Massimo Galli

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi request reprint Vpr and HIV-1 disease progression: R77Q mutation is associated with long-term control of HIV-1 infection in different groups of patients
    Daniela Mologni
    Institute of Infectious and Tropical Diseases, University of Milan, L Sacco Hospital, Milan, Italy
    AIDS 20:567-74. 2006
  2. ncbi request reprint Body habitus changes and metabolic alterations in protease inhibitor-naive HIV-1-infected patients treated with two nucleoside reverse transcriptase inhibitors
    Massimo Galli
    Institute of Infectious Diseases and Tropical Medicine, L Sacco Hospital, University of Milan, Italy
    J Acquir Immune Defic Syndr 29:21-31. 2002
  3. ncbi request reprint Correlates of risk of adipose tissue alterations and their modifications over time in HIV-1-infected women treated with antiretroviral therapy
    Massimo Galli
    Institute of Infectious Diseases and Tropical Medicine, L Sacco Hospital, University of Milan, Milan, Italy
    Antivir Ther 8:347-54. 2003
  4. ncbi request reprint Cytokine production in women with antiretroviral treatment-associated breast fat accumulation and limb wasting
    Massimo Galli
    Institute of Infectious and Tropical Diseases, University of Milan, Sacco Hospital, Milan, Italy
    AIDS 17:S155-61. 2003
  5. ncbi request reprint Incidence of adipose tissue alterations in first-line antiretroviral therapy: the LipoICoNa Study
    Massimo Galli
    Institute of Infectious Diseases and Tropical Medicine, University of Milan, L Sacco Hospital, Via G B Grassi, 74 20157 Milan, Italy
    Arch Intern Med 162:2621-8. 2002
  6. doi request reprint Effect of antioxidants on mitochondrial function in HIV-1-related lipoatrophy: a pilot study
    Laura Milazzo
    Universita degli Studi di Milano, Department of Clinical Sciences, L Sacco Hospital, Section of Infectious Diseases and Immunopathology, Milan, Italy
    AIDS Res Hum Retroviruses 26:1207-14. 2010
  7. ncbi request reprint Genetic polymorphisms differently influencing the emergence of atrophy and fat accumulation in HIV-related lipodystrophy
    Barbara Zanone Poma
    Department of Clinical Sciences, Luigi Sacco Hospital, University of Milan, Milan, Italy
    AIDS 22:1769-78. 2008
  8. ncbi request reprint Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART
    Giulia Marchetti
    Department of Clinical Sciences, Chair of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Via G B Grassi 74, 20157 Milan, Italy
    AIDS 20:1727-36. 2006
  9. ncbi request reprint IL-7/IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patients
    Giulia Marchetti
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
    Antivir Ther 9:447-52. 2004
  10. pmc Short communication: impact of hepatitis C viral clearance on CD4+ T-lymphocyte course in HIV/HCV-coinfected patients treated with pegylated interferon plus ribavirin
    Laura Milazzo
    Department of Clinical Sciences, Section of Infectious Diseases and Immunopathology L Sacco, Universita degli Studi di Milano, L Sacco Hospital, Milan, Italy
    AIDS Res Hum Retroviruses 28:989-93. 2012

Detail Information

Publications88

  1. ncbi request reprint Vpr and HIV-1 disease progression: R77Q mutation is associated with long-term control of HIV-1 infection in different groups of patients
    Daniela Mologni
    Institute of Infectious and Tropical Diseases, University of Milan, L Sacco Hospital, Milan, Italy
    AIDS 20:567-74. 2006
    ..Recent studies have focused on the role of a mutation at position 77 that might be associated with the condition of long-term non-progression, but data are still controversial...
  2. ncbi request reprint Body habitus changes and metabolic alterations in protease inhibitor-naive HIV-1-infected patients treated with two nucleoside reverse transcriptase inhibitors
    Massimo Galli
    Institute of Infectious Diseases and Tropical Medicine, L Sacco Hospital, University of Milan, Italy
    J Acquir Immune Defic Syndr 29:21-31. 2002
    ..Cross-sectional and retrospective surveys suggest that nucleoside reverse transcriptase inhibitors (NRTIs) contribute to the metabolic and morphologic alterations observed in patients on antiretroviral therapy (ART)...
  3. ncbi request reprint Correlates of risk of adipose tissue alterations and their modifications over time in HIV-1-infected women treated with antiretroviral therapy
    Massimo Galli
    Institute of Infectious Diseases and Tropical Medicine, L Sacco Hospital, University of Milan, Milan, Italy
    Antivir Ther 8:347-54. 2003
    ..To assess the correlates of risk of the different types of lipodystrophy and their modifications over time in a cohort of HIV-positive women receiving antiretroviral therapy (ART)...
  4. ncbi request reprint Cytokine production in women with antiretroviral treatment-associated breast fat accumulation and limb wasting
    Massimo Galli
    Institute of Infectious and Tropical Diseases, University of Milan, Sacco Hospital, Milan, Italy
    AIDS 17:S155-61. 2003
    ..To test the cytokine production of peripheral blood mononuclear cells in a group of HIV-infected women with breast enlargement and lower limb wasting while receiving antiretroviral therapy (ART) including a protease inhibitor...
