperitoneum on respiratory function in morbidly obese patients undergoing laparoscopic gastric banding...
  47. ncbi Physiologic rationale for ventilator setting in acute lung injury/acute respiratory distress syndrome patients
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico IRCCS, Milano, Italy
    Crit Care Med 31:S300-4. 2003
    ..To review the physiologic approach to setting mechanical ventilation in acute lung injury/acute respiratory distress syndrome...
  48. ncbi How to monitor lung recruitment in patients with acute lung injury
    Pietro Caironi
    Istituto di Anestesiologia e Rianimazione, Dipartimento di Anestesia, Rianimazione, e Terapia del Dolore, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Universita degli Studi di Milano, Milan, Italy
    Curr Opin Crit Care 13:338-43. 2007
    ..We review recent findings on this topic and attempt to provide a clinical approach to estimating lung recruitment...
  49. ncbi Prone position delays the progression of ventilator-induced lung injury in rats: does lung strain distribution play a role?
    Franco Valenza
    Universita degli Studi di Milano, Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano IRCCS, Via F Sforza 35, 20122 Milano, Italy
    Crit Care Med 33:361-7. 2005
    ..To investigate if prone position delays the progression of experimental ventilator-induced lung injury, possibly due to a more homogeneous distribution of strain within lung parenchyma...
  50. ncbi Case of exogenous lipoid pneumonia: steroid therapy and lung lavage with an emulsifier
    Riccarda Russo
    Istituto di Anestesia e Rianimazione, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico IRCCS, Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milano, Italy
    Anesthesiology 104:197-8. 2006
  51. ncbi The concept of "baby lung"
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Universita degli Studi, Milan, Italy
    Intensive Care Med 31:776-84. 2005
    ....
  52. ncbi The role of CT-scan studies for the diagnosis and therapy of acute respiratory distress syndrome
    Luciano Gattinoni
    Istituto di Anestesiologia e Rianimazione, Dipartimento di Anestesia, Rianimazione, e Terapia del Dolore, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Universita degli Studi di Milano, Milano, Italy
    Clin Chest Med 27:559-70; abstract vii. 2006
    ..CT assessment of lung recruitability seems to be a prerequisite for a rational setting of positive end-expiratory pressure...
  53. ncbi A blunt complex abdominal trauma: total hepatectomy and liver transplantation
    D Chiumello
    Istituto di Anestesia e Rianimazione, Universita di Milano, Ospedale Policlinico IRCCS, Via Francesco Sforza, 35, 20122 Milano, Italy
    Intensive Care Med 28:89-91. 2002
    ..After 36 h in this anhepatic state, the patient received the new graft. The graft showed immediate recovery. In cases of severe and complex liver trauma, performing a total hepatectomy followed by liver transplantation is justified...
  54. ncbi Equal increases in respiratory system elastance reflect similar lung damage in experimental ventilator-induced lung injury
    Silvio Sibilla
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano, IRCCS, Via F Sforza n 35, 20122 Milan, Italy
    Intensive Care Med 28:196-203. 2002
    ..We hypothesized that a 50% increase in respiratory system elastance (Ers) would indicate similar degree of lung damage (equi-damage, ED), independently of ventilation strategy...
  55. ncbi Intra-abdominal pressure may be decreased non-invasively by continuous negative extra-abdominal pressure (NEXAP)
    Franco Valenza
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Universita degli Studi di Milano, Via F Sforza 35, 20122, Milan, Italy
    Intensive Care Med 29:2063-7. 2003
    ..To investigate the possibility of artificially decreasing intra-abdominal pressure (IAP) by applying continuous negative pressure around the abdomen...
  56. doi Positive end-expiratory pressure
    Luciano Gattinoni
    Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli Regina Elena di Milano, Milan, Italy
    Curr Opin Crit Care 16:39-44. 2010
    ..In the last 2 years, several reports have dealt with recruitment/positive end-expiratory pressure (PEEP) selection. Most of them confirm previous results and few add new information...
  57. ncbi Noninvasive positive pressure ventilation delivered by helmet vs. standard face mask
    Davide Chiumello
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore Policlinico IRCCS, Universita degli Studi di Milano, Via Francesco Sforza 35, 20122 Milan, Italy
    Intensive Care Med 29:1671-9. 2003
    ..This bench and human study compared large and small helmets with face mask (FM) for delivery of noninvasive positive pressure ventilation...
  58. pmc Bench-to-bedside review: chest wall elastance in acute lung injury/acute respiratory distress syndrome patients
    Luciano Gattinoni
    Institute of Anesthesia and Critical Care, University of Milan, Policlinico IRCCS Hospital, Milan, Italy
    Crit Care 8:350-5. 2004
    ..It is always important in the most critically ill patients to assess the intra-abdominal pressure and the chest wall elastance...