  5. ncbi request reprint Incidence of adipose tissue alterations in first-line antiretroviral therapy: the LipoICoNa Study
    Massimo Galli
    Institute of Infectious Diseases and Tropical Medicine, University of Milan, L Sacco Hospital, Via G B Grassi, 74 20157 Milan, Italy
    Arch Intern Med 162:2621-8. 2002
    ..Adipose tissue alterations (ATAs) are a frequent untoward effect of antiretroviral therapy, the causes of which remain incompletely explained...
  6. doi request reprint Effect of antioxidants on mitochondrial function in HIV-1-related lipoatrophy: a pilot study
    Laura Milazzo
    Universita degli Studi di Milano, Department of Clinical Sciences, L Sacco Hospital, Section of Infectious Diseases and Immunopathology, Milan, Italy
    AIDS Res Hum Retroviruses 26:1207-14. 2010
    ..Our study showed that antioxidant supplementation may have a protective role on mitochondrial function, with limited effects on the reversal of clinical lipodystrophic abnormalities in HIV-1-infected patients...
  7. ncbi request reprint Genetic polymorphisms differently influencing the emergence of atrophy and fat accumulation in HIV-related lipodystrophy
    Barbara Zanone Poma
    Department of Clinical Sciences, Luigi Sacco Hospital, University of Milan, Milan, Italy
    AIDS 22:1769-78. 2008
    ..Crude rates of lipoatrophy and fat accumulation and adjusted relative rates were calculated using Poisson regression...
  8. ncbi request reprint Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART
    Giulia Marchetti
    Department of Clinical Sciences, Chair of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Via G B Grassi 74, 20157 Milan, Italy
    AIDS 20:1727-36. 2006
    ..A better understanding of the relationship between T-cell dynamics and the HIV intracellular reservoir in HIV-infected patients failing to recover CD4 cell count following long-term HAART, is required...
  9. ncbi request reprint IL-7/IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patients
    Giulia Marchetti
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
    Antivir Ther 9:447-52. 2004
    ..Our data confirm the pivotal role of IL-2 and IL-7 in the regulation of T-lymphocyte homeostasis in HIV infection...
  10. pmc Short communication: impact of hepatitis C viral clearance on CD4+ T-lymphocyte course in HIV/HCV-coinfected patients treated with pegylated interferon plus ribavirin
    Laura Milazzo
    Department of Clinical Sciences, Section of Infectious Diseases and Immunopathology L Sacco, Universita degli Studi di Milano, L Sacco Hospital, Milan, Italy
    AIDS Res Hum Retroviruses 28:989-93. 2012
    ..The clearance of HCV replication did not affect the CD4(+) changes after Peg-IFN-RBV therapy in coinfected patients on efficient cART. Liver fibrosis and higher BMI were negative determinants of immune recovery...
  11. ncbi request reprint Description of a "trans-Saharan" strain of human T-lymphotropic virus type 1 in West Africa
    Gianguglielmo Zehender
    Department of Clinical Sciences L Sacco, Section of Infectious Diseases, University of Milan, Milan, Italy
    J Acquir Immune Defic Syndr 47:269-73. 2008
    ....
  12. pmc Spatial and temporal dynamics of hepatitis B virus D genotype in Europe and the Mediterranean Basin
    Gianguglielmo Zehender
    Department of Clinical Sciences Luigi Sacco, Section of Infectious Diseases, University of Milan, Milano, Italy
    PLoS ONE 7:e37198. 2012
    ..We hypothesise that the main route of dispersion of genotype D was the unsafe use of injections and drug addiction...
  13. doi request reprint Reconstruction of the evolutionary dynamics of hepatitis C virus subtypes in Montenegro and the Balkan region
    Gianguglielmo Zehender
    Department of Biomedical and Clinical Sciences L Sacco, Infectious Diseases and Tropical Medicine Chair, University of Milan, Milan, Italy
    Infect Genet Evol 17:223-30. 2013
    ..Our data suggest multiple introduction of HCV subtypes in the area, supported by different causes of dispersion: adverse social conditions and unsafe medical practices for HCV-1b and i.v. drug use for HCV-3a...
  14. ncbi request reprint Thrombotic microangiopathy in patients with acquired immunodeficiency syndrome before and during the era of introduction of highly active antiretroviral therapy
    Cristina Gervasoni
    Institute of Infectious Diseases and Tropical Medicine, L Sacco Hospital, University of Milan, 20157 Milano, Italy
    Clin Infect Dis 35:1534-40. 2002
    ....
  15. doi request reprint Late presenters in new HIV diagnoses from an Italian cohort of HIV-infected patients: prevalence and clinical outcome
    Antonella d'Arminio Monforte
    Clinic of Infectious and Tropical Diseases, Department of Medicine, Surgery and Dentistry, S Paolo Hospital, University of Milan, Milan, Italy
    Antivir Ther 16:1103-12. 2011
    ..To study the prevalence, predictors and outcome of late HIV diagnosis in the Icona cohort, according to the new European consensus definition of late diagnosis...
  16. pmc Within-host dynamics of the hepatitis C virus quasispecies population in HIV-1/HCV coinfected patients
    Flavia Bernini
    Department of Clinical Sciences L Sacco, University of Milan, Milan, Italy
    PLoS ONE 6:e16551. 2011
    ..We hypothesize that an important role is played by the enlargement of the viral replicative space...
  17. ncbi request reprint Increased CD36 expression on circulating monocytes during HIV infection
    Luca Meroni
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
    J Acquir Immune Defic Syndr 38:310-3. 2005
    ..CD36 is a multifunctional receptor with a wide tissue distribution that plays a crucial role in the cellular uptake and metabolism of lipids...
  18. ncbi request reprint Interleukin-2 immunotherapy exerts a differential effect on CD4 and CD8 T cell dynamics
    Giulia Marchetti
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Italy
    AIDS 18:211-6. 2004
    ..The hallmark of interleukin-2 (IL-2)-induced immune reconstitution is the selective outgrowth of CD4 through undefined mechanisms...
  19. doi request reprint Fluvastatin as an adjuvant to pegylated interferon and ribavirin in HIV/hepatitis C virus genotype 1 co-infected patients: an open-label randomized controlled study
    Laura Milazzo
    Department of Clinical Sciences, University of Milan, L Sacco Hospital, Milan, Italy
    J Antimicrob Chemother 65:735-40. 2010
    ..We evaluated in this open-label, randomized controlled study the efficacy of fluvastatin as adjuvant to pegylated-(PEG)-IFN and ribavirin in HIV/HCV genotype 1 co-infected patients...
  20. doi request reprint Reconstruction of the epidemic history of hepatitis B virus genotype D in Albania
    Gianguglielmo Zehender
    Department of Clinical Sciences Luigi Sacco, Chair of Infectious Diseases, University of Milan, Milan, Italy
    Infect Genet Evol 12:291-8. 2012
    ..Our data suggest that political and socio-economic factors played an important role in determining the rapid spread of HBV infection in Albania...
  21. doi request reprint Rapid molecular evolution of human bocavirus revealed by Bayesian coalescent inference
    Gianguglielmo Zehender
    Universita degli Studi di Milano, Dipartimento di Scienze Cliniche L Sacco, Sezione di Malattie Infettive, Via G B Grassi, 74 20157 Milano, Italy
    Infect Genet Evol 10:215-20. 2010
    ..The low level of polymorphism is probably due to a relatively recent divergence between the circulating genotypes and strong purifying selection acting on viral antigens...
  22. ncbi request reprint Phylogeny of human T cell lymphotropic virus type 1 in Peru: a high degree of evolutionary relatedness with South African isolates
    Gianguglielmo Zehender
    Department of Clinical Sciences L Sacco, Section of Infectious Diseases, University of Milan, Italy
    AIDS Res Hum Retroviruses 23:1146-9. 2007
    ..These data show a high prevalence of HTLV-1 infection in HIV-1-positive subjects living in Lima and confirm the presence in Latin America of HTLV-1 strains probably arising from South Africa...
  23. ncbi request reprint Telbivudine in the treatment of chronic hepatitis B: experience in HIV type-1-infected patients naive for antiretroviral therapy
    Laura Milazzo
    Department of Clinical Sciences, Infectious Diseases and Immunopathology, University of Milan, Milan, Italy
    Antivir Ther 14:869-72. 2009
    ....
  24. doi request reprint Recombination analysis and structure prediction show correlation between breakpoint clusters and RNA hairpins in the pol gene of human immunodeficiency virus type 1 unique recombinant forms
    Andrea Galli
    Department of Clinical Sciences L Sacco, University of Milan, Milan, Italy
    J Gen Virol 89:3119-25. 2008
    ..These findings suggest that such hairpins may play a role in the higher recombination rates detected at these positions...
  25. doi request reprint Different evolutionary rates and epidemic growth of hepatitis B virus genotypes A and D
    Gianguglielmo Zehender
    Department of Clinical Sciences Luigi Sacco, Section of Infectious Diseases, University of Milan, Milan, Italy
    Virology 380:84-90. 2008
    ..These results show the usefulness of phylodynamic studies in reconstructing the history of epidemics due to highly variable DNA viruses, and in evaluating the long-term efficacy of prophylactic measures...
  26. ncbi request reprint Gender differences in antiretroviral drug-related adipose tissue alterations. Women are at higher risk than men and develop particular lipodystrophy patterns
    Massimo Galli
    Institute of Infectious and Tropical Diseases, University of Milan, Italy
    J Acquir Immune Defic Syndr 34:58-61. 2003
    ..Our results indicate that women are at higher risk of developing antiretroviral treatment-related ATAs and show a particular and complex ATA pattern...
  27. doi request reprint Phylogeography and epidemiological history of West Nile virus genotype 1a in Europe and the Mediterranean basin
    Gianguglielmo Zehender
    Department of Clinical Sciences L Sacco, University of Milan, c o Ospedale L Sacco, Via G B Grassi 74, Milan, Italy
    Infect Genet Evol 11:646-53. 2011
    ....