  59. ncbi Effects of continuous negative extra-abdominal pressure on cardiorespiratory function during abdominal hypertension: an experimental study
    Franco Valenza
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano Istituto di Ricovero e Cura a Carattere Scientifico, Universita degli Studi di Milano, Via F Sforza 35, 20122 Milan, Italy
    Intensive Care Med 31:105-11. 2005
    ..To investigate whether negative extra-abdominal pressure (NEXAP) improves respiratory function and induces a blood shift from the intrathoracic compartment and to assess whether these effects are influenced by abdominal pressure...
  60. doi Acute lung injury/acute respiratory distress syndrome pathophysiology: what we have learned from computed tomography scanning
    Pietro Caironi
    Istituto di Anestesiologia e Rianimazione, Dipartimento di Anestesia, Rianimazione e Terapia del Dolore, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Universita degli Studi di Milano, Milano, Italy
    Curr Opin Crit Care 14:64-9. 2008
    ..Here, we review recent findings derived from computed tomography scanning during acute respiratory distress syndrome, particularly concerning setting positive end-expiratory pressure and mechanisms of ventilator-induced lung injury...
  61. ncbi Effect of different cycling-off criteria and positive end-expiratory pressure during pressure support ventilation in patients with chronic obstructive pulmonary disease
    Davide Chiumello
    Dipartimento di Anestesia e Rianimazione, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Milan, Italy
    Crit Care Med 35:2547-52. 2007
    ..This study evaluated the effect of two different cycling-off criteria on breathing pattern, respiratory effort, and gas exchange in patients with chronic obstructive pulmonary disease...
  62. ncbi Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome
    Pier Paolo Terragni
    Universita di Torino, Dipartimento di Anestesiologia e Rianimazione, Ospedale S Giovanni Battista Molinette, Corso Dogliotti 14, 10126 Turin, Italy
    Am J Respir Crit Care Med 175:160-6. 2007
    ..Computed tomography demonstrated a small, normally aerated compartment on the top of poorly aerated and nonaerated compartments that may be hyperinflated by tidal inflation...
  63. doi Refining ventilatory treatment for acute lung injury and acute respiratory distress syndrome
    Luciano Gattinoni
    JAMA 299:691-3. 2008
  64. pmc Effects of thoraco-pelvic supports during prone position in patients with acute lung injury/acute respiratory distress syndrome: a physiological study
    Davide Chiumello
    Dipartimento di Anestesia e Rianimazione, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Via F, Sforza 35, 20122 Milan, Italy
    Crit Care 10:R87. 2006
    ....
  65. ncbi Sigh in supine and prone position during acute respiratory distress syndrome
    Paolo Pelosi
    Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi dell Insubria, Ospedale di Circolo, Fondazione Macchi, Varese
    Am J Respir Crit Care Med 167:521-7. 2003
    ..82, p < 0.001). We conclude that adding a recruitment maneuver such as cyclical sighs during ventilation in the prone position may provide optimal lung recruitment in the early stage of ARDS...
  66. ncbi Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study
    Manu L N G Malbrain
    Intensive Care Unit Director, Medical Intensive Care Unit, Ziekenhuis Netwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, B 2060 Antwerpen 6, Belgium
    Crit Care Med 33:315-22. 2005
    ....
  67. ncbi [Use of positive end-expiratory pressure in acute respiratory distress syndrome: current views]
    Pietro Caironi
    Istituto di Anestesiologia e Rianimazione, Dipartimento di Anestesia, Rianimazione e Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano
    Recenti Prog Med 98:509-17. 2007
    ..At present, computed tomography represents the most accurate technique for its measurement...
  68. ncbi Anemia and blood transfusion in critically ill patients
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, Brussels, 1070, Belgium
    JAMA 288:1499-507. 2002
    ..Anemia is a common problem in critically ill patients admitted to intensive care units (ICUs), but the consequences of anemia on morbidity and mortality in the critically ill is poorly defined...
  69. ncbi An increase of abdominal pressure increases pulmonary edema in oleic acid-induced lung injury
    Michael Quintel
    Institut fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum, Mannheim, Mannheim, Germany
    Am J Respir Crit Care Med 169:534-41. 2004
    ..We conclude that in OA-injured lung, the increase of IAP increases the amount of edema...
  70. ncbi Ventilatory management of acute respiratory distress syndrome: a consensus of two
    John J Marini
    University of Minnesota, Regions Hospital, St Paul 55101, USA
    Crit Care Med 32:250-5. 2004
    ..To synthesize the emerging body of experimental, observational, and clinical trial data into a practical guideline for safe and effective ventilatory management of acute respiratory distress syndrome...
  71. pmc Ventilation in the prone position: for some but not for all?
    Luciano Gattinoni
    Istituto di Anestesiologia e Rianimazione, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Universita degli Studi di Milano, Italy
    CMAJ 178:1174-6. 2008