  28. pmc Transmission of resistant HIV type 1 variants and epidemiological chains in Italian newly diagnosed individuals
    Alessia Lai
    Department of Clinical Sciences L Sacco Hospital, Section of Infectious Diseases and Immunopathology, University of Milan, Milan, Italy
    AIDS Res Hum Retroviruses 28:857-65. 2012
    ..Intervention strategies of public health are needed to limit HIV-1 transmission and the associated TDR...
  29. ncbi request reprint Liver-related factors associated with low vitamin D levels in HIV and HIV/HCV coinfected patients and comparison to general population
    Laura Milazzo
    Section of Infectious Diseases and Immunopathology, Department of Clinical Sciences L Sacco, Universita degli Studi di Milano, L Sacco Hospital, Milan, Italy
    Curr HIV Res 9:186-93. 2011
    ..Furthermore, hypovitaminosis D was reported in HIV-infected individuals, but its role in liver disease progression in HIV/HCV coinfection is unknown...
  30. doi request reprint Population dynamics of HIV-1 subtype B in a cohort of men-having-sex-with-men in Rome, Italy
    Gianguglielmo Zehender
    Department of Clinical Sciences, L Sacco, University of Milan, Milan, Italy
    J Acquir Immune Defic Syndr 55:156-60. 2010
    ..Epidemiological clusters originating in the early 2000s suggest a recent re-emergence of HIV in Italian MSM...
  31. ncbi request reprint Thalidomide in the treatment of chronic hepatitis C unresponsive to alfa-interferon and ribavirin
    Laura Milazzo
    Institute of Infectious and Tropical Diseases, University of Milan, Milan, Italy
    Am J Gastroenterol 101:399-402. 2006
    ....
  32. ncbi request reprint Immunomodulation induced by tucaresol in HIV infection: results of a 16 week pilot Phase I/II trial
    Andrea Gori
    Institute of Infectious Diseases and Tropical Medicine, L Sacco Hospital, University of Milan, Milan, Italy
    Antivir Ther 9:603-14. 2004
    ..In a Phase I/II clinical trial performed on HIV-positive patients we analysed the safety and immunomodulating effects of tucaresol, a novel compound that has previously been described tn enhance cell-mediated immune responses...
  33. doi request reprint Noncirrhotic portal hypertension in HIV-infected patients: a case control evaluation and review of the literature
    Miriam Cesari
    Section of Infectious Diseases and Immunopathology, Department of Clinical Sciences, Universita di Milano, L Sacco Hospital, Milan, Italy
    AIDS Patient Care STDS 24:697-703. 2010
    ....
  34. doi request reprint Trends and predictors of non-AIDS-defining cancers in men and women with HIV infection: a single-institution retrospective study before and after the introduction of HAART
    Marco Franzetti
    Infectious Diseases Section, L Sacco Department of Clinical Sciences, University of Milan, Milan, Italy Institute of Biomedical Technologies, National Research Council, Segrate, Milan, Italy Division of Pathology, L Sacco Hospital, Milan, Italy
    J Acquir Immune Defic Syndr 62:414-20. 2013
    ..Most studies of the risk and spectrum of NADCs are primarily based on male populations, and only a few have provided specific information regarding females...
  35. ncbi request reprint Prospective observational study of fever in hospitalized returning travelers and migrants from tropical areas, 1997-2001
    Spinello Antinori
    Institute of Infectious and Tropical Diseases, L Sacco Hospital, University of Milan, Via GB Grassi 74, 20157 Milan, Italy
    J Travel Med 11:135-42. 2004
    ..We conducted a 5-year prospective observational study on the causes of fever in patients admitted to a university teaching hospital after returning from the tropics...
  36. pmc Reconstruction of the evolutionary dynamics of the A(H1N1)pdm09 influenza virus in Italy during the pandemic and post-pandemic phases
    Gianguglielmo Zehender
    Dipartimento di Scienze Cliniche e Biomediche Luigi Sacco, Sezione di Malattie Infettive, Universita degli Studi di Milano, Milan, Italy
    PLoS ONE 7:e47517. 2012
    ..In conclusion, the A(H1N1)pdm09 virus was introduced into Italy in the spring of 2009 by means of multiple importations. This was followed by repeated founder effects in the post-pandemic period that originated specific Italian clades...
  37. pmc Comparison of the in vivo pharmacokinetics and in vitro dissolution of raltegravir in HIV patients receiving the drug by swallowing or by chewing
    Dario Cattaneo
    Department of Infectious Diseases, L Sacco University Hospital, Milan, Italy
    Antimicrob Agents Chemother 56:6132-6. 2012
    ..This is related to problems in tablet disintegration and to erratic drug absorption. The amelioration of the RAL pharmaceutical formulation could improve drug pharmacokinetics...
  38. pmc Efficacy and safety of a dual boosted protease inhibitor-based regimen, atazanavir and fosamprenavir/ritonavir, against HIV: experience in a pediatric population
    Stefano Rusconi
    Department of Biomedical and Clinical Science Luigi Sacco, Infectious Diseases, University of Milan, Milan, Italy
    BMC Infect Dis 12:179. 2012
    ....
  39. pmc Increased bone marrow interleukin-7 (IL-7)/IL-7R levels but reduced IL-7 responsiveness in HIV-positive patients lacking CD4+ gain on antiviral therapy
    Giusi Maria Bellistri
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
    PLoS ONE 5:e15663. 2010
    ....
  40. ncbi request reprint Long-term efficacy of the surgical treatment of buffalo hump in patients continuing antiretroviral therapy
    Cristina Gervasoni
    Institute of Infectious Diseases and Tropical Medicine, L Sacco Hospital, University of Milan, Bicocca, Italy
    AIDS 18:574-6. 2004
    ....
  41. doi request reprint Microbial translocation predicts disease progression of HIV-infected antiretroviral-naive patients with high CD4+ cell count
    Giulia Marchetti
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Italy
    AIDS 25:1385-94. 2011
    ..We investigated the significance of microbial translocation measured on average 3 years after HIV seroconversion in driving disease progression in HIV untreated patients with high CD4(+) cell count...
  42. pmc Bayesian phylogeography of Crimean-Congo hemorrhagic fever virus in Europe
    Gianguglielmo Zehender
    Department of Clinical Sciences Luigi Sacco, Section of Infectious Diseases, University of Milan, Milano, Italy
    PLoS ONE 8:e79663. 2013
    ..Given the close proximity of the infected areas, our data suggest that the movement of wild and domestic ungulates from endemic areas was probably the main cause of the dissemination of the virus in eastern Europe. ..
  43. pmc Low body weight in females is a risk factor for increased tenofovir exposure and drug-related adverse events
    Cristina Gervasoni
    Department of Infectious Disease, L Sacco University Hospital, Milan, Italy
    PLoS ONE 8:e80242. 2013
    ....
  44. ncbi request reprint Does GSS still maintain relevance on HAART outcome after the introduction of newest active antiretroviral drugs? 48 weeks results
    Massimiliano Ortu
    Clinical Sciences Department Luigi Sacco, Infectious Diseases and Immunopathology Section, University of Milan, Italy
    Curr HIV Res 9:625-9. 2011
    ....
  45. ncbi request reprint [13C]Methionine breath test: a novel method to detect antiretroviral drug-related mitochondrial toxicity
    Laura Milazzo
    Institute of Infectious and Tropical Diseases, University of Milan, L Sacco Hospital, Via GB Grassi 74, 20157 Milan, Italy
    J Antimicrob Chemother 55:84-9. 2005
    ..We used the [(13)C]methionine breath test to investigate hepatic mitochondrial oxidation in HIV-1-infected patients receiving antiretroviral therapy...
  46. ncbi request reprint Skewed T-cell maturation and function in HIV-infected patients failing CD4+ recovery upon long-term virologically suppressive HAART
    Giulia Marchetti
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
    AIDS 24:1455-60. 2010
    ..Analysis of functionally defined T-cell differentiation in HIV-infected patients with low CD4(+) on virologically suppressive HAART is crucial to design clinically efficacious treatments...
  47. ncbi request reprint High level of genetic heterogeneity in S and P genes of genotype D hepatitis B virus
    Chiara De Maddalena
    Department of Clinical Sciences Luigi Sacco, Section of Infectious Diseases, University of Milan, Milan, Italy
    Virology 365:113-24. 2007
    ....
  48. doi request reprint Prevalence and risk determinants of HIV-1 and HIV-2 infections in pregnant women in Bissau
    Erika Gianelli
    Infectious Diseases and Immunopathology Section, Department of Clinical Sciences, University of Milan, L Sacco Hospital, Via GB Grassi 74, 20157 Milano, Italy
    J Infect 61:391-8. 2010
    ..To analyse the risk determinants of HIV-1 and HIV-2 infections in pregnant women in Bissau...
  49. doi request reprint Subtype assignment and phylogenetic analysis of HIV type 1 strains in patients from Swaziland
    Lorenzo Dehò
    Department of Clinical Sciences, Infection Diseases Section, Luigi Sacco Hospital, University of Milan, Milan, Italy
    AIDS Res Hum Retroviruses 24:323-5. 2008
    ..This finding may be explained by multiple introduction of C strains...
  50. ncbi request reprint Enfuvirtide administration in HIV-positive transgender patient with soft tissue augmentation: US evaluation
    Eugenia Gabrielli
    Clinical Science Department, Section of Infectious Diseases, University of Milan, L Sacco Hospital, Milan, Italy
    New Microbiol 33:263-5. 2010
    ..US can be useful in the correct management of those patients with liquid silicone oil soft tissue augmentation who require subcutaneously injected drugs...
  51. ncbi request reprint Abacavir hypersensitivity reaction after switching from the twice-daily to the once-daily formulation
    Cristina Gervasoni
    Clinical Science Department, Section of Infectious Diseases, University of Milan, L Sacco Hospital, Via GB Grassi 74 20157 Milan, Italy
    AIDS Patient Care STDS 21:1-3. 2007
    ..At the time of this change, his CD4 count was 1069 cell/mm(3) and HIV-RNA undetectable. Our case suggests that patients should be carefully monitored after switching, and warned about the potential effects...
  52. ncbi request reprint Analysis of the env V3 sequences obtained from patients with HIV type 1 infection treated with the immune modulant agent tucaresol
    Elisabetta Bulgheroni
    Institute of Infectious and Tropical Diseases, University of Milan, Ospedale Luigi Sacco, 20157 Milan, Italy
    AIDS Res Hum Retroviruses 21:815-9. 2005
    ..The administration of tucaresol did not accelerate env V3 evolution thus preventing modifications of HIV-1 tropism over time...
  53. pmc A nonparametric procedure for defining a new humoral immunologic profile in a pilot study on HIV infected patients
    Chiara Brombin
    Centro Universitario di Statistica per le Scienze Biomediche, University Centre of Statistics in the Biomedical Sciences, Vita Salute San Raffaele University, Milan, Italy
    PLoS ONE 8:e58768. 2013
    ..Virus neutralization of primary virus strains and antibodies to gp41 were required to classify patients, suggesting that clinical profiles strongly rely on functional activity against HIV...
  54. pmc Expression of interleukin-15 and interleukin-15Rα in monocytes of HIV type 1-infected patients with different courses of disease progression
    Maciej Tarkowski
    Department of Clinical Sciences, Section of Infectious Diseases and Tropical Medicine, University of Milan, Milan, Italy
    AIDS Res Hum Retroviruses 28:693-701. 2012
    ..They also provide important information concerning the mechanisms of infection and the potential use of IL-15 as a therapeutic agent...
  55. doi request reprint Bayesian skyline plot inference of the Toscana virus epidemic: a decline in the effective number of infections over the last 30 years
    Gianguglielmo Zehender
    Department of Clinical Sciences L Sacco, Section of Infectious Diseases, University of Milan, Milan, Italy
    Infect Genet Evol 9:562-6. 2009
    ..In conclusion, our data suggest that continuous and prolonged perturbations of vector/phlebovirus interactions due to the relatively recent climate changes may have contributed to gradually reducing the viral population in endemic areas...
  56. ncbi request reprint Maintenance of breast size reduction after mastoplasty and switch to a protease inhibitor-sparing regimen in an HIV-positive woman with highly active antiretroviral therapy-associated massive breast enlargement
    Cristina Gervasoni
    Institute of Infectious Diseases and Tropical Medicine, University of Milan, Milan, Italy
    AIDS Patient Care STDS 16:307-11. 2002
    ..Here we describe the successful and lasting treatment of a massive and movement/posture-hampering breast hypertrophy with reductive mastoplasty...
  57. ncbi request reprint Increased risk of developing peripheral neuropathy in patients coinfected with HIV-1 and HTLV-2
    Gianguglielmo Zehender
    Istituto di Malattie Infettive e Tropicali, Universita degli Studi di Milano, Milan, Italy
    J Acquir Immune Defic Syndr 31:440-7. 2002
    ....
  58. ncbi request reprint Risk factors for HIV/AIDS in a low HIV prevalence site of sub-Saharan Africa
    Francesco Croce
    Infectious Diseases Unit, Department of Clinical Sciences L Sacco, University of Milan, Milano, Italy
    Trop Med Int Health 12:1011-7. 2007
    ..HIV/AIDS prevention strategies must primarily be addressed to traditional high-risk groups and secondarily to unsafe health care procedures in relatively preserved sub-Saharan areas...
  59. ncbi request reprint Phylogeography and phylodynamics of European genotype 3 hepatitis E virus
    Gianguglielmo Zehender
    Department of Biomedical and Clinical Sciences L Sacco, University of Milan, Milan, Italy Electronic address
    Infect Genet Evol 25:138-43. 2014
    ....
  60. doi request reprint Recommendations for the management of mixed cryoglobulinemia syndrome in hepatitis C virus-infected patients
    Maurizio Pietrogrande
    Medicina Interna, Department of Medicine, Surgery and Dentistry, Policlinico San Marco of Zingonia, University of Milan, Italy
    Autoimmun Rev 10:444-54. 2011
    ..The objective of this review was to define a core set of recommendations for the treatment of HCV-associated mixed cryoglobulinemia syndrome (MCS) by combining current evidence from clinical trials and expert opinion...
  61. ncbi request reprint High prevalence of human T-lymphotropic virus type 1 (HTLV-1) in immigrant male-to-female transsexual sex workers with HIV-1 infection
    Gianguglielmo Zehender
    Istituto di Malattie Infettive e Tropicali Università di Milano, Centro Interdisciplinare per gli Studi Biomolecolari e le Applicazioni Industriali CISI, Milan, Italy
    J Med Virol 74:207-15. 2004
    ..These results suggest the independent origin of each infection in the patient's birthplace. The data raise concerns about the further spread of HTLV infections mainly through the sexual route...
  62. ncbi request reprint Identification of a new HIV-1 BC circulating recombinant form (CRF60_BC) in Italian young men having sex with men
    Francesco Roberto Simonetti
    Department of Biomedical and Clinical Sciences, Infectious Diseases and Immunopathology Section, L Sacco Hospital, University of Milan, Italy
    Infect Genet Evol 23:176-81. 2014
    ..These recombinant isolates, designated CRF60_BC, led to the identification of the first Italian circulating recombinant form, which gave rise to an epidemic burst mainly involving MSM. ..
  63. doi request reprint Reversible posterior leukoencephalopathy syndrome in 2 HIV-infected patients receiving antiretroviral therapy
    Anna Lisa Ridolfo
    Department of Clinical Sciences, Section of Infectious Diseases and Immunopathology, University of Milan, Milan, Italy
    Clin Infect Dis 46:e19-22. 2008
    ..We discuss the role of antiretroviral therapy-associated metabolic alterations in endothelial damage, hypertension, and reversible posterior leukoencephalopathy syndrome...
  64. ncbi request reprint Low-dose prolonged intermittent interleukin-2 adjuvant therapy: results of a randomized trial among human immunodeficiency virus-positive patients with advanced immune impairment
    Giulia Marchetti
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
    J Infect Dis 186:606-16. 2002
    ..Thus, adjuvant IL-2 therapy in immunologic nonresponders resulted in a clinical benefit, suggesting that the quantitative cell recovery involves functionally competent immune cells...
  65. ncbi request reprint Accumulation of drug-related mutations in HIV-1 genome and virus replicative capacity in multi-drug failure subjects
    Stefano Rusconi
    Istituto di Malattie Infettive e Tropicali, Universita di Milano, Ospedale Luigi Sacco, Milano, Italy
    J Antimicrob Chemother 49:427-9. 2002
  66. doi request reprint New macrocyclic amines showing activity as HIV entry inhibitors against wild type and multi-drug resistant viruses
    Stefano Rusconi
    Dipartimento di Scienze Cliniche Luigi Sacco, Sezione di Malattie Infettive e Immunopatologia, Universita degli Studi, Ospedale Luigi Sacco, Milano, Italy
    Molecules 14:1927-37. 2009
    ..These macrocyclic polyamines constitute a promising class of HIV entry inhibitors...
  67. pmc Compartmentalization of hepatitis C virus quasispecies in blood mononuclear cells of patients with mixed cryoglobulinemic syndrome
    Gianguglielmo Zehender
    Istituto di Malattie Infettive e Tropicali, Università di Milano c o Ospedale L Sacco, Via G B Grassi 74, 20157 Milan, Italy
    J Virol 79:9145-56. 2005
    ..The frequent HCV quasispecies compartmentalization in patients' PBMC suggests a possible pathogenetic significance...
  68. ncbi request reprint ADAMTS 13 genotype and vWF protease activity in an Italian family with TTP
    Giovanna Bestetti
    Institute of Infectious Disease and Tropical Medicine, L Sacco Hospital, Via G B Grassi, 74 20157 Milan, Italy
    Thromb Haemost 90:955-6. 2003
  69. doi request reprint Inter- and intra-patient variability of raltegravir pharmacokinetics in HIV-1-infected subjects
    Dario Cattaneo
    Unit of Clinical Pharmacology, Luigi Sacco University Hospital, Universita di Milano, Milan, Italy
    J Antimicrob Chemother 67:460-4. 2012
    ..The present study was designed to evaluate in parallel the inter- and intra-patient variability of raltegravir pharmacokinetics in HIV-1-infected patients during routine therapeutic drug monitoring (TDM)...
  70. ncbi request reprint Evolution of the HIV-1 protease region in heavily pretreated HIV-1 infected patients receiving Atazanavir
    Barbara Vergani
    Sezione di Malattie Infettive e Immunopatologia, Dipartimento di Scienze Cliniche Luigi Sacco, Universita degli Studi, Milano, Italy
    J Clin Virol 41:154-9. 2008
    ..In treatment-experienced patients ATV resistance is characterised by the accumulation of at least four mutations among those that confer cross-resistance to the PIs...
  71. doi request reprint Comparability of echographic and tomographic assessments of body fat changes related to the HIV associated adipose redistribution syndrome (HARS) in antiretroviral treated patients
    Rosario Gulizia
    Division of Infectious and Tropical Diseases, Foundation IRCCS S Matteo, University of Pavia, Pavia, Italy
    Ultrasound Med Biol 34:1043-8. 2008
    ..Given the proven efficacy on the HARS assessments, if well standardized, US could be a reliable method, simpler than CT in the management of body fat changes related to HARS...
  72. doi request reprint Untangling the immunological implications of nadir on CD4+ cell recovery during suppressive highly active antiretroviral therapy
    Laurenzia Ferraris
    Clin Infect Dis 46:149-50. 2008
  73. ncbi request reprint Reduced levels of CD4 cell spontaneous apoptosis in human immunodeficiency virus-infected patients with discordant response to protease inhibitors
    Luca Meroni
    J Infect Dis 186:143-4. 2002
  74. ncbi request reprint Low expression of inhibitory natural killer receptors in CD8 cytotoxic T lymphocytes in long-term non-progressor HIV-1-infected patients
    Paola Costa
    Dipartimento di Medicina Interna, University of Genova, Genoa, Italy
    AIDS 17:257-60. 2003
    ..The lack of iNKR-mediated functional inhibition of HIV-1-specific cytotoxic T lymphocytes in vitro could provide an additional mechanism for the efficient control of virus spread in LTNP patients...
  75. ncbi request reprint Relationship between HAART adherence and adipose tissue alterations
    Adriana Ammassari
    Clinica delle Malattie Infettive, Universita Cattolica del S Cuore, Roma, Italy
    J Acquir Immune Defic Syndr 31:S140-4. 2002
    ..Better adherence is associated with a higher risk of subsequent occurrence of ATA, while patient-perceived onset of morphologic alterations can reduce adherence to antiretroviral therapy...
  76. ncbi request reprint Pneumocystis carinii pneumonia after the discontinuation of long-term antiretroviral therapy in an HIV-1-infected pregnant woman
    Cristina Gervasoni
    AIDS 17:940-1. 2003
  77. ncbi request reprint Increased mitochondrial DNA content in peripheral blood lymphocytes from HIV-infected patients with lipodystrophy
    Andrea Cossarizza
    Department of Biomedical Sciences, Section of General Pathology, University of Modena and Reggio Emilia School of Medicine, Modena, Italy
    Antivir Ther 8:315-21. 2003
    ..However, further studies are needed to confirm these initial observations and ascertain whether the quantification of mtDNA in PBL is a useful and reliable marker to investigate and monitor HAART-related changes in fat distribution...
  78. ncbi request reprint Absence of new thymidine-associated mutations and evidence of an immune virologic response over a 12-month period in a cohort of antiretroviral-experienced HIV-1-infected subjects treated with tenofovir combination therapy
    Mirko Lo Cicero
    J Acquir Immune Defic Syndr 40:238-41. 2005
  79. ncbi request reprint Increased CD36 expression in vertically human immunodeficiency virus-infected children unrelated to antiretroviral therapy
    Luca Meroni
    Pediatr Infect Dis J 24:576-7. 2005
  80. ncbi request reprint Hepatitis B virus genotype distribution in HIV-1 coinfected patients
    Gianguglielmo Zehender
    Gastroenterology 125:1559-60; author reply 1660. 2003
  81. ncbi request reprint Unusual codon 69 insertions: influence on human immunodeficiency virus type 1 reverse transcriptase drug susceptibility
    Elisabetta Bulgheroni
    Istituto di Malattie Infettive e Tropicali, Universita degli Studi, Ospedale Luigi Sacco, Via GB Grassi 74, 20157 Milan, Italy
    J Clin Virol 29:27-32. 2004
    ..It may take place through different pathways: one of these is the codon 69 insertion, which can involve several 2-amino acid patterns...
  82. ncbi request reprint Incidence and characteristics of non-Hodgkin lymphomas in a multicenter case file of patients with hepatitis C virus-related symptomatic mixed cryoglobulinemias
    Giuseppe Monti
    Unità Operativa di Medicina Generale, Saronno Hospital, Italy
    Arch Intern Med 165:101-5. 2005
    ..Some patients with cryoglobulinemic syndrome (CS) develop frank non-Hodgkin lymphoma (NHL), but the incidence and timing of this event are still poorly defined...
  83. ncbi request reprint Delayed-type hypersensitivity skin testing can predict CD4 count increase in HIV patients with poor immunologic response to HAART
    Luca Meroni
    J Acquir Immune Defic Syndr 33:277-8. 2003
  84. ncbi request reprint Analysis of protease inhibitor combinations in vitro: activity of lopinavir, amprenavir and tipranavir against HIV type 1 wild-type and drug-resistant isolates
    Elisabetta Bulgheroni
    Istituto di Malattie Infettive e Tropicali, Universita degli Studi, Ospedale Luigi Sacco, Via GB Grassi 74, 20157 Milano, Italy
    J Antimicrob Chemother 53:464-8. 2004
    ..Despite the increasing number of antiretroviral compounds, the number of useful drug regimens is limited owing to the high frequency of cross-resistance...
  85. ncbi request reprint Is switching protease inhibitor-based effective antiretroviral therapy safe in patients with AIDS-associated Kaposi's sarcoma?
    Anna Lisa Ridolfo
    AIDS 18:1224-6. 2004
  86. ncbi request reprint Controversy concerning role of ultrasonographic lipoatrophy assessments in HIV patients
    Rosario Gulizia
    AIDS 20:789-90. 2006
  87. ncbi request reprint The pavia consensus statement
    Paul A Volberding
    University of California, San Francisco, USA
    AIDS 17:S170-9. 2003
  88. ncbi request reprint Establishment of an ex vivo model of monocytes-derived macrophages differentiated from peripheral blood mononuclear cells (PBMCs) from HIV-1 transgenic rats
    Renata Mazzucchelli
    Division of Basic Science, Institute of Human Virology, University of Maryland, 725 W Lombard St, Baltimore MD, 21201, USA
    Mol Immunol 41:979-84. 2004
    ..This model can be used to study function of HIV-infected MDM and their behavior like HIV-1 reservoir. Ultimately, these studies may be helpful in defining approaches to control HIV-1 spread...